Neonatal rat brain evidence hypoxia ischemia. Medical search. Frequent questions

In adult rat melatonin given after focal cerebral ischemia improves short term evaluations of infarct size and neurobehavioral outcomes (41) suggesting that melatonin treatment may be applicable to global brain ischemia in the neonate. (techuniq.com)
The fate of the brain tissue after focal cerebral ischemia is determined by the degree and duration of ischemia, and even without preconditioning, resident brain cells naturally respond to brain ischemia by mobilizing a host of defences and counter responses to mitigate cell injury and death [ 5 ]. (biomedcentral.com)

After hypoxia and ischemia, the production of reactive oxygen species (ROS) rapidly accumulates and leads to mitochondrial dysfunction and delayed neuronal death. (frontiersin.org)
In neonatal hypoxia-ischemia, an increase in reactive oxygen species (ROS) is known to occur in the brain at 96 h after a hypoxic-ischemic episode, to which the antioxidant system responds by increasing the activity of superoxide dismutase (SOD) and catalase (CAT) at postnatal day (PND) 11, which decreases afterward [ 5 ]. (hindawi.com)

Hypoxic-ischemic encephalopathy (HIE) at high-altitudes leads to neonatal mortality and long-term neurological complications without effective treatment. (bvsalud.org)
Hypoxic-ischemic encephalopathy (HIE) is associated with excessive inflammation, blood-brain barrier dysfunction, and oxidative stress. (bvsalud.org)
Hypoxic-ischemic encephalopathy (HIE) following intrauterine ischemia (IUI) is one of the leading causes of brain injury in neonates, and the effects can endure until adulthood [ 1 , 2 ]. (hindawi.com)
Hypoxic ischemic encephalopathy (HIE) occurs in 1-6 per 1,000 live full-term births and is caused by the interruption of blood and/or oxygen supply to the brain in the perinatal period ( 1 , 2 ). (nature.com)

Our previous studies suggested that brain-derived neurotrophic factor (BDNF)/tropomyosin-related kinase B (TrkB) axis inhibited cardiomyocyte apoptosis in myocardial infarction (MI). (ijbs.com)
Abrupt cessation may exacerbate myocardial ischemia. (nih.gov)

Here, we found that compared with continuous hypoxia (CH), intermittent hypoxia (IH) significantly improved cerebral blood flow and oxygen saturation in mice without causing neurological impairment. (bvsalud.org)
By analyzing cerebrovascular microcirculation from mice, we found that the IH mode (13%, 5*10) with 13% O2, 5 min interval, and 10 cycles per day significantly improved the cerebrovascular microcirculation by promoting angiogenesis without affecting the integrity of the blood-brain barrier. (bvsalud.org)
The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic-ischemic brain damage in mice is mediated by CB(2) and adenosine receptors. (greenmedinfo.com)
By combining operant tasks that assess discrete aspects of motivated behavior and decision-making in male mice and rats with subsecond dopamine monitoring via fast-scan cyclic voltammetry, we defined the role of G-CSF in these processes as well as the neural mechanism by which it modulates dopamine function to exert these effects. (jneurosci.org)
These mice exhibit manic behavior and loss of brain volume which is reversed by lithium treatment. (jeffreydachmd.com)
More encouragingly melatonin provided to neonatal mice before and after severe hypoxia significantly increased hippocampal neuronal survival at 3 7 and 14 days as well as functional motor outcomes two weeks following insult (43). (techuniq.com)
We previously described that peripheral administration to neonatal mice of the TLR2 ligand PAM3CSK4 (P3C), a prototypic Gram-positive bacterial lipopeptide, induces the migration of innate immune cells to the CSF. (biomedcentral.com)

Mangiferin potentiates neuroprotection by isoflurane in neonatal hypoxic brain injury. (greenmedinfo.com)

We therefore investigated the impact of global brain hypoxia-ischemia on the thalamic circuit function in the somatosensory system of young rats. (cdc.gov)
The young rats were treated with the TAK1 inhibitor takinib or the RIPK1 inhibitor necrostatin-1 (Nec-1) before surgery, and old rats received adeno-associated virus (AAV)-TAK1 before surgery. (imperial.ac.uk)
RESULTS: Old rats had low TAK1 expression and were more susceptible to surgery-induced POCD and neuroinflammation than young rats. (imperial.ac.uk)
TAK1 inhibition exacerbated surgery-induced pRIPK1 expression, neuroinflammation and cognitive dysfunction in young rats, and this effect was reversed by a RIPK1 inhibitor. (imperial.ac.uk)

