• Neointimal hyperplasia refers to proliferation and migration of vascular smooth muscle cells primarily in the tunica intima, resulting in the thickening of arterial walls and decreased arterial lumen space. (wikipedia.org)
  • Neointimal hyperplasia is the major cause of restenosis after percutaneous coronary interventions such as stenting or angioplasty. (wikipedia.org)
  • Neointimal hyperplasia first develops with damage to the arterial wall, followed by platelet aggregation at the site of injury, recruitment of inflammatory cells, proliferation and migration of vascular smooth muscle cells, and collagen deposition. (wikipedia.org)
  • C-reactive protein is a systemic inflammatory mediator correlated with neointimal hyperplasia, but it is still unknown if this protein is a marker of increased risk or a causative agent of the condition. (wikipedia.org)
  • P radioactive β-emitting stents were used in coronary artery lesions with results showing inhibition of neointimal hyperplasia in a dose-dependent manner. (wikipedia.org)
  • However, more recent studies have shown that patients have a late progression of in-stent neointimal hyperplasia after 1 year of radioactive stent implantation, suggesting a delay in the development of neointimal hyperplasia rather than a prevention or decline of the condition. (wikipedia.org)
  • Drug-eluting stents coated with anti-proliferative chemicals are used to counteract neointimal hyperplasia after stents placement. (wikipedia.org)
  • Drug-eluting stents that release resveratrol and quercetin show promise with marked reduction in intimal hyperplasia compared to bare, metal stents. (wikipedia.org)
  • Anti-inflammatory treatment is effective in limiting the development of neointimal hyperplasia. (wikipedia.org)
  • In rabbits, the use of IL-10 to reduce function of circulating monocytes and inhibition of leukocyte adhesion with antibodies reduced formation of neointimal hyperplasia after angioplasty and stenting. (wikipedia.org)
  • Nitric oxide-based treatment for the treatment of cardiovascular pathologies has shown promise in the treatment of neointimal hyperplasia. (wikipedia.org)
  • However, the difficulty in controlled, local release of nitric oxide has limited its clinical use for neointimal hyperplasia. (wikipedia.org)
  • Polymer-based perivascular wraps are attracting growing interest for their potential use to deliver nitric oxide and other drugs in the treatment of neointimal hyperplasia. (wikipedia.org)
  • Exendin-4, a glucagon-like peptide-1 receptor (GLP-1) agonist used as drug treatment for type 2 diabetes inhibits neointimal hyperplasia. (wikipedia.org)
  • Exendin-4 inhibits TNFα production by macrophages to reduce inflammation, which may play another role in inhibiting neointimal hyperplasia. (wikipedia.org)
  • Paclitaxel Stent Coating Inhibits Neointimal Hyperplasia at 4 Weeks in a Porcine Model of Coronary Restenosis. (hopkinsmedicine.org)
  • Cilostazol, a phosphodiesterase III inhibitor, has been shown to significantly improve high on-treatment platelet reactivity in patients receiving both aspirin and clopidogrel and has antiproliferative effects (inhibiting neointimal hyperplasia and smooth muscle proliferation), thus reducing the risk of restenosis after coronary stent implantation. (nih.gov)
  • The drug helps prevent neointimal hyperplasia (scar tissue growth) caused by trauma when the vessel segment is treated for atherosclerotic lesions with balloon angioplasty. (researchandmarkets.com)
  • In-stent restenosis is the renarrowing o f the artery lumen within a stent predominantly due to excessive growth of neointimal hyperplasia. (dcu.ie)
  • Administration of LABR-312 at the time of PCI will reduce restenosis compared with placebo as assessed by the OCT endpoint of % neointimal hyperplasia (%NIH) volume at 9 months in patients with DM. (vchri.ca)
  • Coronary stents are generally indicated to increase coronary vessel diameter in the setting of ischemia due to coronary blockage, either by a combination of acute recoil, arterial contraction of a previously treated segment, and/or local neointimal hyperplasia. (medscape.com)
  • Neointimal hyperplasia with vascular smooth muscle cells is even more exaggerated with stent placement than with conventional angioplasty. (elsevierpure.com)
  • This procedure had major drawbacks such as acute vessel closure due to arterial recoil, coronary artery dissection, acute arterial thrombosis, and restenosis due to neointimal hyperplasia. (statpearls.com)
  • Commonly used drugs act to block signal transduction and cell cycle progression in different phases, thereby blocking smooth muscle cell (SMC) proliferation or intimal hyperplasia in the stented arterial site. (statpearls.com)
  • Although BMS work in this sense, they have been closely associated with risks such as neointimal hyperplasia which subsequently causes in-stent restenosis [ 1 ][ 2 ]. (ukessays.com)
  • In animal trials, the Dylyn single layer stent coating has demonstrated safety and biocompatibility, with decreased thrombogenicity and a tendency towards lower neointimal hyperplasia when compared to stainless steel stents. (medgadget.com)
  • The development of BRS would have the benefit of mechanical support to prevent early vessel recoil and treat dissection similar to BMS and DES, without the permanent metallic struts that would lead to medi- um- and long-term complications such as hampered vasomotion, neo-intimal hyperplasia, and in-stent restenosis/thrombosis. (clijournal.com)
