• Castration of male rats at birth prevented the development of sex differences in metabolism in adult life. (aspetjournals.org)
  • The effects of neonatal castration of male rats on the development of sex differences in adult life were reversed by treatment of the neonate with testosterone but not by estradiol or dihydrotestosterone treatment. (aspetjournals.org)
  • Improving the effects of human adipose tissue-derived mesenchymal stem cells (ASCs) on the demyelination and neurobehavioral function was investigated in an experimental model of neonatal hypoxic-ischemic encephalopathy (HIE). (rbio.co.kr)
  • Specifically, we overexpressed the inducible form of Hsp70 (Hsp70i) or Hsp90 in rat neonatal cardiomyocytes and evaluated PKCδ or PKCϵ expression by immunoblotting and immunofluorescent confocal microscopy. (bioone.org)
  • The data suggest that overexpression of Hsps differentially modulates expression of PKC isoforms in rat neonatal cardiomyocytes. (bioone.org)
  • Sonya D. Coaxum , Jody L. Martin , and Ruben Mestril "Overexpression of heat shock proteins differentially modulates protein kinase C expression in rat neonatal cardiomyocytes," Cell Stress & Chaperones 8(4), 297-302, (1 October 2003). (bioone.org)
  • The aim of this work was to study the effects of Tl + on intracellular Ca 2+ dynamics in rat neonatal cardiomyocytes as well as on sodium penetrability of the IMM and Tl + -induced mitochondrial permeability transition pore (MPTP) opening in isolated Ca 2+ -loaded rat heart mitochondria (RHM). (ukrbiochemjournal.org)
  • These results indicate that ischaemia activates caspases shortly after reperfusion and that the sex of the animal may strongly influences apoptotic pathways in the pathogenesis of neonatal brain injury. (nih.gov)
  • Unfortunately, the pathogenesis of neonatal WMI is unclear and no specific therapies are currently available other than supportive treatment [ 9 ]. (researchsquare.com)
  • Using neonatal ventricular myocytes, we tested the hypothesis that chronic lactate exposure could decrease the activity of cardiac mitochondria that could lead to metabolic inflexibility in the heart and other tissues. (frontiersin.org)
  • Neonatal rat ventricular myocytes (NRVMs) were treated for 48 h with 5, 10, or 20 mM lactate and CPT I and II activities were tested using radiolabelled assays. (frontiersin.org)
  • The aim of the study was to evaluate the effect of miRs on the expression level of myosin heavy chain (MHC), which is responsible for regulation of cardiac functions in neonatal rat ventricular myocytes and mice. (archivesofmedicalscience.com)
  • The miRs were suppressed in neonatal rat ventricular myocytes using small interfering RNAs (siRNAs) against Dicer followed by evaluation of MHC levels. (archivesofmedicalscience.com)
  • Automated quantification of opioid withdrawal in neonatal rat pups using Ethovision? (uams.edu)
  • Maternal opioid use during pregnancy is a growing national problem and can lead to newborns developing neonatal opioid withdrawal syndrome (NOWS) soon after birth. (frontiersin.org)
  • We and others have shown that exposure to BPA at doses below the no-observed-adverse-effect level can disrupt the sex-specific expression of estrogen-responsive genes in the neonatal rat brain including estrogen receptors (ERs). (nih.gov)
  • Effects of gestational BPA and EE exposure on neonatal hypothalamic ER expression. (nih.gov)
  • Impairment of the context preexposure facilitation effect in juvenile rats by neonatal alcohol exposure is associated with decreased Egr-1 mRNA expression in the prefrontal cortex. (biblicalpsychiatry.com)
  • Thus, this study examined the long-term effects of neonatal alcohol exposure on circadian behavioral activity in adult rats. (internetandpsychiatry.com)
  • At 2 months of age, rats from the EtOH, GC, and suckle control (SC) groups were housed individually, and properties of the circadian rhythm in wheel-running behavior were continuously analyzed during exposure to a 12-hr light:12-hr dark photoperiod (LD 12:12) or constant darkness (DD). (internetandpsychiatry.com)