Peripherally administered EPO crosses the blood-brain barrier and activates in the brain anti-apoptotic, anti-oxidant and anti-inflammatory signaling in neurons, glial and cerebrovascular endothelial cells and stimulates angiogenesis and neurogenesis. (biomedcentral.com)
Here, we investigated the role of Sirt1 in the pathogenesis of brain injuries after modulating its activity in primary cultured hippocampal neurons. (frontiersin.org)
Additionally, evidence has revealed that enhancing Sirt1 activity can reduce ROS production, reduce inflammation of neurons and glial cells, so as to reduce neuronal cell death ( 8 ). (frontiersin.org)
Neurotrophic factors, including brain-derived neurotrophic factor (BDNF), are indispensable regulators for the survival of glial cells and neurons in the central nervous system (CNS) [ 13 ]. (degruyter.com)
We used single neuron recordings and controlled whisker deflections to examine responses of thalamocortical neurons to sensory stimulation in rat survivors of 9 min of asphyxial cardiac arrest incurred on post-natal day 17. (cdc.gov)
One of the surprising findings in Bipolar Disorder recently made visible by new MRI brain imaging techniques is the loss of hippocampus neurons, and loss of brain volume characteristic of Bipolar disorder. (jeffreydachmd.com)
Virtually all of the neurons and glia that populate the mature brain arise from neural precursors (NPs) that reside immediately adjacent to the lateral ventricles. (karger.com)

At 48 h after the injections, hypoxic-ischemic (HI) injury was induced by unilateral carotid artery ligation followed by hypoxia for 65 min. (biomedcentral.com)

Previous studies showed that Sirt1 can regulate diabetes-induced cardiac dysfunction and brain ischemic reperfusion injuries by preventing mitochondrial dysfunction and alleviating hepatic steatosis ( 2 - 4 ). (frontiersin.org)
It was discovered in 2007 that inhaled hydrogen had genuine protection against brain damage caused by ischemia and reperfusion because of its anti-inflammatory and anti-apoptotic properties (Fukuda et al. (healthandhydrogen.com)

However, little is known about how hypoxia affects the ability of microglia, resident CNS macrophages, to respond to subsequent inflammatory challenges that are often present during neurodegenerative processes. (frontiersin.org)
To test this, we pre-exposed immortalized N9 and primary microglia to hypoxia (1% O 2 ) for 16 h and then challenged them with pro-inflammatory lipopolysaccharide (LPS) either immediately or 3-6 days following hypoxic exposure. (frontiersin.org)
We found that microglia exhibited enhanced responses to LPS 3 days and 6 days post-hypoxia. (frontiersin.org)
Collectively, our data provide evidence that activated microglia and complement cascade c1q signaling in the hippocampus may account for synaptic loss and cognitive impairments in a mouse model of neuroinflammation induced by repeated LPS injections. (imperial.ac.uk)

Male Wistar rats were subjected to coronary artery ligation, and primary neonatal rat ventricular myocytes were treated with hypoxia or hydrogen peroxide (H 2 O 2 ). (ijbs.com)

However, the role of Sirt1 in perinatal brain injuries is not completely understood. (frontiersin.org)
2008. Dr M-C.COHEN, I.SCHEIMBERG : Evidence of occurence of intradural and subdural hemorrhage in the perinatal and neonatal period in the context of HIE. (atide-asso.org)
Prematurity and other perinatal complications including early-onset systemic infections, neonatal meningitis, or hypoxic/ischemic episodes can induce severe neurological deficiencies including cerebral palsy and are associated with an increased risk of neuropsychiatric sequelae such as autistic and schizophrenic syndromes in later life. (biomedcentral.com)

The results demonstrated that propofol-induced impairment in spatial learning and memory of rats and promoted oxidative stress, neuronal injury and apoptosis in rat hippocampal tissues. (degruyter.com)

