• NOV (nephroblastoma overexpressed) also known as CCN3 is a matricellular protein that in humans is encoded by the NOV gene. (wikipedia.org)
  • In the current study, we performed cDNA microarray-based gene expression profiling and found significant upregulation of CCN3, a matricellular protein encoded by the nephroblastoma overexpressed ( NOV ) gene in humans. (biomedcentral.com)
  • Nephroblastoma Overexpressed Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
  • A CCN protein family member found at high levels in NEPHROBLASTOMA cells. (childrensmercy.org)
  • This graph shows the total number of publications written about "Nephroblastoma Overexpressed Protein" by people in this website by year, and whether "Nephroblastoma Overexpressed Protein" was a major or minor topic of these publications. (childrensmercy.org)
  • Below are the most recent publications written about "Nephroblastoma Overexpressed Protein" by people in Profiles. (childrensmercy.org)
  • We discovered CCN3 protein being up-regulated in melanocytes right after coculture with keratinocytes. (axlinhibitor.com)
  • The CCN3 protein was secreted into the culture medium and affected two basic attributes of melanocytic physiology: it inhibited the proliferation of melanocytes and was necessary for the 3D organization in the melanocyte network around the basal membrane of human skin equivalent. (axlinhibitor.com)
  • Proteolysis of the secreted full-length CCN proteins that has been reported in the case of CCN2 and CCN3 might result in the production of CCN-derived peptides with high affinity for ligands that full-length CNN proteins bind only poorly. (neuromics.com)
  • Although the molecular processes underlying the production of these secreted isoforms is presently unknown, it is important to note that proteolysis occur at the same amino acid residues in both CCN2 and CCN3. (neuromics.com)
  • Gene expression profiling of non-cancerous hepatic tissues obtained from patients with metastatic HCC exhibit a unique immune response signature, including upregulation of CCN3. (biomedcentral.com)
  • The CCN family presently consists of six members in human also known as: Cyr61 (Cystein rich 61), CTGF (Connective Tissue Growth Factor), Nov (Nephroblastoma Overexpressed gene), WISP-1, 2 and 3 (Wnt-1 Induced Secreted Proteins). (neuromics.com)
  • CCN3/NOV promotes metastasis and tumor progression via GPNMB-induced EGFR activation in triple-negative breast cancer. (nih.gov)
  • CCN3 Proteins as a diagnostic marker in osteosarcoma patients: A case control study. (nih.gov)
  • Compared with conditioned media from wild-type LO2 cells, conditioned media from hepatic cell line LO2 activated by LX2 (aLO2-CM) induced CCN3 expression and HCC cell proliferation and metastasis. (biomedcentral.com)
  • CCN3 was secreted from hepatic cells activated by HSCs and increased MAPK signaling, EMT, proliferation and metastasis of HCC cells. (biomedcentral.com)
  • We found that CCN3 was secreted from hepatic cells and explored signaling pathways related to HCC malignant progression. (biomedcentral.com)
  • Prostate cancer-secreted CCN3 uses the GSK3β and β-catenin pathways to enhance osteogenic factor levels in osteoblasts. (nih.gov)
  • However, the role of CCN3 secreted from non-cancerous hepatic tissues in the progression of HCC remains unclear. (biomedcentral.com)
  • In addition, CCN3 localization and mechanisms of HCC progression were investigated in tissues and cell lines. (biomedcentral.com)
  • The goal of the present study was to explore expression and functional effects of CCN3 in non-cancerous hepatic tissues in correlation with HCC progression. (biomedcentral.com)
  • In addition, CCN3 stimulated the adhesion of melanocytes to basal membrane collagen IV but not to dermal collagen I, as confirmed by the siRNA-mediated down-regulation of CCN3 and two-photon (2P) microscopy. (axlinhibitor.com)
  • Amino-truncated CCN2 isoforms were biologically active whereas no specific biological activity has been attributed to the truncated CCN3. (neuromics.com)