  • Neonatal alcohol exposure had distinctive effects on the rhythmic properties and quantitative parameters of adult wheel-running behavior. (internetandpsychiatry.com)
  • In DD, circadian regulation of wheel- running behavior was altered by neonatal alcohol exposure such that the free- running period of the activity rhythm was shorter in EtOH-exposed rats than in control animals. (internetandpsychiatry.com)
  • These data indicate that neonatal alcohol exposure produces permanent changes in the circadian regulation of the rat activity rhythm and its entrainment to LD cycles. (internetandpsychiatry.com)
  • 1. Retinoic acid receptors and retinoids are up-regulated in the developing and adult rat prostate by neonatal estrogen exposure. (nih.gov)
  • 3. Neonatal estrogen exposure up-regulates estrogen receptor expression in the developing and adult rat prostate lobes. (nih.gov)
  • 5. Developmental exposure to estrogens alters epithelial cell adhesion and gap junction proteins in the adult rat prostate. (nih.gov)
  • 7. Effects of neonatal estrogen exposure on prostatic secretory genes and their correlation with androgen receptor expression in the separate prostate lobes of the adult rat. (nih.gov)
  • 12. Neonatal estrogen exposure induces lobe-specific alterations in adult rat prostate androgen receptor expression. (nih.gov)
  • 17. The developmental pattern of androgen receptor expression in rat prostate lobes is altered after neonatal exposure to estrogen. (nih.gov)
  • We report here the behavioral effects of developmental exposure to IDPN in the rat. (wikigenes.org)
  • These data demonstrate that short-term, neonatal exposure to IDPN in the rat produced persistent alterations in sensory, motor, and cognitive aspects of nervous system function. (wikigenes.org)
  • The effects of neonatal gonadectomy and the neonatal administration of steroid hormones on the development of sex differences in hepatic drug metabolism in the adult rat have been investigated. (aspetjournals.org)
  • The amiloride-sensitive channels responsible for salt recognition and response is functional in adult rats but not neonatal rats. (wikipedia.org)
  • In this study, we investigated the effect of ZJU-37 on myelination and neurobehavioral function in a neonatal rat WMI model induced by hypoxia and ischemia. (researchsquare.com)
  • The current study examined the impact of neonatal alcohol on Egr-1 mRNA expression in the infralimbic (IL) and prelimbic (PL) subregions of the mPFC, the CA1 of dorsal hippocampus (dHPC), and the lateral nucleus of the amygdala (LA), following the preexposure and training phases of the CPFE. (biblicalpsychiatry.com)
  • To elucidate the mechanisms, intrarenal HA content was followed during neonatal completion of nephrogenesis with or without angiotensin converting enzyme inhibition (ACEI) together with mRNA expression of hyaluronan synthases (HAS), hyaluronidases (Hyal), urinary hyaluronidase activity and cortical lymphatic vessels, which facilitate the drainage of HA from the tissue. (diva-portal.org)
  • Studies thus far have suggested that remyelination is one of the pivotal mechanisms in promoting functional recovery following neonatal WMI [ 6 , 10 , 11 ] and that the inhibition of demyelination is one of the key challenges of therapeutic peptides. (researchsquare.com)
  • 1980. Inhibition by bran of the colonic cocarcinogenicity of bile salts in rats given dimethylhydrazine. (cdc.gov)
  • Neonatal inhibition of the RAS in rats results in long-term pathological renal phenotype and causes hyaluronan (HA), which is involved in morphogenesis and inflammation, to accumulate. (diva-portal.org)
  • 2. We have used a model of rotavirus diarrhoea in neonatal rats to compare the effects on water and solute absorption of varying the concentration of a glucose polymer (mean chain length five glucose residues) in experimental oral rehydration solutions. (portlandpress.com)
  • We hypothesized that human umbilical cord-derived MSCs (hUC-MSCs) improve survival in experimental neonatal sepsis. (eur.nl)
