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  • Protein
  • Here, we combined cellular, biochemical, molecular and pharmacological approaches to demonstrate that low micromolar concentrations of KYNA strongly induce neprilysin (NEP) gene expression, protein level and enzymatic activity increase in human neuroblastoma SH-SY5Y cells. (ovid.com)
  • Neprilysin is an Enzyme (protein catalyst) that plays a significant role in regulating the brain as well as participating in the progression or regressions of cancer. (thegalkinalab.co.uk)
  • Neprilysin (NEP) is a transmembrane protein with a cell surface peptidase activity that degrades select pro- and anti-inflammatory neuropeptides and may take part in signaling cascades by directly coupling to intracellular proteins via peptidase-independent mechanisms. (grantome.com)
  • A cell surface protein, Neprilysin, may play an important role in preventing this abnormal growth. (grantome.com)
  • The majority of these regions are also known to contain the neprilysin protein. (ndsl.kr)
  • 24.11
  • Localization of neprilysin (EC 3.4.24.11) mRNA in rat brain by in situ hybridization. (ndsl.kr)
  • The distribution of the messenger RNA (mRNA) coding for neprilysin (EC 3.4.24.11) has been studied by in situ hybridization in the adult rat brain. (ndsl.kr)
  • peptide
  • Neprilysin is also a major degrading enzyme of amyloid-beta peptide (A-beta) in the brain, indicating that down-regulation of neprilysin activity, which could be caused by aging, can contribute to the development of Alzheimer's disease by promoting A-beta accumulation. (reliatech.de)
  • Activity of neprilysin (NEP), the major protease which cleaves amyloid-β peptide (Aβ), is reportedly reduced in the brains of patients with Alzheimer's disease (AD). (bioscirep.org)
  • Alzheimer's
  • Neuropeptide Y fragments derived from neprilysin processing are neuroprotective in a transgenic model of Alzheimer's disease. (nih.gov)
  • enzymes
  • Increasing evidence has shown that Aβ accumulation enhances its production and decreases its degradation through the actions of several Aβ-degrading enzymes, including neprilysin (NEP), insulin-degrading enzyme, and endothelin-converting enzyme [ 9-12 ]. (bioscirep.org)
  • clinical
  • These and other observations have resulted in considerable clinical interest in neprilysin as a potential target for analgesics and antihypertensive drugs. (reliatech.de)
  • Heart Failure
  • Bodey, F , Hopper, I & Krum, H 2015, ' Neprilysin inhibitors preserve renal function in heart failure ' International Journal of Cardiology , vol. 179, pp. 329-330. (monash.edu)
  • Mouse
  • This project will draw on lung tissue from patients with pulmonary hypertension, human vascular cells, genetically engineered mouse models, and unique reagents to determine the extent to which Neprilysin can protect against this disease process. (grantome.com)
  • High
  • High quantities are usually associated with the suppression of transformed or cancerous cells whereas low quantities of Neprilysin can encourage the growth of a tumour and also inhibit the memory process. (thegalkinalab.co.uk)
  • On the other hand, the globus pallidus, the substantia nigra, and the central gray matter, which show a high or a moderate amount of neprilysin, did not contain any neprilysin mRNA. (ndsl.kr)
  • data
  • These data support the possibility that long-term neprilysin gene therapy improves behavioral and neurodegenerative pathology by reducing intracellular Aβ. (biomedcentral.com)
  • show
  • We show that the sustained expression of neprilysin for up to 6 months lowered not only the amyloid plaque load but also reduced the levels of intracellular Aβ immunoreactivity. (biomedcentral.com)