Loading...
  • pathways
  • Blocking connexin hemichannels within the first 3 h after hypoxia-ischemia has been shown to improve outcomes in term equivalent fetal sheep but it is important to also understand the downstream pathways linking membrane channel opening with the development of injury in order to identify new therapeutic targets. (frontiersin.org)
  • Protective
  • Protective effects of intermittent hypoxia on brain and memory in a mouse model of apnea of prematurity. (nih.gov)
  • Hydrogen gas alone is also protective against ischemia-reperfusion injuries, primarily by neutralizing free radicals, but utilizing highly flammable hydrogen gas in a clinical setting poses a safety risk. (biologists.org)
  • ligation
  • The Vannucci model (unilateral ligation of the common carotid artery followed by a period of hypoxia) is widely used to study the brain injury resulting from HI and we have previously shown, in 60-day-old rats, evidence of a concomitant retinopathy. (arvojournals.org)
  • mortality and morbidity
  • The key neuroprotective effect of hydrogen is apparently its ability to neutralize free radicals, and while suspended animation and space travel may yet be a long way off, research such as this offers hope that we can begin to significantly decrease the mortality and morbidity associated with strokes, heart attacks and neonatal brain disorders. (biologists.org)
  • cerebral palsy
  • These findings demonstrate that endogenous BAX plays a role in regulating cell death in the central nervous system (CNS) following neonatal H-I, a model of cerebral palsy. (biomedcentral.com)
  • It is worth noting that neonatal HIBD often leads to long-lasting neurological deficits such as mental deficiency, cerebral palsy, and learning disabilities, which develop in the immature brain. (springer.com)
  • model
  • We hypothesized that PAT can detect a reduction in cerebral hemoglobin optical absorption, and therefore CBF, in a neonatal model of hypoxia-ischemia. (edu.pl)
  • We conclude that a reduction in global and regional MOA, and hence CBF, could be identified by PAT in a neonatal rat model of HIE. (edu.pl)
  • This is the first study described in the literature utilizing a neonatal rat model of HIE to demonstrate in vivo alterations in cerebral hemodynamics in a non-invasive and near real-time fashion. (edu.pl)
  • apoptotic
  • In this study, we investigate whether a cascade of events (including death receptor activation, alteration in the ratio of proapoptosis- and antiapoptosis-regulating proteins in mitochondria, altered mitochondrial activity and location, cytochrome c accumulation, and cleavage of caspases into active subunits) leads to apoptotic neurodegeneration in the thalamus after neonatal hypoxia-ischemia. (jneurosci.org)
  • Delayed cell death that follows neonatal HI is morphologically characterised by either apoptotic (programmed), necrotic (uncontrolled) and more recently, necroptotic (programmed necrosis) phenotype [ 11 , 16 - 21 ]. (biochemsoctrans.org)