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  • distal nerve
  • For example, in a rat model, large bundles of greater than 20 axons are found exiting the L5 dorsal root ganglion, while smaller bundles of average 3 axons are found in distal nerve segments. (wikipedia.org)
  • repair and regeneration
  • In humans, PRP has been investigated and used as a clinical tool for several types of medical treatments, including chronic tendinitis, osteoarthritis, for bone repair and regeneration, in oral surgery, and in plastic surgery, for example using a platelet-rich fibrin matrix method. (wikipedia.org)
  • upregulation
  • Blockade of RAGE may be beneficial in the acute complications of diabetic neuropathy, at least in part, via upregulation of regeneration signals. (diabetesjournals.org)
  • This is accomplished by the upregulation of a vast array of regeneration-associated genes (RAGs) including the rapid induction of transcription factors and enhanced synthesis of adhesion molecules, cytoskeletal elements, growth factors, cytokines, neuropeptides, and other molecules involved in regeneration. (frontiersin.org)
  • methods
  • By Methods include stem cell therapy, direct nerve repair, nerve grafting and others. (sbwire.com)
  • increasing number of geriatric individuals alongside developing interest for holding youthful and beauty and the advantages of Reconstructive surgery such as reduction from possibly harmful surgical methods, reduce the surgical danger for elderly patients are also growing the market for nerve reconstructive. (sbwire.com)
  • growth
  • Building nerve grafts and manipulating enzymes and other molecular components involved in cell growth are some of the techniques which are being investigated to attempt to engineer optic nerve regeneration. (wisegeek.com)
  • BDNF is a growth factor expressed by the BDNF gene, and is important in neuronal development in the optic nerve. (wisegeek.com)
  • Over-production of this growth factor through gene therapy has resulted in regeneration of nerve connections in mice. (wisegeek.com)
  • The nervous system is capable of being modified to a level where we can achieve nerve fiber growth. (rxpgnews.com)
  • Tissue engineering related to growth factors has arisen as an alternative approach for triggering and improving nerve regeneration. (go.jp)
  • Therefore, the aim of this review is to provide a comprehensive analysis related to growth factors as tools for optimizing the regeneration process. (go.jp)
  • Studies and reviews on the use of growth factors for nerve regeneration were compiled over the course of the review. (go.jp)
  • Activation of B-RAF enables regenerative axon growth in the crush-lesioned optic nerve via the canonical effectors MEK1/MEK2. (arvojournals.org)
  • D) Regenerative growth in lesioned kaB-RAF expressing optic nerve. (arvojournals.org)
  • The term nerve growth factor usually refers to the 2.5S, 26-kDa beta subunit of the protein, the only component of the 7S NGF complex that is biologically active (i.e. acting as signaling molecules). (wikipedia.org)
  • Moreover
  • Moreover, the regenerative capacity of corneal nerves following wounding is impaired in the corneas of diabetic patients compared to normal B6 mouse corneas. (medindia.net)
  • Moreover, the continuity of coapted nerves or an explicit gap in the unrepaired group was detectable at every time point. (biomedsearch.com)
  • CNTF
  • Yu said the impairment of sensory nerve regeneration in diabetic corneas is due to decreased ciliary neurotrophic factor, as evidenced by the fact that dendritic cells express ciliary neurotrophic factor (CNTF) in normal and healing corneas but decrease in diabetic corneas due to the reduced infiltration of dendritic cells. (medindia.net)
  • Dendritic cells mediate sensory nerve innervation and regeneration through direct cell-to-cell contact and CNTF secretion. (medindia.net)
  • Yu further mentioned that the study showed that the application of exogenous CNTF - and, more strikingly, its soluble receptor CNTFR-alpha - can partially reverse the adverse effects of diabetes on sensory nerve and nerve regeneration. (medindia.net)
  • Intravitreal application of CNTF further enhances axon regeneration from SOCS3-deleted RGCs. (wingsforlife.com)
  • gene therapy
  • Professor Joost Verhaagen (NIN) explains: "The stealth gene switch is an important step forward towards the development of gene therapy for nerve damage. (eurekalert.org)