Loading...
  • NTDs
  • One of these is neglected tropical diseases (NTDs). (project-syndicate.org)
  • The collective UHC agenda cannot be delivered without addressing the diagnostic and treatment technology gaps that hinder the effective treatment of patients, and are required to tackle the rising threat of drug resistance and for the sustainable elimination of infectious diseases, including hepatitis and NTDs. (who.int)
  • Infecting more than 1 billion people globally, the 7 major Neglected Tropical Diseases (NTDs) cause blindness, disfigurement, anemia and cognitive impairment, and yet can be controlled or even eliminated by taking pills once or twice a year. (worldbank.org)
  • NTDs are not simply neglected in terms of awareness and resource allocation but also in the sense that they affect some of the most neglected communities on the planet - those at the end of the road, those for whom fresh water and hygiene are challenging and those whose access to the health care is limited. (worldbank.org)
  • Last month, I joined a panel in Washington D.C. to discuss the launch of a new report, The Economic Case for Neglected Tropical Disease Control and Elimination from the Hudson Institute and the Global Network for NTDs. (worldbank.org)
  • Neglected tropical diseases ( NTDs ) are a diverse group of tropical infections which are especially common in low-income populations in developing regions of Africa , Asia , and the Americas . (wikipedia.org)
  • Twenty neglected tropical diseases are prioritized by the World Health Organization (WHO), though other organizations define NTDs differently. (wikipedia.org)
  • human African trypano
  • Human African Trypanosomiasis (HAT) is classified among the 17 neglected tropical diseases endemic in central Africa, with many of its cases being reported in the Democratic Republic of Congo. (hiiraan.com)
  • Of these 20, two were targeted for eradication ( dracunculiasis (guinea-worm disease) by 2015 and yaws by 2020), and four for elimination ( blinding trachoma , human African trypanosomiasis , leprosy and lymphatic filariasis by 2020). (wikipedia.org)
  • DNDi
  • Basel, Switzerland - 7 September After having built the world's largest drug development pipeline for the most neglected diseases, the Drugs for Neglected Diseases initiative (DNDi) has unveiled plans for a more flexible, dynamic portfolio approach, integrating various operating models to better respond to the needs of patients, notably in low- and middle-income countries. (eurekalert.org)
  • DNDi will remain focused on reaching our treatment targets for the most neglected diseases, but we are now in a position to apply new R&D models, where patient needs drive drug development over profits, and where prices of drugs are delinked from the cost of their development,' he added. (eurekalert.org)
  • DNDi will continue developing its pipeline of over 30 projects for the most neglected diseases. (eurekalert.org)
  • As the organization matures, DNDi will continue to learn, innovate, and adapt its operational models to guarantee that R&D capacity is built where needed while continuously identifying and addressing neglected patients' needs through the best science. (eurekalert.org)
  • vaccines
  • Drug companies and nonprofit organizations are joining forces to develop new drugs and vaccines to target so-called "neglected" diseases that claim millions of lives in the developing world each year. (redorbit.com)
  • A third of new drugs (six out of 18) and two thirds of new vaccines (six of 10) for neglected diseases registered since 2000 have had Indian involvement. (bmj.com)
  • Dr. Maria-Elena Bottazzi , Deputy Director of Texas Children's Hospital Center for Vaccine Development, said, "The scientific knowledge exchange from this partnership will catalyze and accelerate the product development of much-needed vaccines against the diseases of poverty. (medindia.net)
  • In 2011, Baylor launched the National School of Tropical Medicine, which together with Texas Children's Hospital Center for Vaccine Development is leading an innovative product development partnership model for the research & development of new vaccines to combat the world's neglected tropical diseases. (medindia.net)
  • tackle
  • Hotez and colleagues argue that integrating efforts to tackle these diseases and the big three makes even more sense since they often overlap geographically. (scidev.net)
  • They add that donor agencies and major partnerships working to tackle the big three should expand their activities to incorporate efforts to tackle neglected diseases. (scidev.net)
  • Dr Richard Seabrook, Head of Business Development at the Wellcome Trust, said: "We are pleased to be co-funding with the Bill & Melinda Gates Foundation on this exciting UK project, bringing together internationally renowned experts in the biology of infectious diseases with a first-class drug discovery unit to tackle some of the world's most profound medical needs. (healthcanal.com)