METHODS: Young (2-month-old) and old (24-month-old) Sprague-Dawley rats were subjected to splenectomy under isoflurane anaesthesia. (imperial.ac.uk)
Two groups of Sprague-Dawley rats ( n =6 per group) were either exposed to hypoxia (10% O 2 ) or normoxia (21% O 2 ) for 3 weeks. (cams.cn)

IUI alters cerebral metabolism because it causes a deficiency of oxygen and nutrients essential for maturing the neurochemical circuitry in the neonatal phase, particularly the glutamatergic and GABAergic pathways in the cerebral cortex [ 8 , 9 ]. (hindawi.com)
However, oxygen therapy might cause the accumulation of distal bronchial viscous secretions because of positive pressure ventilation mode, and thus increase airway resistance, aggravate systemic hypoxia [15]. (researchgate.net)
To explore these mechanisms further, we exposed mouse brain organotypic slice cultures to oxygen and glucose deprivation (OGD) and then treated the brain slices with cells from CB or adult peripheral blood (PB). (biorxiv.org)
Global hypoxia-ischemia interrupts oxygen delivery and blood flow to the entire brain. (cdc.gov)
But many chronically ill people exist in a state of cellular hypoxia, meaning there is not enough oxygen reaching the inside of the cells to fuel cellular machinery . (healthimpactnews.com)
I had a large multiplace chamber in Great Barrington, MA where I treated the late effects of brain injury and other promising but off label indications with hyperbaric oxygen, including neuroinflammatory conditions like autism and treatment resistant Lyme Disease. (healthimpactnews.com)
Searching for molecular hypoxia sensors among oxygen-dependent enzymes. (ucsf.edu)

This comprehensive review aims to concentrate on the potential neuroprotective agents that have demonstrated efficacy in addressing various pathogenic factors associated with neonatal HIBD, encompassing oxidative stress, calcium overload, mitochondrial dysfunction, endoplasmic reticulum stress, inflammatory response, and apoptosis. (bvsalud.org)

Cerebral hypoxia-ischemia causes cardiac damage in a rat model. (otago.ac.nz)

Oxidative stress is an important mechanism of neonatal hypoxic-ischemic brain damage. (frontiersin.org)
These results collectively indicate the chronicity of oxidative stress and an inadequate antioxidant response after a cerebral hypoxia-ischemia event and have motivated the development of preventive and therapeutic approaches against oxidative stress. (hindawi.com)
This results in a considerable improvement in injury caused by oxidative stress produced by different ischemia of cerebral areas of brain. (healthandhydrogen.com)

Jiao W, Chatton JY, Genoud C. Mitochondria morphometry in 3D datasets obtained from mouse brains with serial block-face scanning electron microscopy. (unil.ch)

Altogether our FACS (fluorescence-activated cell sorter) analyses reveal that the neonatal subventricular zone is far more heterogeneous than previously suspected and our studies provide new insights into the signals and mechanisms that regulate their self-renewal and proliferation. (karger.com)

In the UK there is a network of charity chambers salvaged from the North Sea that treat MS and, more recently, cerebral palsy and other brain injured children for free or a minimal donation. (healthimpactnews.com)
Despite advances in neonatal intensive care, survivors of premature birth remain highly susceptible to unique patterns of developmental brain injury that manifest as cerebral palsy and cognitive-learning disabilities. (nartsignaling.com)

However, the combined effect of prophylactic zinc administration and therapeutic taurine treatment on intrauterine ischemia- (IUI-) induced cerebral damage remains unknown. (hindawi.com)
Mounting evidence has demonstrated that AQP4, a water channel protein, is closely correlated with brain edema and could be an optimal therapeutic target for the reduction of ischemic brain edema. (benthamscience.com)

