• Among patients with HER2-positive early breast cancer who had residual invasive disease after completion of neoadjuvant therapy, the risk of recurrence of invasive breast cancer or death was 50% lower with adjuvant T-DM1 than with trastuzumab alone. (nih.gov)
  • Conversely, there are many arguments in favor of performing ND only for patients who have evidence of residual neck disease because of the very low probability of isolated neck recurrence following a complete response. (nih.gov)
  • SRS or some type of radiation therapy is typically performed for patients with residual tumor or tumor recurrence after resection. (cns.org)
  • But because the general recurrence rate [residual neoplasia] is higher after cold snare, careful selection of the target lesion should be made," he said. (medscape.com)
  • Minimal residual disease (MRD) refers to the small number of malignant cells that remain after therapy when the patient is in remission and shows no symptoms or overt signs of disease. (smw.ch)
  • Trichilemmal carcinomas (TCs) are rare, malignant, adnexal neoplasms that differentiate from the outer root sheath (ORS) of the hair follicle. (jcadonline.com)
  • Such clinical phenotypes can mimic infectious and autoimmune causes of meningoencephalitis.Objective: To ascertain whether CSF metagenomic next-generation sequencing (mNGS) can identify aneuploidy, a hallmark of malignant neoplasms, in difficult-to-diagnose cases of CNS malignant neoplasm.Design, Setting, and Participants: Two case-control studies were performed at the University of California, San Francisco (UCSF). (stanford.edu)
  • The first study used CSF specimens collected at the UCSF Clinical Laboratories between July 1, 2017, and December 31, 2019, and evaluated test performance in specimens from patients with a CNS malignant neoplasm (positive controls) or without (negative controls). (stanford.edu)
  • The second study evaluated patients who were enrolled in an ongoing prospective study between April 1, 2014, and July 31, 2019, with presentations that were suggestive of neuroinflammatory disease but who were ultimately diagnosed with a CNS malignant neoplasm. (stanford.edu)
  • The test performance study used 125 residual laboratory CSF specimens from 47 patients with a CNS malignant neoplasm and 56 patients with other neurological diseases. (stanford.edu)
  • In this new context, we aimed to reassess the value of conventional risk factors with regard to new genetic alterations and early response to therapy, as assessed by immunoglobulin/T-cell receptor minimal residual disease (MRD) levels. (unige.ch)
  • Minimal residual disease monitoring: the new standard for treatment evaluation of haematological malignancies? (smw.ch)
  • Deep-sequencing approach for minimal residual disease detection in acute lymphoblastic leukemia. (smw.ch)
  • Campana D. Should minimal residual disease monitoring in acute lymphoblastic leukemia be standard of care? (smw.ch)
  • Prospective minimal residual disease monitoring to predict relapse of acute promyelocytic leukemia and to direct pre-emptive arsenic trioxide therapy. (smw.ch)
  • Minimal residual disease assessment in childhood acute lymphoblastic leukaemia: a Swedish multi-centre study comparing real-time polymerase chain reaction and multicolour flow cytometry. (smw.ch)
  • It has a non-debatable contribution to the diagnosis of hematolymphoid neoplasm as well as in minimal residual disease. (ijpmonline.org)
  • Establishing optimal quantitative-polymerase chain reaction assays for routine diagnosis and tracking of minimal residual disease in JAK2-V617F-associated myeloproliferative neoplasms: a joint European LeukemiaNet/MPN&MPNr-EuroNet (COST action BM0902) study. (cdc.gov)
  • Microarray-based classification of a consecutive series of 121 childhood acute leukemias: prediction of leukemic and genetic subtype as well as of minimal residual disease status. (lu.se)
  • We conducted a phase 3, open-label trial involving patients with HER2-positive early breast cancer who were found to have residual invasive disease in the breast or axilla at surgery after receiving neoadjuvant therapy containing a taxane (with or without anthracycline) and trastuzumab. (nih.gov)
  • Patients who have residual invasive breast cancer after receiving neoadjuvant chemotherapy plus human epidermal growth factor receptor 2 (HER2)-targeted therapy have a worse prognosis than those who have no residual cancer. (nih.gov)
