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Precursor T-Cell Lymphoblastic Leukemia-LymphomaLeukemia-Lymphoma, Adult T-CellPrecursor Cell Lymphoblastic Leukemia-LymphomaPrecursor B-Cell Lymphoblastic Leukemia-LymphomaImmunoglobulin Light Chains, SurrogateLymphomaPrecursor Cells, B-LymphoidB-LymphocytesLeukemiaPre-B Cell ReceptorsB-Lymphocyte SubsetsLymphoma, B-CellLymphoma, T-CellLeukemia, LymphoidLymphoma, Non-HodgkinCell DifferentiationHematopoietic Stem CellsReceptors, Antigen, B-CellBurkitt LymphomaLeukemia, B-CellImmunoglobulin mu-ChainsAntigens, CD19Leukemia, Myeloid, AcuteBone Marrow CellsInterleukin-7Immunoglobulin Heavy ChainsLeukemia, T-CellImmunoglobulin Light ChainsFlow CytometryProtein PrecursorsGenes, ImmunoglobulinAsparaginaseLymphoma, Large B-Cell, DiffuseAgammaglobulinemiaImmunoglobulin lambda-ChainsSuccinimidesBone MarrowHuman T-lymphotropic virus 1Gene Expression Regulation, LeukemicCells, CulturedImmunophenotypingLymphoma, FollicularLeukemia, Lymphocytic, Chronic, B-CellStem CellsGene Rearrangement, B-LymphocyteImmunoglobulin MLeukemia, ExperimentalRemission InductionTranslocation, GeneticMolecular Sequence DataBase SequenceMice, KnockoutLymphoma, B-Cell, Marginal ZoneKaryotypingGene RearrangementApoptosisLeukemia, Myelogenous, Chronic, BCR-ABL PositiveT-LymphocytesCell LineageFluoresceinsHTLV-I InfectionsNeoplasm, ResidualVincristineMice, Inbred C57BLGene Rearrangement, B-Lymphocyte, Light ChainLymphoma, T-Cell, CutaneousCell LineLeukemic InfiltrationAntineoplastic Combined Chemotherapy ProtocolsMice, TransgenicPhiladelphia ChromosomeAntigens, CDPrognosisLymphoma, T-Cell, PeripheralTumor Cells, CulturedPolymerase Chain ReactionSignal TransductionTranscription FactorsCell DivisionMutationPrecursor Cells, T-LymphoidAntineoplastic Agents6-MercaptopurineImmunohistochemistryRNA, MessengerMethotrexateReceptor, Notch1Deltaretrovirus InfectionsAntibodies, MonoclonalMyeloid-Lymphoid Leukemia ProteinLymphoma, Mantle-CellCell ProliferationTreatment OutcomeAntigens, NeoplasmDNA, NeoplasmImmunoglobulin Variable RegionPhenotypeCell Line, TumorNeprilysinMice, SCID
Chronic lymphocyLarge Cell LymphomasProteinsMyeloidRefractoryChemotherapyTumorsSurvivalRelapseTransplantationBlood and bone marrowMyeloproliferative neoplasmsHodgkinTumorMutationPediatricFollicular lymphomaProliferationRemissionCancersChildhood acute lymphoblBoneAdult acuteDiffusePrognosisCancerMarrowDiagnosisNasalPatientsMalignantClassificationPrevalentManifestAbnormalClinicalExtranodalHead and NeckGeneticLymphocytesDifferentiation
Chronic lymphocy4
  • There is a similar category of disease for the lymphoid lineage, the lymphoproliferative disorders acute lymphoblastic leukemia, lymphomas, chronic lymphocytic leukemia and multiple myeloma. (wikipedia.org)
  • Age-related clonal hematopoiesis and monoclonal B-cell lymphocytosis/chronic lymphocytic leukemia: a new association? (haematologica.org)
  • 1q23.1 homozygous deletion and downregulation of Fc receptor-like family genes confer poor prognosis in chronic lymphocytic leukemia. (cancerindex.org)
  • The identification of chromosome 1 translocations and deletions is a rare and poorly investigated event in chronic lymphocytic leukemia (CLL). (cancerindex.org)
Large Cell Lymphomas2
  • In addition, cytoplasmic vacuoles are not uncommon in large cell lymphomas involving body cavities. (cytojournal.com)
  • Diffuse large cell lymphomas and their mimics. (llu.edu)
Proteins1
  • The roles of clonal hematopoiesis, RNA-binding proteins, and alterations in metabolism and cell signaling (e.g. (cshlpress.com)
Myeloid11
  • In rare cases, some MPNs such as primary myelofibrosis may accelerate and turn into acute myeloid leukemia. (wikipedia.org)
