Negatively regulate protein micro rna that regulates. Medical search. Frequent questions

However, there are few reports on the microRNA (miRNA/miR) regulation of NEK6. (hindawi.com)
Small noncoding RNAs called microRNAs (miRNA) negatively regulate gene expression by sequence-specific targeting of protein-coding transcripts [ 6 ]. (researchsquare.com)
Binding of a miRNA to a complementary sequence in a target mRNA is mediated by Argonaute proteins leading to degradation of the mRNA or translational inhibition, thereby lowering protein levels in cells [ 7 ]. (researchsquare.com)
As highlighted above, MiRNA-134 is a brain-specific microRNA which is expressed in neuronal dendrites. (2011globalhealth.org)
Furthermore, it was shown that inhibition of miRNA-134 with antisense oligonucleotide restores CREB and BDNF levels, two proteins involved in synaptic plasticity, and rescues the impairment of long-term potentiation and plasticity observed in Z-WEHD-FMK a knockout mice model [37]. (2011globalhealth.org)
It was also shown that the brain-enriched miRNA-138, which is located in the dendritic compartment on rat hippocampal neurons, negatively regulates the size of dendritic spines. (2011globalhealth.org)
Indeed, miRNA-138 targets the expression of acyl protein thioesterase 1 (APT1), an enzyme known to depalmitoylate a number of substrates implicated in synaptic plasticity, including the G13 subunits of G proteins [101]. (2011globalhealth.org)
Thanks to genetic approaches performed in Drosophila, other studies have provided direct evidence that miRNA pathways regulate learning and memory. (2011globalhealth.org)
A genetic screen identified four microRNAs, miRNA-9c, miRNA-31a, miRNA-974, mirNA-305 that reduced olfactory learning and memory formation and one microRNA, MiRNA-980 that, when inhibited, enhances memory formation [104]. (2011globalhealth.org)
Interestingly, it was shown that miRNA-205, which is highly expressed in wild Rabbit Polyclonal to NCAPG type mouse midbrain DN, directly inhibits the expression of LRRK2 protein. (2011globalhealth.org)
The nature of imperfect binding specificity means that a single miRNA can regulate a large number of mRNA targets involved in complex cellular processes, thereby tightly controlling genetic networks during development and in response to stress ( Pocock, 2011 ). (elifesciences.org)
Non-coding RNA (ncRNA) such as microRNA (miRNA) and long non-coding RNA (lncRNA) regulates the translation and/or stability of multiple mRNA targets either directly or by modulation of signal transduction pathways. (frontiersin.org)
Oncogenic miRNA and breast cancer Since the early 2000's, the field of RNA has been contributing to major discoveries in cancer research. (atlasofscience.org)
McroRNAs are small RNA molecules (miRNA), inhibit the messenger RNAs that produce our proteins. (atlasofscience.org)
The mature miRNAs are loaded onto ARGONAUTE (AGO) proteins, forming a miRNA-induced gene silencing complex (miRISC). (biomedcentral.com)
miRNAs are a class of small non-coding RNAs transcribed from miRNA genes ( MIRs ). (biomedcentral.com)
The binding of miRNA- protein complexes to mRNA causes translation inhibition or destabilisation of target transcripts. (ukessays.com)
Based on our identified miRNA-regulated network, we discovered three drugsBX-912, daunorubicin, and midostaurinthat can be repositioned to treat lung cancer, which was not known before. (cdc.gov)
Based on our identified miRNA-regulated molecular machinery, an inhibitor of PDK1/Akt BX-912, an anthracycline antibiotic daunorubicin, and a multi-targeted protein kinase inhibitor midostaurin were discovered as potential repositioning drugs for treating lung cancer. (cdc.gov)

