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  • Gene
  • The activated transcription factor c-Jun regulates nuclear transcription via AP-1 to increase pro-apoptotic gene transcription. (wikipedia.org)
  • A Phase II clinical study of Ceregene's CERE-110, a gene therapy product designed to deliver nerve growth factor (NGF) to the brain for the treatment of Alzheimer's disease (AD) is currently underway. (adcs.org)
  • This Phase II study is a randomized, double blind, placebo-controlled trial and employs gene therapy to deliver nerve growth factor (NGF) directly into the brain. (adcs.org)
  • Cytokines
  • Because nerve growth factor (NGF) plays a cardinal role in inflammation and pain, and because it interacts with multiple proinflammatory cytokines, we hypothesized that NGF acts as a key endogenous molecule involved in the orchestration of cancer-related inflammation. (aacrjournals.org)
  • In addition, altered expression of cytokines, chemokines, and angiogenic and apoptotic related factors has been identified in the vitreous of patients with DME and PDR [ 23 - 27 ]. (hindawi.com)
  • derive
  • Researchers Xiao-lin He (left) and Chris Garcia sit in front of a computer screen that shows an electron density map created by X-ray imaging that helped derive the structure of nerve growth factor. (extropy.org)
  • Rats
  • Incorporation of H 3 -leucine into dorsal root ganglion cells in rats was markedly increased over that of controls following section of sciatic and femoral nerves. (sciencemag.org)
  • The behavioral effects of human nerve growth factor (NGF) were assessed in Fischer-344 rats of two ages: 4 months old (4MO) and 23 months old (23MO). (jneurosci.org)
  • Survival
  • As its name suggests, NGF is involved primarily in the growth, as well as the maintenance, proliferation, and survival of nerve cells (neurons). (wikipedia.org)
  • accumulation
  • Our previous studies have demonstrated that diabetes-induced oxidative stress alters homeostasis of retinal nerve growth factor (NGF) resulting in accumulation of its precursor, proNGF, at the expense of NGF which plays a critical role in preserving neuronal and retinal function. (hindawi.com)
  • metabolic
  • The NGF-stimulated growth response has been amply described from both metabolic and ultrastructural viewpoints. (springer.com)
  • Mechanism
  • Researchers at the School of Medicine have just discovered an unexpected new type of lock-and-key mechanism that provides a critical step in reproducing nerve growth factor, crucial to all aspects of nerve formation and function. (extropy.org)
  • chronic
  • Summary Background Data Chronic pancreatitis is a painful disease associated with characteristic nerve changes, including an increase in nerve number and diameter. (ovid.com)
  • content
  • Tear fluid samples were collected to detect the content of NFG at different time points in the follow-up period (day 1 preoperatively and days 1, 7, 30, and 90 postoperatively) and analyzed correlations between NFG content and age, infective factors, and variables of the surgical procedure as well as with subepithelial nerve repair at 30 and 90 days postoperatively. (ovid.com)
  • Postoperatively, at day 30, small nerve buds were observed in the periphery of the corneal graft in 13 eyes (43.3% of cases) but not in 17 eyes (56.7% of cases), which showed a significant correlation with the NFG content of tear fluid (coefficient = −3.370, P = 0.010). (ovid.com)
  • By postoperative day 90, small nerve buds were observed in the periphery of the corneal graft in 24 eyes (80.0% of cases) and showed a significant correlation with the NFG content of tear fluid (coefficient = −2.750, P = 0.006). (ovid.com)
  • Study
  • This is a really interesting finding which links the mitochondrial degeneration in Parkinson's disease with nerve growth factors," reports Rüdiger Klein, the head of the research study. (healthcanal.com)
  • cell death
  • Endothelial cell death and acellular capillary formation further impair the retinal blood supply leading to proliferative diabetic retinopathy (PDR) which is characterized by growth of fragile, leaky blood vessels and loss of vision [ 7 , 8 ]. (hindawi.com)
  • beta
  • It was previously dubbed ovulation-inducing factor (OIF) in semen before it was identified as beta-NGF in 2012. (wikipedia.org)