  • hUC-MSCs enhance survival and bacterial clearance in experimental neonatal sepsis. (eur.nl)
  • In adults, a diminution of the corticosterone feedback appeared in DEP5 rats in a stressful situation, whereas a transitory increase of the ACTH response was observed in DEP14 rats. (univ-lorraine.fr)
  • We show for the first time that the perturbation of neonatal maturation modifies persistently feeding behaviour, and this modification depends on the age at which deprivation is experienced. (univ-lorraine.fr)
  • 2022. Sex differences in 50 kHz call subtypes emitted during tickling-induced playful behaviour in rats. (awionline.org)
  • D-JNKI1, a cell -permeable peptide inhibitor of the c-Jun N-terminal kinase (JNK) pathway, has been shown to be a powerful neuroprotective agent after focal cerebral ischemia in adult mice and young rats . (bvsalud.org)
  • There are similarities between the tastes the chorda tympani picks up in sweeteners between mice and primates, but not rats. (wikipedia.org)
  • Here we investigated the potential of therapeutic bile acids ursodeoxycholic acid (UDCA) and obeticholic acid (OCA, 6-α-ethyl-CDCA), a farnesoid-X-receptor (FXR) agonist, as preventive treatment options for neonatal hyperbilirubinemia using the hUGT1*1 humanized mice and Ugt1a-deficient Gunn rats. (nih.gov)
  • SL651498 elicited anxiolytic-like activity similar to that of diazepam [minimal effective dose (MED): 1-10 mg/kg, i.p.] in three conflict models, in the elevated plus-maze, the light/dark test, and the defense test battery in rats and mice. (aspetjournals.org)
  • There is little information about itch-associated responses in neonatal rodents. (elsevierpure.com)
  • Despite the need for safe and effective postoperative analgesia in neonates, research regarding pain management in neonatal rodents is relatively limited. (awionline.org)
  • In vivo , the therapeutic potential of BMSCs was assessed in a chronic hyperoxia-induced model of BPD in newborn rats. (cheoresearch.ca)
  • In vivo , chronic hyperoxia in newborn rats led to air space enlargement and loss of lung capillaries, and this was associated with a decrease in circulating and resident lung BMSCs. (cheoresearch.ca)
  • MSC treatment preserved alveolar structure in a model of chronic lung disease in newborn rats caused by severe hyperoxia, which may be due to a paracrine effect on lung cells. (cheoresearch.ca)
  • This study was conducted to examine the protective effect of the Coenzyme Q10 (CoQ10) in newborn rats from pregnant rats pre-treated with PQ. (ac.ir)
  • Sixteen days after parturition, the lungs were removed from the newborn rats, paraffin sections were made and stained with hematoxylin and eosin, and analyzed histomorphometrically and stereologically. (ac.ir)
  • control rats were not separated from the mother. (univ-lorraine.fr)
  • In 6-8days old control rats cortical HA content was high and reduced by 93% on days 10-21, reaching adult low levels. (diva-portal.org)
  • Patterned neuronal activity such as spindle bursts in the neonatal cortex is likely to promote the maturation of cortical synapses and neuronal circuits. (jneurosci.org)
  • Nous montrons pour la première fois que la perturbation de la maturation néonatale modifie de façon persistante le comportement alimentaire, et ce de façon dépendant de l'âge où elle est subie. (univ-lorraine.fr)
  • Melatonin inhibits GnRH-stimulated release of LH from neonatal rat pituitary cells, probably by inhibiting GnRH-induced elevation of intracellular Ca2+. (nih.gov)
  • Membrane potential and intracellular Ca2+ were studied in neonatal rat pituitary cells in suspension, using bis-oxonol and Fluo-3 as fluorescent indicators, respectively. (nih.gov)
  • Melatonin inhibits gonadotropin-releasing hormone-induced elevation of intracellular Ca2+ in neonatal rat pituitary cells. (nih.gov)
  • One hour after infection, rats were treated intravenously with normal saline, hUC-MSCs, or with interferon-γ preconditioned hUC-MSCs (107 cells/kg). (eur.nl)
  • In addition, the activation of glial cells and NLRP3 inflammasome was reduced by ZJU-37 or/and OPCs treatment in the neonatal rat WMI model. (researchsquare.com)
