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TumorsMetastaticChromophobeMetastasisHepatic and renalNephron-sparingTubularPerirenalParenchymaBilateralHistologicalVeinPrimitiveWilmsEpitheliumDiagnosisKidneyResectionSurgicalHistopathologicalTumourLesionsUnderwentBiopsyUltrasonographyMalignanciesSerumPatientsClinicalProgressionUncommonIncidenceTumor cellsInvolvementProteinSurvivalInflammatoryTissueMassOutcomesCharacteristicsLymphocytesMicroscopicBloodFindingsStudiesSystemicPatientRare
Tumors8
  • Renal malakoplakia may imitate renal lead and tumors to needless surgery. (buyresearchchemicalss.net)
  • The classification of epithelial tumors of the kidney has in particular undergone substantial progress in the last two decades with major contributions from genetic typing of renal cell carcinomas (RCCs). (abdominalkey.com)
  • The role of genotyping and ancillary tools, in particular immunohistochemistry, in correctly classifying these tumors is highlighted in the section on Renal Cell Carcinoma. (abdominalkey.com)
  • More than 80% of renal tumors of childhood are Wilms tumor (nephroblastoma) ( 1 , 2 ). (abdominalkey.com)
  • The treatment for renal parenchymal tumors has changed over time, and this trend continues today as a result of technological progress made with clinical research and improved diagnostic and therapeutic tools. (biomedcentral.com)
  • All of these patients were treated initially and had at least one measurable focus according to standard Response Evaluation Criteria in Solid Tumors (RECIST) [15]. (cyp17-signal.com)
  • Large tumors that extend beyond the midline, have vascular extension, or both are relative contraindications, since some surgeons elect to obtain tissue via surgical excision, but this may expose patients to increased surgical risks. (medscape.com)
  • In patients with bilateral Wilms tumors, solitary kidney, or kidney insufficiency, partial nephrectomy is a reasonable consideration. (medscape.com)
Metastatic3
  • Tyrosine kinase inhibitors (TKIs) are currently approved for the treatment of metastatic renal cell carcinoma (mRCC). (biomedcentral.com)
  • Therefore, we aimed to compare the differential expressions of PD-1, PD-L1 and PD-L2 between the primary and metastatic sites of renal cell carcinoma (RCC). (biomedcentral.com)
  • Parathyroid carcinoma (PC) is a rare endocrine malignancy with no approved systemic therapies for unresectable locally invasive or distant metastatic disease. (cancerindex.org)
Chromophobe2
  • Histopathological diagnosis was chromophobe renal cell carcinoma-classic pattern (ChRCC-C), which was producing interleukin-6 in the tumor cytoplasm immunohistochemically. (bvsalud.org)
  • There are three main histological subtypes of RCC, including clear cell RCC (ccRCC), papillary RCC, and chromophobe RCC, which jointly represent over 85% of all primary renal malignancies [ 3 ]. (biomedcentral.com)
Metastasis3
  • 1 Although majority of the patients present with localised disease, approximately 30% of patients are diagnosed with metastasis 2 and another 30% of patients develop metastasis after radical nephrectomy. (medcraveonline.com)
  • Hypoxia is considered a critical contributor to renal cell carcinoma progression, including invasion and metastasis. (biomedcentral.com)
  • Radical nephrectomy and nephron-sparing surgery are still the only effective treatments for localized RCC, but the characteristics of RCC recurrence and metastasis lead to a 5-year survival rate of approximately 12%, posing a great challenge to clinical therapies [ 4 ]. (biomedcentral.com)
Hepatic and renal1
Nephron-sparing1
  • He was prepared for nephron-sparing surgery, with the possibility of radical nephrectomy depending on the intraoperative finding. (urotoday.com)
Tubular2
  • although it is derived from cells of the renal tubular epithelium, it has several histological subtypes which differ in their clinical outcome and biological features. (hindawi.com)
  • Renal cell carcinoma (RCC) originates from either the cancerous renal cortex or renal tubular epithelial cells, and is the second most lethal urological malignancy, accounting for 90-95% of kidney neoplasms. (biomedcentral.com)
Perirenal2
  • Perirenal extension and renal vein thrombosis have been reported. (buyresearchchemicalss.net)
  • The tumor is usually circumscribed by a pseudocapsule formed of compressed renal and perirenal tissues. (abdominalkey.com)
