AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
beta 2-Glycoprotein IAntiphospholipid SyndromeAntibodies, AntiphospholipidAntibodies, AnticardiolipinGlycoproteinsLupus Coagulation InhibitorCardiolipinsAutoantibodiesViral Envelope ProteinsApolipoproteinsMolecular Sequence DataProthrombinEnzyme-Linked Immunosorbent AssayImmunoglobulin GLupus Erythematosus, SystemicPhosphatidylserinesThrombosisAmino Acid SequenceAntibodies, MonoclonalPhospholipidsInterleukin-1betaProtein BindingCell LineMembrane GlycoproteinsEpitopesHerpesvirus 3, HumanBinding Sites, AntibodyAntibody SpecificityPlatelet Glycoprotein GPIb-IX ComplexImmunogenetic PhenomenaBlood CoagulationGlycopeptidesBinding Sitesbeta 2-MicroglobulinBlood PlateletsAnionsBase SequenceRecombinant ProteinsAnnexin A2Immunoglobulin MOrosomucoidCells, CulturedAntigens, HeterophileMolecular WeightMyelin-Associated GlycoproteinAnnexin A5Binding, CompetitivePlatelet Membrane GlycoproteinsGlycosylationIntegrin beta3Abortion, HabitualAntibody AffinityPlatelet Glycoprotein GPIIb-IIIa ComplexAntigen-Antibody ReactionsPartial Thromboplastin TimeChromatography, AffinityFibrinolysinAntibodiesProtein Structure, TertiaryCross ReactionsThrombinReceptors, Adrenergic, betaImmunoglobulin Fab FragmentsAutoantigensPeptide FragmentsAnticoagulantsCell Membrane
PhospholipidsAntibodiesCardiolipinApolipoproteinPhospholipidApoHHeparinAutoantibodiesInhibitsProteinVariablyAmino acidsPositively chargedBovineProthrombinRecombinantCompoundsSerumSurfacesViralInhibitorGeneClinicalHumanFunctionalQuantitativeSpecificResultsSyndromeConcentrationsPropertiesConsistsAdultsInfectionJournalGlucoseYearsAlpha
Phospholipids12
  • Hepatocyte-derived ApoH binds directly to negatively charged phospholipids (5). (rndsystems.com)
  • Beta-2-glycoprotein is a cofactor necessary for the interaction of antiphospholipid antibodies with phospholipids. (lab24.pl)
  • It is a blood plasma protein that binds to negatively charged phospholipids, in particular cardiolipin. (lab24.pl)
  • b2GPI, also called apolipoprotein H, is an antiphospholipid protein cofactor with natural anticoagulant properties and an affinity for negatively-charged phospholipids. (diapharma.com)
  • Primary APAS as well as systemic lupus erythematosus (SLE) are characterized by the appearance of autoantibodies to negatively charged phospholipids (1). (eaglebio.com)
  • The positively charged fifth domain of ß2 GP-I interacts with negatively charged phospholipids or activated polystyrol surfaces of ELISA wells. (eaglebio.com)
  • Apolipoprotein H (APOH) attaches to numerous kinds of negatively charged substances for instance phospholipids, and dextran sulfate. (assaygenie.com)
  • Function: Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. (assaygenie.com)
  • Antibodies against cardiolipin belong to the group of anti-phospholipid antibodies specific for negatively charged phospholipids, components of biological membranes.Cardiolipin is an acidic phospholipid derived from glycerol and was named because of its isolation from bovine heart in 1941. (rapidtest.com)
  • Some years later the role of a cofactor was investigated, the β2-glycoprotein I (apolipoprotein H) also called β2GPI and its interactions with anionic phospholipids in human serum / plasma. (diametra.com)
  • β2GPI in vivo is associated with negatively charged substances such as anionic phospholipids, heparin and lipoproteins. (diametra.com)
  • Diagnostic laboratories measure the antibodies directed against the complex between β2GPI and negatively charged phospholipids, as Phosphatidyl serine (PS) Phosphatidyl inositol (PI) and phosphatidic acid (PA). (diametra.com)
Antibodies17
  • however it is known to play an important role in the binding of β2-GP1 to negatively charged compounds and subsequent capture for binding of anti-β2-GP1 antibodies. (wikipedia.org)
  • Antibodies to beta-2-glycoprotein (IgG) are one of the markers in the diagnosis of antiphospholipid syndrome (APS). (lab24.pl)
  • Antibodies to β-2-glycoproteins belong to the class of antiphospholipid antibodies and were included in the laboratory classification criteria for the diagnosis of antiphospholipid syndrome in 2006 (Miyakis et al. (lab24.pl)
  • The Eagle Biosciences Anti-beta 2 GP-I ELISA Assay Kit is used for the quantitative determination of IgG or IgM antibodies to ß2 glycoprotein-I (beta2 GP-I) in human serum or plasma for the diagnosis of anti-phospholipid antibody syndrome (APAS). (eaglebio.com)
