AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation ScienceNamed GroupsHealth Care
Liver Neoplasms, ExperimentalLiver NeoplasmsCarcinoma, HepatocellularLiverLiver DiseasesLiver TransplantationLiver CirrhosisMicrosomes, LiverLiver RegenerationFatty LiverLiver Function TestsMitochondria, LiverDrug-Induced Liver InjuryLiver ExtractsLiver CirculationLiver Failure, AcuteLiver AbscessLiver Diseases, AlcoholicHepatectomyHepatocytesLiver Cirrhosis, ExperimentalLiver Cirrhosis, AlcoholicLiver, ArtificialLiver GlycogenAlanine TransaminaseEnd Stage Liver DiseaseRats, Inbred StrainsHepatitisCarbon TetrachlorideRNA, MessengerKupffer CellsTime FactorsKineticsCytochrome P-450 Enzyme SystemRats, WistarPortal VeinTissue DistributionRats, Sprague-DawleyHepatic ArteryBile DuctsOrgan SizeBilirubinPerfusionLiving DonorsRats, Inbred F344KidneyPhenobarbitalCholestasisMolecular Sequence DataBase SequenceLiver Abscess, PyogenicHepatic VeinsDisease Models, AnimalAdenoma, Liver CellOrgan SpecificityLiver Diseases, Parasiticgamma-GlutamyltransferaseBileLipid MetabolismTreatment OutcomeCarbon Tetrachloride PoisoningBiotransformationIsoenzymesHepatitis, AnimalHepatic Stellate CellsMice, KnockoutDrug-Induced Liver Injury, ChronicDiethylnitrosamine
LesionsHepaticTumorsEpithelialDiseasesSpleenTumorCancerCirrhosisLymph nodesIncidencesCellsLungOrgansRatsAdenomasBiopsyBoneHepatocellularMiceEnzymesVascularAcuteExposureTissueTumoursHemangiosarcomaPhotomicrographsKidney weightsMalesNAFLDPeroxisomeProteinsBloodGroupSeverePhysiciansMajorDevelopmentEffects
Lesions4
  • neoplastic lesions. (cdc.gov)
  • At post mortem examination of the three heifers, there was predominance of acute liver lesions. (scielo.br)
  • Neoplastic cells originated in the splenic lymphatic cells and systemically caused severe metastatic lesions in the heart, liver, kidney, digestive tracts, gills and the lateral musculature. (int-res.com)
  • The incidence of pre-neoplastic lesions and liver tumors was measured 3 and 12 months after the start of treatments, respectively. (usp.br)
Hepatic6
  • More than 900 drugs, toxins, and herbs have been reported to cause liver injury, and drugs account for 20-40% of all instances of fulminant hepatic failure. (medscape.com)
  • Drug-induced hepatic injury is the most common reason cited for withdrawal of an approved drug, and one-third of all drugs withdrawn from the market are withdrawn for liver injury. (medscape.com)
  • The manifestations of drug-induced hepatotoxicity are highly variable, ranging from asymptomatic elevation of liver enzymes to fulminant hepatic failure. (medscape.com)
  • Rodent primary hepatic stellate cells (HSCs), mouse liver tumor-initiating stem cell-like cells (TICs), and human hepatocellular carcinoma (HCC) cell lines were exposed to Wnt signaling inhibitors and changes in gene expression patterns were analyzed. (nih.gov)
  • BACKGROUND: Alcohol consumption is an important risk factor for hepatic neoplastic and non-neoplastic diseases. (ox.ac.uk)
  • Animals treated with ArtinM had fewer pre-neoplastic foci and hepatic tumors than the animals that receiving mycotoxin alone, as well as showing greater hepatic expression of tumor suppressor proteins. (usp.br)
Tumors3
  • We assessed the functions of SCD by pharmacologic and conditional genetic manipulation in mice with hepatotoxic or cholestatic induction of liver fibrosis, orthotopic transplants of TICs, or liver tumors induced by administration of diethyl nitrosamine. (nih.gov)
  • Conditional disruption of Scd2 in activated HSCs prevented growth of tumors from TICs and reduced the formation of diethyl nitrosamine-induced liver tumors in mice. (nih.gov)
  • Components of the identified loop linking HSCs and TICs might be therapeutic targets for liver fibrosis and tumors. (nih.gov)
Epithelial1
  • Neoplastic polyps show epithelial dysplasia by definition and include adenomas and carcinomas . (webpathology.com)
Diseases5
  • Alcohol drinking and risks of liver cancer and non-neoplastic chronic liver diseases in China: a 10-year prospective study of 0.5 million adults. (ox.ac.uk)
  • Female current regular drinkers had significantly higher risk of ALD, but not other liver diseases, than female abstainers. (ox.ac.uk)
  • CONCLUSIONS: In Chinese men, alcohol intake was associated with significantly increased risks of several major chronic liver diseases, and certain drinking patterns (e.g. drinking daily, drinking without meals) may further exacerbate the disease risks. (ox.ac.uk)
  • Since the C. intermedium poisoning is uncommon in dairy cattle, we are describing it for the first time in the Central-Eastern Mesoregion of RS, and represents a differential diagnosis of other acute toxic liver diseases in cattle. (scielo.br)