  • 2. Use of the anti-inflammatory agent bindarit to control neointimal hyperplasia Chemokines are a family of proteins that regulate the migration of circulating leukocytes to sites of arterial injury as well as the activation of SMCs. (unina.it)
  • Among the causes of such restenosis are, intimal hyperplasia (excessive tissue growth) and thrombus accumulation. (justia.com)
  • DCBs are also used to treat in-stent restenosis due to scar tissue proliferation inside stents, which can cause a vessel to occlude. (researchandmarkets.com)
  • Restenosis after bare-metal stenting (BMS) is mostly due to neointimal proliferation. (ecrjournal.com)
  • The true measure of the efficacy of DES, representing the best angiographic surrogate of neointimal proliferation with the unique ability to separate it from other procedural and intrinsic vessel variables, is in-stent late luminal loss (LL). (ecrjournal.com)
  • Early recoil, alteration in blood vessels, release of vasoactive and thrombogenic factors and neo-intimal proliferation have been suggested as significant contributors to the restenosis after coronary angioplasty (1, 2). (hvt-journal.com)
  • 2nd-generation: everolimus, ridaforolimus, zotarolimus) bonded to the metal that limit neointimal proliferation to reduce the risk of restenosis. (msdmanuals.com)
  • An electronic stent that incorporates an ultrathin stretchable wireless sensor for continuous surveillance of restenosis along with neointimal proliferation and plaque deposition. (gatech.edu)
  • Because sirolimus (rapamycin) inhibits the proliferation of lymphocytes and smooth-muscle cells, we compared a sirolimus-eluting stent with a standard uncoated stent in patients with angina pectoris. (qxmd.com)
  • As compared with a standard coronary stent, a sirolimus-eluting stent shows considerable promise for the prevention of neointimal proliferation, restenosis, and associated clinical events. (qxmd.com)
  • Future directions include investigative work on biodegradable stents and growth stents to address issues related to increase in vessel size in infants and children, use of drug eluding stents to prevent neo-intimal proliferation to avoid pulmonary vein restenosis and refinement of stent technology in hybrid procedures such as neonatal palliation of hypoplastic left heart syndrome and transcatheter completion of Fontan procedure. (longdom.org)
  • The most problematic complication of PCI, with or without stent implantation, is the restenosis defined as the re-narrowing of the enlarged artery and characterized by an immune/inflammatory response going with a hyperplastic reaction, involving smooth muscle cell (SMC) migration/proliferation, and remodelling of the arterial wall. (unina.it)
  • In addition, the NBD peptide (0.01 to 1 μM) reduced rat SMC proliferation, migration, and invasion in vitro, processes contributing to the injury-induced neointimal formation in vivo. (unina.it)
  • Our results demonstrate that the NBD peptide reduces neointimal formation and SMC proliferation/migration, both effects associated with the inhibition of NF-κB activation. (unina.it)
  • In recent years numerous animals experiments and feasibility clinical pilot trials have demonstrated that low doses of radiation when applied during coronary intervention reduce neointimal proliferation, prevent vessel contraction and alter the restenosis rate. (aarogya.com)
  • Intracoronary beta-irradiation prevents excessive in-stent neointimal proliferation in de novo lesions of patients with high plasma ACE levels. (univr.it)
  • Impairment of vasorelaxation in nonstented proximal and distal segments of stented coronary arteries is more severe with drug-eluting stents than bare-metal stents, and stent-induced flow disturbances resulting in complex spatiotemporal shear stress can also contribute to increased thrombogenicity and inflammation. (nature.com)
  • The process of neoatherosclerosis occurs more rapidly, and more frequently, following deployment of drug-eluting stents than bare-metal stents. (nature.com)
  • Drug-eluting stents (DES) improved the principles of bare metal stents (BMS) by local drug release to inhibit neointimal growth. (scirp.org)
  • 2009) 5-Year Clinical Outcomes after Sirolimus-Eluting Stent Implantation Insights from a Patient-Level Pooled Analysis of 4 Randomized Trials Comparing Sirolimus-Eluting Stents with Bare-Metal Stents. (scirp.org)
  • The first-generation drug-eluting stent (DES) was associated with remarkably reduced rates of in-stent restenosis and much less need for subsequent target lesion revascularization (TLR) compared to bare-metal stents (BMS). (acc.org)
  • Initially, drug-eluting stents (DES) were compared to bare-metal stents (BMS) for efficacy. (medscape.com)
  • Intracoronary in-stent restenosis (ISR) is more common with bare metal stents. (ijcdw.org)
  • Bare metal stents (BMS) are made of nickel-titanium alloy. (msdmanuals.com)
  • Drug-eluting stents (DES) are usually created by coating bare-metal stents with polymer film and loading it with drugs. (ukessays.com)
  • Coronary stents are hollow devices, usually bare-metal stents (BMS) inserted into an obstructed natural passage to open and eliminate the block. (ukessays.com)
  • DES are metal stents coated with a polymer film which is loaded with antiproliferative drugs that are released gradually (usually over a period of 28 days) to prevent inflammation response [ 1 ]. (ukessays.com)