  • Clonetics TM Neonatal Rat Retinal Cells [P3-4] are ready-to-use, high quality primary cells from Sprague Dawley rats. (lonza.com)
  • Bone marrow-derived mesenchymal stem cells (BMSCs) prevent adult lung injury, but their therapeutic potential in neonatal lung disease is unknown. (cheoresearch.ca)
  • In some settings, mesenchymal stem cells (MSCs) show promise for organ repair, but whether MSC treatment can enhance lung structure after neonatal lung injury is unknown. (cheoresearch.ca)
  • Seven-day-old male rats were subjected to hypoxia-ischemia-lipopolysaccharide and intracerebroventricularly transplanted with human ASCs (4 ´ 105 cells/rat) once at postnatal day 10 (PND10) or repeatedly at PND10, 17, 27, and 37. (rbio.co.kr)
  • McCall D, Zimmer LJ, Katz AM. Effect of ischemia-related metabolic factors on thallium exchange in cultured rat myocardial cells. (ukrbiochemjournal.org)
  • The aim of this work was to study immediate and persistent effects of a neonatal stress (maternal deprivation) on the hypothalamo-pituitary-adrenal (HPA) axis and on the food intake in the rat. (univ-lorraine.fr)
  • In neonatally ACEI-treated rats the reduction in HA was abolished. (diva-portal.org)
  • 2. Estrogen receptor-beta messenger ribonucleic acid ontogeny in the prostate of normal and neonatally estrogenized rats. (nih.gov)
  • We performed behavioral tests to elucidate itch-associated scratching and wriggling behaviors induced by compound 48/80 (C48/80) in 7- and 14-day-old rats. (elsevierpure.com)
  • The molecular localization of zinc in rat milk and pup intestine was determined by gel chromatography. (nih.gov)
  • Zinc-binding ligands in milk and intestine: a role in neonatal nutrition? (nih.gov)
  • Immunohistochemical localization of superoxide dismutases in fetal and neonatal rat tissues. (docksci.com)
  • Tickling' induces positive affective states in laboratory rats as evidenced by the production of 50-kHz ultrasonic vocalisations (USVs), although this has mostly been investigated in males. (awionline.org)
  • Limited role of the c-Jun N-terminal kinase pathway in a neonatal rat model of cerebral hypoxia-ischemia. (bvsalud.org)
  • We have investigated the potential neuroprotective effect of D-JNKI1 and the involvement of the JNK pathway in a neonatal rat model of cerebral hypoxia-ischemia (HI). (bvsalud.org)
  • MSCs may have therapeutic potential for preventing neonatal lung diseases characterized by alveolar damage. (cheoresearch.ca)
  • Potential of therapeutic bile acids in the treatment of neonatal Hyperbilirubinemia. (nih.gov)
  • We show that focal removal of SPNs in rats shortly after birth prevents spindle bursts, while having little effect on the occurrence of sharp potentials. (jneurosci.org)
  • Treatment of neonatal female rats with testosterone had no effect on the development of a feminine pattern of metabolism unless the ovaries were removed before puberty, suggesting that the effects of neonatal imprinting by testosterone can be repressed by the actions of the ovaries in adulthood. (aspetjournals.org)
  • Effects of gestational BPA and EE on neonatal hippocampal ER expression. (nih.gov)
  • In conclusion, unlike in adult ischemic models, JNK is only moderately activated after severe cerebral HI in neonatal rats and the observed positive effects of D-JNKI1 are insufficient to give neuroprotection . (bvsalud.org)
  • 1978. Effects of short-term administration of maleic hydrazide or hydrazine on rat hepatic microsomal enzymes. (cdc.gov)
  • Thus, memory processes that engage the mPFC during the context-shock association may be most susceptible to the teratogenic effects of neonatal alcohol. (biblicalpsychiatry.com)
  • Kiliç GA, Kutlu M. Effects of exogenous metallothionein against thallium-induced oxidative stress in rat liver. (ukrbiochemjournal.org)
  • We further demonstrate that in Ugt1a-deficient Gunn rats, UDCA but not OCA significantly decreases plasma bilirubin, indicating that at least some of the hypobilirubinemic effects of UDCA are independent of UGT1A1. (nih.gov)