  • Liver cancer, also documented as primary liver cancer or hepatoma, is usually caused by cirrhosis or scarring of the liver, which may be due to alcohol abuse, autoimmune diseases of the liver, hepatitis B or C, or hemochromatosis. (fortherecordmag.com)
Spleen3
  • Exposure to 2-nitrotoluene has also been associated with non-cancer effects in experimental animals, including developmental and reproductive effects as well as effects in the lungs, liver, spleen, bone marrow and the hematopoietic system. (gc.ca)
  • Photograph of the liver and spleen from an eastern screech owl ( Megascops asio ) that was found dead with no signs of trauma. (avma.org)
  • CML ensues when an abnormal pluripotent hematopoietic progenitor cell initiates excessive production of all myeloid lineage cells, primarily in the bone marrow but also in extramedullary sites (eg, spleen, liver). (msdmanuals.com)
Tumor5
  • We investigated whether and how SCD promotes liver fibrosis and tumor development in mice. (nih.gov)
  • In rodent HSCs and TICs, we found SCD expression to be regulated by Wnt-β-catenin signaling, and MUFAs produced by SCD provided a forward loop to amplify Wnt signaling via stabilization of Lrp5 and Lrp6 mRNAs, contributing to liver fibrosis and tumor growth. (nih.gov)
  • SCD expressed by HSCs promoted liver tumor development in mice. (nih.gov)
  • The oncogenic role of TLR4 activated by endotoxin has been confirmed by others in a different liver tumor model 10 . (nature.com)
  • There is an unmet clinical need to extract living circulating tumor cells (CTCs) for functional studies and in vitro expansion to enable drug testing and predict responses to therapy in metastatic cancer. (lu.se)
Cancer18
  • After median 10 years' follow-up, 2531 incident liver cancer, 2040 liver cirrhosis, 260 alcoholic liver disease (ALD), and 1262 non-alcoholic fatty liver disease (NAFLD) cases were recorded among 492,643 participants without prior cancer or chronic liver disease at baseline. (ox.ac.uk)
  • After adjustment for the total amount of weekly alcohol consumption, daily drinkers had significantly increased risk of ALD (2.15, 1.40-3.31) compared with non-daily drinkers, and drinking without meals was associated with significantly greater risks of liver cancer (1.32, 1.01-1.72), liver cirrhosis (1.37, 1.02-1.85), and ALD (1.60, 1.09-2.33) compared with drinking with meals. (ox.ac.uk)
  • In contrast, ADAR1 overexpression is associated with increased malignancy of breast, lung and liver cancer. (cancerindex.org)
  • One in two people will develop cancer at some point in their lives. (biomedcentral.com)
  • Incredible advancements in cancer screening, early detection and treatments mean that more patients with cancer are living longer. (biomedcentral.com)
  • These effects of honey have been thoroughly investigated in certain cancers such as breast, liver and colorectal cancer cell lines. (mdpi.com)
  • Typically, cancer found in the liver has metastasized there from another part of the body. (fortherecordmag.com)
  • The cancer cells detach from the primary site, such as the breast or the lungs, and travel through the circulatory or lymphatic system to the liver. (fortherecordmag.com)
  • Primary liver cancer is classified to ICD-9-CM code 155.0. (fortherecordmag.com)
  • Secondary liver cancer, also called metastasis to the liver, is classified to code 197.7. (fortherecordmag.com)
  • If liver cancer is documented with no further specification stating primary or secondary, assign code 155.2. (fortherecordmag.com)
  • Common signs and symptoms that may appear in a patient with liver cancer are a loss of appetite, weight loss, right upper quadrant abdominal pain (which may extend into the back and right shoulder blade), bleeding or bruising that occurs easily, nausea and vomiting, general weakness and fatigue, an enlarged liver, ascites, or jaundice. (fortherecordmag.com)
  • Most types of liver cancer are not diagnosed early since symptoms do not appear in the early stages and because liver cancers can grow quickly. (fortherecordmag.com)
  • If liver cancer is suspected, the physician may perform one or more diagnostic tests, including abdominal ultrasound, an abdominal CT scan, CT angiography, an MRI, a liver scan, liver enzyme testing (liver function tests), serum alpha fetoprotein testing, or a liver biopsy. (fortherecordmag.com)
  • Recurrent: cancer has returned to the liver or another part of the body after treatment. (fortherecordmag.com)
  • The treatment for liver cancer depends on the stage and the type of cancer plus a patient's age, overall health, and personal preferences. (fortherecordmag.com)