miRNAs expressed in a wide variety of human cancers can regulate posttranscriptional gene expression by binding to the 3′ untranslated region of the target mRNAs and act as oncogenes or tumor suppressors to regulate cell signaling pathways, affecting tumorigenesis and tumor progression [ 17 ]. (hindawi.com)
We aimed to determine the signaling pathway regulating cell metabolism and the mechanism related to the regulation of human tumor-associated macrophages (TAMs) in gastric cancer (GC). (cancerindex.org)
Tumor-infiltrated macrophages were isolated from human GC tissues using magnetic beads, gene transcription was determined by real-time PCR, protein expression was monitored using western blots, metabolites were determined using HPLC, and transcriptional regulation was analyzed by the luciferase-based reporter gene system. (cancerindex.org)
It has been proven that the miR-183 expression is up-regulated in tumor tissues and patient serum in BC, which indicates its possibly an oncogenic role 15 , 16 . (nature.com)
Abnormal expression of 5-Lipoxygenase Activating Protein (FLAP) has been detected in many tumor cells. (biomedcentral.com)
Based on the findings, the inhibition of miR-543 was found to play a tumor suppressive role in PA through the down-regulation of Wnt/β-catenin pathway by negatively regulating Smad7. (cancerindex.org)
[ 1 ] His prediction was subsequently supported by the cloning of the retinoblastoma tumor suppressor gene ( RB1 ) and by functional studies of the retinoblastoma protein, Rb. (medscape.com)
Like Rb protein, many of the proteins encoded by tumor suppressor genes act at specific points in the cell cycle. (medscape.com)

microRNAs act by lowering the expression of genes by binding to target sites in the 3' UTR of the mRNAs. (wikipedia.org)
BMP2 controls bone cell determination by inducing miRNAs that target muscle genes but mainly by down-regulating multiple miRNAs that constitute an osteogenic program, thereby releasing from inhibition pathway components required for cell lineage commitment establish a mechanism for BMP morphogens to selectively induce a tissue-specific phenotype and suppress alternative lineages. (wikipedia.org)
Enrichment analysis illustrated that most defense-related genes were down-regulated in the dark and the shade, and up-regulated under hard light and normal light. (bvsalud.org)
Under hard light, some defense genes in infected soybean were down-regulated to reduce the degree of oxidative damage. (bvsalud.org)
functional" genes encoding proteins such as late embryogenesis-associated proteins, detoxification enzymes, heat shock proteins and molecular chaperones, which directly protect plants from abiotic stress, and "regulatory" genes encoding proteins such as protein kinases and transcription factors (TFs), which have roles in the perception and transduction of stress signals. (biomedcentral.com)
The central dogma of molecular biology stated that genes encode for proteins and that DNA, which makes up our genomes, mainly produces RNAs which are translated into proteins. (atlasofscience.org)
To date, 1527 human miRNAs have been identified (Sanger miRBase 18 http://www.miRbase.org/index.shtml), forming less than 1% of all human genes, potentially regulating more than 10% of all protein coding genes [ 1 ]. (intechopen.com)
In participating UK research institutions, investigators can publish open access in Genome Research, Genes & Development, RNA, and Learning & Memory without article publication charges and all staff can read the entire renowned Cold Spring Harbor journal collection. (cshlpress.com)
80% test accuracy) while using two novel predicted protein coding genes (Gm5067, Gm6089) as features. (fortuneonline.org)
1) The alternation of protein levels of critical oncogenes or tumour suppressor genes, which causes by miRNAs deregulation may also lead to proliferative diseases such as cancer. (ukessays.com)
In most cases, circRNAs usually act as a competitive endogenous RNA (ceRNA) that can absorb miRNAs to regulate the expression of targeted genes [ 9 ]. (hindawi.com)
Experimentally confirmed target genes were identified for the 73 diagnostic miRNAs, from which proliferation genes were selected from CRISPR-Cas9/RNA interference (RNAi) screening assays. (cdc.gov)
Pansensitive and panresistant genes to 21 NCCN-recommended drugs with concordant mRNA and protein expression were identified. (cdc.gov)

