Nematode caenorhabditis elegans. Medical search. Frequent questions

In 1965 Sydney Brenner chose the free-living nematode Caenorhabditis elegans as a promising model system for a concerted genetic, ultrastructural, and behavioral attack on the development and function of a simple nervous system. (cshlpress.com)
Defining a behavior that requires the function of specific neurons in the free-living nematode Caenorhabditis elegans can allow one to screen for mutations that disrupt the specification or function of those neurons. (jneurosci.org)
We have exploited the free-living nematode Caenorhabditis elegans to examine its suitability as an alternative system for recombinant expression of parasitic nematode vaccine candidates. (gla.ac.uk)
A powerful tool in this process may be the free living nematode Caenorhabditis elegans. (europa.eu)

We identified serotonin-immunoreactive neurons required for tail curling or "turning" behavior exhibited by C. elegans males during mating. (jneurosci.org)
It shows that even a simple nematode with a nervous system of 302 neurons can show complex regulation of feeding behaviours, involving multiple pathways, which conceptually resonates with higher organisms' organisation. (bl.uk)
The nematode Caenorhabditis elegans has a compact nervous system with only 302 neurons. (nature.com)
Our results demonstrate that we can excite specific neurons expressing ChR2 while simultaneously monitoring G-CaMP fluorescence in several other neurons, making it possible to rapidly decipher functional connections in C. elegans neural circuits. (nature.com)
Optical imaging of calcium transients in neurons and pharyngeal muscle of C. elegans . (nature.com)
The nematode worm Caenorhabditis elegans (C. elegans) is tiny and only has 302 neurons. (interconnected.org)
These neurons may be analogous to the AFD finger neurons in C. elegans . (wormatlas.org)
C. elegans has far fewer neurons and neuron-neuron connections, making it a great starting point," they say. (discovermagazine.com)
Optogenetics will allow researchers to activate neurons in C. elegans with light and to record the responses across the nervous system. (discovermagazine.com)
By exhaustively mapping these functional connections between neurons, this large-scale initiative aims to reverse engineer a complete simulation of the C. elegans brain. (discovermagazine.com)
Neuroendocrine regulation of diverse behaviors of Caenorhabditis elegans is under the control of the DAF-7/TGF-β ligand that is secreted from sensory neurons. (elifesciences.org)
Our results suggest that regulation of gene expression in sensory neurons can function in the integration of a wide array of sensory information and facilitate decision-making behaviors in C. elegans . (elifesciences.org)
The sensory neurons that release DAF-7 are found in both sexes of C. elegans but the specific way that the male worms express this signal encourages them to search for mates. (elifesciences.org)

By relating the steps of male tail morphological evolution to the phenotypic changes brought about by developmental mutations induced experimentally in C. elegans, the goal is to identify genes responsible for morphological evolution. (nyu.edu)
The primary focus of this project is to analyse the in vivo fu nction in C. elegans of the metallopeptidase, cysteine proteinase and activation associated secreted protein families and to identify the key genes in each family. (europa.eu)
I had an experiment which Francis dissuaded me from doing, which was to see if nematode genes would work in bacteria. (webofstories.com)
Transcriptome studies reveal that co-culture upregulates stress response genes, including xenobiotic-metabolizing enzymes (XMEs), in C. elegans intestine and AMsh glial cells. (bvsalud.org)

Since then, with the help of a growing number of investigators, knowledge about the biology of "the worm" has accumulated at a steadily accelerating pace to the extent that C. elegans is now probably the most completely understood metazoan in terms of anatomy, genetics, development, and behavior. (cshlpress.com)
Brenner, S. The genetics of Caenorhabditis elegans . (nature.com)
Biologist regularly use C. elegans to gain insight into topics ranging from embryonic development and aging to genetics and neurobiology. (discovermagazine.com)

To try to overcome some of these limitations in this study, we have used Caenorhabditis elegans (nematode) and Danio rerio embryos (zebrafish) as alternative assays for DART hazard assessment of some candidate chemicals being considered for a new commercial application. (nih.gov)

With the problem of parasitic nematode drug resistance increasing, vaccine development offers an alternative sustainable control approach. (gla.ac.uk)

The decline of aging C. elegans male's mating behavior is correlated with the increased excitability of the cholinergic circuitry that executes copulation. (elifesciences.org)
Here, we show that C. elegans males exhibit an altered, male-specific expression pattern of daf-7 in the ASJ sensory neuron pair with the onset of reproductive maturity, which functions to promote male-specific mate-searching behavior. (elifesciences.org)
It is also possible to analyze the underlying factors that contribute to behavior in C. elegans , because it has a relatively simple and well-defined nervous system. (elifesciences.org)

The soil nematode Caenorhabditis elegans has served as a useful model to study the mechanism of action of avermectins. (nih.gov)

What's more, in C. elegans every neuron receives inputs from dozens of others. (discovermagazine.com)