  • However, liver cancer is rarely diagnosed in the early stages. (fortherecordmag.com)
  • Globally, HCC is the sixth most prevalent cancer and the third-most prevalent reason for neoplastic disease-related deaths. (wjgnet.com)
Cirrhosis2
  • Excessive alcohol consumption causes alcoholic liver disease, which progresses from fatty liver to alcoholic steatohepatitis, cirrhosis, and ultimately hepatocellular carcinoma (HCC). (nature.com)
  • Sera concentration of circulating sCD40L and IL-10 were assayed using ELISA in 30 HCV-positive patients with HCC, 30 HCV-positive patients with liver cirrhosis and 30 age-matched healthy volunteers with negative anti-HCV-Ab as a control group. (who.int)
Lymph nodes1
  • The liver is the second most common site for metastatic disease, with lymph nodes being the first. (fortherecordmag.com)
Incidences2
  • The incidences of hemangiosarcoma of the liver occurred with a positive trend in males, and the incidences were significantly increased in the 40 and 80 mg/kg groups. (nih.gov)
  • The trend in neoplastic incidences in mice correlated well with model-esti- mated SO concentration in the terminal bronchioles. (cdc.gov)
Cells7
  • The impact of the type and quantity of malignant cells of the neoplastic specimen on the quality of mutation analysis remains to be elucidated, and only empirical and sporadic data are available. (spandidos-publications.com)
  • The aim of the present study was to investigate the impact of tissue type and content of neoplastic cells in the specimen on the quality of EGFR mutation analysis among patients with lung adenocarcinoma. (spandidos-publications.com)
  • Formalin‑fixed paraffin embedded tissue samples were used for the mutation analysis and the content of the neoplastic cells was evaluated using light microscopy. (spandidos-publications.com)
  • Diseased fish displayed severe anemia and markedly increased numbers of neoplastic lymphocytoid and lymphoblastoid cells in the blood. (int-res.com)
  • In this paper, we describe light and electron microscopic features of neoplasms and neoplastic cells. (int-res.com)
  • Potential y neoplastic cel s that of the effect increases with increasing tem to respond effectively to foreign arise natural y, or that have been dose or continuing exposure - and is antigens, including surface antigens transformed by carcinogens acting usually transient: immune function on tumour cells. (who.int)
  • Although granulocyte production predominates, the neoplastic clone includes red blood cells, megakaryocytes, monocytes, and even some T cells and B cells. (msdmanuals.com)
Lung4
  • Liver and lung samples were collected for cell proliferation and apoptosis analyses. (nih.gov)
  • liver and lung samples were collected for induction of glutathione, cytochromes P450 and P450 2E1, and DNA adduct formation, and blood was collected for measurement of urethane and ethanol serum concentrations. (nih.gov)
  • IARC Monographs act entirely or largely by immuno- heart, liver, or lung) can be trans- carcinogenic to humans (Group 1). (who.int)
  • Is lung involvement a favorable prognostic factor for pancreatic ductal adenocarcinoma with synchronous liver metastases? (lu.se)
Organs1
  • An increased incidence of tumours was reported in multiple tissues, such as the mesothelial tissues (tunica vaginalis of the testis, epididymis, abdominal wall or surface of abdominal organs), skin (subcutaneous tissues), mammary gland, liver and lungs, in rats exposed via the diet. (gc.ca)
Rats1
Adenomas1
  • Serrated adenomas , which are related to hyperplastic polyps, have malignant potential and are now considered neoplastic. (webpathology.com)
Biopsy5
  • Photomicrographs of liver tissue sections (obtained with the use of ultrasound-guided biopsy needle) from a 4-year-old 4.52-kg spayed female domestic shorthair cat evaluated because of lethargy, abdominal effusion, and an abdominal mass. (avma.org)
  • Compared with baseline values, bile acid concentration and γ-glutamyl transferase activity were not affected by liver biopsy or crush injury. (bioone.org)
  • If the liver biopsy is done by a laparoscope, assign code 50.14. (fortherecordmag.com)
  • If the physician performs a needle biopsy of the liver through a laparotomy, assign codes 54.11, Exploratory laparotomy, and 50.11, Closed liver biopsy ( AHA Coding Clinic for ICD-9-CM , 1988, fourth quarter, page 12). (fortherecordmag.com)
  • Transjugular or transvenous liver biopsy is assigned to code 50.13. (fortherecordmag.com)
Bone1
  • Liver transplant alone is not curative for erythropoietic protoporphyria (EPP) but instead needs to be combined with bone marrow transplant. (medscape.com)
Hepatocellular2