MicroRNAs regulate target gene expression post-transcriptionally in a myriad of cell types and play critical roles in diverse physiological and pathological processes, including cardiomyocyte development, differentiation, and regeneration. (biomedcentral.com)
MicroRNAs (miRNAs) are small noncoding RNAs (~22 nucleotides in length) that regulate gene expression post-transcriptionally by imperfect binding to the 3′ untranslated region of target mRNAs in a wide variety of cell types. (biomedcentral.com)
MicroRNAs (miRNAs) negatively regulate gene expression post-transcriptionally by binding to the 3'-untranslated region (3'-UTR) of the target mRNA sequences and have been shown to be involved in various types of cancers. (biomedcentral.com)

These findings indicate that miR-323a-3p regulates the proliferation, migration, invasion, and apoptosis of COAD cells by targeting NEK6. (hindawi.com)
Rap 1 is a member of a group of proteins involved in the regulation of cell proliferation and differentiation. (medscape.com)
MicroRNAs control the levels of numerous cell cycle regulators that controls cell proliferation. (ukessays.com)

Studies in the past decade have demonstrated the essential roles of several AJC protein, including underlying actinomyosin components, actin isoforms, and intracellular signal transducer and activator of transcription (STAT) transcription factors, and nuclear factor-κB (NF-κB) in the maintenance and remission of IBD progression ( 5 ). (frontiersin.org)
Abnormal expression of ribosomal proteins has an important regulatory effect on the progression of cancer. (biomedcentral.com)
These findings suggest that RPL5 plays an important role in regulating COAD progression and may serve as a prognostic biomarker for COAD. (biomedcentral.com)
Regarding the important role of microRNAs in breast cancer, investigating the molecular mechanisms of miRs and their impacts on breast cancer progression is critical. (nature.com)
Previous studies have demonstrated that microRNAs (miRs) serve important roles in the progression of human cancer types, including pancreatic cancer (PC), a highly lethal malignancy. (spandidos-publications.com)
T he presence and activity of various proteins are required in the cell cycle progression. (ukessays.com)
Circular RNAs (circRNAs) are a form of noncoding and closed loop RNA molecules and play vital roles in the progression of various types of cancer in humans. (hindawi.com)
Noncoding RNAs, including circRNAs, microRNAs, and lncRNAs, have become a significant focus of research attention due to their crucial role in regulating the progression of multiple malignancies [ 5 ], including bladder cancer, gastric cancer, nasopharyngeal carcinoma, and pancreatic cancer. (hindawi.com)
The CDK4-cyclinD complex normally phosphorylates the retinoblastoma protein (Rb protein), leading to release of the E2F transcription factor and cell cycle progression. (medscape.com)

BC-related differentially expressed microRNAs (DE-miRs) were recognized and assessed in the present study. (nature.com)
Micro-RNA (miRNAs or miRs) are small noncoding RNAs that negatively regulate protein coding gene transcripts and exert an important role in the control of gene expression. (atlasofscience.org)
MicroRNAs (miRNAs or miRs) are small non-coding RNAs that participate in diverse cellular processes and negatively regulate gene expression at the post-transcriptional level by binding with 3′-untranslated regions (3′-UTRs) ( 2 - 4 ). (spandidos-publications.com)
A number of studies have demonstrated that altered expression of miRs serves critical roles in human cancers by directly regulating cell behaviors ( 5 - 7 ). (spandidos-publications.com)
However, to the best of our knowledge, the miRs that regulate RUNX2 expression in tumors are unknown. (spandidos-publications.com)

Currently, an increasing number of studies have indicated that miRNAs and small noncoding RNA molecules have great potential for the cancer treatment. (hindawi.com)
In many cancers, RAS proteins are constitutively activated by their oncogenic mutations or activation of their upstream molecules. (atlasofscience.org)