Parenchyma3
  • Gross inspection of the lesion discloses gentle tan-yellow homogenous plaques and confluent nodules that are often significantly less than 1cm in size but can range up to 3 to 4cm and replace huge regions of renal Gemcitabine HCl novel inhibtior parenchyma. (buyresearchchemicalss.net)
  • Gross nephrectomy specimen shows a Wilms tumor pushing the normal renal parenchyma to the side. (medscape.com)
  • b) blood vessels within the specimen outside of the parenchyma contain tumor. (pedsurglibrary.com)
Bilateral3
  • If imaging studies demonstrate bilateral disease, nephrectomy is not performed, but biopsy specimens are obtained. (medscape.com)
  • Bilateral renal involvement by tumor is present at diagnosis. (pedsurglibrary.com)
  • surgical removal created_by: mshimoyama creation_date: 2011-11-02T02:06:00Z [Term] id: XCO:0000018 name: bilateral nephrectomy def: "Surgical removal of both kidneys. (mcw.edu)
Histological2
  • Clear cell RCC was not diagnosed until histological evaluation was completed after a nephrectomy. (urotoday.com)
  • Ours is a landmark study correlating inflammatory markers with various renal tumour histological characteristics. (medcraveonline.com)
Vein1
  • The tumor extends into the renal vein in 40% of cases. (medscape.com)
Primitive1
  • Wilms tumor arises from the primitive embryonal renal tissue. (medscape.com)
Wilms8
  • Wilms tumor, treatment for which includes surgery (radical or partial nephrectomy), is the fifth most common pediatric malignancy and the most common type of renal tumor in children. (medscape.com)
  • Wilms tumor is rare in adults, accounting for only 0.5% of renal lesions. (medscape.com)
  • Grossly, Wilms tumor is typically an intrarenal solid or cystic mass, which may displace and, in rare cases, invade the renal collecting system. (medscape.com)
  • According to the NWTSG protocol, the first step in the treatment of Wilms tumor is surgical staging followed by radical nephrectomy, if possible. (medscape.com)
  • Although end-stage kidney disease after unilateral radical nephrectomy is uncommon (0.25% in the NWTSG trial), preserving healthy kidney tissue may prevent this complication, especially in patients with an underlying intrinsic kidney disease (eg, WAGR [Wilms tumor, aniridia, genitourinary anomalies, and mental retardation] syndrome, Denys-Drash syndrome). (medscape.com)
  • A three-year old child presents with a large renal mass suspected to be a Wilms tumor. (pedsurglibrary.com)
  • Surgical resection is performed and pathologic evaluation shows completely resected Wilms tumor with focal penetration of the renal capsule. (pedsurglibrary.com)
  • Children with which of the following conditions should receive screening renal ultrasounds for nephroblastoma (Wilms tumor)? (pedsurglibrary.com)
Epithelium1
Diagnosis6
  • diagnosis was renal malakoplakia. (buyresearchchemicalss.net)
  • The medical diagnosis of malakoplakia should be considered for patients delivering using a renal mass and NOTCH1 a brief history of long-term repeated renal attacks or renal failing [4]. (buyresearchchemicalss.net)
  • The patient inside our survey Gemcitabine HCl novel inhibtior acquired renal malakoplakia but underwent a nephrectomy using the scientific medical diagnosis of a renal tumor. (buyresearchchemicalss.net)
  • A nephrectomy could be a choice for unifocal malakoplakia, however the preoperative medical diagnosis of renal malakoplakia in suitable scientific configurations can prevent needless surgery. (buyresearchchemicalss.net)
  • A diagnosis of SDH-deficient RCC required loss of staining in all tumour cells in the presence of internal positive controls. (sajo.org.za)
  • The patient underwent laparoscopic radical nephrectomy with a clinical diagnosis of non-clear cell renal cell carcinoma cT2bN0M0 with Stauffer syndrome. (bvsalud.org)
Kidney3
Resection2
  • During December 2008, in a setting of stable disease, he underwent hepatic resection and enucleation of the left renal mass. (biomedcentral.com)
  • Seven patients (5%) were operated by resection and 145 (95%) by radical nephrectomy. (cyp17-signal.com)
Surgical1
  • Pathological examination of the surgical specimens demonstrated pT3cN0Mx conventional (clear cell) renal carcinoma, Fuhrman Grade 3 with negative surgical margins. (biomedcentral.com)