  • Here we studied the effect of subplate removal in the neonatal rat primary somatosensory cortex (S1). (jneurosci.org)
  • Thus, subplate neurons are crucially involved in the generation of particular types of early network activity in the neonatal cortex, which are an important feature of cortical development. (jneurosci.org)
  • In vivo , P3 rat pups were subjected to right common carotid artery ligation and hypoxia, and then treated with ZJU-37 or/and hOPCs, and OPCs apoptosis, myelination, glial cell and NLRP3 inflammasome activation together with cognitive outcome were evaluated at 12 weeks after transplantation. (researchsquare.com)
  • Seven-day-old rats underwent a permanent ligation of the right common carotid artery followed by 2 h of hypoxia (8% oxygen ). (bvsalud.org)
  • 4. Neonatal estrogen down-regulates prostatic androgen receptor through a proteosome-mediated protein degradation pathway. (nih.gov)
  • Juvenile rats emit distinctive 50-kHz USV subtypes. (awionline.org)
  • 19. Expression, protein stability and transcriptional activity of retinoic acid receptors are affected by microtubules interfering agents and all-trans-retinoic acid in primary rat hepatocytes. (nih.gov)
  • Studies on recombinant rat GABA A receptors confirm these data ( K i , α 1 β 2 γ 2 = 17, α 2 β 2 γ 2 = 73, α 5 β 3 γ 2 = 215 nM) and indicate intermediate affinity for the α 3 β 2 γ 2 subtype ( K i = 80 nM). (aspetjournals.org)
  • SL651498 behaves as a full agonist at recombinant rat GABA A receptors containing α 2 and α 3 subunits and as a partial agonist at recombinant GABA A receptors expressing α 1 and α 5 subunits. (aspetjournals.org)
  • Following ischaemia in P7 rats, males and females displayed different time course and pattern of cytochrome c release and active p17 caspase 3 during the first 24 h of recovery. (nih.gov)
  • Male Rat Was Made Pregnant and Had Pups. (medscape.com)
  • 28 adult female pregnant Wistar-Albino rats were separated into four groups. (heraldopenaccess.us)
  • Balazadeh F, Shahrooz R, Shalizar Jalali A, Karimi H, Zadeh Hashem E. Histomorphometrical and Stereological Study of the Lungs in Neonatal Rats Born to Paraquat-poisoned Pregnant Rats: Protective Effect of Coenzyme Q10. (ac.ir)
  • In the present study, a third generation dipeptidyl broad-spectrum caspase inhibitor, quinoline-Val-Asp(Ome)-CH2-O-phenoxy (Q-VD-OPh), was tested in a model of unilateral focal ischaemia with reperfusion in 7-day-old rats. (nih.gov)
  • Zierold K. Heavy metal cytotoxicity studied by electron probe X-ray microanalysis of cultured rat hepatocytes. (ukrbiochemjournal.org)
  • With treated gels, all of the zinc in rat milk eluted with high molecular weight proteins (MW greater than or equal to 30,000). (nih.gov)
  • ZJU-37 may promote OPC survival, differentiation and myelination by inhibiting NLRP3 inflammasome activation in a neonatal rat model of WMI with hOPC graft. (researchsquare.com)
  • Very recently, a team of scientists in China at the Naval Medical University in Shanghai tried to create a model to test the hypothesis that you could get a male rat to deliver babies. (medscape.com)
  • This thesis examines a rat model of human perinatal stroke populations most at risk to study the long-term behavioural, neurophysiological, and anatomical outcomes in maturity. (uleth.ca)
  • 2021. Sustained release buprenorphine effectively attenuates postoperative hypersensitivity in an incisional pain model in neonatal rats (Rattus norvegicus). (awionline.org)
  • 2021. Buprenorphine, but not lidocaine, effectively attenuates post-operative thermal hypersensitivity in an incisional model in neonatal rats (Rattus norvegicus). (awionline.org)
  • Neonatal imprinting of sex differences in the hepatic metabolism of a chlorinated cyclodiene by rat liver microsomes. (aspetjournals.org)
  • The SOD levels have previously been investigated in fetal rat liver (Pittschieler et al. (docksci.com)
  • 1989). To our knowledge, fetal rat immunoreactive SODs have been investigated only in the lung, kidney, liver, and heart (Pittschieler et al. (docksci.com)
