NeuritisAutosomal dominantLeber'sFibersNeuropathiesMuscle atrophyCerebellar AtrophyNeuropathyRetinaTreatment for opticDrusenDiagnosisRetinal ganglTumorAcuteDisordersGlaucomaNerve'sPeripapillaryPeripheral nervesCongenitalDamageSpinal cordAxonsClinicallyGlaucomatousMyelinSymptomsDeteriorationDysfunctionCranial nerveStemImpulsesRegenerationMitochondrialIntracranialSevereLateralEdemaFibresConductionGraduallyNutritionalDiseaseVisualFiber layerDisorderMusclesVision
Neuritis13
- Optic neuritis is an inflammation of the optic nerve. (medlineplus.gov)
- The aim of this review is to summarize the latest information about optic neuritis, its differential diagnosis and management. (openophthalmologyjournal.com)
- Optic Neuritis (ON) is defined as inflammation of the optic nerve, which is mostly idiopathic. (openophthalmologyjournal.com)
- According to Optic Neuritis Treatment Trial (ONTT) the first line of treatment is intravenous methylprednisolone with faster recovery and less chance of recurrence of ON and conversion to MS. However oral prednisolone alone is contraindicated due to increased risk of a second episode. (openophthalmologyjournal.com)
- The term optic neuritis (ON) refers to inflammation of the optic nerve due to many causes, indicated by sub-acute unilateral painful visual loss mostly in a young healthy female and by excluding glaucoma, ON is the most common optic neuropathy in persons under 50 years coming to general ophthalmic practice. (openophthalmologyjournal.com)
- This article reviews available studies published in English and Spanish regarding optic neuritis, its differential diagnosis and management. (openophthalmologyjournal.com)
- VEP is clearly more sensitive than physical examination in detecting optic neuritis. (medscape.com)
- The role of intravenous steroids is a proven treatment in case of optic neuritis or arthritic anterior ischemic optic neuropathy. (stemcellcareindia.com)
- Multiple sclerosis causes optic neuritis, which is an inflammation (swelling) of the optic nerve. (stemcellcareindia.com)
- Optic neuritis, an inflammation or swelling that affects the optic nerve area, this is the reason of multiple sclerosis. (stemcellcareindia.com)
- Optic neuritis is an inflammatory injury of the optic nerve that causes vision loss, which is common in MS and other CNS inflammatory disorders. (medscape.com)
- While Leber's hereditary optic neuropathy (LHON) and optic neuritis (ON) are both clinically significant causes for optic atrophy, both relatively rare in the general population, contributing to limitations in obtaining large imaging datasets. (bvsalud.org)
- Typical symptoms of relapses may be referable to demyelinating pathology involving the optic nerves (e.g. optic neuritis), brainstem (e.g. internuclear ophthalmoplegia) or spinal cord (e.g. partial myelitis), although non-specific symptoms referable to the cerebral hemispheres or other brain regions can also occur (Katz Sand and Lublin, 2013). (medscape.com)
Autosomal dominant6
- Autosomal dominant optic atrophy (ADOA), caused by mutations in OPA1, is a neurodegenerative disease affecting mainly retinal ganglion cells (RGCs). (omicsdi.org)
- Mitochondrial oxidative phosphorylation compensation may preserve vision in patients with OPA1-linked autosomal dominant optic atrophy. (omicsdi.org)
- Autosomal Dominant Optic Atrophy (ADOA) is the most common inherited optic atrophy where vision impairment results from specific loss of retinal ganglion cells of the optic nerve. (omicsdi.org)
- Mitochondrial oxidative phosphorylation in autosomal dominant optic atrophy. (omicsdi.org)
- Autosomal dominant optic atrophy (ADOA), a form of progressive bilateral blindness due to loss of retinal ganglion cells and optic nerve deterioration, arises predominantly from mutations in the nuclear gene for the mitochondrial GTPase, OPA1. (omicsdi.org)
- Her research lab aims to identify the first genes for autosomal dominant optic disc drusen. (stanford.edu)
Leber's3
- ON in neuromyelitis optica (NMO) is initially misdiagnosed as ON in MS or other conditions such as Anterior Ischemic Optic Neuropathy (AION) and Leber's disease. (openophthalmologyjournal.com)
- An hereditary syndrome in which a person loses vision in one eye and then the other (known as Leber's inherited optic neuropathy). (stemcellcareindia.com)
- This condition is known as Leber's optic neuropathy. (stemcellcareindia.com)
Fibers10
- The optic nerve is a bundle of more than 1 million nerve fibers that carry visual messages. (medlineplus.gov)
- Clinically, the light incident from the ophthalmoscope undergoes total internal reflection through the axonal fibers, and subsequent reflection from the capillaries on the disc surface gives rise to the characteristic yellow-pink color of a healthy optic disc. (medscape.com)