  • It causes a lower rate of in-stent restenosis compared to the metal stents that were used initially, meaning, fewer patients need to return to the hospital for repeat treatments [ 1 ] [ 3 ]. (ukessays.com)
  • Nearly 96.0% and 94.0% of participants in normal and elevated Lp-PLA2 groups were placed with drug-eluting stents, and the others were with bare-metal stents. (biomedcentral.com)
  • Paclitaxel-eluting stents decrease angiographic and clinical restenosis following percutaneous coronary intervention compared to bare metal stents. (biomedcentral.com)
  • Are drug-eluting stents safer than bare-metal stents? (sdu.dk)
  • Delayed arterial healing, characterized by poor endothelialization, is the primary cause of late (1 month-1 year postimplantation) and very late stent thrombosis following implantation of drug-eluting stents. (nature.com)
  • The incompetent endothelium leads to late stent thrombosis and the development of in-stent neoatherosclerosis. (nature.com)
  • The concern of stent thrombosis still an issue and dual antiplatlets therapy (DAPT) is mandatory for variable time ranging from one month to one year. (scirp.org)
  • One acute stent thrombosis due to untreated dissection. (terumo-europe.com)
  • ST, stent thrombosis. (terumo-europe.com)
  • However, excessive inhibition of neointimal formation caused delayed vascular healing with incomplete endothelialization, which has been associated with an increased risk of late stent thrombosis (ST). (acc.org)
  • Post PTCA adverse events in the form of stent thrombosis, recurrent ischemia, unplanned revascularization, recurrent hospitalization etc. result in morbidity as well as mortality. (hvt-journal.com)
  • Outcome measure was taken to be freedom from cardiac related adverse events, including rehospitalization, unplanned repeat revascularization, definite stent thrombosis, transient ischemic attack, stroke and all-cause mortality. (hvt-journal.com)
  • Prolonged dual antiplatelet therapy and avoidance of a new stent has been shown to reduce late thrombosis in patients treated with vascular brachytherapy. (elsevierpure.com)
  • This causes adverse effects like late stent thrombosis. (ukessays.com)
  • Though the loaded drugs have been proven to offer favourable results, the polymer coatings of the first generation DES like Cypher and Taxus were found to cause negative effects such as late stent thrombosis (LST) [ 1 ][ 3 ]. (ukessays.com)
  • There were no episodes of stent thrombosis. (qxmd.com)
  • 5 However, current standard treatment with metallic stents has its shortcomings, such as late in-stent restenosis, late and very late stent thrombosis, impaired vasomotion in the stented segment 6-8 and hindrance of repeat revascularisations. (radcliffecardiology.com)
  • Another potential benefit of the ABSORB BVS in bifurcation lesions might be a lower risk of late stent thrombosis, due to the absorption of non-apposed SB (NASB) struts at long term. (radcliffecardiology.com)
  • These NASB struts are known to be often uncovered and thus a potential nidus for stent thrombosis. (radcliffecardiology.com)
  • A 6-month follow up post-implantation of the radioactive stents showed little adverse side-effects in the patients. (wikipedia.org)
  • Percutaneous coronary intervention (PCI) was then undertaken, which, due to the complex nature of the stenosis, required implantation of two drug-eluting stents (DESs) (Xience V, Abbot, Temecula, Calif, USA) on both bifurcations. (hindawi.com)
  • 1994) A Comparison of Balloon-Expandable-Stent Implantation with Balloon Angioplasty in Patients with Coronary Artery Disease. (scirp.org)
  • Current ACC/American Heart Association/Society for Cardiovascular Angiography and Interventions recommendations suggest, at a minimum, patients should be treated with clopidogrel 75 mg and aspirin 325 mg for 1 month after BMS implantation, 3 months after sirolimus-eluting stent (SES) implantation, 6 months after paclitaxel DES implantation, and, ideally, up to 12 months for patients not at high risk for bleeding. (acc.org)
  • Drug-eluting stents (DES) are a standard metallic coronary stent with a polymer coating and an antiproliferative drug, which allows drug elution into the coronary wall for weeks to months after stent implantation. (medscape.com)
  • Attached to the stent is a polymer that is embedded with an antiproliferative drug, which allows drug elution into the coronary wall for weeks to months after stent implantation to reduce the local proliferative healing response. (medscape.com)
  • In a 5-year study of outcomes from the j-CYPHER registry which compared sirolimus-eluting stent treatment in 397 patients with ostial right coronary artery (RCA) lesions with 3716 patients with nonostial RCA lesions, researchers concluded that sirolimus-eluting stent implantation for ostial RCA was associated with a higher risk of target legion revascularization than when used in patients with nonostial RCA lesions. (medscape.com)
  • [ 4 ] Restenosis remains an issue in coronary drug-eluting stent implantation for ostial RCA lesions. (medscape.com)
  • 6. Percutaneous stent implantation in an adult with left pulmonary artery stenosis and absent right pulmonary artery. (prime-cardiology.com)
  • One such technique delivers a radioactive dose via catheter, prior to stent implantation. (justia.com)