Fetal cell/tissue transplantation has been arduously studied as a potential way to repair the injured brain. (jneurosci.org)
Archives of Disease in Childhood: Fetal and Neonatal Edition. (monash.edu)
Thus, the fetal sheep has provided unique experimental access to the complex pathophysiological processes that contribute to injury to the human brain during successive periods in development. (nartsignaling.com)
2022. Dr O.AMI et al : Using magnetic resonance imaging during childbirth to demonstrate fetal head moldability and brain compression. (atide-asso.org)
2018. Dr O.AMI, J-C.MARAN, P.GABOR et al : Three-dimensional magnetic resonance imaging of fetal head molding and brain shape changes during the second stage of labor. (atide-asso.org)
2010. Dr B.SCHIFRIN et al : Fetal brain injury associated with uterine hyperstimulation and cranio-cerebral compression during labor. (atide-asso.org)
2021. Dr V.VLASYUK : Fetal and neonatal trauma in dystocic labor and delivery. (atide-asso.org)

Moreover, knocking down BDNF partially reversed esketamine-mediated activation of the mBDNF/TrkB/PI3K signaling pathway and inhibition of neuronal apoptosis in propofol-induced rats. (degruyter.com)
Hang P, Sun C, Guo J, Zhao J, Du Z. BDNF-mediates Down-regulation of MicroRNA-195 Inhibits Ischemic Cardiac Apoptosis in Rats. (ijbs.com)
Cardiac function and apoptosis were detected in MI rats intravenously injected with antagomiR-195. (ijbs.com)

Esketamine activated the mature brain-derived neurotrophic factor/tropomyosin receptor kinase B/phosphatidylinositide 3-kinase (mBDNF/TrkB/PI3K) signaling pathway in propofol-administrated rats. (degruyter.com)
Many preclinical studies suggest that CB-MNC protect the brain after HI by releasing neurotrophic and anti-inflammatory factors that stimulate repair by host cells [ 8 , 9 ]. (biorxiv.org)
The Neurotrophic theory says that clinical depression is caused by reduced or absent brain neurogenesis, rather than chemical imbalances in the brain. (jeffreydachmd.com)

Our results showed that taurine alone or in combination with zinc provides neuroprotection in the IUI rat model. (hindawi.com)
Pre-treatment with poly I:C did not offer neuroprotection in P7 rat brains. (biomedcentral.com)

In this review, we conducted an analysis of the precise molecular pathways by which these drugs elicit neuroprotective effects in animal models of neonatal hypoxic-ischemic brain injury (HIBD). (bvsalud.org)
Neuroinflammation in ischemic brain injury as an adaptive process. (otago.ac.nz)
Cannabidiol administration after hypoxia-ischemia to newborn rats reduces long-term brain injury and restores neurobehavioral function. (greenmedinfo.com)
Cannabidiol reduces lung injury induced by hypoxic-ischemic brain damage. (greenmedinfo.com)
EPO and its receptors (EPOR) are expressed in multiple brain cells during brain development and upregulated in the adult brain after injury. (biomedcentral.com)
These mechanisms underlie its potent tissue protective effects in experimental models of stroke, cerebral hemorrhage, traumatic brain injury, neuroinflammatory and neurodegenerative disease. (biomedcentral.com)
There is evidence in a brain injury model that RSV has a protective effect ( 13 , 14 ). (frontiersin.org)
Herein, we investigated the role of esketamine in propofol-induced brain injury. (degruyter.com)
A rat model of propofol-induced brain injury was established with or without the treatment of esketamine. (degruyter.com)
Overall, esketamine mitigates propofol-induced cognitive dysfunction and brain injury in rats by activating mBDNF/TrkB/PI3K signaling. (degruyter.com)
However, whether esketamine has an effect on propofol-induced brain injury has not been investigated. (degruyter.com)
We hypothesized that TLRs other than TLR-4 may mediate preconditioning against cerebral ischemic injury in the developing brain. (biomedcentral.com)
Brains were removed 1 week after HI injury and infarct volumes were compared in H&E stained sections between the two groups. (biomedcentral.com)
This is the first study to show that TLR-3 is expressed in the immature brain and mediates preconditioning against ischemic injury. (biomedcentral.com)
The expression of TLRs and their role in inflammation and ischemic injury in the adult brain is well documented. (biomedcentral.com)
Taken together, these results indicate the TLRs play an important role in ischemia-induced injury in the adult brain. (biomedcentral.com)
However, the role of TLRs in ischemic injury of the developing brain is yet to be determined. (biomedcentral.com)
After a certain delay, the brain develops tolerance to ischemic injury caused by the injurious stimulus. (biomedcentral.com)
Previous studies of global brain hypoxia ischemia have primarily focused on injury to the cerebral cortex and to the hippocampus. (cdc.gov)
If treated with cardiopulmonary resuscitation, however, cardiac arrest is survivable, but survivors often show evidence of injury in selectively vulnerable regions of the brain. (cdc.gov)
These cellular effects have led to extensive investigation of melatonin as a treatment for HI brain injury. (techuniq.com)
A randomized double-blind placebo phase I study evaluating the effect of melatonin on infants undergoing hypothermia as treatment for HI brain injury is planned to begin in late 2013 (48). (techuniq.com)
Neonatal trials following HI brain injury have been limited. (techuniq.com)
In fact in a randomized double blind placebo-controlled study of 53 pregnant women whose fetuses demonstrated evidence of hypoxia arterial cord blood from infants of allopurinol-treated mothers exhibited lower levels of S-100B a marker of brain injury KU 0060648 a very short-term outcome. (techuniq.com)
Topiramate Topiramate is a newer anti-epileptic drug that has attracted interest as a potential neuroprotective agent for HI brain injury. (techuniq.com)
This potentially anti-excitotoxicity effect suggests topiramate as a candidate therapy for HI brain injury. (techuniq.com)
The developing brain is particularly susceptible to cerebral white matter AZD0530 injury related to hypoxia-ischemia. (nartsignaling.com)
Reference ranges and interest for early identification of newborns with brain injury. (atide-asso.org)
In the scenario of IT, PC stimulus primes the brain for subsequent injurious ischemic injury. (biomedcentral.com)
The use of antioxidant molecules have proved useful to protect the neonatal brain from injury. (biomedcentral.com)
N-acetylcysteine reduced the injury induced by hypoxia-ischemia in P3C-sensitized neonatal rats. (biomedcentral.com)

