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  • peripheral
  • When the peripheral retina (where it's more vulnerable) gets too ischemic, it releases VEGF and other angiogenic factors leading to neovascularization and proliferative diabetic retinopathy. (eyeguru.org)
  • This has been reported for coronary ( 10 ) and peripheral ( 11 ) atherosclerotic lesions, cardiac transplant vasculopathy ( 12 ), diabetic nephropathy ( 13 ), mortality in coronary heart disease ( 14 ), restenosis after peripheral and coronary angioplasty ( 15 ) or stenting ( 16 ), and cardiovascular disease in diabetic individuals ( 17 ). (diabetesjournals.org)
  • glomerular
  • The authors demonstrated that macrophages incubated with glomerular basement membranes from diabetic rats produced greater amounts of interleukin (IL) -1 and tumor necrosis factor (TNF) -α compared to macrophages incubated with membranes from normal rats. (scidoc.org)
  • rats
  • Finally, Zinc Chloride was able to boost the antioxidant defenses of the kidney by increasing the reduced glutathione content and decreasing lipid peroxides content in addition to significantly decreasing kidney nitric oxide content compared to diabetic control rats. (scirp.org)
  • role
  • Astilbin can exert an early renal protective role to diabetic nephropathy (DN), inhibit production of transforming growth factor-beta1 (TGF-beta1) and connective tissue growth factor (CTGF).Astilbin also alleviates contact hypersensitivity through a unique mechanism involving a negative cytokine regulation through stimulating IL-10, which is distinct from the immunosuppressant cyclosporin A. (chemfaces.com)
  • Renoprotective role in diabetic nephropathy of Oryeongsan was evaluated by [ 3 H]-thymidine incorporation, Western blot, RT-qPCR and immunofluorescence microscopy assay. (biomedcentral.com)