  • Intracoronary Radiation Before Stent Implantation Inhibits Neointimal Formation In Stented Porcine Coronary Arteries," Circulation, 1995:92:1383-1386. (justia.com)
  • The activity levels of radioactive stents are upto 10,000 times lower than activity levels of sources used for catheter based vascular Brachytherapy, They allow uniform dose distribution with precise dosimetry because of direct source contact with the circumference of the vessel.Radioactive stents have been produced by cyclotron activation, ion implantation and proton bombardment for both beta, gamma and combination isotopes. (aarogya.com)
  • We have herein reported the first case of radioactive stent implantation in a native coronary artery in Pune. (aarogya.com)
  • 34 U/l.Thirty-one patients (33 stenoses) were allocated to stent implantation (control group) and 30 patients (31 stenoses) to VBT and stented angioplasty. (univr.it)
  • All patients were carriers of the D allele of the ACE gene, with plasma ACE levels >34 U/l.Thirty-one patients (33 stenoses) were allocated to stent implantation (control group) and 30 patients (31 stenoses) to VBT and stented angioplasty. (univr.it)
  • A randomized comparison of coronary-stent placement and balloon angioplasty in the treatment of coronary artery disease. (hopkinsmedicine.org)
  • 1987) Intravascular Stents to Prevent Occlusion and Restenosis after Transluminal Angioplasty. (scirp.org)
  • Although it has been shown that low-power laser illumination may stimulate bone healing ( 1 - 3 ), endothelial regeneration ( 4 ), smooth muscle relaxation ( 5 ) and reduce restenosis rate after coronary angioplasty procedures ( 6 - 9 ), little is still known about cellular mechanisms underlying these effects. (iiarjournals.org)
  • To follow up the restenosis in arteries stented during an angioplasty is an important current clinical problem. (us.es)
  • Stents were conceived to make balloon angioplasty safer and more effective. (ecrjournal.com)
  • The decrease in restenosis rates compared with conventional angioplasty, stable angiographic results with a subsequent decreased need for urgent or emergency coronary bypass graft surgery, and reliable treatment of acute or threatened closure resulting from conventional angioplasty have all made stents the treatment of choice for many patients undergoing percutaneous intervention. (elsevierpure.com)
  • Percutaneous coronary interventions (PCI) include percutaneous transluminal coronary angioplasty (PTCA) with or without stent insertion. (msdmanuals.com)
  • The new and thickened layer of scar tissue that forms on a PROSTHESIS, or as a result of vessel injury especially following ANGIOPLASTY or stent placement. (lookformedical.com)
  • This revascularization procedure is termed as a percutaneous coronary intervention (PCI) or coronary angioplasty with stent placement. (statpearls.com)
  • In a pre-stent era, balloon angioplasty was the mainstay of coronary revascularization in which an inflatable balloon-tipped catheter was inserted percutaneously through an arterial entry site in the extremity and advanced into the coronary arteries. (statpearls.com)
  • To address elastic recoil of vessel wall and intimal dissection that can follow balloon angioplasty, stents have been designed and these appear to produce more effective relief of obstruction. (longdom.org)
  • The usefulness of stents in the management of vascular obstructive lesions not amenable to balloon angioplasty is well established and has been successfully used to treat branch pulmonary artery stenosis, coarctation of the aorta, stenotic right ventricular outflow tract conduits, obstructive lesions of the systemic and pulmonary veins and others. (longdom.org)
  • In this study, we investigated the effect of NBD peptide on neointimal formation using two animal models of arterial injury: rat carotid artery balloon angioplasty and wire-induced carotid injury in apolipoproteinE-deficient (apoE-/-) mice. (unina.it)
  • Recently, the use of ionising radiations received much interest as a new treatment tool to reduce restenosis after coronary angioplasty. (aarogya.com)
  • From the introduction of balloon angioplasty by Andreas Grüntzig in 1977 1 to metallic drugeluting stents with thin stent struts coated with cytotoxic or cytostatic drugs, 2,3 with biocompatible/biodegradable polymers, 4 with or without endothelial progenitor cell-capturing technology. (radcliffecardiology.com)
  • After angioplasty, in-stent MLD was similar in the two groups. (univr.it)
  • Thus new improvements to balloons and stents are always necessary to achieve the best results from percutaneous coronary intervention (PCI). (scirp.org)
  • The main objective of this study is to assess the safety, efficacy and dose response of LABR-312 administered intravenously at the time of percutaneous coronary intervention (PCI) with a drug eluting stent in reducing restenosis as measured by Optical Coherence Tomography (OCT) at 9 months post procedure in patients with diabetes mellitus (DM). (vchri.ca)
  • It was introduced into clinical practice in 2002, bringing in the current drug-eluting stent (DES) era of interventional cardiology. (ecrjournal.com)
  • The main objective o f this study is to use the finite element method to simulate these stenting procedures, and to examine the stresses induced within the stented arterial vessel walls by the stents, thus enabling the mechanical stimuli for in-stent restenosis to be identified. (dcu.ie)