- In conditions with primary optic atrophy (eg, pituitary tumor, optic nerve tumor, traumatic optic neuropathy, multiple sclerosis), optic nerve fibers degenerate in an orderly manner and are replaced by columns of glial cells without alteration in the architecture of the optic nerve head. (medscape.com)
- Optic nerve fibers exhibit marked degeneration, with excessive proliferation of glial tissue. (medscape.com)
- The optic nerve contains millions of nerve fibers carrying images of what the eye sees to the brain. (stemcellcareindia.com)
- The damage caused to the nerve fibers leads to different types of eye disorders. (stemcellcareindia.com)
- Nerve fibers within the optic nerve gradually wither and fray, diminishing its ability to relay information effectively. (viezec.com)
- Human nerve growth factor, which stimulates regeneration of damaged nerve fibers, is being studied, esp. (unboundmedicine.com)
- Most nerve fibers inside and outside the brain are wrapped with many layers of tissue composed of a fat (lipoprotein) called myelin. (merckmanuals.com)
- Sometimes the nerve fibers are also damaged. (merckmanuals.com)
Neuropathies4
- Identification of genetic variants that enable this response may provide novel therapeutic insights into OXPHOS compensation for preventing vision loss in optic neuropathies. (omicsdi.org)
- Early diagnosis and prompt o ptic nerve atrophy stem cell treatment in Delhi India can help the patients with compressive and toxic neuropathies. (stemcellcareindia.com)
- Dr. Liao's research is focused on the pathogenesis and novel treatment of optic neuropathies, which are diseases affecting the 1.2 million axons connecting the eye (captures visual information) and the brain (interprets visual information). (stanford.edu)
- and (3) testing of novel treatment for optic neuropathies, including neuroprotection and regenerative therapy. (stanford.edu)
Muscle atrophy1
- The end result, which the new study helps to explain, is dysfunction of motor neurons that control muscle along with muscle atrophy and weakness. (regenerativemedicine.net)
Cerebellar Atrophy1
- We identified biallelic variants in PMPCB in individuals of four families including one family with two affected siblings with neurodegeneration and cerebellar atrophy. (regenerativemedicine.net)
Neuropathy5
- But the most common situation occurs as isolated episodes, or epidemics of methanol poisoning and its toxic optic neuropathy, which are seen due to the contamination of handmade liquor, smuggled alcohol, and so forth with methyl alcohol. (org.sa)
- This condition is also called optic atrophy and optic neuropathy. (stemcellcareindia.com)
- Anterior optic ischemic neuropathy is a form of stroke that affects the optic nerve. (stemcellcareindia.com)
- Stroke, known as anterior ischemic optic neuropathy. (stemcellcareindia.com)
- In particular, Dr. Liao is studying OPTIC NERVE STROKE (also called anterior ischemic optic neuropathy), which is the most common acute optic neuropathy in those older than 50 years of age, and OPTIC DISC DRUSEN, which is associated with deposition of calcified deposits in the optic nerve and the most common cause of young-onset optic nerve stroke. (stanford.edu)
Retina3
- The optic nerve comprises of approximately 1.2 million axons that originate at the ganglion cell layer of the retina. (medscape.com)
- It is important to keep in mind that although the axons from the nasal half of the retina decussate at the optic chiasm, the temporal axons do not. (medscape.com)
- Neural progenitor cells delivered to the vitreous can add into the ganglion cell layer of the retina, turn on neurofilament genes, and migrate into the host's optic nerve. (stemcellcareindia.com)
Treatment for optic1
- Till date there is no proven treatment for optic atrophy. (stemcellcareindia.com)
Drusen2
- Features typically associated with AMD such as drusen, retinal pigmentary changes or atrophy are seen in PCV, as precursors and in the fellow eye. (bvsalud.org)
- She has served as Director of the Neuro-Ophthalmology since 2008 and Founding Director of the Stanford Center for Optic Disc Drusen since 2019. (stanford.edu)
Diagnosis1
- The differential diagnosis for optic atrophy can be challenging and requires expensive, time-consuming ancillary testing to determine the cause. (bvsalud.org)
Retinal gangl1
- The optic nerve fiber is made of axons from the retinal ganglion cells, that usually doesn't regenerate after an injury, resulting in a lifelong visual loss. (stemcellcareindia.com)
Tumor2
- Retrograde degeneration - Degeneration starts from the proximal portion of the axon and proceeds toward the optic disc (eg, optic nerve compression by intracranial tumor). (medscape.com)
- A tumor putting pressure on the optic nerve. (stemcellcareindia.com)
Acute1
- Acute or chronic inflammatory myelin damage may be the first sign of peripheral nerve involvement. (unboundmedicine.com)
Disorders6
- Tests for optic nerve disorders may include eye exams, ophthalmoscopy (an examination of the back of your eye), and imaging tests . (medlineplus.gov)