What pathways are this gene/protein implicaed in? (cancerindex.org)
In this review, we focus on the impact of ncRNA post-transcriptional regulatory mechanisms, especially those of microRNAs and lncRNAs, in RA signalling pathways during differentiation and disease. (mdpi.com)
In recent years, emerging studies have highlighted the critical role of these pathways and their regulation by microRNAs (miRNAs) in cancer invasion and metastasis. (intechopen.com)
In addition, Ingenuity Pathway Analysis (IPA) integrated with PCR array data showed that the JAK1/STAT3 pathway was significantly altered in cells overexpressing DEFB1, suggesting this to be one of the pathways by which defensin regulates IAV replication in HBEpCs. (cdc.gov)

miRNAs are small, evolutionarily conserved, noncoding RNAs that negatively regulate gene expression and have fundamental roles in cancer growth and metastasis. (biogenex.com)
MicroRNAs (miRNAs) are single-stranded, endogenously expressed, short, noncoding RNAs with a length of 18-25 nucleotides. (nature.com)

Thus, it would be of interest to identify molecular biomarkers which indicate predisposition to the development of HD, and as microRNAs (miRNAs) circulate in bio-fluids they would be particularly useful biomarkers. (fortuneonline.org)

MiRNAs, short (18-24 nucleotides) non-coding RNAs, are derived from long transcripts pri-miRNAs and pre-miRNAs [ 26 - 30 ].By targeting 3' untranslated regions (3'UTRs) of cognate mRNAs, miRNAs post-transcriptionally regulate gene expression and induce translational repression [ 29 , 30 ]. (intechopen.com)

miRNAs regulate proteins expressions by arresting or degrading the mRNAs. (cancerindex.org)

It was shown to negatively regulate the size of dendritic spines of rat hippocampal neurons by inhibiting the expression of Lim-domain-containing protein kinase 1 (LIMK1) which reorganizes the actin cytoskeleton dynamics Z-WEHD-FMK through phosphorylation and thereby inactivation of the actin depolymerizing factor cofilin [100]. (2011globalhealth.org)

Besides -synuclein, the leucine-rich repeat kinase 2 (LRRK2), an enzyme involved in the early development Z-WEHD-FMK of neuronal processes [121], is another key protein involved in the etiology of PD. (2011globalhealth.org)
Peli1 regulates the activation of a metabolic kinase, mTORC1, through its interaction with mTORC1 inhibitory proteins TSC1 and TSC2. (medscape.com)
The first layer of immunity, known as pathogen-associated molecular pattern- (PAMP-) triggered immunity (PTI), is activated following recognition of the fungal pattern molecule chitin, by four lysin motif- (LysM-) containing protein (LYP) receptors, i.e., chitin elicitor binding protein (CEBiP), chitin elicitor receptor kinase (CERK1), LYP4 and LYP6 (Shimizu et al. (biomedcentral.com)

miRNAs are essential for brain development and function, with multiple miRNAs enriched in specific cell types where they regulate differentiation, structure and neurophysiological properties [ 9 , 10 ]. (researchsquare.com)
Hamartin and tuberin are thought to act synergistically to regulate cellular growth and differentiation. (medscape.com)
works in concert with bone morphogenetic protein-2 (BMP-2) to potentiate osteogenic differentiation of bone marrow-derived mesenchymal stem/stromal cells (BMSCs). (omicsdi.org)
can potentiate bone morphogenetic protein-2 (BMP-2)-stimulated osteogenic differentiation and chemotaxis of BMSCs in vitro. (omicsdi.org)

Selective permeability of IECs is achieved by apical junctional complex (AJC) proteins which comprise tight junctions, adherens junctions, and desmosomes to maintain the apicobasal cell polarity and intestinal tissue integrity ( 4 ). (frontiersin.org)
EMT is an embryologically conserved genetic program by which epithelial cells down regulate intercellular tight junctions, loose polarity, express mesenchymal markers, and manifest a migratory phenotype [ 1 ]. (intechopen.com)

The primary barriers for invading respiratory pathogens are the respiratory tract epithelial cells and antimicrobial proteins generated by these cells. (cdc.gov)

The efficacy can be increased by entering the RNA Interference (RNAI) molecule. (mirnaprofile.com)