  • Finite element models o f thin and thick strut stents were developed and the stents were deployed in various stenosed vessel geometries such that the stresses induced within the stented vessels by the two stents could be compared. (dcu.ie)
  • Brachytherapy with both gamma and beta sources has been found to result in improved outcome with less angiographic restenosis and decreased target vessel revascularization. (elsevierpure.com)
  • The need for repeated treatment of restenosis of a treated vessel remains the main limitation of percutaneous coronary revascularization. (qxmd.com)
  • The difference was due entirely to a higher rate of revascularization of the target vessel in the standard-stent group. (qxmd.com)
  • The PERSEUS Workhorse study is a prospective, randomized (3:1), single-blind, non-inferiority trial in subjects with lesion length ≤28 mm and vessel diameter ≥2.75 mm to ≤4.0 mm which compares TAXUS Element to the TAXUS Express 2 paclitaxel-eluting stent system. (biomedcentral.com)
  • Thinner stent struts also facilitate deliverability through tortuous vessel anatomy. (biomedcentral.com)
  • Background Poor vessel wall apposition of flow diverter (FD) stents poses risks for stroke-related complications when treating intracranial aneurysms, necessitating long-term surveillance imaging. (bmj.com)
  • One complication of the known treatments of stenotic regions is restenosis (i.e. re-narrowing) of the vessel following treatment. (justia.com)
  • At 6 months, a higher need for target vessel revascularization (TVR) was observed in the control group: 35.5\% versus 13.3\% (P=.04).This randomized study confirms that patients with high plasma ACE concentrations are exposed to an increased risk for ISR after coronary stenting. (univr.it)
  • Uses of balloon catheters or BMS for the treatment of coronary artery lesions shows good short-term results but long-term follow up revealed restenosis in up to 20%-30% of patients. (scirp.org)
  • Drug-eluting stents (DES) were developed in the early 2000s to reduce restenosis (ie, recurrent narrowing) rates in stented coronary lesions. (medscape.com)
  • These stents are FDA approved for single de novo coronary lesions of limited length within specific diameter size ranges. (medscape.com)
  • [ 1 ] which compared the sirolimus-eluting CYPHER stent with its noncoated counterpart, the BX velocity stent, in 238 patients with de novo lesions less than 18 mm in length in native coronary arteries 2.5-3.5 mm in diameter. (medscape.com)
  • The SIRIUS trial, which included 1058 patients with workhorse lesions who were randomly assigned to either sirolimus-eluting stents or BMS, demonstrated the long-term efficacy and safety of sirolimus-eluting stents. (medscape.com)
  • A pivotal randomised controlled trial (RCT) was the Randomized Study with the Sirolimus-coated Bx Velocity Balloon- Expandable Stent in the Treatment of Patients with De Novo Native Coronary Artery Lesions (RAVEL), 1 in which 238 patients were randomised to a single SES and a BMS. (ecrjournal.com)
  • This was followed by the larger (1,058 patients) Sirolimus-eluting Stent in De Novo Native Coronary Lesions (SIRIUS) trial 2 in the US, and the E-SIRIUS 3 (n=352) in Europe and C-SIRIUS 4 (n=100) in Canada. (ecrjournal.com)
  • Stents are now used frequently for acute myocardial infarction, ostial or left main disease, chronic total occlusions, and bifurcation lesions. (msdmanuals.com)
  • We performed a randomized, double-blind trial to compare the two types of stents for revascularization of single, primary lesions in native coronary arteries. (qxmd.com)
  • The PERSEUS trials include two parallel studies of the TAXUS Element stent in single, de novo coronary atherosclerotic lesions. (biomedcentral.com)
  • The PERSEUS program evaluates the TAXUS Element stent for the treatment of single de novo atherosclerotic lesions using a novel Bayesian statistical approach to increase efficiency. (biomedcentral.com)
  • Analysis of the cellular composition in neointimal lesions of apoE-/- mice treated with bindarit showed that the relative content of macrophages and the number of SMCs were reduced by 66% and 30%, respectively, compared with the control group. (unina.it)
  • Despite the improved outcomes with stenting, restenosis occurs at a high rate, especially in smaller vessels and in longer lesions. (aarogya.com)
  • The use of bioresorbable technology in coronary bifurcation lesions may have potential benefits compared with metallic stents. (radcliffecardiology.com)
  • This device will profoundly decrease the number of healthcare dollars spent on repeated revascularization due to restenosis in CAD. (gatech.edu)
  • A randomized comparison of a sirolimus-eluting stent with a standard stent for coronary revascularization. (qxmd.com)
  • The higher restenosis rate of the thicker strut stent, reported in the ISAR-STEREO clinical study, was found to be the result of the higher luminal gain achieved by the thicker strut stent, due to the lower recoil of the stent structure when both stents were expanded to the same initial lumen diameter. (dcu.ie)
  • Therefore, it is proposed that the use of preclinical testing tools, such as finite element modelling, could be used to predetermine the deployment protocol and optimum luminal gain of a particular stent design in order to minimise the mechanical stimuli for in-stent restenosis. (dcu.ie)