- With some optic nerve disorders, you may get your vision back. (medlineplus.gov)
- VEPs are most useful for testing optic nerve function and less useful for assessing postchiasmatic disorders. (medscape.com)
- Optic nerve disorders can cause vision problems and can affect one or both eyes. (stemcellcareindia.com)
- Disorders that affect the brain, spinal cord, and nerves are called neurologic disorders. (merckmanuals.com)
- Craniocervical junction disorders are abnormalities of the bones that join the head and neck. (merckmanuals.com)
Glaucoma3
- Glaucoma usually happens when the fluid pressure inside the eyes slowly rises and damages the optic nerve. (medlineplus.gov)
- Translational Relevance: Longitudinal changes in peripapillary atrophy area measured by OCT can be an indicator of structural and functional glaucoma progression. (bvsalud.org)
- From traumatic injuries to the silent progression of glaucoma, we'll navigate the underlying factors that challenge our optic nerves. (viezec.com)
Nerve's3
- In the case of optic atrophy, something is interfering with the optic nerve's ability to transmit these signals. (stemcellcareindia.com)
- It creeps into one's life, elevating intraocular pressure and slowly eroding the optic nerve's vitality. (viezec.com)
- Visual field tests, optical coherence tomography (OCT), and fundus photography are among the tools utilized to assess the optic nerve's health and function. (viezec.com)
Peripapillary1
- Purpose: To determine whether peripapillary atrophy (PPA) area is an indicator of glaucomatous structural and functional damage and progression. (bvsalud.org)
Peripheral nerves4
- Direct infection of peripheral nerves by HIV, resulting in sensory and motor changes due to destruction of axons or their myelin covering. (unboundmedicine.com)
- Diagnostic biopsies of peripheral nerves show inflammatory changes and loss of myelin. (unboundmedicine.com)
- Damage to peripheral nerves causing pain, muscle weakness, or autonomic failure after treatment with medications like cisplatin, vincristine, or taxol. (unboundmedicine.com)
- The nervous system consists of the brain, spinal cord, and nerves that connect the brain and spinal cord to the rest of the body ( peripheral nerves). (merckmanuals.com)
Congenital2
- A congenital problem is improper optic nerve growth (the person is born with it). (stemcellcareindia.com)
- Leber congenital amaurosis (LCA) is the name given to a group of more severe rod-cone dystrophies that lead to greater sight loss in very early childhood, often detected at birth. (rnib.org.uk)
Damage6
- Damage to an optic nerve can cause vision loss . (medlineplus.gov)
- Optic nerve atrophy is damage to the optic nerve. (medlineplus.gov)
- If vitamin B12 deficiency is not treated with a vitamin B12 supplement, then anemia, intestinal problems, and irreversible nerve damage may occur. (empowerpharmacy.com)
- The coincidence of bilateral optic nerve damage and bilateral putaminal necrosis in a young or middle-aged male is very suspicious for methanol-induced damage. (org.sa)
- The spinal cord is the bundle of nerves that runs down the middle of the back, and damage to these nerves disrupts how the brain and body communicate. (nihr.ac.uk)
- ABBR: AN Hearing loss that results from nerve damage or impaired nervous system processing of normal signals received from sensory hair cells in the Organ of Corti. (unboundmedicine.com)
Spinal cord2
- The nervous system has two distinct parts: the central nervous system (the brain and spinal cord) and the peripheral nervous system (the nerves outside the brain and spinal cord). (merckmanuals.com)
- Every body movement, from raising a hand to smiling, involves a complex interaction between the central nervous system (brain and spinal cord), nerves, and muscles. (merckmanuals.com)
Axons2
- The optic nerve head sits at a major transition between an area of high pressure to an area of low pressure (intracranial pressure) and is composed of 4 types of cells: ganglion cell axons, astrocytes, capillary-associated cells, and fibroblasts. (medscape.com)
- Degenerated axons lose this optical property, explaining the pallor in optic atrophy. (medscape.com)
Clinically1
- [ 1 ] Clinically, optic atrophy manifests as changes in the color and the structure of the optic disc (cupping) associated with variable degrees of visual dysfunction. (medscape.com)
Glaucomatous1
- Increased mitochondrial fission and volume density by blocking glutamate excitotoxicity protect glaucomatous optic nerve head astrocytes. (omicsdi.org)
Myelin2
- Much like the insulation around an electrical wire, the myelin sheath enables nerve signals (electrical impulses) to be conducted along the nerve fiber with speed and accuracy. (merckmanuals.com)
- When the myelin sheath is damaged, nerves do not conduct electrical impulses normally. (merckmanuals.com)