  • As of 2016, the World Health Organization lists the following subcategories of MPNs: Chronic myeloid leukemia (CML) Chronic neutrophilic leukemia (CNL) Polycythemia vera (PV) Primary myelofibrosis (PMF) PMF, Prefibrotic Stage PMF, Overt Fibrotic Stage Essential thrombocythemia (ET) Chronic eosinophilic leukemia (not otherwise specified) MPN, unclassifiable (MPN-U) MPNs arise when precursor cells (blast cells) of the myeloid lineages in the bone marrow develop somatic mutations which cause them to grow abnormally. (wikipedia.org)
  • According to WHO diagnostic criteria published in 2016, myeloproliferative neoplasms are diagnosed as follows: Chronic myeloid leukemia (CML) has a presence of the hallmark Philadelphia Chromosome (BCR-ABL1) mutation. (wikipedia.org)
  • LMO2 plays a role in angiogenesis and hematopoesis, and its expression has been detected in erythroid and myeloid precursors, megakaryocytes, and also in lymphoblastic and acute myeloid leukemias. (genomeme.ca)
  • Clinical relevance of IDH1/2 mutant allele burden during follow-up in acute myeloid leukemia. (haematologica.org)
  • Cross-sectional study of 36 children with acute lymphoblastic leukemia (ALL) or acute myeloid leukemia (AML). (bvsalud.org)
  • Acute myeloid leukemia (AML), which accounts for 15-20% of all leukemias in childhood, belongs to a heterogeneous group of hematopoietic malignancies of monoclonal origin, which result from the malignant transformation of a stem cell. (bvsalud.org)
  • These neoplasms can manifest with a myeloid, erythroid, or platelet precursor phenotype, or a combination thereof 5 . (bvsalud.org)
  • A New Complex Karyotype Involving a KMT2A-r Variant Three-Way Translocation in a Rare Clinical Presentation of a Pediatric Patient with Acute Myeloid Leukemia. (cancerindex.org)
  • Patients with childhood acute myeloid leukemia (AML) with complex karyotypes (CKs) have a dismal outcome. (cancerindex.org)
  • Occasionally, people with PDGFRA -associated chronic eosinophilic leukemia develop other blood cell cancers, such as acute myeloid leukemia or B-cell or T-cell acute lymphoblastic leukemia or lymphoblastic lymphoma. (medlineplus.gov)
Refractory4
  • Adults with relapsed or refractory B-precursor acute lymphoblastic leukaemia have an unfavourable prognosis. (nih.gov)
  • In a multicentre, single-arm, open-label phase 2 study, we enrolled adult patients with Philadelphia-chromosome-negative, primary refractory or relapsed (first relapse within 12 months of first remission, relapse within 12 months after allogeneic haemopoietic stem-cell transplantation [HSCT], or no response to or relapse after first salvage therapy or beyond) leukaemia. (nih.gov)
  • Single-agent blinatumomab showed antileukaemia activity in adult patients with relapsed or refractory B-precursor acute lymphoblastic leukaemia characterised by negative prognostic factors. (nih.gov)
  • Phase 1 clinical trial of CRISPR-engineered CAR19 universal T cells for treatment of children with refractory B cell leukemia. (nih.gov)
Chemotherapy3
  • Treatment typically includes combination chemotherapy to achieve remission, intrathecal and systemic chemotherapy and/or corticosteroids for CNS prophylaxis, and sometimes cerebral irradiation for intracerebral leukemic infiltration, consolidation chemotherapy with or without stem cell transplantation, and maintenance chemotherapy for up to 3 years to avoid relapse. (msdmanuals.com)
  • CLINICAL CASE: 7-year-old male schoolboy diagnosed with T-precursor acute lymphoid leukemia, finishing induction chemotherapy cycle with PETHEMA 2013 protocol. (bvsalud.org)
  • Purpose: To determine the tolerability and serum concentration of epratuzumab, a humanized monoclonal antibody targeting CD22, administered alone and in combination with reinduction chemotherapy in children with relapsed acute lymphoblastic leukemia (ALL), and to preliminarily assess tumor targeting and efficacy. (johnshopkins.edu)