  • Strut spacing, thickness, luminal protrusion, and malapposition were systematically investigated and a comparison made between two commercially available stents (Omega and Biomatrix). (researchgate.net)
  • Local hemodynamics worsened with luminal protrusion of the stent and with stent malapposition, adverse high WSS and WSSG were identified around peak flow and throughout the cardiac cycle respectively. (researchgate.net)
  • The primary end point was in-stent late luminal loss (the difference between the minimal luminal diameter immediately after the procedure and the diameter at six months). (qxmd.com)
  • Secondary end points included the percentage of in-stent stenosis of the luminal diameter and the rate of restenosis (luminal narrowing of 50 percent or more). (qxmd.com)
  • The new balloons broadened physicians' treatment options for peripheral artery disease (PAD) patients with a high risk of restenosis and expand the Stellarex portfolio. (researchandmarkets.com)
  • In addition, failure to deploy the stent optimally at the time of the initial placement may result in increased restenosis. (elsevierpure.com)
  • Whether increased Lp-PLA2 level is associated with re-stenosis after stent-placement is unclear. (biomedcentral.com)
  • Totally 326 participants eligible for stent-placement were enrolled and divided into two groups according to baseline Lp-PLA2 levels (named normal and elevated groups). (biomedcentral.com)
  • Owing to the significant and unequivocal implications of Lp-PLA2 on the initiation and progression of atherosclerosis and CAD, we speculated that increased plasma level of Lp-PLA2 at baseline might contribute to re-stenosis in patients with stent placement. (biomedcentral.com)
  • After angiographic evaluation, patients diagnosed as significant CHD and eligible for stent-placement were enrolled after written informed consent was obtained. (biomedcentral.com)
  • Drug-eluting stents (DES) are balloon-mounted, expandable, slotted tubular or multilink scaffolds constructed of a stainless steel or cobalt chromium matrix. (medscape.com)
  • An unusual no-reflow phenomenon due to neointimal tissue embolization during drug eluting balloon intervention in stent restenosis: A case report. (amedeo.com)
  • The TAXUS Element stent is a novel, balloon-expandable, 81 μm, platinum chromium alloy stent pre-mounted on a high-pressure delivery balloon. (biomedcentral.com)
  • Of the two types of stents, namely, balloon expandable and self expandable, balloon expandable stents are most commonly used in children. (longdom.org)
  • Treatment of rats with bindarit (200 mg/kg/day) significantly reduced balloon injury-induced neointimal formation by 39% at day 14 without affecting re-endothelialisation and reduced the number of medial and neointimal proliferating cells at day 7 by 54% and 30%, respectively. (unina.it)
  • The finite element studies successfully identified differences between the mechanical loading of the arterial tissue in the vessels stented with the two different stents. (dcu.ie)
  • The Cypher ® stent utilises a non-erodable methacrylate co-polymer matrix for controlled endovascular delivery of the drug to the arterial tissue. (ecrjournal.com)
  • Effect of NBD peptide on injury-induced neointimal formation The activation of nuclear factor-κB (NF-κB) is a crucial step in the arterial wall's response to injury. (unina.it)
  • For the Biomatrix stent, the adverse effect of thicker struts was mitigated by greater strut spacing, radial cell offset and flow-aligned struts. (researchgate.net)
  • Reservoirs were embedded on to the stent struts which were then loaded with drugs for sustained release over a longer period of time. (ukessays.com)
  • It has been proposed that the thickness of stent struts may impact the ability of the stent to reduce restenosis. (biomedcentral.com)
  • The development of an antiproliferative drug-coated stent followed extensive research on the understanding of vascular biology, pharmacology and experimental and clinical research. (ecrjournal.com)
  • While DEB has only antiproliferative drug coating without an underlying metallic structure of the stent, BRS is also devoid of metallic structure and is entirely resorbed in a few months after serving their purpose. (statpearls.com)
  • They also have been investigated in clinical trials to prevent coronary artery in-stent restenosis. (researchandmarkets.com)
  • Clinical studies have found that stent design is a key determinant in the propensity o f stents to cause restenosis, indicating a vital link between the biomechanics o f stents and the development of the disease. (dcu.ie)
  • The ISAR-STEREO Trial specifically assessed the effect o f strut thickness on restenosis outcome and found that for the same stent design, a thinner strut stent was associated with a significant reduction o f angiographic and clinical restenosis compared to the same stent with a thicker strut. (dcu.ie)
  • The investigators noted that 1 year of clinical follow-up may not be sufficient to assess late outcomes (very late ST). Also, because very high-risk patients were not included, the results cannot be generalized to the entire population of patients undergoing stenting. (acc.org)
  • [ 2 , 3 ] There was significant improvement in angiographic results (in stent late lumen loss: 0.17 mm vs 1.00 mm) as well as clinical outcomes (binary in-lesion restenosis: 8.9% vs 36.3%) in the sirolimus stent treatment group relative to the BMS group. (medscape.com)