In this study, ASO administration contributed to reduced neuronal cell edema and improved motor ability in HIE rats at a simulated 4500-meter altitude. (bvsalud.org)
Excess neuronal nitric oxide (NO) production might cause adenosine triphosphate loss and cellular damage in hypoxic brain parenchyma. (asahq.org)
The cytokine granulocyte-colony stimulating factor (G-CSF) is known to have trophic and neuroprotective properties in the brain, and we recently identified it as a modulator of neuronal and behavioral plasticity. (jneurosci.org)

2019. Dr V.VLASYUK : Compression of the skull, brain and increased intracranial pressure. (atide-asso.org)
2019. Dr V.VLASYUK : Compression circulatory hypoxia of the brain as a type of intrapartum hypoxia. (atide-asso.org)

Thus, the molecular pathways of how lithium increases new brains cells has been worked out by basic science. (jeffreydachmd.com)
In this review, we discuss the consequences of hypoxia, as well as the molecular and physiological processes that occur in subjects exposed to HBOT. (mdpi.com)

Hypoxia is an effective way of restoring blood perfusion by improving cerebrovascular microcirculation, while the effect varies greatly depending on hypoxic mode. (bvsalud.org)

2009. Dr O.BAUD : Complications néonatales des extractions instrumentales. (atide-asso.org)

Research over the last decade has revealed that lithium's effects as mood stabilization and regeneration of new brain cells (neurogenesis), are mainly due to the inhibition of a key enzyme called GSK-3β, glycogen synthase kinase-3β. (jeffreydachmd.com)
Moreover, inhibition of miR-195 significantly improved cardiac function of MI rats. (ijbs.com)

In the 1990's, newer imaging techniques revealed neurogenesis in the hippocampus and olfactory bulb, specific areas of the brain where new cells are generated. (jeffreydachmd.com)

In the developing mouse brain expression of EPO and EPOR peaks during midgestation and decreases to adult levels in late gestation [ 43 ]. (biomedcentral.com)
TLR-4 expression has been observed in the meninges, choroid plexus, and circumventricular organs of the adult rat brain [ 2 ]. (biomedcentral.com)
While there is accumulating knowledge on the expression and function of TLRs in the adult CNS, little is known about TLRs in the developing brain. (biomedcentral.com)
With the recent discovery that adult olfactory bulb neurogenesis in the human brain likely ceases after 18 months of age, there is increased interest in studying the NPs of the neonate [ 1 ]. (karger.com)