Tumors1
  • The most common malignant neoplasms of childhood are the leukemias, central nervous system tumors, and the lymphomas 2 . (bvsalud.org)
Survival5
  • Neural factors are a class of protein molecules with neurotrophic activity that can promote the survival and regeneration of nerve cells. (acrobiosystems.com)
  • When the CRLF2 receptor is activated by its ligand, TSLP, downstream pathways (JAK/STAT and PI3/AKT/mTOR) that promote leukemia cell survival, proliferation, and chemoresistance are induced through processes normally kept in check by the Ikaros tumor suppressor. (psu.edu)
  • The objective of this investigation is to assess the impact of VZV infection on patients' long-term survival following allogeneic hematopoietic stem cell transplantation (allo-HSCT). (bvsalud.org)
  • These signaling pathways control many important cellular processes, such as cell growth and division (proliferation) and cell survival. (medlineplus.gov)
  • As a result, the signaling pathways are constantly turned on (constitutively activated), which increases the proliferation and survival of cells. (medlineplus.gov)
Relapse3
  • This disparity is due, in part, to a subtype of B-cell precursor ALL (B-ALL) that occurs five times more frequently among Hispanic children than others and has a high relapse rate. (psu.edu)
  • This type of leukemia, called CRLF2 B-ALL, is characterized by two genetic alterations: a) overexpression of the cytokine receptor, CRLF2, and b) deletion or inactivation of one allele of the Ikaros (IKZF1) tumor suppressor which is strongly associated with relapse. (psu.edu)
  • CONCLUSION: T-cell depletion with CAMPATH-1 effectively prevents GVHD, particularly the severe acute forms, without leading to excessive risk of relapse in acute leukemia. (ox.ac.uk)
Transplantation4
  • Hematopoietic stem cell transplantation can be a curative treatment for a small group of patients, however MPN treatment is typically focused on symptom control and myelosuppressive drugs to help control the production of blood cells. (wikipedia.org)
  • BACKGROUND: Preventing graft-versus-host disease (GVHD) by depletion of T lymphocytes from the stem cell graft for transplantation remains controversial, mainly because of the perceived increase in disease recurrence. (ox.ac.uk)
  • METHODS: This retrospective study investigated the association between varicella-zoster virus (VZV) reactivation and outcomes in 219 individuals who received allogeneic hematopoietic stem cell transplantation (allo-HSCT) at the Sun Yat-sen University's First Affiliated Hospital. (bvsalud.org)
  • Management of adults and children receiving CAR T-cell therapy: 2021 best practice recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE) and the European Haematology Association (EHA). (nih.gov)
Blood and bone marrow1
  • A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. (curehunter.com)
Myeloproliferative neoplasms2
  • Myeloproliferative neoplasms (MPNs) are a group of rare blood cancers in which excess red blood cells, white blood cells or platelets are produced in the bone marrow. (wikipedia.org)
  • Trials of these inhibitors are in progress for the treatment of the other myeloproliferative neoplasms. (wikipedia.org)
Hodgkin2
Tumor2
  • Advances in tumor cell biology have led to the ability to subclassify NHL via the World Health Organization (WHO) classification of lymphomas (see below). (medscape.com)
  • Extraneural recurrence of an intracranial nongerminomatous germ cell tumor to cervical lymph nodes in a pediatric patient: Case report. (uc.edu)
Mutation4
  • The overproduction of blood cells is often associated with a somatic mutation, for example in the JAK2, CALR, TET2, and MPL gene markers. (wikipedia.org)