  • He is responsible for intellectual property, and as Medical Director is responsible for the clinical scientific research in the Spiral Laminar Flow™ field and stent technology. (weecreative.uk)
  • It can reliably predict the restenosis propensity and the clinical consequence of target lesion revascularisation (TLR). (ecrjournal.com)
  • Biodegradable stents are being developed, but use is currently limited to clinical trials. (msdmanuals.com)
  • Stent induced hemodynamic changes in the coronary arteries are associated with higher risk of adverse clinical outcome. (researchgate.net)
  • Clinical and experimental evidence added to the existing literature all of which pointed to the negative effects of permanent and biodegradable polymer coating such as extensive inflammatory response and neointimal thickening within pig coronary arteries [ 3 ]. (ukessays.com)
  • Numerous new stents were contrived and they are presently under trial or clinical examinations to defeat the deficiencies of the stents that have been utilized clinically. (gujaratresearchsociety.in)
  • The safety and efficacy of the TAXUS Element stent are being evaluated in the pivotal PERSEUS clinical trials. (biomedcentral.com)
  • The TAXUS PERSEUS clinical trial program uses a novel statistical approach to evaluate whether design and metal alloy iterations in the TAXUS Element stent platform provide comparable safety and improved procedural performance compared to the previous generation Express stent. (biomedcentral.com)
  • However, no prospective randomised clinical data with optical coherence tomography (OCT) imaging for different bifurcation stenting techniques are available. (radcliffecardiology.com)
  • Dual antiplatelet therapy with aspirin plus thienopyridines has become the standard treatment of patients undergoing coronary stenting. (hindawi.com)
  • who found elevated levels of soluble CD54 in patients with early restenosis ( 14 ). (iiarjournals.org)
  • The preventive use of VBT in these patients reduced neointimal formation by 65\% such that the MLD at follow-up was increased by 29\% compared with the control group. (univr.it)
  • This study was undertaken to study the predictive significance of periprocedural plasma fibrinogen levels for coronary stenting outcomes. (hvt-journal.com)
  • Sex-based treatment and outcomes for coronary bifurcation stenting: A report from the e-ULTIMASTER registry. (amedeo.com)
  • A new approach to monitor the growth of neointimal tissue inside the stent is proposed on the basis of electrical impedance spectroscopy (EIS) sensors and the oscillation-based test (OBT) circuit technique. (us.es)
  • Creganna Medical Devices from Ireland, developed the process to apply the biodegradable polymer to the metal surface of the stent, with or without a drug component. (medgadget.com)
  • DES reduced the incidence of in-stent restenosis. (scirp.org)
  • With the introduction of drug-eluting stents (DESs), the incidence of ISR has markedly decreased. (ijcdw.org)
  • There is no existing system that offers a clinically practical solution for continuous, real- time detection of both restenosis incidence and progression. (gatech.edu)
  • The present invention relates to implantable medical apparatus, especially radioactive stents for reducing the incidence of restenosis, and to a method for imparting radioactive properties to substrate materials such as stents, in particular by creating a surface layer of a radioactive isotope such as .sup.32 P. (justia.com)
  • The pharmacological agent, paclitaxel, is incorporated into a triblock polymer matrix and applied to the surface of the stent to provide controlled release of available paclitaxel (see Appendix A for a detailed description of TAXUS Element and comparison to previous platforms). (biomedcentral.com)
  • In this study, polymer-free DES were created by applying three different surface treatments to three different stents to test their effectiveness in inducing different surface roughness. (ukessays.com)
  • 2.75 mm that compares TAXUS Element with a matched historical bare metal Express stent control. (biomedcentral.com)
  • p32 is a pure particle emitting radioisotope and has a short half-life (14.3 days) and a limited range of tissue penetration (3-4mm) It is the radioactive isotope being used in the Isonipsi trial to assess the role of beta radiation in reducing the rate of restenosis. (aarogya.com)
  • Other stents like bifurcation stents and covered stents are designed for special circumstances such as lesion over vascular bifurcation or coronary artery perforation, respectively. (statpearls.com)
  • Together with the paclitaxel-eluting stent (PES), approved later, they form the so-called first-generation DES. (ecrjournal.com)
  • TAXUS Element is a third-generation paclitaxel-eluting stent which incorporates a novel, thinner-strut, platinum-enriched metal alloy platform. (biomedcentral.com)
  • The stent is intended to have enhanced radiopacity and improved deliverability compared to other paclitaxel-eluting stents. (biomedcentral.com)
  • Similar results were observed in apoE-/- mice in which bindarit administration resulted in a 42% reduction of the number of proliferating cells at day 7 after carotid injury and in a 47% inhibition of neointimal formation at day 28. (unina.it)
  • An apparatus and method of forming a radioactive stent having a radioactive layer. (justia.com)