However, the transcriptome profile in peripheral blood under hypoxia is still unidentified. (cams.cn)
The present work aimed to explore the transcriptional profile alteration of peripheral blood in chronic hypoxia. (cams.cn)
Peripheral blood was collected and total RNA was extracted for RNA-Seq at the end of the hypoxia treatment. (cams.cn)
Conclusions Our study demonstrated the transcriptional profile alteration in peripheral blood of chronic hypoxia rat model. (cams.cn)
Transcriptional Profile Alteration of Peripheral Blood in Chronic Hypoxia[J].Chinese Medical Sciences Journal, 2020, 35(1): 54-64. (cams.cn)

The elusive nature of the underlying mechanisms responsible for neonatal HIBD presents a significant obstacle in the effective clinical application of numerous pharmaceutical interventions. (bvsalud.org)
Hypoxic ischemia (HI) involves multiple mechanisms, but the detailed pathogenesis is still unclear. (frontiersin.org)
Determining which cell types in CB-MNC enhance brain tissue repair, and the mechanisms by which they do so, will optimize decisions on dosing, route of administration, treatment frequency, and other critical clinical and regulatory parameters. (biorxiv.org)
Since the first landmark experimental demonstration of ischemic tolerance in the gerbil brain in early 1990's, basic scientific knowledge on the mechanisms of cerebral ischemic tolerance increased substantially. (biomedcentral.com)
Danger signal evoked in the brain by the stressing preconditioning stimulus induces complex endogenous protective mechanisms resulting to a latent protective phenotype. (biomedcentral.com)

Surprisingly, however, the majority of primed genes were not enriched for H3K4me3 acutely following hypoxia exposure. (frontiersin.org)

Conversely, genetic TAK1 overexpression attenuated surgery-induced pRIPK1 expression, neuroinflammation and cognitive dysfunction in old rats. (imperial.ac.uk)

Ischemic tolerance defines transient resistance to lethal ischemia gained by a prior sublethal noxious stimulus (i.e., preconditioning). (biomedcentral.com)

Our objective was to provide a comprehensive overview of potential neuroprotective agents for the treatment of neonatal HIBD in animal experiments, with the ultimate goal of enhancing the feasibility of clinical translation and establishing a solid theoretical foundation for the clinical management of neonatal HIBD. (bvsalud.org)

Therefore, studies aiming to reducing morbidity and mortality of neonates with brain injuries are still needed. (frontiersin.org)
Zinc and taurine are known to protect against hypoxic-ischemic brain damage in adults and neonates. (hindawi.com)
2020. Dr V.KUMPULAINEN et al : Prevalence and risk factors of incidental findings in brain MRIs of healthy neonates. (atide-asso.org)

Yang B, Ma T, Verkman A. cDNA cloning, gene organization, and chromosomal localization of a human mercurial insensitive water channel evidence for distinct transcriptional units. (benthamscience.com)

Here we showed in neonatal rats exposed to P3C that the migration of neutrophils into the CSF, which occurred through the choroid plexuses, is abolished following administration of the antioxidant drug N-acetylcysteine. (biomedcentral.com)
Because alpha-lipoic acid seems to work like an antioxidant, it might provide protection to the brain and also be helpful in certain liver diseases. (medlineplus.gov)

The results thus demonstrated that delaying transplantation within a specific time window increased graft survival and integration into host brain tissue. (jneurosci.org)
performed additional studies to compare the effect of 7 d delay and immediate transplantation on survival and integration of grafted cells into host brain tissue at 4, 7, and 14 d after transplantation. (jneurosci.org)
Ischemic tolerance or preconditioning is a phenomenon by which a sub-injurious stimulus is applied to a tissue such as the brain. (biomedcentral.com)

Methods The present study used a chronic hypoxia rat model to simulate the hypoxic state of CCHD patients. (cams.cn)

We, therefore, tested the hypothesis that hypoxia would enhance or "prime" microglial pro-inflammatory gene expression in response to a later inflammatory challenge without programmatically increasing basal levels of pro-inflammatory cytokine expression. (frontiersin.org)
the receptor for obestatin, but current evidence does not support this hypothesis. (nartsignaling.com)