  • Chronic neutrophilic leukemia (CNL) is characterized by a mutation in the CSF3R gene and an exclusion of other causes of neutrophilia. (wikipedia.org)
  • The somatic mutation occurs initially in a single cell, which continues to grow and divide, producing a group of cells with the same mutation (a clonal population). (medlineplus.gov)
  • When the FIP1L1-PDGFRA fusion gene mutation or point mutations in the PDGFRA gene occur in blood cell precursors, the growth of eosinophils (and occasionally other blood cells, such as neutrophils and mast cells) is poorly controlled, leading to PDGFRA -associated chronic eosinophilic leukemia. (medlineplus.gov)
Pediatric1
  • To overcome this obstacle our team engineered immune deficient mice that provide normal human serum levels of human TSLP (+T mice) and generated PDX by injecting these mice with CRLF2 B-ALL cells from Hispanic pediatric patients (+T PDX). (psu.edu)
Follicular lymphoma1
  • LMO2 protein expression has been noted in diffuse large B-cell lymphoma, the most common adult non-Hodgkin's lymphoma, as well as follicular lymphoma, a neoplasm derived from germinal center B-cells that accounts for a number of cases of non-Hodgkin's lymphomas. (genomeme.ca)
Proliferation4
  • Malignant transformation and uncontrolled proliferation of an abnormally differentiated, long-lived hematopoietic progenitor cell results in a high circulating number of blasts, replacement of normal marrow by malignant cells, and the potential for leukemic infiltration of the central nervous system (CNS) and testes. (msdmanuals.com)
  • Abnormal proliferation, clonal expansion, aberrant differentiation, and diminished apoptosis (programmed cell death) lead to replacement of normal blood elements with malignant cells. (msdmanuals.com)
  • Childhood cancer corresponds to a group of diseases characterized by the uncontrolled proliferation of atypical cells, which may occur anywhere in the body 1 . (bvsalud.org)
  • Introduction:Childhood cancer correspondsto a group of several diseases that have in common the uncontrolled proliferation of abnormal cells and that can occur anywhere in the body. (bvsalud.org)
Remission1
  • It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia. (lookformedical.com)
Cancers1
Childhood acute lymphobl1
  • Does minimal central nervous system involvement in childhood acute lymphoblastic leukemia increase the risk for central nervous system toxicity? (regionh.dk)
Bone6
  • Myelo refers to the bone marrow, proliferative describes the rapid growth of blood cells and neoplasm describes that growth as abnormal and uncontrolled. (wikipedia.org)
  • Depending on the nature of the myeloproliferative neoplasm, diagnostic tests may include red cell mass determination (for polycythemia), bone marrow aspirate and trephine biopsy, arterial oxygen saturation and carboxyhaemoglobin level, neutrophil alkaline phosphatase level, vitamin B12 (or B12 binding capacity), serum urate or direct sequencing of the patient's DNA. (wikipedia.org)
  • Ex vivo depletion of T cells from bone marrow grafts with CAMPATH-1 in acute leukemia: graft-versus-host disease and graft-versus-leukemia effect. (ox.ac.uk)
  • 20% bone marrow blasts) or as a lymphoma Overview of Lymphoma when blasts infiltrate mainly extramedullary tissue. (msdmanuals.com)
  • LMO2, also known as LIM-Only Transcription Factor 2, RBTN2, or TTG2, is an oncoprotein that is expressed in normal germinal center B-cells, as well as bone marrow hematopoietic precursors and endothelial cells. (genomeme.ca)
  • Among the leukemias, the most prevalent type is acute lymphoblastic leukemia (ALL), which is characterized by accumulation of immature lymphoid cells in the bone marrow 2,3 and accounts for roughly 80% of all cases of leukemia in childhood. (bvsalud.org)