  • This is a systematic review of studies in the PubMed database to April 2013, which fit the eligibility criterion of "Inflammatory Breast Neoplasms" (MeSH Terms), filtered by Languages (English OR Portuguese OR Spanish). (bvsalud.org)
  • What has been researched about inflammatory breast neoplasms? (bvsalud.org)
  • Thymic epithelial neoplasms or tumors, also known as thymoma and thymic carcinoma, are the most common primary neoplasms of the anterior mediastinum. (medscape.com)
  • The aim of this study was to compare the prognostic discrimination power of different histological regression grading systems: (i) the fibrosis/tumour ratio within the primary tumour (Mandard classification), (ii) the percentage of residual vital tumour cells (VTC) compared to the original primary tumour (Cologne Regression) and (iii) the ypT category, in patients with cT3 carcinoma of the oesophagus after neoadjuvant chemoradiation. (unige.ch)
  • Importance: Cerebrospinal fluid (CSF) cytologic testing and flow cytometry are insensitive for diagnosing neoplasms of the central nervous system (CNS). (stanford.edu)
  • Radiosurgery and radiation therapy are recommended for treatment of residual or recurrent NFPAs to lower the risk of subsequent tumor progression. (cns.org)
  • When no residual tumor is present or only a small intrasellar tumor exists postoperatively, serial neuroimaging studies are recommended. (cns.org)
  • Radiosurgery or radiation therapy for NFPAs is recommended when residual/recurrent sellar or parasellar tumor exists and the risk of a repeat resection is high. (cns.org)
  • The patient underwent radiation therapy with favorable regression of the residual tumor on subsequent imaging studies. (researchwithrutgers.com)
  • Influence of extent of resection of contrast enhanced tumor on progression-free survival and overall survival was analyzed, measured as relative extent of resection (EOR) and absolute residual tumor volume (RTV). (lu.se)
  • Results: Quantitative volumetric measurements, especially residual tumor volume of ≤1,6 mL, showed prognostic significance for longer progression-free and overall survival. (lu.se)
  • Flat tumors, termed en plaque, infiltrate the dura and grow as a thin carpet or sheet of tumor along the convexity dura, falx, or tentorium. (medscape.com)
  • To complement The ASCO Post 's continued comprehensive coverage of the 2021 American Society of Hematology (ASH) Annual Meeting & Exposition, here are several abstracts selected from the meeting proceedings focusing on allogeneic transplantation for hematologic neoplasms in adults. (ascopost.com)
  • It has been postulated that monitoring measurable residual disease (MRD) could be used as a surrogate marker of progression-free survival (PFS) in chronic lymphocytic leukemia (CLL) patients after treatment with immunochemotherapy regimens. (haematologica.org)
  • Future prospective studies are required to test different strategies that can improve the rates and quality (based on measurable residual disease [MRD] assessment) of remissions prior to and after allo-HCT using less toxic and more effective induction, conditioning, and maintenance therapies. (ascopost.com)
  • Intracranial neoplasms can arise from any of the structures or cell types present in the cranial vault, including the brain, meninges, pituitary gland, skull, and even residual embryonic tissue. (cancernetwork.com)
  • They represent approximately 38% of all intracranial neoplasms in females and 20% in males. (medscape.com)
  • Use of peripheral blood instead of bone marrow to monitor residual disease in children with acute lymphoblastic leukemia. (smw.ch)
  • This thesis therefore aimed at deciphering the metabolic phenotype of residual breast cancer which survived docetaxel treatment, \(in\) \(vitro\) and \(in\) \(vivo\), quantifying polar metabolite levels and conducting pathway tracing and metabolic flux analysis using stable isotope (\(^{13}\)C) labelled tracers. (bham.ac.uk)
  • In conclusion, this thesis demonstrated that metabolic phenotyping is a valid approach to uncover key metabolic alterations in residual tumours both \(in\) \(vitro\) and \(in\) \(vivo\), and could be further exploited to design personalised treatments aimed at restoring sensitivity to therapies. (bham.ac.uk)
  • Assessment of Residual Cancer Burden and Event-Free Survival in Neoadj" by W Fraser Symmans, Christina Yau et al. (providence.org)
  • Assessment of Residual Cancer Burden and Event-Free Survival in Neoadjuvant Treatment for High-risk Breast Cancer: An Analysis of Data From the I-SPY2 Randomized Clinical Trial. (providence.org)