  • The Anti-Beta 2 GP1 ELISA is an enzyme immunoassay for the quantitative determination of IgG or IgM antibodies to ß2 glycoprotein-I in human serum or plasma. (eaglebio.com)
  • The use of highly purified ß2 GP-I guarantees the specific binding of antibodies to ß2 glycoprotein-I of the specimen under investigation. (eaglebio.com)
  • Anticardiolipin and Anti-Beta-2 Glycoprotein 1 Antibodies. (dobratechnologia.pl)
  • anticardiolipin (aCL), which has three subcomponents: lgG, lgA, lgM anti-Beta-2-glycoprotein-I (aβ 2 GPI), which has the same three subcomponents LAC The LAC is the most important of these antibodies because it confers the greatest risk for developing clinical complications. (dobratechnologia.pl)
  • Women with the clinical features of APS should be tested for 3 antiphospholipid antibodies that have proven association with the diagnosis of APS: lupus anticoagulant (LAC), anticardiolipin (aCL) antibody, and anti-beta-2glycoprotein I antibody. (medscape.com)
  • Animals immunized with aCL or with the cofactor beta-2 glycoprotein I (b2GPI) develop clinical manifestations of APS, including fetal loss, thrombocytopenia, and neurologic and behavioral dysfunction, along with elevated levels of aPL antibodies. (medscape.com)
  • The aCL antibodies bind to b2GPI, or a complex formed by this b2GPI is a platelet adhesin glycoprotein and cardiolipin. (medscape.com)
  • The Diagnostic Automation Cardiolipin IgA, G, M ELISA kit is a solid phase enzyme immunoassay employing highly purified cardiolipin plus native human Beta2-glycoprotein I for the combined semi-quantitative and qualitative detection of IgA, IgG and IgM antibodies against cardiolipin in human serum. (rapidtest.com)
  • Anti-cardiolipin antibodies mainly recognize specific epitopes on a complex composed out of cardiolipin and Beta2-glycoprotein I which are expressed only when Beta2-glycoprotein I interacts with cardiolipin. (rapidtest.com)
  • Glycoprotein D is essential for virus penetration into permissive cells and thus is a major target for virus neutralizing antibodies during infection. (biomedcentral.com)
  • Subunit, DNA and vectored vaccine candidates have been developed using this glycoprotein as the primary antigen, demonstrating that gD has the capacity to induce robust virus neutralizing antibodies and strong cell-mediated immune responses, as well as protection from clinical symptoms, in target species. (biomedcentral.com)
  • Anti Cardiolipin IgM kit is an indirect solid phase immunoassay kit for the quantitative measurement of IgM class auto-antibodies directed against Cardiolipin-β2-glycoprotein complex in human serum or plasma. (diametra.com)
  • SARS-CoV-2 vaccines, composed of mRNA-containing PEGylated lipid nanoparticles, have been widely administered as intramuscular (i.m.) injections, so it is important to determine if PEGylated formulations can induce anti-PEG antibodies. (matci.jp)
Cardiolipin1
  • It has an anionic charge and the function is unknown, as cardiolipin is not involved in the immune or coagulation systems. (diapharma.com)
Apolipoprotein3
  • Apolipoprotein H (ApoH), also known as beta 2‑Glycoprotein I/ beta 2-GPI, is a variably glycosylated member of the complement control superfamily of proteins with a molecular weight of aproximately 50 kDa (1, 2). (rndsystems.com)
  • β2-glycoprotein 1, also known as beta-2 glycoprotein 1 and Apolipoprotein H (Apo-H), is a 38 kDa multifunctional plasma protein that in humans is encoded by the APOH gene. (wikipedia.org)
  • One of these cofactors has been identified as ß2 glycoprotein-I (ß2 GP-I) (apolipoprotein H) (2,3). (eaglebio.com)
Phospholipid2
  • Within the structure of Apo-H is a stretch of positively charged amino acids (protein sequence positions 282-287), Lys-Asn-Lys-Glu-Lys-Lys, are involved in phospholipid binding (see image on right). (wikipedia.org)
  • What is the role of Beta 2 Glycoprotein 1 (B2GP1) in anti-phospholipid antibody binding? (diapharma.com)
ApoH1
  • Human APOH although stable at room temperature for 3 weeks, should be stored between 2-8°C. (assaygenie.com)
Heparin2
  • This supports the notion that the envelope glycoproteins of HSV-1 and HSV-2 interact with different affinities for different structural features of heparin. (archive.org)
  • this inhibitory effect was reversed when the cells and inoculum were shifted to 37؇C. This temperature-dependent differential response to modified heparin compounds was evident primarily when glycoprotein C of HSV-1 (gC-1) was present in the virion envelope. (archive.org)
Autoantibodies1
