• One of the five, nelfinavir, was selected for further testing because it appeared to work better than the others on HER2-positive cells and, says Liu, seemed to interfere with the protein HER2 itself. (newswise.com)
  • Through RNA sequencing, we determined that nelfinavir and bortezomib tip the balance of ER protein homeostasis of the already ER-stressed TSC2-deficient cells in favor of cell death. (cf.ac.uk)
  • Methods: Intestinal epithelial cell lines HT-29/B6, T84, LS 174T and Caco-2 were incubated with saquinavir and nelfinavir. (fu-berlin.de)
  • Results: In all tested cell lines apoptotic rate increased significantly after incubation with 30 - 90 µM saquinavir and 35 - 140 µM nelfinavir. (fu-berlin.de)
  • Through RNA sequencing, we determined that nelfinavir and bortezomib tip the balance of ER protein homeostasis of the already ER-stressed TSC2-deficient cells in favor of cell death. (cf.ac.uk)
  • Methods: Intestinal epithelial cell lines HT-29/B6, T84, LS 174T and Caco-2 were incubated with saquinavir and nelfinavir. (fu-berlin.de)
  • Results: In all tested cell lines apoptotic rate increased significantly after incubation with 30 - 90 µM saquinavir and 35 - 140 µM nelfinavir. (fu-berlin.de)
  • In order to determine the effects of Nelfinavir on HER2-positive breast cancer, Joong Sup Shim, Ph.D., of the Department of Pharmacology and Molecular Sciences at Johns Hopkins School of Medicine and colleagues screened the Johns Hopkins Drug Library and identified a number of inhibitors of breast cancer cells, a subset of which was then used to pharmacologically profile seven genotypically individual breast cancer cell lines. (eurekalert.org)
  • NELFINAVIR (nel FIN a veer) is an antiretroviral medicine. (planetdrugsdirect.com)