Neonatal hypoxic-ischemic brain damage (HIBD) is a prominent contributor to both immediate mortality and long-term impairment in newborns. (bvsalud.org)
The cannabinoid CB 2 receptor agonist GW405833 does not ameliorate brain damage induced by hypoxia-ischemia in rats. (otago.ac.nz)
The severity of these disabilities depends on the ischemia duration, damage expansion, and the affected brain region. (hindawi.com)
We have shown that preconditioning by lipopolysaccharide (LPS) will result in 90% reduction in ischemic brain damage in P7 rats. (biomedcentral.com)

BDNF level in rat ventricles was measured by enzyme linked immunosorbent assay (ELISA). (ijbs.com)
Meanwhile, BDNF protein level was rapidly increased in MI rats and H 2 O 2 -treated cardiomyocytes. (ijbs.com)
BDNF mitigated the pro-apoptotic effect of miR-195 in rat cardiomyocytes. (ijbs.com)

if MCAO is applied during this phase, mainly cortical areas are spared (early ischemia-tolerant phenotype). (biomedcentral.com)

The preclinical data in support of the use of EPO in brain disease have already been translated to first clinical pilot studies with encouraging results with the use of EPO as a neuroprotective agent. (biomedcentral.com)
Cord blood (CB) mononuclear cells (MNC) are being tested in clinical trials to treat hypoxic-ischemic (HI) brain injuries. (biorxiv.org)
Varespladib in the Treatment of Snakebite Envenoming: Development History and Preclinical Evidence Supporting Advancement to Clinical Trials in Patients Bitten by Venomous Snakes. (ucsf.edu)

cerebral ischemia decreased the extent KU 0060648 of neutrophil emigration and macrophage/activated microglial infiltration 48 hours later and only in the ischemic hemisphere (41). (techuniq.com)

Among all, 803 genes were down-regulated, while only 69 genes were up-regulated in the hypoxia group. (cams.cn)
Red dot represents down-regulated genes, blue dot represents up-regulated genes and gray dot represents not changed genes in the hypoxia group. (cams.cn)

Global brain hypoxia-ischemia during cardiac arrest has a long-term impact on processing and transfer of sensory information by thalamic circuitry. (cdc.gov)

2-3) Lithium was also found protective in stroke and traumatic brain industry animal models models. (jeffreydachmd.com)
2016. Dr N-N.RABELO, H.MATUSHITA, D-D.CORDEAL : Traumatic brain lesion in newborns. (atide-asso.org)

Antisense oligonucleotides were infused at a constant rate into the cerebral lateral ventricles of rats and their effect on anxiety-like behavior and food intake was monitored. (nartsignaling.com)
Brain, Behavior, and Immunity. (wustl.edu)

Anatomy31

Organisms11

Diseases27

Chemicals and Drugs38

Analytical, Diagnostic and Therapeutic Techniques and Equipment30

Psychiatry and Psychology1

Phenomena and Processes42

Disciplines and Occupations2

Information Science4

Health Care3

Focal cerebral ischemia2

Reactive oxygen2

Encephalopathy4

Myocardial2

Mice7

Hypoxic brain injury1

Young Rats4

Neurons7

Carotid artery ligation1

Reperfusion2

Microglia4

Ligation1

Perinatal3

Hippocampal1

Sprague-Dawley2

Oxygen7

Endoplasmic reticulum stress1

Cardiac damage1

Oxidative3

Mouse brains1

Subventricular zone1

Cerebral palsy2

Therapeutic2

Fetal7

Apoptosis3

Neurotrophic3

Neuroprotection2

Injury31

Neuronal3

20192

Molecular2

Cerebrovascular1

Complications1

Inhibition2

Hippocampus1

Adult4

Peripheral blood5

Mechanisms5

Acutely1

Cognitive dysfunction1

Transient1

Neuroprotective agents1

Neonates3

Transcriptional1

Antioxidant2

Tissue3

Methods1

Hypothesis2

Damage4

BDNF3

Cortical1

Clinical3

Microglial1

Genes2

Circuitry1

Traumatic2

Behavior2