• Methods and Results- This study investigated vein graft neointimal cell origins using a model of vein-to-artery cross-transplantation between transgenic Rosa26 mice (constitutive expression of bacterial β-galactosidase marker gene) and wild-type mice. (ahajournals.org)
  • Conclusions- Vein graft neointimal cells arise predominantly from vein-derived cells, suggesting clinical relevance of stenosis-inhibiting therapies directed at the vein graft. (ahajournals.org)
  • Local administration of NO may prevent neointimal hyperplasia by inhibiting isopeptidase T levels and activity in the vasculature, thereby inhibiting the 26S proteasome in VSMCs. (sigmaaldrich.com)
  • It was hypothesized that neointimal cells arise primarily from the cells of the vein graft. (ahajournals.org)
  • 1,2 Despite high early success rates of these procedures, it is estimated that 20% to 50% of cases undergo stenotic occlusion of the graft within 5 years, 3-5 caused by an inward growth of neointimal cells. (ahajournals.org)
  • The source of neointimal cells remains controversial. (ahajournals.org)
  • 11-15 Studies using vein graft models have supported adjacent arterial media as a major source for neointimal cells. (ahajournals.org)
  • 15,17-19 A recent study using a murine vein graft model demonstrated that the neointimal cells within the graft arise from both the vein graft and the recipient artery. (ahajournals.org)
  • With time distinct neointimal thickening occurs, associated with disappearance of proliferative activity and a phenotypic shift of the smooth muscle cells. (bmj.com)
  • Two-week interval optical coherence tomography: imaging evidence on neointimal coverage completion after implantation of the Endeavor zotarolimus-e. (nih.gov)
  • Anastomotic neointimal hyperplasia (ANH) is known as a contributing factor of graft occlusion after implantation and the difference of mechanical properties between a vascular prosthesis and its host arteries, abnormal graft flow, intimal trauma due to surgical procedure, platelet aggregation in a surface of anastomotic site, suture material and method are suggested the factors of ANH. (nii.ac.jp)
  • However, the difficulty in controlled, local release of nitric oxide has limited its clinical use for neointimal hyperplasia. (wikipedia.org)
  • 6 Experimental models that mimic clinical vein grafting show a characteristic burst of neointimal cell proliferation early after grafting (3 to 7 days), which leads to a thickened intimal layer by 1 month. (ahajournals.org)
  • 7,8 This neointimal growth appears to stabilize beyond 1 to 2 months in animal models 9,10 and does not create significant graft stenosis at any time, thus differing from the clinical progression of this complication. (ahajournals.org)
  • C-reactive protein is a systemic inflammatory mediator correlated with neointimal hyperplasia, but it is still unknown if this protein is a marker of increased risk or a causative agent of the condition. (wikipedia.org)
  • The covered strut is defined as the strut has definite neointimal over it. (clinicaltrials.gov)
  • Neointimal thickening was greater at the proximal and, to a lesser extent, distal ends, in comparison to the middle of the graft. (ahajournals.org)
  • Neointimal area was assessed in multiple slices, incrementally spaced by 1 mm from fracture site to distal and proximal sites. (onlinejacc.org)
  • In this paper, a mathematical model will be used to understand neointimal hyperplasia in individual patients, combining information from biological experiments and patient-specific data to analyze some aspects of the disease, particularly with regard to mechanical stimuli due to shear stresses on the vessel wall. (pubmedcentralcanada.ca)
  • The patented Spiral Luminal Flow[TM] technology was designed to prevent neointimal hyperplasia by decreasing turbulence and creating a spiral flow that mimics the blood flow of a native AV fistula into the venous system (Vascular Flow Technologies, 2017b). (thefreedictionary.com)
  • The relative neointimal wall thickness is much greater in this model compared with other murine and larger-species vein graft models, even showing near-occlusive stenosis of the perianastomotic region. (ahajournals.org)
  • In this episode, Anil Chauhan, Manish Jain, and colleagues reveal that smooth muscle cell- specific fibronectin containing an extra domain A mediates phenotypic switching and neointimal hyperplasia. (jci.org)