  • Taste preferences of feminine rats: Modification by neonatal hormones, meals deprivation, and prior expertise. (ehd.org)
  • 20. Marginal Vitamin A Deficiency Affects the Expression Levels and Localization of Retinoic Acid Receptor and Retinoid X Receptor in Rats Meibomian Gland. (nih.gov)
  • hUC-MSCs and preconditioned hUC-MSCs decreased splenocyte apoptosis in E. coli infected rats. (eur.nl)
  • Finally, LL-37 plasma levels were elevated in neonatal rats treated with hUC-MSCs or preconditioned hUC-MSCs. (eur.nl)
  • hUC-MSCs may be an effective adjunct therapy to reduce neonatal sepsis-related morbidity and mortality. (eur.nl)
  • These results demonstrate the importance of sample preparation and chromatographic conditions when studying trace element ligands and also suggest that rat milk is not analogous to human milk in regard to zinc binding. (nih.gov)
  • These results suggest that wriggling behavior is limited early in life and neonatal rats are available to reveal mechanisms of itch sensation and scratching behavior provoked by diseases specific to neonates or infants. (elsevierpure.com)
  • Light and electron microscopic studies of acute and chronic thallium intoxication in rats. (ukrbiochemjournal.org)
  • An earlier report from our laboratory demonstrated that there were sex differences in the dendritic tree of granule neurons from the rat dentate gyrus (Juraska, Fitch, Henderson, & Rivers, 1985). (illinois.edu)
  • After 1 month in the differential environments, the rats' brains were stained with Golgi-Cox, and the dendritic fields of granule neurons were quantified from 28 animals. (illinois.edu)
  • Their effect in neonatal sepsis has never been explored. (eur.nl)
  • 3H-dialkylhydrazines in the neuroendocrine system and their antigonadotropic effect in rats. (cdc.gov)
  • Distribution of the anticonvulsant felbamate to cerebrospinal fluid and brain tissue of adult and neonatal rats. (aspetjournals.org)
  • The concentrations of felbamate (FBM) and its three metabolites were determined in plasma, cerebrospinal fluid (CSF), and brain tissue of adult and neonatal rats that received single oral doses of FBM at amounts varying from 250 to 2000 mg/kg for adults and from 100 to 500 mg/kg for neonates. (aspetjournals.org)
  • Further analysis showed that neonatal HI induced an immediate decrease in JNK phosphorylation (reflecting mainly JNK1 phosphorylation ) followed by a slow progressive increase (including JNK3 phosphorylation 54 kDa), whereas c-jun and c-fos expression were both strongly activated immediately after HI. (bvsalud.org)
  • 1987. The influence of physical activity in 1 ,2dimethylhydrazine induced colon carcinogenesis in the rat. (cdc.gov)
  • Total amount of daily wheel-running activity in EtOH- treated rats was greater than that observed in the SC group. (internetandpsychiatry.com)
  • In addition, the circadian activity patterns of EtOH-exposed rats were fragmented such that the duration of the active phase and the number of activity bouts per day were increased. (internetandpsychiatry.com)
  • 9. Sonic hedgehog-patched Gli signaling in the developing rat prostate gland: lobe-specific suppression by neonatal estrogens reduces ductal growth and branching. (nih.gov)
  • 195, 240 320 mosmol/kg) solutions were perfused in normal and rotavirus-infected neonatal rats. (portlandpress.com)
  • Lo and behold, the male with the transplanted uterus and the donated embryos gave birth to 10 rat cubs, and they seemed normal. (medscape.com)
  • They took a male and a female rat and literally joined their blood circulation to get female hormones into the male bloodstream. (medscape.com)
  • Then they transplanted the uterus of the female rat into the male rat. (medscape.com)
  • To investigate the hormonal basis for these sex differences, we castrated or sham-operated male rats within hours of birth. (illinois.edu)
  • The primary outcome measures were safety [heart rate monitoring, Neonatal Infant Pain Scale (NIPS), and skin irritation] and morphine length of treatment (LOT). (frontiersin.org)