  • Indispensable requirement to tackle the issue of neglected diseases, however, is a concerted commitment of all stakeholders on national and international levels. (brillonline.com)
  • endemic
  • Eradicating the disease, according to WHO, would result into a 29 percent jump in economic returns for the agricultural sector of countries where it is no longer endemic. (nextbillion.net)
  • For-profit companies see little economic justification to invest in treating diseases that affect the poor, but "creative capitalism," as Gates put it, could lure companies into solving some of the world's most pressing problems by bringing to market new treatments for endemic tropical diseases. (bmj.com)
  • Dr Ahmed Hassa Fahal of the Mycetoma research centre in Khartoum said that it was time that Africans invested in research in order to be able to treat the diseases endemic to the continent rather than wait for help from the west. (hiiraan.com)
  • Neglected diseases are especially endemic in low-income populations in developing regions of Africa, Asia, and the Americas. (blogspot.com)
  • Lancet Infectious Diseases
  • He published several papers in international journals, and in different areas, such as the Review of Economics Dynamics, Theory and Decision, Economics Letters, Theoretical Computer Science, The Lancet Infectious Diseases, Drug Discovery Today, Trends in Pharmacological Sciences. (unu.edu)
  • researchers
  • Examining recent progress toward fighting these diseases, researchers from the Drugs for Neglected Diseases initiative, Doctors Without Borders and other medical groups found only a handful of clinical trials underway or in development. (voanews.com)
  • But other researchers of this disease are conflicted about the study's method, fearing there is no way to be sure that all of the tiny parasites have been evicted from the hosts when the trial ends. (nytimes.com)
  • Our members and researchers around the world applaud this unprecedented level of international cooperation to improve the lives of the 1.4 billion people around the world who are disabled, blinded and suffer needlessly from neglected tropical diseases," according to the statement by the American Society of Tropical Medicine and Hygiene. (newsmax.com)
  • pharmaceutical
  • As most patients with such diseases live in developing countries and are too poor to pay for drugs, the pharmaceutical industry has traditionally ignored these diseases. (bmj.com)
  • Yet some infectious diseases-the world's "most neglected" diseases-are still being ignored not just by the pharmaceutical industry but also by public-private partnerships. (bmj.com)
  • C&EN Senior Editor Lisa Jarvis explains that just a decade ago major pharmaceutical companies had largely abandoned developing treatments for these neglected diseases. (redorbit.com)
  • For those diseases where there are no or poor interventions available, the pharmaceutical and medical technology industries have chosen not to develop new and better interventions because there is no money to pay for them - no profit. (edu.au)
  • Indeed, the actual cost of NTD programs is close to zero for most diseases, due largely to drug donations from the pharmaceutical industry. (worldbank.org)
  • This article provides an introduction to the problem of pharmaceutical research and development of medicinal products for neglected diseases in developing countries. (brillonline.com)
  • There a few things that infuriate me about the pharmaceutical industry: the obscene returns on investment it gets, how it games the patent system, and how it neglects some important infectious diseases. (blogspot.com)
  • It was run in conjunction with the creation of G-FINDER, arguably the most comprehensive database on neglected disease R&D. The way I like introducing this topic to those unfamiliar with it is by contrasting big pharmaceutical firms traditionally spending massive sums on often cosmetic wants in the West--think of your Viagra and Botox. (blogspot.com)
  • While I remain convinced that it is more likely that firms in the developing world will provide their own affordable solutions to neglected diseases than a wholesale change in attitude by Western pharmaceutical giants, these results may yet prove me wrong. (blogspot.com)
  • kinetoplastid diseases
  • Funders may also look at the state of existing therapies, preferring to focus on areas where no safe effective treatments exist (for example, some kinetoplastid diseases) to areas where treatments exist even though they may be limited or sub-optimal (for example, some helminth infections). (blogspot.com)
  • populations