RhoA expression is negatively regulated by miR-133a in bronchial smooth muscles (BSM)and miR-133a downregulation causes an upregulation of RhoA, resulting in an augmentation of contraction and BSM hyperresponsiveness. (wikipedia.org)
Nicotine activates α7-nAChR and downregulates the levels of miR-133 and miR-590 leading to significant upregulation of expression of TGF-β1 and TGF-βRII at the protein level establishing miR-133 and miR-590 as repressors of TGF-β1 and TGF-βRII. (wikipedia.org)
MicroRNAs perform important roles in the post-transcriptional regulation of gene expression. (researchsquare.com)
Scope includes mutations and abnormal protein expression. (cancerindex.org)
MicroRNA-30c expression was suppressed by hypoxia-inducible factor-1α activation and related to decreased mTOR activity as well as glycolysis in human GC TAMs. (cancerindex.org)
Hypoxia-regulated miR-30c downregulated REDD-1 expression by targeting its 3'UTR. (cancerindex.org)
By employing microRNA expression profiling and functional knockdown studies on human embryonic stem cell-derived cardiomyocytes, the authors identified miR-363 as an upstream negative regulator of left ventricular specification transcription factor HAND1 . (biomedcentral.com)
We also studied the microRNAs that affect NEK2 expression. (oncotarget.com)
More recently, it was shown that miR-980 overexpression impaired olfactory memory in Drosophila by targeting expression of the autism-susceptibility gene, A2bp1, a known RNA binding protein involved in alternative splicing [105]. (2011globalhealth.org)
showed significant upregulation of miR-301a in the heart of diabetic ventricles to regulate expression of voltage-gated potassium channel (Kv4.2) by direct interaction with 3′UTR in the diabetes mouse (db/db) model ( 9 ). (frontiersin.org)
Mechanistic studies revealed that the expression of p-MEK1/2, p-ERK, c-Myc were down-regulated, and the expression of FOXO3 was up-regulated after down-regulation of RPL5, ERK activator (TBHQ) could partially reverse the above-mentioned effects caused by siRPL5. (biomedcentral.com)
More and more studies have found that abnormal expression or mutation of ribosomal proteins has an important regulatory effect on the occurrence and development of cancer [ 5 ]. (biomedcentral.com)
Western blot was utilized to assess the effect of miR-183 on PTEN protein expression. (nature.com)
It was revealed that cellular oncogenicity is positively regulated by miR-183 by inhibiting the expression of PTEN. (nature.com)
After selecting the data sets based on our criteria, quality control, and normalization, each data set of the microRNAs expression profile was analyzed. (nature.com)
We demonstrated that miR-146a expression is overexpressed, while FLAP protein and mRNA are suppressed in hepatocellular carcinoma tissues and HepG2 cells compared to para-carcinoma tissues and HL-7702 cells. (biomedcentral.com)
MicroRNAs (miRNAs), with the length of 18-22 nucleotides, have been shown to downregulate target mRNA expression post-transcriptionally by binding to the 3'-untranslated region (UTR) of the target mRNA sequences [ 9 ]. (biomedcentral.com)
Model based on GA and DNN for prediction of mRNA-Smad7 expression regulated by miRNAs in breast cancer. (cancerindex.org)
Further investigation has identified heat shock protein 70 as a direct target of let-7c and has demonstrated that the expression of HSP70 in fibroblasts is negatively correlated with let-7c levels. (molcells.org)
DEFB1 expression after transfection with two micro RNAs (miRNAs), hsa-miR-186-5p and hsa-miR-340-5p, provided evidence that DEFB1 expression could be modulated by these miRNAs and hsa-miR-186-5p had a higher binding efficiency with DEFB1. (cdc.gov)

Simple Summary: This study identified a set of 73 microRNAs (miRNAs) that can accurately detect lung cancer tumors from normal lung tissues. (cdc.gov)
This study identified a set of 73 microRNAs (miRNAs) that classified lung cancer tumors from normal lung tissues with an overall accuracy of 96.3% in the training patient cohort (n = 109) and 91.7% in unsupervised classification and 92.3% in supervised classification in the validation set (n = 375). (cdc.gov)