  • A solution containing a radioactive isotope depositing substance in solution is provided and placed into contact with the stent or any other substrate material capable of receiving the radioactive isotope. (justia.com)
  • The radioactive isotope is deposited on the stent or substrate material. (justia.com)
  • Another way of applying radiation to inhibit restenosis is through the use of radioactive stents. (justia.com)
  • Examples of radioactive stents are described, in U.S. Pat. (justia.com)
  • A disadvantage of the known radioactive stents is undue complexity in the manufacturing process making the manufacture and handling of such stents difficult. (justia.com)
  • The other approach is based on a stent rendered radioactive for long exposure and continuous low dose treatment. (aarogya.com)
  • Radioactive stents deliver ionising radiation at very low dose rates according to the half life of the incorporated radiosotopes. (aarogya.com)
  • Neoendothelial cell harm is viewed as brought about by erosion between the cells what's more, stent swaggers due to the flimsy neointima between them that may go about as a pad. (gujaratresearchsociety.in)
  • Subsequently, advancement of a DES that causes a fitting thickness (around 100 m) of the neointima is an expected choice with which to forestall neoendothelial cell harm and subsequent LST while forestalling restenosis. (gujaratresearchsociety.in)
  • Particle-Emitting Stents Inhibit Neointima Formation in Rabbits," Circulation, 1996:93:641-645. (justia.com)
  • With the introduction of coronary stents, coronary dissection and vascular recoil were eliminated due to the expandable, metallic meshwork of the stent, which prevents negative remodeling. (statpearls.com)
  • How should I treat a bioresorbable vascular scaffold edge restenosis and intra-scaffold dissection? (sdu.dk)
  • The burst release of drugs within the first few days by the Yukon stent point to the fact it is not superior to the Taxus stent. (ukessays.com)
  • The BioFreedom stent showed comparable long-term efficacy as the Taxus stent [ 3 ]. (ukessays.com)
  • The Workhorse study employs a novel Bayesian statistical approach that uses prior information to limit the number of study subjects exposed to the investigational device and thus provide a safer and more efficient analysis of the TAXUS Element stent. (biomedcentral.com)
  • We report a case of clopidogrel-induced bone marrow toxicity manifesting with severe neutropenia in a patient treated with multiple coronary stents and provide suggestions for an alternative treatment. (hindawi.com)
  • Drug-eluting stents (DES) are associated with a major milestone in coronary heart disease treatment. (ukessays.com)
  • Flow diverter (FD) stents provide a safe and effective technique for endovascular treatment of unruptured intracranial aneurysms. (bmj.com)
  • In an effort to improve on current therapy for restenosis we are prompted to consider new strategies for prevention and treatment, focusing on understanding of molecular mechanisms and identifying possible therapeutic targets. (unina.it)
  • The introduction of the ABSORB bioresorbable vascular scaffold (BVS) provides a new tool for stenting in interventional cardiology. (radcliffecardiology.com)
  • Drug-coated balloons (DCB), also referred to as drug-eluting balloons (DEB), were created as a way to reduce very high restenosis rates in peripheral vessels. (researchandmarkets.com)
  • Reduce junctional zone restenosis. (weecreative.uk)
  • It is known to reduce the occurrence of restenosis by placing a stent device at the site of the treated region. (justia.com)
  • Sirolimus is blended with the polymer and a thin coating is applied to the surface of the Bx Velocity™ Cordis stent. (ecrjournal.com)
  • The quantity of sirolimus loaded onto each stent is approximately 140mg/cm 2 , and the system provides controlled release of sirolimus over a period of four weeks. (ecrjournal.com)
  • The sirolimus-eluting stent (SES) was the first stent-based pharmacological therapy approved for the prevention of restenosis and the first to be approved by the European Community. (ecrjournal.com)
  • The stress analyses were used to determine the level of vascular injury caused to the artery by different strut thickness stents. (dcu.ie)
  • Further stenting analyses, however, found that the thicker strut stent resulted in a lower percentage of volume stressed at high levels compared with the thinner strut stent when it was expanded to the same final lumen diameter. (dcu.ie)
  • This suggests that a thicker strut stent may in fact have the potential to be expanded to an optimal diameter whereby the in-stent restenosis is minimised. (dcu.ie)
  • Zotarolimus-eluting stents (ZES) have been associated with a higher rate of neointimal coverage at 8 months than SES on intravascular ultrasound (IVUS) and had a pattern of neointimal coverage similar to that of BMS on angioscopy. (acc.org)
  • Because one of the strongest predictors for ST is early discontinuation of clopidogrel, prolonged dual antiplatelet therapy (DAPT) is highly recommended post-stenting. (acc.org)
  • At 6 months in the control group, in-stent MLD had decreased to 1.74+/-0.8 versus 2.25+/-1.05 mm in the VBT group (P=.04). (univr.it)
  • The mean in-stent diameter was 2.3+/-0.8 mm in the control group versus 2.9+/-1.05 mm after VBT (P=.02), and the restenosis rate was 37.5\% versus 17.9\%, respectively (P=.08). (univr.it)