  • 6 7 Neglected diseases predominantly affect poor and marginalised populations and do not constitute a market that is attractive enough to stimulate private sector investment. (bmj.com)
  • A key measure of UHC will therefore be the extent to which it provides quality health care to the most vulnerable: the poor, children, those with neglected or stigmatized diseases, other neglected populations. (who.int)
  • treat
  • Many people thought: Why should I be concerned about this disease which is not common, which is difficult to diagnose, and difficult to treat? (medicalxpress.com)
  • Increased international attention to the lack of health tools to prevent or treat diseases affecting impoverished regions has raised the discussion on how to encourage sustainable innovation in this area with little or no market. (brillonline.com)
  • infections
  • While there is much achieved including in increasing access to healthcare, there is need to do more to eradicate the neglected diseases-- a group of tropical infections-- that plague the continent. (hiiraan.com)
  • Other candidates being developed alone include a Phase II topical product for skin and nail infections, anti-inflammatories in Phase I and II development for psoriasis and atopic dermatitis, and compounds in early clinical studies for periodontal disease and acne. (genengnews.com)
  • while dengue had a disease burden 20 times lower than helminth infections at 600,000 DALYs in 2004 but received nearly twice as much funding. (blogspot.com)
  • eradicate
  • The foundation, named after Microsoft co-founder Bill Gates and his wife, has already invested more than $100 million in the effort to eradicate the disease. (newsmax.com)
  • Gates Foundation has joined 13 drug firms in pledging $363 million to eradicate 10 tropical diseases that strike millions around the world. (newsmax.com)
  • deadly
  • Our aim is to collaborate with partners in Dundee and beyond to identify lead compounds, potential drug targets and novel tools and approaches to develop improved treatments for a wide range of debilitating and deadly diseases. (healthcanal.com)
  • drug
  • Infectious diseases can be considered "neglected" when there is a lack of effective, affordable, or easy to use drug treatments. (bmj.com)
  • Nearly 12% of drug, diagnostic, and vaccine candidates for neglected diseases in the R&D pipeline are from India. (bmj.com)
  • At the 2008 World Economic Forum in Davos, Gates highlighted a new US Food and Drug Administration (FDA) law that rewards sponsors of drugs for tropical diseases with a voucher that entitles the bearer to a "priority review" of another new drug application. (bmj.com)
  • However, despite significant efforts in early stage drug discovery, there is a bottleneck when it comes to the lead optimisation stage of molecules targeting these diseases. (healthcanal.com)
  • Professor Wyatt said, "One of the main aims of the Drug Discovery Unit is to make inroads into developing drugs for diseases that affected the developing world. (healthcanal.com)
  • The long treatment regimen contributes to high treatment default rates that can lead to increased disease transmission, drug resistance, and death. (healthcanal.com)
  • The Drug Discovery Unit (DDU) is the only fully operational, fully integrated drug discovery group working across multiple diseases based within a UK university. (healthcanal.com)
  • Priority Review Vouchers (PRVs) are awarded in the US to companies that gain approval there for a new drug for one of sixteen tropical diseases, under a law passed in 2007. (ohe.org)
  • The Vouchers are transferable, i.e., not limited to use by the company that gained approval of the neglected-disease drug. (ohe.org)
  • Anacor Pharmaceuticals is reporting separate deals with the Global Alliance for TB Drug Development and Drugs for Neglected Diseases initiative (DND i ) that leverage its boron platform. (genengnews.com)
  • Frank Müller-Langer studies how the discovery and provision of drug preventing and treating currently neglected infectious diseases could be improved. (blogspot.com)
  • collaboration
  • The collaboration includes training and exchange of technical know-how in process development and formulation, filling knowledge gaps that exist from research and development to manufacturing, with a focus on neglected and emerging diseases. (medindia.net)
  • This collaboration, together with Merck's recently announced public-private partnership with the Australian Institute of Tropical Health and Medicine (James Cook University, Queensland ), the Australian Government's investment promotion agency, and Baylor College of Medicine , furthers both parties' commitment to advancing research in neglected diseases globally. (medindia.net)
  • We are pleased to have leading experts in the field share the latest approaches to collaboration against neglected diseases: Dr. Christopher Cooper of TB Alliance, and Dr. Matt Segall of Optibrium. (collaborativedrug.com)