  • Using tissue microarrays, we examined CCN3 in non-cancerous hepatic tissues of patients with HCC and correlated expression with clinical and pathological features. (biomedcentral.com)
  • CCN3 expression in non-cancerous hepatic tissues also correlated with the degree of liver fibrosis. (biomedcentral.com)
  • CCN3 was primarily localized to hepatic cells of non-cancerous hepatic tissues and was associated with vascular invasion and poor prognosis in patients with HCC. (biomedcentral.com)
  • Finally, CCN3 was inversely related to cirrhosis in the prognosis of HCC and negatively regulated hepatic stellate cells (HSCs) in vitro with downregulation of α-SMA, TGF-β, and collagens. (biomedcentral.com)
  • Finally, we confirmed the antagonistic role of CCN3 on hepatic stellate cells (HSCs). (biomedcentral.com)
  • Finally, correlations between CCN3 and cirrhosis were explored in patients. (biomedcentral.com)
  • NOV (nephroblastoma overexpressed) also known as CCN3 is a matricellular protein that in humans is encoded by the NOV gene. (wikipedia.org)
  • 15. CCN3/nephroblastoma overexpressed matricellular protein regulates integrin expression, adhesion, and dissemination in melanoma. (nih.gov)
  • Interestingly, NOV/CCN3, a founder member of the family of matricellular proteins called CCN (CYR61/CCN1, CTGF/CCN2, NOV/CCN3), has been involved in the regulation of cytokines, chemokines and MMP in several cell systems and therefore represents an attractive candidate for this role. (biomedcentral.com)
  • 9. Differential expression of CCN1/CYR61, CCN3/NOV, CCN4/WISP1, and CCN5/WISP2 in neurofibromatosis type 1 tumorigenesis. (nih.gov)
  • 11. Decreased expression of the angiogenic regulators CYR61 (CCN1) and NOV (CCN3) in human placenta is associated with pre-eclampsia. (nih.gov)
  • 3. Yin/Yang expression of CCN family members: Transforming growth factor beta 1, via ALK5/FAK/MEK, induces CCN1 and CCN2, yet suppresses CCN3, expression in human dermal fibroblasts. (nih.gov)
  • 10. Roles of heterotypic CCN2/CTGF-CCN3/NOV and homotypic CCN2-CCN2 interactions in expression of the differentiated phenotype of chondrocytes. (nih.gov)
  • Our work indicates that CCN3 functions to promote the formation of prostate cancer bone metastases and supports its use, after further validation, as a biomarker that predicts metastasis to bone," said lead investigator Peter M. Siegel, Ph.D., of the Goodman Cancer Research Centre, McGill University, Montreal, Canada. (medicineworldcouncil.com)
  • Investigators analyzed prostate cancer specimens to assess CCN3 content and compare the levels to patients' clinical data. (medicineworldcouncil.com)
  • The risk of dying from prostate cancer was also found to be greater in patients with high CCN3 expression. (medicineworldcouncil.com)
  • The investigators also measured CCN3 levels in different types of prostate cancer cells. (medicineworldcouncil.com)
  • 4. NOV (CCN3) regulation in the growth plate and CCN family member expression in cartilage neoplasia. (nih.gov)
  • CCN3, also known as nephroblastoma overexpressed gene (NOV), is a member of the CCN family of signaling proteins secreted into the extracellular matrix, which is the space outside of cells that supports cells, like a scaffold, and hosts intercellular communication. (medicineworldcouncil.com)
  • Evidence points to a founder member of the matricial CCN family, NOV/CCN3, as a modulator of these inflammatory mediators. (biomedcentral.com)
  • Immunohistochemical analysis of paraffin-embedded human nephroblastoma using 55449-1-AP (NOV antibody) at dilution of 1:50 (under 10x lens). (ptglab.com)
  • Immunohistochemical analysis of paraffin-embedded human nephroblastoma using 55449-1-AP (NOV antibody) at dilution of 1:50 (under 40x lens). (ptglab.com)
  • However, no significant differences in survival rates were found between CCN3-high and -low expressing groups. (medicineworldcouncil.com)
  • 12. New target genes for NOV/CCN3 in chondrocytes: TGF-beta2 and type X collagen. (nih.gov)