Adult acute1
Diffuse1
  • T-cell/histiocyte-rich large B-cell lymphoma - a distinct clinicopathologic entity or a variant of diffuse large B cell lymphoma? (llu.edu)
Prognosis3
  • The prognosis for B-cell precursor acute lymphoblastic leukemia patients with Mixed-Lineage Leukemia (MLL) gene rearrangements (MLLr BCP-ALL) is still extremely poor. (ox.ac.uk)
  • The 2016 World Health Organization (WHO) classification of lymphoid neoplasms incorporates genetic data, clinical features, cell morphology, and immunophenotype, all of which have important implications for disease prognosis and management. (msdmanuals.com)
  • This is a good prognosis leukemia. (nih.gov)
Cancer4
  • The National Cancer Institute's Working Formulation, originally proposed in 1982, classified and grouped lymphomas by morphology and clinical behavior (ie, low, intermediate, or high grade) with 10 subgroups labeled A to J. (medscape.com)
  • It is the most common cancer in children and accounts for the vast majority of all childhood leukemias. (lookformedical.com)
  • The American Cancer Society estimates that in the United States in 2023 there will be over 6500 new cases of acute lymphoblastic leukemia (ALL) and almost 1400 deaths will have occurred. (msdmanuals.com)
  • Acute lymphocytic leukemia (ALL), for example, is the most common childhood cancer, but these diseases can occur in individuals of all ages. (cshlpress.com)
Marrow1
  • A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. (lookformedical.com)
Diagnosis4
  • A quarter of all extranodal lymphomas occur in the head and neck, and 8% of findings on supraclavicular fine-needle aspirate biopsy yield a diagnosis of lymphoma. (medscape.com)
  • Symptoms and signs of acute lymphoblastic leukemia may be present for only days to weeks before diagnosis. (msdmanuals.com)
  • The diagnosis and differential diagnosis of 'small' B cell lymphomas. (llu.edu)
  • Acute Leukemia Diagnosis - A Practical Morphologic, Immunophenotypic, and Cytogenetic Approach. (llu.edu)
Nasal1
  • CT scan of a patient with a natural killer (NK)/T-cell lymphoma of the right nasal cavity and maxillary sinus. (medscape.com)
Patients8
  • Patients with otherwise unexplained thrombosis and with neoplasms that cannot be classified in one of the other categories. (wikipedia.org)
  • Preclinical studies of CRLF2 B-ALL typically use patient-derived xenograft (PDX) models, where primary leukemia cells from patients with CRLF2 B-ALL are injected into immune deficient mice. (psu.edu)
  • Overall, 11 patients (22%) relapsed (4 of 33 acute myeloblastic leukemia in CR1) at a median of 235 (range 46-528) days. (ox.ac.uk)
  • OUTLINE: Patients are stratified by disease characteristics (disseminated lymphoblastic lymphoma vs localized lymphoblastic lymphoma [localized lymphoblastic lymphoma is closed to accrual as of 10/2005]) and age. (knowcancer.com)
  • Patients with localized lymphoblastic lymphoma (closed to accrual as of 10/2005) are not randomized. (knowcancer.com)
  • Arm I (closed to accrual as of 4/2006): Patients receive same induction, consolidation, and interim maintenance therapy schedule as localized lymphoblastic lymphoma patients. (knowcancer.com)
  • Maintenance (84 day course): Patients receive same therapy as localized lymphoblastic lymphoma patients, except methotrexate IT is administered on day 0 and 28 (for first 4 courses). (knowcancer.com)
  • Objective:Identify the most frequent types of neoplasms in childhood and adolescence and analyze the clinical-epidemiological profile of patients. (bvsalud.org)
Malignant4
  • [ 3 ] Previous terms for NK-cell malignancies and other forms of non-B-cell NHL included lethal midline granuloma, angiocentric lymphoma, malignant granuloma, malignant midline reticulosis, and polymorphic reticulosis. (medscape.com)