Macrophages are essential inflammatory cells which regulate the features of immune reactions within tumors. (cancerindex.org)

control the stability and translation of protein-coding mRNAs. (ukessays.com)

It can also compete with eukaryotic translation initiation factor (eIF)4G and RNA for eIF4A binding and trap eIF4A in an inactive conformation to inhibit translation initiation via its two highly conserved MA3 domains [3] - [6] . (plos.org)

Individual miRNAs are capable of regulating gene networks by interacting with multiple targets or by suppressing transcriptional controllers [ 6 , 8 ]. (researchsquare.com)

Therefore, specific inhibitors targeting proteins of the PI3K/AKT pathway are now being evaluated in clinical trials as a new approach against breast cancer 14 . (nature.com)

The p16INK4A protein is a cell-cycle inhibitor that acts by inhibiting activated cyclin D:CDK4/6 complexes, which play a crucial role in the control of the cell cycle by phosphorylating Rb protein. (medscape.com)

Sequencing as well as functional studies using antisense oligonucleotides, indicate important roles for microRNAs during the development of epilepsy through targeting transcripts involved in neuronal structure, gliosis and inflammation. (researchsquare.com)

targeting heat shock protein 70 in a human neuroblastoma cell line [120]. (2011globalhealth.org)

We selected miR-183 for study among the considerably dys-regulated microRNAs in breast cancer. (nature.com)
The Smad7 protein is negative regulator of the TGF-β signaling pathway, which is upregulated in patients with breast cancer. (cancerindex.org)

In COAD cells, NEK6 was highly expressed, whereas miR-323a-3p was expressed at low levels and negatively regulated NEK6. (hindawi.com)
Appropriate regulation of autophagy is crucial for clearing toxic proteins from cells. (elifesciences.org)
Here, we report that the microRNA miR-1 regulates the autophagy pathway through conserved targeting of the orthologous T re-2/ B ub2/ C DC16 (TBC) Rab GTPase-activating proteins TBC-7 and TBC1D15 in Caenorhabditis elegans and mammalian cells, respectively. (elifesciences.org)
Fusion of autophagosomes with lysosomes results in degradation of their contents and thereby removes toxic proteins and damaged organelles from cells to maintain homeostasis. (elifesciences.org)
Innate immunity in gastrointestinal system includes epithelial cell layers that express tight cell-cell contact, secreted mucous layer which prevent entry of microbes, protective plasma protein, and circulating leukocytes, such as phagocytic macrophages, neutrophils, dendritic cells (DC), natural killer (NK) cells, NK T-cell, and innate lymphoid cells. (frontiersin.org)
miR-301a is initially identified as a novel ncRNA to be upregulated in T-helper cells in response to myelin oligodendrocyte protein antigen in the multiple sclerosis ( 8 ). (frontiersin.org)
The ribosomal protein RPL5 is a component of the ribosome, a large ribonucleoprotein complex responsible for protein synthesis in cells. (biomedcentral.com)
En face co-immunostaining of the mouse aortic arch revealed a low level of PDCD4 in endothelial cells undergoing pulsatile shear stress. (plos.org)
Application of unidirectional pulsatile shear stress to human umbilical vein endothelial cells (HUVECs) decreased PDCD4 protein but not mRNA level. (plos.org)
potentiates bone morphogenetic protein-2-stimulated osteoinduction of genetically engineered bone marrow-derived mesenchymal stem cells in vitro. (omicsdi.org)
In conclusion, the reduction in IAV copy number in DEFB1 overexpressing cells suggests that beta-defensin-1 plays a key role in regulating IAV survival through STAT3 and is a potential target for antiviral drug development. (cdc.gov)

The recent publication by Wagh and colleagues sought to identify the novel miRNAs regulating cardiac-specific transcription factors that determine left versus right ventricular determination [ 1 ]. (biomedcentral.com)