The evolutionary pathway that has led to male tails of diverse morphology among species of the nematode family Rhabditidae was reconstructed. (nyu.edu)
This family includes the well-studied model species Caenorhabditis elegans. (nyu.edu)
Is the uploaded nematode a new species? (interconnected.org)
Many experiments on aging have been performed on worms belonging to the species C. elegans . (elifesciences.org)

This "Book of the Worm" serves as a reference source for C. elegans investigators as well as an introductory monograph for other biologists. (cshlpress.com)
Here, we take advantage of the nematode C. elegans to understand the effects of space microgravity on worm body wall muscle. (lancs.ac.uk)
Despite these similarities, no reduction in worm burden or faecal egg count was observed following immunisation of sheep with C. elegans-expressed recombinant H11 protein. (gla.ac.uk)
One of the workhorses of in any biology lab is Caenorhabditis elegans or nematode worm just 1mm long. (discovermagazine.com)

Treatment of Caenorhabditis elegans or C. brissage with flavones induced embryonic and larval lethality that was pronounced in early larval stages. (molcells.org)
The infective juvenile, a 3rd larval stage analogous to the C. elegans dauer, migrates towards warm temperatures, which may signify the presence of a susceptible host animal. (wormatlas.org)

In 1986, C. elegans became the first to have its entire nervous system mapped out. (discovermagazine.com)
Now Gal Haspel at the New Jersey Institute of Technology in Newark and colleagues, say that the goal of reverse-engineering C. elegans entire nervous system is now within grasp. (discovermagazine.com)
Haspel and co say these innovations should finally make it possible to reverse engineer C. elegans nervous system at last. (discovermagazine.com)
Modelling these interdependencies will reveal the computational rules embedded in the structure of C. elegans' nervous system. (discovermagazine.com)
Having a virtual version of the C. elegans nervous system will allow rapid, inexpensive hypothesis testing. (discovermagazine.com)

Thus, Piperazine seemed the most toxic compound for both nematodes and zebrafish. (nih.gov)
The results of the nematode and zebrafish studies were in alignment with data obtained from conventional mammalian toxicity studies indicating that these have potential as developmental toxicity screening systems. (nih.gov)

Adult worms that had fed on six pathogenic E. coli strains (highly persistent in the nematode intestine) were treated with three chemical solutions. (korea.ac.kr)
Now, Hilbert and Kim show that a signal that influences how C. elegans explores in response to chemicals in its environment is expressed differently in male and hermaphrodite worms. (elifesciences.org)

Although these studies are still at an early stage, these results strongly suggest that parallel studies of developmental mutants in C. elegans and of morphological and developmental evolution among related nematodes will help define genetic changes underlying the evolution of form. (nyu.edu)
if I could get a mutant of Bacillus subtilis , and I could make it so it wouldn't revert itself, which is make double mutants, then I could take nematode DNA and see if I could restore the gene to Bacillus subtilis . (webofstories.com)

de Bono, M. & Maricq, A.V. Neuronal substrates of complex behaviors in C. elegans . (nature.com)
Modern machine-learning based modelling should then enable a simulation of C. elegans' impressive breadth of brain states and behaviors," say the team. (discovermagazine.com)

The genome of a related nematode, Caenorhabditis briggsae , was sequenced by a whole genome shotgun (WGS) sequencing approach. (genome.gov)

A promising indicator of neurobehavioral toxicity using the nematode Caenorhabditis elegans and computer tracking. (cdc.gov)

Fitch, DHA 1997, ' Evolution of male tail development in rhabditid nematodes related to Caenorhabditis elegans ', Systematic Biology , vol. 46, no. 1, pp. 145-179. (nyu.edu)
And without him it is inconceivable that the nematode, Caenorhabditis elegans, Would have become a major contributor to our understanding of cellular and developmental biology, and exceedingly unlikely that the pufferfish, Fugu rubripes, would have been one of the first vertebrates to have a draft genome sequence, which is likely to shed great light on the evolution of the human genome. (the-scientist.com)

A C. elegans messenger RNA expressed in Xenopus oocytes encodes an avermectin-sensitive glutamate-gated chloride channel. (nih.gov)

However, biochemical analysis of the fractions have shown that they contain multiple members of nematode protein families, such as metallopeptidases, cysteine proteinases and activation associated secreted proteins. (europa.eu)
In a second step we will apply this technology to investigate the function of an additional nematode specific gene family, i.e. transthyretin-like protein family. (europa.eu)

Four of the unequivocal character state changes on unambiguously supported branches closely resemble the phenotypic changes brought about by known mutations in C. elegans. (nyu.edu)

Here, we report novel persistent behavioral responses caused by electric stimuli in the nematode Caenorhabditis elegans. (northeastern.edu)
In C. elegans , bimodal responses to CO 2 are determined by the dauer arrest decision. (wormatlas.org)
Different C. elegans wild isolates harbor sequence polymorphisms in nhr-156, resulting in phenotypic diversity in AMsh glia responses to microbe exposure. (bvsalud.org)

