• This is an important step to fully understand how axonal degeneration occurs, and thus facilitates development of therapies to prevent or halt this damaging biological event," Dr Hilliard said. (neurosciencenews.com)
  • We identified mec-17 from a genetic screening method aimed at identifying molecules that cause axonal degeneration when they become inactive through genetic mutations," Dr Neumann said. (neurosciencenews.com)
  • We confirmed these results and demonstrated inhibition of Hpse led to an acceleration of axonal degeneration, accompanied by an increase in β-catenin. (gla.ac.uk)
  • Inhibition of β-catenin and the addition of Heparinase I both attenuated axonal degeneration. (gla.ac.uk)
  • Building on the earlier work, the current study demonstrates that NMN in injured axons works together with SARM1, a protein involved in the innate immune system - the body's first line of defence against potential pathogens - that plays a key role in axon degeneration, and kicks off a chain reaction leading to toxic levels of calcium and axon fragmentation. (healthcanal.com)
  • Dr Laura Conforti said: "This study adds a new layer to our understanding about the connections between NAD metabolism and axon degeneration as it identifies a signalling role for NMN, a molecule previously known only as an NAD precursor. (healthcanal.com)
  • This discovery suggests that controlling the levels of NMN and the downstream signals it evokes may have an unexpected therapeutic potential in neurological disorders where axon degeneration is an underlying cause. (healthcanal.com)
  • Whitehead, M. J. , McGonigal, R. , Willison, H. J. and Barnett, S. C. (2018) Heparanase attenuates axon degeneration following sciatic nerve transection. (gla.ac.uk)
  • CONCLUSIONS: Axon degeneration in preterminal nerves of the soft palate is associated with pharyngeal dysfunction in snorers and patients with sleep apnea. (diva-portal.org)
  • These results indicate that the gene transfer of GDNF, BDNF, TGFβ2, and GIF and oral administration of T-588 may prevent the degeneration of motoneurons in adult humans with motoneuron injury and motor neuron diseases. (nii.ac.jp)
  • The increase in blood vessel number was also accompanied by the restoration of motor and sensory nerve functions. (genomenewsnetwork.org)
  • CHEP amplitudes showed the highest sensitivity for diagnosing small-fiber sensory nerve degeneration and exhibited the strongest correlation with IENF density in multiple linear regression as compared with quantitative sensory testing and nerve conduction study parameters. (medznat.ru)
  • Receiver operating characteristic analysis remarked that CHEP has a better performance in diagnosing small-fiber sensory nerve degeneration than thermal thresholds.CHEPs showed superior classification accuracy with respect to evoked pain. (medznat.ru)
  • At last, it was interpreted that CHEP appeared as a sensitive tool to evaluate pathophysiology of small-fiber sensory nerve and serves as a physiological signature of neuropathic pain symptoms. (medznat.ru)
  • Eight weeks after the rabbits had received the VEGF gene the researchers found that the number of blood vessels surrounding a nerve in the leg rose from 16 to 49, which was similar to non-diabetic animals. (genomenewsnetwork.org)
  • Deterioration of nerves in the legs, feet and hands can make injuries more likely because individuals are less sensitive to pain. (genomenewsnetwork.org)
  • The goal of this study was to investigate whether nerve injuries in the upper airways of snorers and patients with sleep apnea are associated with pharyngeal dysfunction and severity of sleep apnea. (diva-portal.org)
  • The most likely cause for the nerve injuries is traumatic snoring vibrations and tissue stretch, leading to swallowing dysfunction and increased risk for upper airway obstruction during sleep. (diva-portal.org)
  • The present study shows that all SCI individuals were able to maintain MAP by increasing leg vascular resistance during head-up tilt, despite nerve degeneration in L and lack of centrally mediated sympathetic control in all SCI individuals. (ru.nl)
  • The resulting A-T fruit fly, in which expression of the gene ATM (Ataxia telangiectasia mutated) is knocked down by RNA interference, allowed them to identify genes that are directly involved in preventing or promoting A-T-associated nerve degeneration. (uwhealth.org)
  • For the study, Wassarman's graduate student, Stacey Rimkus, screened 650 of the 13,000 genes contained in the fruit fly, looking for those that affect nerve degeneration in the absence of ATM. (uwhealth.org)
  • Rimkus found three genes that partially curb progressive nerve death in the fly and three that worsen it. (uwhealth.org)
  • Introducing blood vessel-promoting genes into diabetic animals has reversed nerve damage caused by poor circulation. (genomenewsnetwork.org)
  • The team, led by Jeffrey Isner of Tufts University School of Medicine in Boston, Massachusetts, injected the VEGF-1 and VEGF-2 genes into the leg muscles of diabetic rats and rabbits to stimulate blood vessel growth around degenerating nerves. (genomenewsnetwork.org)
  • The right facial nerves of adult Fischer 344 male rats were avulsed and adenoviral vectors encoding glial cell line-derived neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF), transforming growth factor-β2 (TGFβ2), and growth inhibitory factor (GIF) were injected into the facial canal. (nii.ac.jp)
  • It's our hope that this could one day lead to more effective treatments for patients suffering from conditions causing neuronal degeneration," Dr Hilliard said. (neurosciencenews.com)
  • Among these biomarkers, Contact heat-evoked potentials (CHEPs) had become a promising procedure for assessing small-fiber sensory nerves. (medznat.ru)
  • It suggests that, in people with fibromyalgia, small-fiber neuropathy (nerve damage) may be responsible for at least some of the pain. (fibrowarrior.co)
  • Nerves that originate in the ganglia, trunks, and plexuses of the autonomic nervous system constitute a specific group. (thefreedictionary.com)
  • The peripheral nervous system in animals and man consists of aggregations of nerves. (thefreedictionary.com)
  • These neural stem cells are then manipulated in the lab to give rise to several types of nerve cells, including those that make up the peripheral nervous system throughout the arms, legs and the rest of the body. (neuropathyhomeremedy.com)
  • This, combined with earlier research on small nerve fiber damage in the skin, could mean that the degeneration is not confined to the central nervous system but may extend to the peripheral nervous system, which includes the nerves in the limbs, hands, and feet. (fibrowarrior.co)
  • Other areas of the nervous system that have been affected are the phrenic nerves and the recurrent laryngeal. (wikipedia.org)
  • Nerves and muscle were analyzed with immunohistochemical and morphologic methods, and the findings were correlated with swallowing function and degree of sleep apnea. (diva-portal.org)
  • Different biomarkers were used for estimating the neuropathy of small nerve fibres like the histamine-induced skin flare response and intra-epidermal fibres (IEF), contact heat evoked potential (CHEP) and quantitative sensory testing (QST). (medznat.ru)
  • the cordlike association of nerve tissues that links the brain and nerve ganglia by innervation to the other organs and tissues of the body. (thefreedictionary.com)
  • Possible candidates could include autoimmunity, which would involve the immune system going haywire and attacking the nerves as if they were bacteria or viruses, and problems with how the body uses substances that grow or maintain nerves. (fibrowarrior.co)