  • IMPORTANCE: Residual cancer burden (RCB) distributions may improve the interpretation of efficacy in neoadjuvant breast cancer trials. (providence.org)
  • MAIN OUTCOMES AND MEASURES: Residual cancer burden (pathological measure of residual disease) and event-free survival (EFS). (providence.org)
  • Thirteen individuals with FPC (6.1%) underwent surgical resection for a suspected PRL, but only four (1.9%) had high-risk lesions (ie, high-grade intraductal papillary mucinous neoplasms or grade 3 pancreatic intraepithelial neoplasms). (medscape.com)
  • Of the 283 patients who were included in this analysis, residual neoplasia at the first endoscopic follow up was 24.8% in the cold snare group vs 15% in the hot snare group ( P = .037). (medscape.com)
  • In benign prostatic hyperplasia normal values for NEC and TC were determined in stages without residual urine. (uni-muenchen.de)
  • No significant associations were found with upper or lower respiratory infections, otitis media, any infectious diseases, neoplasms, sensory disorders, urgent and inpatient health services use, pediatric complex chronic conditions, or mortality. (bmj.com)
  • Involution may result in residual telangiectasias, pallor, atrophy, textural changes and sometimes fibrofatty residuum. (wikipedia.org)
  • A systematic review of the treatment options for residual or recurrent NFPAs was performed. (cns.org)
  • As planned surgery will only benefit patients with residual disease in the neck alone, there is a high rate of unnecessary ND with its associated morbidity. (nih.gov)
  • Bone marrow (BM) MRD analysis was performed after the last planned induction course and every 6 months in cases with detectable residual disease during the 36 months of maintenance therapy. (haematologica.org)
  • Thirty-seven patients (44%) did not have detectable residual disease in the BM prior to maintenance therapy. (haematologica.org)
  • Interestingly, 29 patients with detectable residual disease in the BM after induction no longer had detectable disease in the BM following maintenance therapy. (haematologica.org)
  • After a median followup of 6.30 years, the median overall survival (OS) and PFS had not been reached in patients with either undetectable or detectable residual disease in the BM, who had achieved a complete response at the time of starting maintenance therapy. (haematologica.org)
  • As per protocol, 15 patients (17.8%), who achieved a complete response and undetectable peripheral blood and BM residual disease after four courses of induction, were allowed to stop fludarabine and cyclophosphamide and complete two additional courses of rituximab and continue with maintenance therapy for 18 cycles. (haematologica.org)
  • Should patients with recurrent or residual nonfunctioning pituitary adenomas (NFPAs) undergo stereotactic radiosurgery (SRS), fractionated radiation therapy (eg, XRT, fractionated stereotactic radiotherapy [SRT], or intensity modulated radiotherapy[IMRT]), or repeat resection? (cns.org)
  • However, patients may require intervention during childhood, because 50% of IH leave residual fibrofatty tissue, redundant skin, or damaged structures after involution. (wikipedia.org)
  • Repeat resection, SRS, SRT, and XRT play a role in the management of patients with recurrent or residual NFPAs. (cns.org)
  • These recommendations apply to adult patients with recurrent or residual nonfunctioning pituitary adenomas (NFPAs). (cns.org)
  • After involution residual telangiectasias can be treated with laser therapy. (wikipedia.org)
  • Repeat resection is recommended for the treatment of symptomatic recurrent or residual NFPAs. (cns.org)
  • Residual confounding may explain the small associations observed with increased asthma and reduced gastrointestinal infections. (bmj.com)
  • Separately evaluate disabling effects other than disfigurement that are associated with individual scar(s) of the head, face, or neck, such as pain, instability, and residuals of associated muscle or nerve injury, under the appropriate diagnostic code(s) and apply § 4.25 to combine the evaluation(s) with the evaluation assigned under this diagnostic code. (cornell.edu)
  • Tangential shave biopsy of the lesion was performed and the histopathologic report revealed an adnexal neoplasm with trichilemmal differentiation, desmoplastic component, and atypia with margins involved (Figures 2A, 2B, 3A, and 3B). (jcadonline.com)