The roundworm Caenorhabditis elegans has two sexes, hermaphrodites and males. (elifesciences.org)

The most common of these nematodes are the cattle parasite Ostertagia ostertagi and the sheep parasites Haemonchus contortus an d Teladorsagia circumcincta. (europa.eu)
We are also interested in drug resistance in important nematode parasites of livestock, where resistance already poses a substantial economic challenge. (mcgill.ca)
The avermectins are a family of macrocyclic lactones used in the control of nematode and arthropod parasites. (nih.gov)

The National Human Genome Research Institute (NHGRI) has supported a number of sequencing projects aimed at producing draft assemblies of roundworm (Caenorhabditis) genomes. (genome.gov)
CB5161 -- and subsequent analyses to compare the resulting data to the existing roundworm genomes should allow for more thorough annotation of the C. elegans genome. (genome.gov)

Such comparative analyses of different factors causing muscle atrophy in C. elegans could provide a way to identify novel genetic factors regulating space microgravity-induced muscle atrophy. (lancs.ac.uk)

Hilbert and Kim showed that the biological sex in combination with multiple other inputs - including the animal's past diet and age - regulate how the DAF-7 signal is expressed in C. elegans . (elifesciences.org)

Overall, this thesis provides new insight into the neural substrates of behavioural plasticity in C. elegans. (bl.uk)
The neural circuit for touch sensitivity in Caenorhabditis elegans . (nature.com)

The past few years have seen the completion of two major long-term projects that provide new insights into C. elegans development and lay important groundwork for future investigation: completion of the cell lineages of both sexes, from zygote to adult, and description of the complete anatomy at the level of electron microscope resolution, providing a complete "wiring diagram" of cell contacts in the animal. (cshlpress.com)
Nematodes exposed to Piperazine and one of the analogs tested showed a slight delay in development compared to untreated animals but only at high concentrations and with Piperazine as the most sensitive compound. (nih.gov)
From these analyses models of drug resistance development in parasitic nematodes are being developed. (mcgill.ca)

Nematodes can respond to both dissolved chemicals and volatile gasses. (wormatlas.org)

The model presented is based closely on the body mechanics, behavioral analyses, neuroanatomy and neurophysiology of C. elegans, each imposing constraints rel(cid:173) evant for information processing. (nips.cc)

Chronis, N., Zimmer, M. & Bargmann, C.I. Microfluidics for in vivo imaging of neuronal and behavioral activity in Caenorhabditis elegans . (nature.com)

For some parasitic nematodes, native extracts enriched for specific proteins are highly protective. (gla.ac.uk)
The endoribonuclease PUCH, a trimer of Schlafen-like-domain proteins, initiates piRNA processing in the nematode Caenorhabditis elegans through 5′-end piRNA precursor cleavage. (nature.com)

Grazing ruminants are continuously exposed to nematode infection which, if uncontrolled, would restrict agricultural production. (europa.eu)

In this study, the adaptive behavioural response of the nematode C. elegans to food is used to investigate the fundamental mechanisms underlying feeding behaviour. (bl.uk)
We employed Caenorhabditis elegans as a model to study the effectiveness of sanitizers in killing pathogenic Escherichia coli strains ingested by free-living nematodes. (korea.ac.kr)

As a comparison to spaceflight-induced muscle atrophy, we assessed the effects of acute nutritional deprivation and muscle disuse on C. elegans muscle cells. (lancs.ac.uk)
Bargmann, C.I. & Avery, L. Laser killing of cells in Caenorhabditis elegans . (nature.com)

We found that space microgravity induces muscle atrophy in C. elegans from two independent spaceflight missions. (lancs.ac.uk)
We found that these two factors also induce muscle atrophy in the nematode. (lancs.ac.uk)

We train recurrent networks to control chemotaxis in a computer model of the nematode C. elegans. (nips.cc)

Our studies support the idea that C. elegans NHRs may be regulated by environmental cues. (bvsalud.org)

Taken together, our results indicate that pathogenic E. coli ingested by C. elegans may be protected against washing treatment with commercial sanitizers on raw food materials. (korea.ac.kr)

We focussed on Haemonchus contortus aminopeptidase H11 glycoprotein, which is enriched in a gut membrane fraction capable of inducing significant protection against this important ovine gastrointestinal nematode. (gla.ac.uk)
Thermosensitivity is an important aspect of the life cycle for Strongyloides stercoralis parasitic nematodes. (wormatlas.org)

Reverse engineering C. elegans will provide a Rosetta-stone-like translation between the language of annotated connectomes and functional properties," say Halpern and colleagues. (discovermagazine.com)

Anatomy19

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Psychiatry and Psychology5

Phenomena and Processes81

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Neurons13

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