  • In MPNs, the neoplasm (abnormal growth) starts out as benign and can later become malignant. (wikipedia.org)
  • Malignant transformation usually occurs at the pluripotent stem cell level, although it sometimes involves a committed stem cell with more limited capacity for self-renewal. (msdmanuals.com)
  • The contributors review the normal functions of hematopoietic stem cells-the precursors to white blood cells-and then examine the genetic, epigenetic, and cellular mechanisms that drive malignant transformation. (cshlpress.com)
Classification4
  • This classification divides NHL into two groups: those of B-cell origin and those of T-cell/natural killer (NK)-cell origin. (medscape.com)
  • The WHO modification of the REAL classification of NHL is based on morphology and cell lineage. (medscape.com)
  • The unavailability of this information is demonstrated in previous classification systems, including the Lukes-Collins, Kiel, and Working Formulation systems, which did not identify subclasses of NK/T-cell malignancies. (medscape.com)
  • The Working Formulation, originally proposed in 1982, classified and grouped lymphomas by morphology and clinical behavior (ie, low, intermediate, or high grade) with 10 subgroups labeled A to J.{Ref 1} In 1994, the Revised European-American Lymphoma (REAL) classification attempted to apply immunophenotypic and genetic features in identifying distinct clinicopathologic NHL entities. (medscape.com)
Prevalent1
Manifest1
  • In general, hematolymphoid cells manifest as dyshesive cells in cytological specimens. (cytojournal.com)
Abnormal1
  • Whether NK-cell lymphoma represents the presence of a true NK cell or merely the presence of a T cell with abnormal cell markers is under debate. (medscape.com)
Clinical3
  • Diagnosing hematolymphoid neoplasm by evaluating fine-needle aspiration (FNA) cytology sample is controversial and requires experience and clinical skills. (cytojournal.com)
  • Clinical diagnostics and treatment strategies for Philadelphia chromosome-like acute lymphoblastic leukemia. (nih.gov)
  • Each chapter provides in-depth analysis of a particular aspect of leukemia and/or lymphoma, contributing to a comprehensive review on current biological and clinical understandings of leukemia and lymphoma. (cshlpress.com)
Extranodal1
Head and Neck1
  • Lymphoma is the second most common primary malignancy occurring in the head and neck. (medscape.com)
Genetic3
  • acute lymphoblastic leukemia is caused by a series of acquired genetic aberrations. (msdmanuals.com)
  • Genetic rearrangements and point mutations affecting the PDGFRA gene are somatic mutations, which are mutations acquired during a person's lifetime that are present only in certain cells. (medlineplus.gov)
  • The most common genetic abnormality in PDGFRA -associated chronic eosinophilic leukemia results from a deletion of genetic material from chromosome 4 , which brings together part of the PDGFRA gene and part of the FIP1L1 gene, creating the FIP1L1-PDGFRA fusion gene. (medlineplus.gov)
Lymphocytes1
  • Differentiating between low-grade lymphoma and reactive lymphocytes is often difficult by morphology alone as reactive lymphoid cells may acquire activation morphology from being exposed to different cytokines within the body fluid. (cytojournal.com)
Differentiation2
  • Within the B-cell and T-cell categories, two subdivisions are recognized: precursor neoplasms, which correspond to the earliest stages of differentiation, and more mature differentiated neoplasms. (medscape.com)
  • Explore our series of recombinant neural factors to support the culture and differentiation of nerve cells. (acrobiosystems.com)