  • Hepatocellular carcinoma (HCC) is primarily a malignancy of the liver, advancing from a damaged, cirrhotic liver to HCC. (wjgnet.com)
  • Although the molecular mechanisms that regulate autophagy are not fully understood, recent work indicates that dysfunctional/impaired autophagic functions are associated with the development and progression of nonalcoholic fatty liver disease (NAFLD), alcoholic fatty liver disease (AFLD), and hepatocellular carcinoma (HCC). (hindawi.com)
Mice3
  • Genetic disruption of Scd and pharmacologic inhibitors of SCD reduced HSC activation and TIC self-renewal and attenuated liver fibrosis and tumorigenesis in mice. (nih.gov)
  • In female mice only, absolute and relative liver weights were significantly increased at the highest dose. (canada.ca)
  • Tumours in the circulatory system, large intestine and liver were reported in mice exposed via the dietary route as well. (gc.ca)
Enzymes2
  • The Affymetrix data revealed varied gene expression patterns of the ATP synthesizing and regulating enzymes found in the muscle, liver, and brain. (molvis.org)
  • Enzymes are biological molecules produced by living entities for carrying out biological processes. (preprints.org)
Vascular2
  • I am particularly interested in evaluating how exposure to chemical contaminants, in particular, the polycyclic aromatic hydrocarbons, affects the development of liver, exocrine pancreatic and vascular cancers in wild fishes. (vims.edu)
  • 99% CI, 2.1 to 2.6) and from respiratory, vascular, or neoplastic dis- *The Registrar General of India-Centre for Global Health Research (RGI-CGHR) In- ease. (who.int)
Acute2
  • In the United States, approximately 2000 cases of acute liver failure occur annually and drugs account for over 50% of them (39% are due to acetaminophen, 13% are idiosyncratic reactions due to other medications). (medscape.com)
  • The boxed warning emphasizes the risk for severe liver injury and acute liver failure, which may be fatal. (medscape.com)
Exposure1
  • by experimental animals resulted in Chlorobenzene is a colorless, flammable duration (how long), and the Possible route of exposure by the general damage to the liver (hepatocel ular liquid with an aromatic, almond-like population. (cdc.gov)
Tissue1
  • In the human body, the excess of adipose tissue is involved, as it potentializes the development of cardiovascular, osteomuscular, and neoplastic pathologies 2,3 . (bvsalud.org)
Tumours1
  • The role of radiotherapy and chemoradiation in the management of primary liver tumours. (cancercentrum.se)
Hemangiosarcoma1
Photomicrographs1
  • Photomicrographs of a section of the liver from the screech owl in Figure 1 . (avma.org)
Kidney weights1
Males1
NAFLD1
  • In this review, we summarize how impaired autophagy affects liver function and contributes to NAFLD, AFLD, and HCC progression. (hindawi.com)
Peroxisome1
  • No evidence of peroxisome proliferation in the liver was reported. (canada.ca)
Proteins1
  • In general, autophagy degrades long-lived damaged intracellular proteins, in contrast to the ubiquitin-proteasome system, which controls the degradation of short-lived proteins [ 2 ]. (hindawi.com)
Blood1
  • A mode of action-based physiologi- cally based pharmacokinetic (PBPK) model was developed to predict the concentration of ST and SO in blood, liver, and the respiratory-tract tissues, particularly in terminal bron- chioles (target tisue), in order to conduct interspecies extrapolations and determine the extent to which there is a pharmacokinetic basis for the observed species specificity. (cdc.gov)
Group1
  • Non-neoplastic group includes hyperplastic polyps, hamartomatous polyps (juvenile polyps, Peutz-Jeghers polyps), inflammatory polyps and mucosal polyps . (webpathology.com)
Severe2
  • Between 1998 and 2000, the US Food and Drug Administration (FDA) has recommended withdrawal of 2 drugs from the market for causing severe liver injury: bromfenac and troglitazone. (medscape.com)
  • In the last few years, the US Food and Drug Administration (FDA) has withdrawn 2 drugs from the market for causing severe liver injury: bromfenac and troglitazone. (medscape.com)
Physicians1
  • Physicians must be vigilant in identifying drug-related liver injury because early detection can decrease the severity of hepatotoxicity if the drug is discontinued. (medscape.com)
Major1
  • Colonic polyps are subdivided into two major groups: non-neoplastic and neoplastic . (webpathology.com)
Development1
  • Liver-specific TBC1D15 deficiency or non-p-NUMB expression reduced TIC numbers and HCC development. (nature.com)
Effects1
  • There were no histolog ical (neoplastic or non-neoplastic) effects due to treatment. (fluoridealert.org)