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  • Cytokines
  • Because nerve growth factor (NGF) plays a cardinal role in inflammation and pain, and because it interacts with multiple proinflammatory cytokines, we hypothesized that NGF acts as a key endogenous molecule involved in the orchestration of cancer-related inflammation. (aacrjournals.org)
  • In addition, altered expression of cytokines, chemokines, and angiogenic and apoptotic related factors has been identified in the vitreous of patients with DME and PDR [ 23 - 27 ]. (hindawi.com)
  • increases
  • The NFG content in tear fluid increases with the increasing ratio of small nerve buds indicating corneal nerve regeneration. (ovid.com)
  • dorsal
  • Incorporation of H 3 -leucine into dorsal root ganglion cells in rats was markedly increased over that of controls following section of sciatic and femoral nerves. (sciencemag.org)
  • Crush lesion of dorsal roots did not increase the H 3 -leucine uptake of these cells except in animals which had received nerve growth factor after the operation. (sciencemag.org)
  • mediate
  • In cellular biology, dependence receptors are proteins that mediate programmed cell death by monitoring the absence of certain trophic factors (or, equivalently, the presence of anti-trophic factors) that otherwise serve as ligands (interactors) for the dependence receptors. (wikipedia.org)
  • Regeneration
  • This may be a future therapeutic target for post-keratoplasty corneal nerve regeneration. (ovid.com)
  • To determine the relationship between changes in the content of nerve growth factor (NGF) in tear fluid and corneal subepithelial nerve regeneration in patients after keratoplasty. (ovid.com)
  • derive
  • Researchers Xiao-lin He (left) and Chris Garcia sit in front of a computer screen that shows an electron density map created by X-ray imaging that helped derive the structure of nerve growth factor. (extropy.org)
  • spinal cord
  • Dr. Luigi Aloe, Cellular Biology and Neurobiology Institute, National Research Council, Italy and his team performed a study to investigate whether, by intranasal administration, the nerve growth factor bypasses the blood-brain barrier and turns over the spinal cord neurons. (eurekalert.org)
  • These findings indicate that intranasal nerve growth factor can bypass blood-brain barrier and affect spinal cord neurons in spinal cord injury. (eurekalert.org)
  • These results provide experimental evidence for intranasal nerve growth factor for repair of spinal cord injury. (eurekalert.org)
  • Aloe L, Bianchi P, De Bellis A, Soligo M, Rocco ML. Intranasal nerve growth factor bypasses the blood-brain barrier and affects spinal cord neurons in spinal cord injury. (eurekalert.org)
  • inhibition
  • Various dependence receptors are involved in a range of biological events: developmental cell death (naturally occurring cell death), trophic factor withdrawal-induced cell death, the spontaneous regression characteristic of type IV-S neuroblastoma, neurodegenerative cell death, inhibition of new tumor cells (tumorigenesis) and metastasis, and therapeutic antibody-mediated tumor cell death, as well as programmed cell death in other instances. (wikipedia.org)
  • sensory
  • Recent research has suggested a number of roles for the LNGFR, including in development of the eyes and sensory neurons, and in repair of muscle and nerve damage in adults. (wikipedia.org)
  • tissue
  • Neurotrophic factors are secreted by target tissue and act by preventing the associated neuron from initiating programmed cell death - thus allowing the neurons to survive. (wikipedia.org)
  • Saliva contains cell-derived tissue factor, and many compounds that are antibacterial or promote healing. (wikipedia.org)