Due to the central role of autophagy in the removal of aggregation-prone proteins, a better understanding of mechanisms controlling autophagy is essential for the identification of novel therapeutic opportunities for multiple disease states. (elifesciences.org)
Understanding the underlying mechanisms of the HTT protein can help to investigate how the neurotoxicity from HD is triggered. (fortuneonline.org)

These findings suggest miR-486-5p negatively regulates NEK2, which is a critical prognostic indicator of HCC patient survival after liver transplantation. (oncotarget.com)

Tuberin shows a small region of homologic identity to the catalytic domain of the Rap 1 guanosine triphosphatase (GTPase) activity protein (Rap 1 GAP). (medscape.com)
MicroRNAs (miRNAs) are a class of small (20-24 nucleotides (nt) long) non-coding RNAs. (biomedcentral.com)

MicroRNA-543 promotes cell invasion and impedes apoptosis in pituitary adenoma via activating the Wnt/β-catenin pathway by negative regulation of Smad7. (cancerindex.org)
1) The regulation of these protein levels is vital for the understanding of the cell cycle control and its dysregulation. (ukessays.com)

Each species often encodes multiple microRNAs with identical or similar mature sequence. (wikipedia.org)
For example, the TP53 gene, located on chromosome 17, encodes a 53-kd nuclear protein that functions as a cell cycle checkpoint. (medscape.com)
This locus, however, also encodes a protein from an alternative reading frame, designated p19ARF. (medscape.com)

Defective autophagy results in accumulation of toxic protein aggregates that detrimentally affect cellular function and organismal survival. (elifesciences.org)
A well characterised example is normal HTT proteins bind and sequester REST (repressor element-1 transcription factor) a negative regulator of BDNF (brain-derived neurotrophic factor) which is a neuron survival factor. (fortuneonline.org)

miR-34a negatively regulates mTORC1 and may also contribute to abnormal corticogenesis in tuberous sclerosis complex (TSC). (medscape.com)

Autophagy is a degradation system that involves sequestration of cytoplasmic proteins and organelles by double-layered membranes that form vesicles called autophagosomes. (elifesciences.org)
Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. (cancerindex.org)

Utilizing microRNAs (miRNAs) as a potential biomarker to differentiate BRCA will allow for specialized treatment regimens and increased clinical care. (biogenex.com)

Toward this objective, ChIP-Seq data of 14 S/MAR binding proteins were analyzed and the binding site coordinates of these proteins were used to prepare a non-redundant S/MAR dataset of human genome. (researchgate.net)
Hypoxia decreases macrophage glycolysis and M1 percentage by targeting microRNA-30c and mTOR in human gastric cancer. (cancerindex.org)
A significant decrease in microRNA (miR)-30c and an increase in regulated in development and DNA damage responses 1 (REDD1) were detected in human GC TAMs, the transcription of miR-30c was negatively correlated with REDD1. (cancerindex.org)
Approximately 30-60 % of the human genome, regulated by miRNAs. (ukessays.com)

Some recent reports have demonstrated that both PTI and ETI can be deliberately regulated by immunity-associated regulators that could reduce or abolish the fitness cost (Deng et al. (biomedcentral.com)

Organisms2

Chemicals and Drugs7

Phenomena and Processes4

Information Science3

MiRNA19

Tumor8

Genes13

Gene expression post-transcriptionally3

Proliferation3

Progression9

MiRs5

Molecules2

Pathways4

Noncoding RNAs2

Biomarkers1

Post-transcriptionally regulate1

MiRNAs regulate1

Phosphorylation1

Kinase3

Differentiation4

Tight junctions2

Epithelial cells1

Interference1

Expression20

Lung Cancer2

Tumors1

MRNAs1

Highly conserved1

Targets1

Inhibitors1

Inhibitor1

Transcripts1

Heat shock prot1

Breast Cancer2

Cells11

Transcription Factors1

Mechanisms2

Prognostic1

Small2

Regulation2

Encodes3

Survival2

MTORC11

Degradation2

Biomarker1

Human4

Immunity1