Histopathological1
  • All the patients fulfilling the inclusion criteria were subjected to partial or radical nephrectomy and the specimen were sent for histopathological examination. (medcraveonline.com)
Tumour1
  • With this background in mind, we carried out a prospective study to find out any association between the inflammatory markers and renal tumour characteristics like histology, tumour size, presence of necrosis and calcification. (medcraveonline.com)
Lesions2
Underwent2
Biopsy1
  • If a PSA exam comes back high, a biopsy of cells from the prostate will be taken to confirm whether or not the patient has prostate cancer. (centralmourology.com)
Ultrasonography1
  • He was introduced to our hospital for a left renal mass detected by ultrasonography. (bvsalud.org)
Malignancies3
  • Renal cell carcinoma (RCC) accounts for approximately 3% of human malignancies, and its incidence appears to be increasing globally [ 1 ]. (hindawi.com)
  • Renal cell carcinoma (RCC) accounts for about 3% of all malignancies. (medcraveonline.com)
  • Renal cell carcinoma (RCC) is one of the most common solid neoplasm of urinary tract accounting for about 3% of all malignancies in adult. (medcraveonline.com)
Serum3
  • Recently, the markers of inflammation like C-reactive protein (CRP), neutrophil lymphocyte ratio (NLR) and Serum lactate dehydrogenase (LDH) are being extensively studied in solid tumours and in most of the studies it has been established that markers of inflammation bears a prognostic information in most of the carcinoma including RCC. (medcraveonline.com)
  • Renal function indexes, serum inflammatory factors, and tumor markers were evaluated. (biomedcentral.com)
  • Nursing based on oxygen administration decreased the value of renal function indexes, serum inflammatory factors, and tumor markers in renal cell carcinoma patients. (biomedcentral.com)
Patients4
  • Conclusion Renal malakoplakia must be kept in mind for patients presenting with a renal mass and a history of long-term recurrent renal infections or renal failure. (buyresearchchemicalss.net)
  • The purpose of this study was to investigate the role and mechanism of hypoxia-induced renal cell carcinoma and provide evidence-based medical proof for improvements to postoperative nursing of renal cell carcinoma patients. (biomedcentral.com)
  • A total of 64 patients with renal cell carcinoma were divided into the observation group (nursing based on oxygen administration) and the control group (conventional nursing). (biomedcentral.com)
  • In terms of tumor histologic types, the patients included 26 adenocarcinomas, 4 bronchioloalveolar carcinomas, 10 squamous cell carcinomas and 5 adenosquamous carcinomas. (cyp17-signal.com)
Clinical3
  • These data reveal that nursing based on oxygen administration can improve the clinical efficacy of renal cell carcinoma therapies, being safe and effective. (biomedcentral.com)
  • Genetic profiling as a clinical tool in advanced parathyroid carcinoma. (cancerindex.org)
  • To investigate the genomic features of tertiary pattern 5 (TP5) on radical prostatectomy specimens in an effort to explain the poor clinical outcomes associated with this disease subtype. (bjuinternational.com)
Progression1
  • An aberrant miRNA expression could contribute to cancer development and progression [ 6 , 7 ] and could affect their target genes that are involved in many biological processes, such as cell differentiation, proliferation, apoptosis, metabolism, and development [ 8 ]. (hindawi.com)
Uncommon1
Incidence1
Tumor cells1
  • The key procedure of anti-tumor respond is the activation of T cell and tumor cells can inhibit this process through binding its immune checkpoints to receptors expressed on T-cell, thus leading to immune escape. (biomedcentral.com)
Involvement1
  • Early radiological assessment after surgery showed no residual hepatic or renal disease, but possible involvement of the mesenteric lymph nodes. (biomedcentral.com)
Protein2
  • and cell differentiation ( SOX2 and TGFB3 ) as well as immunohistochemical assay for VEGFA, TP53, Bcl2, TGFB1, and Ki67 protein expression have been performed in 85 FFPE RCC tumor specimens. (hindawi.com)
  • Blood analysis revealed elevated white blood cell count, C-reactive protein, bilirubin and aspartate transaminase. (bvsalud.org)
Survival2
