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  • therapeutic
  • A gamma-secretase inhibitor, DAPT, which inhibits all four Notch receptors and a Notch 4 neutralising antibody were shown to reduce DCIS mammosphere formation, indicating that Notch signalling and other stem cell self-renewal pathways may represent novel therapeutic targets to prevent recurrence of pre-invasive and invasive breast cancer. (ox.ac.uk)
  • Normal
  • Using a non-adherent sphere culture technique we have grown DCIS mammospheres from primary DCIS tissue, where self-renewal capacity, measured by the number of mammosphere initiating cells, were increased from normal breast tissue. (ox.ac.uk)
  • transplant
  • Many groups have extrapolated the cancer stem cell hypothesis from the haematopoietic system to solid cancers, where using in vitro culture techniques and in vivo transplant models have established evidence of cancer stem cells in colon, pancreas, prostate, brain and breast cancers. (ox.ac.uk)
  • biology
  • Functional polymorphisms on chromosome 5p15.33 disturb telomere biology and confer the risk of non-small cell lung cancer in Chinese population. (abcam.com)
  • mechanisms
  • Isolation of an aggressive subpopulation of migratory cells will enable studies of underlying molecular mechanisms. (biomedsearch.com)
  • Although it has long been known that the basis of competition is the ability of growing cells to monitor fitness of their neighbors, and can be induced via differences in protein production capacity, Myc levels and apico-basal cell polarity, only recently have signaling and effector mechanisms been identified. (keystonesymposia.org)
  • The research of Ian's own group is directed toward understanding the mechanisms that bring about reprogramming of nuclei and with exploiting new opportunities for reprogramming cells to study degenerative diseases, such as motor neuron disease. (royalsociety.org)
  • differentiation
  • A) Representative confocal microscopy images of MUC2 (green) in human cultures treated with 10 μM dibenzazepine (DBZ) show differentiation into the goblet cell-lineage as depicted by increased MUC2 expression (B) The number of goblet cells was quantified by counting the number of MUC2+ cells from 10 random fields at 63× magnification. (nih.gov)
  • As previously reported, dibenzazepine (DBZ) mediated Notch inhibition resulted in goblet cell differentiation in cultured mouse intestinal epithelium and adenoma (Additional file 2: Figure S2). (nih.gov)
  • Fraction
  • Fig. 4 illustrates the behavior of the model by following the fraction of positive cells f+ in the two subpopulation for different values of p. (nih.gov)
  • lymphomas
  • Recall the biological reason that many lymphomas contain balanced translocations involving the immunoglobulin and T cell receptor genes. (brainscape.com)
  • Utility of Combined EZH2, p-ERK1/2, p-STAT, and MYC Expression in the Differential Diagnosis of EZH2-positive Hodgkin Lymphomas and Related Large B-Cell Lymphomas. (abcam.com)
  • homeostasis
  • Instead, it is a highly conserved process that promotes the context dependent elimination of less fit cells and stimulates growth of more fit cells during growth and homeostasis. (keystonesymposia.org)
  • cancer cell
  • Endometrial cancer cell line ECC1 was submitted to sphere forming protocols. (springer.com)
  • Resveratrol epigenetically regulates the expression of zinc finger protein 36 in non-small cell lung cancer cell lines. (abcam.com)
  • differentiate
  • Tools for evaluating -morphology:appearance can differentiate -immunophenotyping: use of antibodies to determine substances cells express. (brainscape.com)
  • concentration
  • Evolution of the concentration of positive cells after sorting for the Phenotypic Switching model. (nih.gov)
  • The appendix, traditionally seen as a vestigial organ, has been shown to have a high concentration of lymphatic cells. (wikipedia.org)
  • Progression
  • c-Myc induced upregulation of long non-coding RNA SNHG16 enhances progression and carcinogenesis in oral squamous cell carcinoma. (abcam.com)
  • activation
  • due to natural susceptibility of genome to translocations in periods of genomic instability, especially in initial Ig/Tcell receptor rearrangement -this occurs during B/T cell maturation and class recombination and somatic hypermutation in B cell activation. (brainscape.com)
  • p53 Loss in Breast Cancer Leads to Myc Activation, Increased Cell Plasticity, and Expression of a Mitotic Signature with Prognostic Value. (abcam.com)
  • human
  • Atkin , N. B. , 1970, Cytogenetic studies on human tumors and premalignant lesions: The emergence of aneuploid Cell. (springer.com)
  • Chan RWS, Schwab KE, Gargett CE (2004) Clonogenicity of human endometrial epithelial and stromal cells. (springer.com)
  • The human ERCC4 gene can correct the DNA repair defect in specific ultraviolet light (UV)-sensitive mutant cell lines derived from Chinese hamster ovary cells. (wikipedia.org)
  • Analysis
  • In contrast, microfluidic devices permit single cell analysis because of compatibility with modern microscopy and control over micro-environment. (biomedsearch.com)
  • multiple
  • Drs. Brian G.M. Durie, Joseph Mikhael, and Paul Richardson discusses the Role of Autologous Stem Cell Transplant for multiple myeloma patients during the IMWG Conference Series filmed at ASH 2017 in Atlanta, Georgia. (oncologytube.com)
  • Multiple independent complementation groups of Chinese hamster ovary (CHO) cells have been isolated, and this gene restored UV resistance to cells of complementation group 4. (wikipedia.org)