Symptoms1
- Latest researches have revealed that Umbilical Cord Mesenchymal Stem Cells can differentiate into nerve cells, neovascularise (formation of blood vessels) immunomodulate when injected into the affected area, thereby improving the symptoms and aiding longevity of healthy life. (stemcellcareindia.com)
Deterioration1
- Within the realm of ONA, multiple factors can trigger the deterioration of the optic nerve, each with its own story to tell. (viezec.com)
Dysfunction1
- Prolongation of P100 latency is the most common abnormality and usually represents an optic nerve dysfunction. (medscape.com)
Cranial nerve2
- In both cases the sixth cranial nerve nucleus was absent, as was the sixth nerve, and the lateral rectus muscle was innervated by the inferior division of the third or oculomotor cranial nerve. (bionity.com)
- They had the picture of the actual brainstem seen in the NBME's and you had to identify the cranial nerve based on the stem, which was easy BUT they did not label left or right. (pdfcoffee.com)
Stem3
- However, Optic nerve atrophy stem cell treatment is considered trusted treatment for the ailment. (stemcellcareindia.com)
- You can now cure this disease with optic nerve transplant stem cell. (stemcellcareindia.com)
- Stem cell therapy for optic nerve atrophy. (stemcellcareindia.com)
Impulses1
- The optic nerve contains nerve fibres that transmit impulses to the brain. (stemcellcareindia.com)
Regeneration1
- It assists in the regeneration of optic nerve cells, enabling patients with optic atrophy to see more clearly. (stemcellcareindia.com)
Mitochondrial2
- Optic atrophy gene 1 (OPA1) is an inner membrane protein important for mitochondrial fusion. (omicsdi.org)
- Opa1(enu/+) mice show a slow progressive loss of RGCs, activation of astroglia and microglia, and pronounced mitochondrial fission in optic nerve heads as found by electron tomography. (omicsdi.org)
Intracranial1
- These cells, also through the optic nerve, project directly to the thalamus which is also receiving intracranial nociceptive input. (researchgate.net)
Severe2
- A sudden blow to the head or a severe eye injury can lead to ONA, disrupting the delicate balance of optic nerve function. (viezec.com)
- Though spinal muscular atrophy (SMA) in its most severe form remains incurable and fatal in early childhood, researchers are sustaining a multipronged counterattack for patients and their families. (regenerativemedicine.net)
Lateral1
- In most cases, the abducens nucleus and nerve are absent or hypoplastic, and the lateral rectus muscle is innervated by a branch of the oculomotor nerve. (bionity.com)
Edema1
- In conditions with secondary optic atrophy (eg, papilledema, papillitis), the atrophy is secondary to disc edema (shown in the image below). (medscape.com)
Fibres3
- This misdirection of nerve fibres results in opposing muscles being innervated by the same nerve. (bionity.com)
- As these nerve fibres get damaged, the brain stops receiving information in the correct manner thereby blurring the vision. (stemcellcareindia.com)
- If it appears pale, then it indicates loss of nerve fibres. (stemcellcareindia.com)
Conduction1
- It measures the conduction of the visual pathways from the optic nerve, optic chiasm, and optic radiations to the occipital cortex. (medscape.com)
Gradually1
- 9 however, the optic nerve gradually becomes pale within 30-60 days after ingestion. (org.sa)
Nutritional1
- Lastly, nutritional deficiencies can cast a long shadow over optic nerve health. (viezec.com)
Disease1
- Any disease of the nerves. (unboundmedicine.com)
Visual3
- All patients had optic atrophy bilaterally, and all tested patients had visual field defects. (org.sa)
- However, when the optic nerve faces the ravages of Optic Nerve Atrophy (ONA), this intricate connection falters, plunging individuals into the shadows of visual impairment. (viezec.com)
- Optic Nerve Atrophy (ONA) stealthily encroaches upon one's visual world, often without early warning signs. (viezec.com)
Fiber layer2
- Retinal nerve fiber layer thickness measurement may elucidate the risk of structural and functional sequelae. (researchgate.net)
- Additionally, filters are incorporated into the viewing system for visualizing retinal blood vessels, nerve fiber layer defects, etc. (eophtha.com)
Disorder1
- The disorder of the optic nerve can be caused by the developmental factors or acquired factors. (stemcellcareindia.com)
Muscles1
- Some of the cranial nerves are involved in the special senses (such as seeing, hearing, and taste), and others control muscles in the face or regulate glands. (merckmanuals.com)
Vision2
- A hereditary issue in which the person witnesses a loss of vision that affects one eye, and then in the other. (stemcellcareindia.com)
- Optic Nerve Atrophy (ONA) is a condition that casts a shadow over the world of vision, and its origins are as varied as they are intriguing. (viezec.com)