• In 1965 Sydney Brenner chose the free-living nematode Caenorhabditis elegans as a promising model system for a concerted genetic, ultrastructural, and behavioral attack on the development and function of a simple nervous system. (cshlpress.com)
  • Defining a behavior that requires the function of specific neurons in the free-living nematode Caenorhabditis elegans can allow one to screen for mutations that disrupt the specification or function of those neurons. (jneurosci.org)
  • We have exploited the free-living nematode Caenorhabditis elegans to examine its suitability as an alternative system for recombinant expression of parasitic nematode vaccine candidates. (gla.ac.uk)
  • A powerful tool in this process may be the free living nematode Caenorhabditis elegans. (europa.eu)
  • With the problem of parasitic nematode drug resistance increasing, vaccine development offers an alternative sustainable control approach. (gla.ac.uk)
  • To try to overcome some of these limitations in this study, we have used Caenorhabditis elegans (nematode) and Danio rerio embryos (zebrafish) as alternative assays for DART hazard assessment of some candidate chemicals being considered for a new commercial application. (nih.gov)
  • Using experimental evolution in the highly polymorphic nematode Caenorhabditis remanei, I show that nematode resistance to the two modes of pathogenesis in P. aeruginosa evolves through genetically independent pathways. (uoregon.edu)
  • The soil nematode Caenorhabditis elegans has served as a useful model to study the mechanism of action of avermectins. (nih.gov)
  • I had an experiment which Francis dissuaded me from doing, which was to see if nematode genes would work in bacteria. (webofstories.com)
  • The evolutionary pathway that has led to male tails of diverse morphology among species of the nematode family Rhabditidae was reconstructed. (nyu.edu)
  • This family includes the well-studied model species Caenorhabditis elegans. (nyu.edu)
  • Is the uploaded nematode a new species? (interconnected.org)
  • Thus, Piperazine seemed the most toxic compound for both nematodes and zebrafish. (nih.gov)
  • The results of the nematode and zebrafish studies were in alignment with data obtained from conventional mammalian toxicity studies indicating that these have potential as developmental toxicity screening systems. (nih.gov)
  • Thermosensitivity is an important aspect of the life cycle for Strongyloides stercoralis parasitic nematodes. (wormatlas.org)
  • A promising indicator of neurobehavioral toxicity using the nematode Caenorhabditis elegans and computer tracking. (cdc.gov)
  • Here, we show that the behavioral response of Caenorhabditis elegans to bacterially produced medium-chain alcohols switches from attraction to avoidance when presented in the background of a subset of additional attractive chemicals. (plos.org)
  • Here, we report novel persistent behavioral responses caused by electric stimuli in the nematode Caenorhabditis elegans. (northeastern.edu)
  • The most common of these nematodes are the cattle parasite Ostertagia ostertagi and the sheep parasites Haemonchus contortus an d Teladorsagia circumcincta. (europa.eu)
  • We are also interested in drug resistance in important nematode parasites of livestock, where resistance already poses a substantial economic challenge. (mcgill.ca)
  • The avermectins are a family of macrocyclic lactones used in the control of nematode and arthropod parasites. (nih.gov)
  • Previous studies in nematodes suggest that the pathogenic effects of P. aeruginosa can result from multiple distinct pathways: a toxin-based effect that kills within a few hours and a generalized virulence that kills over the course of multiple days. (uoregon.edu)
  • We employed Caenorhabditis elegans as a model to study the effectiveness of sanitizers in killing pathogenic Escherichia coli strains ingested by free-living nematodes. (korea.ac.kr)
  • Adult worms that had fed on six pathogenic E. coli strains (highly persistent in the nematode intestine) were treated with three chemical solutions. (korea.ac.kr)
  • And without him it is inconceivable that the nematode, Caenorhabditis elegans, Would have become a major contributor to our understanding of cellular and developmental biology, and exceedingly unlikely that the pufferfish, Fugu rubripes, would have been one of the first vertebrates to have a draft genome sequence, which is likely to shed great light on the evolution of the human genome. (the-scientist.com)
  • Although these studies are still at an early stage, these results strongly suggest that parallel studies of developmental mutants in C. elegans and of morphological and developmental evolution among related nematodes will help define genetic changes underlying the evolution of form. (nyu.edu)
  • if I could get a mutant of Bacillus subtilis , and I could make it so it wouldn't revert itself, which is make double mutants, then I could take nematode DNA and see if I could restore the gene to Bacillus subtilis . (webofstories.com)
  • Fitch, DHA 1997, ' Evolution of male tail development in rhabditid nematodes related to Caenorhabditis elegans ', Systematic Biology , vol. 46, no. 1, pp. 145-179. (nyu.edu)
  • However, biochemical analysis of the fractions have shown that they contain multiple members of nematode protein families, such as metallopeptidases, cysteine proteinases and activation associated secreted proteins. (europa.eu)
  • In a second step we will apply this technology to investigate the function of an additional nematode specific gene family, i.e. transthyretin-like protein family. (europa.eu)
  • Nematodes exposed to Piperazine and one of the analogs tested showed a slight delay in development compared to untreated animals but only at high concentrations and with Piperazine as the most sensitive compound. (nih.gov)
  • From these analyses models of drug resistance development in parasitic nematodes are being developed. (mcgill.ca)
  • For some parasitic nematodes, native extracts enriched for specific proteins are highly protective. (gla.ac.uk)
  • The endoribonuclease PUCH, a trimer of Schlafen-like-domain proteins, initiates piRNA processing in the nematode Caenorhabditis elegans through 5′-end piRNA precursor cleavage. (nature.com)
  • Grazing ruminants are continuously exposed to nematode infection which, if uncontrolled, would restrict agricultural production. (europa.eu)
  • In this study, the adaptive behavioural response of the nematode C. elegans to food is used to investigate the fundamental mechanisms underlying feeding behaviour. (bl.uk)
  • Nematodes can respond to both dissolved chemicals and volatile gasses. (wormatlas.org)
  • We train recurrent networks to control chemotaxis in a computer model of the nematode C. elegans. (nips.cc)
  • We found that these two factors also induce muscle atrophy in the nematode. (lancs.ac.uk)
  • We focussed on Haemonchus contortus aminopeptidase H11 glycoprotein, which is enriched in a gut membrane fraction capable of inducing significant protection against this important ovine gastrointestinal nematode. (gla.ac.uk)
  • The National Human Genome Research Institute (NHGRI) has supported a number of sequencing projects aimed at producing draft assemblies of roundworm (Caenorhabditis) genomes. (genome.gov)