  • The terms of the arrangement give DND i a nonexclusive, royalty-free license for any boron-based compound identified through the collaboration for neglected diseases for developing countries. (genengnews.com)
  • suffer
  • Many of the people who suffer from these diseases are not financially stable and as such cannot on their own afford these kinds of treatment. (hiiraan.com)
  • trachoma
  • India has successfully eliminated certain infectious diseases-such as guinea worm, trachoma, and yaws-in recent years. (bmj.com)
  • In fact, diseases such as river blindness, elephantiasis, trachoma, bilharzia, and various types of worms are so closely linked with poverty that they can be used as effective indicators to gauge the success of health systems in terms of equity. (worldbank.org)
  • Innovation
  • After the Medicines Patent Pool for HIV launched by UNITAID and the Pool for Open Innovation for Neglected Tropical Diseases launched by GSK, "WIPO Re:Search represents an additional move towards more open mechanisms", the organisation says. (pharmatimes.com)
  • Can India lead the way in neglected diseases innovation? (bmj.com)
  • With a promising scientific base built on the foundation of an expanding science and technology workforce, 1 the country is well placed to make a substantial contribution to innovation in neglected tropical diseases. (bmj.com)
  • In line with the commission's findings, the resolution acknowledges that although intellectual property rights provide an incentive for innovation, this is not enough to encourage companies to develop products to fight diseases that primarily affect the poor in developing countries. (scidev.net)
  • burden
  • They conclude, 'Despite substantial political attention towards the burden of neglected diseases, we detected no evidence of a substantial improvement in research and development activity compared with previous decades. (voanews.com)
  • Accidental envenoming by snakes and scorpions, fluorosis, hypothyroidism, and organo phosphate poisoning represent a large proportion of the disease burden in rural states such as Maharashtra, Andhra Pradesh, Tamil Nadu, and Puducherry," says his letter. (fluoridealert.org)
  • He points out that the burden of thyroid disease in India in the post-iodisation phase is about 42 million. (fluoridealert.org)
  • The first is that research funding is highly concentrated and has little correlation with burden of disease, as measured by DALYs [disability-adjusted life years]. (blogspot.com)
  • DALYs are the most widely accepted quantitative indicator of burden of disease, but remain an imperfect measure. (blogspot.com)
  • Funders may also want to focus on diseases with a higher relative or absolute mortality, such as dengue or meningitis, rather than diseases with lower relative mortality but a higher DALY burden. (blogspot.com)
  • Thus, far more investment would be needed to develop a meningitis vaccine than a TB diagnostic, irrespective of the lower burden of disease for meningitis or a more advanced state of meningitis vaccine technology. (blogspot.com)
  • research and develop
  • India is one of the top global funders of research and development (R&D) into neglected diseases. (bmj.com)
  • The resolution follows a proposal made in January by Brazil and Kenya to create a new global framework for essential health research and development (see Brazil and Kenya push for neglected-disease research ). (scidev.net)
  • The Gates Foundation commissioned this study with the self-explanatory title of "Neglected Disease Research and Development: How Much Are We Really Spending? (blogspot.com)
  • affect
  • In PLoS Medicine today (31 January), they say that 'neglected diseases' - which affect millions of people in developing countries but get little attention from funding bodies and scientists - often make the big three more lethal. (scidev.net)
  • The World Health Organization last week (27 May) agreed to begin work on a strategy to support "needs-driven" research on diseases that particularly affect developing countries. (scidev.net)
  • Within developed countries , neglected tropical diseases affect the very poorest in society. (wikipedia.org)
  • people
  • There is also growing evidence that people with such diseases have a higher risk of becoming infected with one of the big three. (scidev.net)
  • It is our hope that his entreaties will mobilize greater support for efforts to address a major plight affecting marginalized people: neglected tropical diseases. (project-syndicate.org)
  • These diseases are common in 149 countries, affecting more than 1.4 billion people (including more than 500 million children) and costing developing economies billions of dollars every year. (wikipedia.org)