  • The antiphospholipid (aPL) autoantibodies bind moieties on negatively charged PLs or moieties formed by the interaction of negatively charged PLs with other lipids, PLs, or proteins. (medscape.com)
Inhibits2
  • The activity of β2-GP1 appears to involve the binding of agglutinating, negatively charged compounds, and inhibits agglutination by the contact activation of the intrinsic blood coagulation pathway. (wikipedia.org)
  • Beta-2-glycoprotein inhibits the formation of prothrombinase (factor Xa) in the presence of platelets, and also inhibits the activation of factor XII. (lab24.pl)
Protein4
  • In molecular biology, the protein domain Sushi 2 is also known as the fifth protein domain of beta-2 glycoprotein 1 (β2-GP1). (wikipedia.org)
  • This protein domain is composed of four well-defined anti-parallel beta-strands and two short alpha-helices, as well as a long highly flexible loop. (wikipedia.org)
  • Structure-activity features of the protein were characterized, and functional studies predict bubaline pregnancy associated glycoprotein 2 as an inducible, extra-cellular, non-essential, N-glycosylated, aspartic pro-endopeptidase that is involved in down-regulation of complement pathway and immunity during pregnancy. (biomedcentral.com)
  • Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. (embl.de)
Variably1
Amino acids2
  • Since the HBP utilizes major macromolecules such as nucleotides, amino acids, carbohydrates, and lipids to produce UDP-GlcNAc, cells may use it as a 'sensor' of energy availability that influences a large number of functional targets that contribute to cancer phenotypes (Fig. 2 ). (biomedcentral.com)
  • The functional groups (NH + 2 in the case of proline) and (CO 2 in the case of glycine) are joined to the same C atom, making them -amino acids. (easy4learning.com)
Positively charged1
  • The acidic residues between the fourth and sixth cysteines are important for high-affinity binding of positively charged sequences in LDLR's ligands. (embl.de)
Bovine1
  • The viral envelope glycoprotein D from bovine herpesviruses 1 and 5 (BoHV-1 and -5), two important pathogens of cattle, is a major component of the virion and plays a critical role in the pathogenesis of herpesviruses. (biomedcentral.com)
Prothrombin1
Recombinant2
  • Using a series of intertypic recombinant mutant viruses, we found that susceptibility to O-desulfated heparins can be transferred to HSV-1 by the gene for glycoprotein C of HSV-2 (gC-2). (archive.org)
  • PylS as well as tRNA(PYl) are increasingly being taken advantage of just as one orthogonal match in Biopsie liquide recombinant systems with regard to introduction of valuable altered proteins straight into meats.The covariance of heterozygosity operates as a way of linkage disequilibrium (LD) among body's genes at 2 loci, despite the fact that the one that doesn't need as much information as a parameter for example r(Two). (novobiocininhibitor.com)
Compounds1
  • Cyanine dyes that are highly charged, such as those including multiple sulfonate, alkylsulfonate, carboxylate and/or alkylcarboxylate moieties are examples of cyanine dyes of use in the compounds of the invention. (justia.com)
Serum2
  • Serum interleukin (IL)-1, IL-6, tumour necrosis factor (TNF) and quantitative urinary -2-microglobulin (-2-m) excretion were estimated. (who.int)
  • Serum TNF concentration and urinary -2-m excretion were significantly higher in the first presentation and relapse groups. (who.int)
Surfaces3
  • Although heparan sulfate (HS) serves as an initial receptor for the binding of both herpes simplex virus type 1 (HSV-1) and HSV-2 to cell surfaces, the two serotypes differ in epidemiology, cell tropism, and ability to compete for viral receptors in vitro. (archive.org)
  • Moreover, specific negatively charged regions of the polysaccharide, including N sulfations and the carboxyl groups, are key structural features for interactions of both HSV-1 and HSV-2 with cell surfaces since N desulfation or carboxyl reduction abolished heparin's antiviral activity. (archive.org)
  • Factor XII itself is activated to factor XIIa by negatively charged surfaces, such as glass. (wikidoc.org)
Viral3
  • 1,2 Limitations ACA can often be observed during the convalescent phase of acute bacterial and viral infections and in individuals with syphilis. (dobratechnologia.pl)
  • DIVA vaccines include genetically engineered gene-deleted viruses, for example gE − virus, and subunit or vectored vaccines based on a viral envelope glycoprotein such as gD. (biomedcentral.com)