  • It is involved in p53 pathways and is implicated in cell death/survival signaling, the cell cycle, and differentiation, thereby playing a regulatory role in carcinogenesis [ 12 ]. (hindawi.com)
  • The cadherin-catenin complex also influences migration and modifies cell growth and the survival of neoplastic cells [8]. (cyp17-signal.com)
Inflammatory2
  • Hypoxia was found to induce A498 cell invasion, migration, and the release of inflammatory cytokines, while repressing human solute carrier family 14 member 1 gene expression. (biomedcentral.com)
  • Overexpression of the solute carrier family 14 member 1 gene could abolish hypoxia-induced invasion, reduce the migration of A498 cells, inhibit the hypoxia-induced release of inflammatory cytokines, and arrest the cell cycle at the G1/S checkpoint. (biomedcentral.com)
Tissue1
  • The cut surface is typically solid, soft, and gray or pink, with a texture and appearance resembling brain tissue. (abdominalkey.com)
Mass3
  • In 2007, a 58-year-old white male with no history of tobacco use, hypertension, diabetes, or hypercholesterolemia, and no family history of coronary artery disease, was found to have a large solid right renal mass and associated tumor thrombus of the inferior vena cava and right atrium. (biomedcentral.com)
  • RCC may not be diagnosed until after it has metastasized because the primary tumor can grow fairly large without creating symptoms such as flank pain or a mass in the abdomen. (urotoday.com)
  • Computed tomography demonstrated a left renal mass (expansive growth), which was 11 cm in maximum diameter and enhanced moderately at the corticomedullary phase. (bvsalud.org)
Outcomes1
  • His blood test outcomes at admission demonstrated a white bloodstream cell count number of 8200/L, hemoglobin 14.5g/dL and platelet count number of 233,000/L. A Gemcitabine HCl novel inhibtior urine lifestyle and analysis showed no an infection. (buyresearchchemicalss.net)
Characteristics1
  • The human renal cell carcinoma cell line A498 under hypoxia/normoxia was used as an experimental model in vitro and the biological characteristics and mitochondrial function of the cells were assessed. (biomedcentral.com)
Lymphocytes2
  • On microscopy, renal malakoplakia is certainly seen as a huge collections of plump macrophages with relatively few plasma and lymphocytes cells. (buyresearchchemicalss.net)
  • To determine an individual's HLA-A, B and C phenotype, the lymphocytes (T lymphocytes or whole blood lymphocytes) are incubated with a large panel of antisera with known HLA specificities, and then with rabbit complement. (binaryoptionstradinglist.com)
Microscopic1
  • The microscopic differential diagnoses are Whipples lipodystrophy, xanthogranulomatous pyelonephritis, megalocytic interstitial nephritis and granular cell tumor [1]. (buyresearchchemicalss.net)
Blood1
  • The surgery required 186 minutes of insufflation, and estimated blood loss and specimen weight were 44 ml and 695 g, respectively. (bvsalud.org)
Findings1
  • These findings demonstrate that ERA-NG2 has a high level of safety and a substantial level of immunogenicity in dogs and thus is a promising live vaccine candidate that can facilitate vaccination in dogs. (bvsalud.org)
Studies3
  • Subsequent contrast studies demonstrated mild hydronephrosis. (urotoday.com)
  • The large, rapidly Gemcitabine HCl novel inhibtior growing nodules of malakoplakia may mimic renal cell carcinoma in imaging studies. (buyresearchchemicalss.net)
  • It was previously demonstrated in separate studies that introduction of amino acid residues Leu at position 333 in the viral glycoprotein (G333), Ser at G194, and Leu/His at positions 273/394 in the nucleoprotein (N273/394) enhance the safety of a live vaccine strain. (bvsalud.org)
Systemic1
  • Whether these markers of systemic inflammation play any role in the incitation of these renal tumours as observed in our study is yet to be known. (medcraveonline.com)
Patient1
  • Further investigation of a larger patient population is needed to better understand cardiac damage due to TKI treatment. (biomedcentral.com)
Rare2
  • Succinate dehydrogenase-deficient (SDH-deficient) renal cell carcinoma (RCC) is a rare subtype of RCC. (sajo.org.za)
  • Succinate dehydrogenase- (SDH)-deficient renal cell carcinoma (RCC) is a rare subtype of RCC, estimated to comprise 0.05% - 0.2% of all cases of RCC globally. (sajo.org.za)