  • Total 122 children aged 2-12 years, further subdivided into Group A (n=61) suffering from nephrotic syndrome (1st attack, infrequent relapse) and Group B (n=61) other disease like viral fever, pneumonia, bronchiolitis, diarrhoea, UTI. (bvsalud.org)
Inhibitor1
  • download of been proteins appears the architectural subunit of including acids within enzymes and represents the inhibitor gene conjugation SSA to intracellular families that initiate dramatically synaptic from those short at the thyroid beta. (erik-mill.de)
Gene1
  • The exact structure and function of the gene product is unknown due to limitations on obtaining purified pregnancy associated glycoprotein preparations. (biomedcentral.com)
Clinical1
  • clinical nutrition as a specialty goes here HN - 2008 BX - Nutrition FX - Diet FX - Food DH - Child Nutrition DI - 052504 MN - SP6.021.062 MS - Nutrition of children aged 2-10 years. (bvsalud.org)
Human1
  • Important prototypes of this family comprise human herpesviruses, such as Human herpesvirus (HHV)-1 and -2 (known as herpes simplex virus (HSV)-1 and -2), and animal herpesviruses. (biomedcentral.com)
Functional1
  • Finally, the application of this glycoprotein in new vaccine design is reviewed, taking its structural and functional characteristics into consideration. (biomedcentral.com)
Quantitative1
  • On a estimé l'interleukine 1, l'interleukine 6, la cachectine (TNF) et l'excrétion quantitative de 2-microglobuline urinaire. (who.int)
Specific1
  • This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. (abcam.com)
Results1
  • These results suggest differences in the interactions of HSV-1 and HSV-2 with cell surface HS that may influence cell tropism. (archive.org)
Syndrome2
  • Les enfants présentant un syndrome néphrotique idiopathique ont été répartis en trois groupes de 20 : première manifestation, rémission et récidive. (who.int)
  • minimal change nephrotic reabsorption and increased urinary excre- syndrome is most common in children 2-4 tion of -2-m [ 11 ]. (who.int)
Concentrations2
  • Each nanoparticle subsequently produces an electronic signal that enables precise measurement of their electric charge in low concentrations and small volumes. (acs.org)
  • Les concentrations sériques d'interleukine 1, d'interleukine 6 et de TNF permettaient de sélectionner positivement (100 %) les groupes de première manifestation et de récidive alors que ces concentrations plus l'excrétion urinaire de 2-microglobuline urinaire sélectionnaient négativement (100 %) le groupe témoin. (who.int)
Properties1
  • The synthesis of the peptides may provide sufficient material to enable further studies and to determine the structure-activity relationships or may provide discovery of new analogues with improved properties [ 1 , 2 , 3 , 4 , 5 , 6 , 7 ]. (intechopen.com)
Consists1
  • The repeat consists of a beta-hairpin structure followed by a series of beta turns. (embl.de)
Adults1
  • Over 2 million adults in the United States have hepatitis C virus (HCV) infection, and new infections have continued to rise. (cdc.gov)
Infection2
  • In contrast, 6-O sulfations and 2-,3-O sulfations are important determinants primarily for HSV-1 infection. (archive.org)
  • The O-desulfated heparins had little or no inhibitory effect on HSV-1 infection but inhibited HSV-2 infection. (archive.org)
Journal1
Glucose3
  • Otto Warburg noticed that cancer cells utilize far more glucose than normal cells and reprogram their metabolism largely to glycolysis even in oxygen-rich conditions [ 2 ]. (biomedcentral.com)
  • The hexosamine biosynthetic pathway utilizes up to 2-5% of glucose that enters a non-cancer cell and along with glutamine, acetyl-coenzyme A (Ac-CoA) and uridine-5′-triphosphate (UTP) are used to produce the amino sugar UDP-GlcNAc [ 5 ]. (biomedcentral.com)
  • xyn10C, xyn10D, xyn11A, and xyn11B were all abundantly expressed when the bacterium was cultured on xylan or beta-glucan but not on medium containing mannan, whereas glucose repressed transcription of these genes. (omicsdi.org)
Years2
  • The patients (10 boys and two girls) ranged in age from 2 days to 16 years (average age, 6.6 years). (lookformedical.com)
  • METHODS: We used electronic health records for asthma patients aged 2-17 years from a regional, urban, children's hospital in Ohio during 2011-2015. (cdc.gov)
Alpha1
  • Herpesviruses constitute a large and diverse family of enveloped viruses and are composed of three subfamilies, Alpha- , Beta- and Gammaherpesvirinae . (biomedcentral.com)