Cell ProliferationCell DivisionSignal TransductionCells, CulturedCell Line, TumorApoptosisCell DifferentiationTranscription FactorsCell CycleCell LineMolecular Sequence DataRNA, MessengerPhosphorylationGene Expression RegulationDown-RegulationMice, KnockoutMice, Inbred C57BLBlotting, WesternDNA-Binding ProteinsRepressor ProteinsReverse Transcriptase Polymerase Chain ReactionMutationRNA, Small InterferingBase SequenceBromodeoxyuridineCell MovementCell SurvivalImmunohistochemistryTransfectionRNA InterferenceProtein BindingTranscription, GeneticAmino Acid SequenceGene Expression Regulation, NeoplasticLymphocyte ActivationNuclear ProteinsPromoter Regions, GeneticTumor Cells, CulturedGene Expression Regulation, DevelopmentalTrans-ActivatorsGene ExpressionMice, TransgenicUp-RegulationProliferating Cell Nuclear AntigenPhenotypeCell Cycle ProteinsIntracellular Signaling Peptides and ProteinsProto-Oncogene ProteinsModels, BiologicalFlow CytometryEpithelial CellsProtein-Serine-Threonine KinasesTime FactorsProto-Oncogene Proteins c-aktGenes, RegulatorEnzyme ActivationCell Growth ProcessesFibroblastsT-LymphocytesDose-Response Relationship, DrugGene Knockdown TechniquesKi-67 AntigenStem CellsGene Expression ProfilingCyclin D1Carrier ProteinsMembrane ProteinsCyclin-Dependent Kinase Inhibitor p27Tumor Suppressor ProteinsMice, Inbred BALB CMicroRNAsGene Expression Regulation, BacterialRecombinant ProteinsMice, NudeTumor Suppressor Protein p53Cell Transformation, NeoplasticDNAProtein Structure, TertiaryEnzyme InhibitorsDNA PrimersMAP Kinase Signaling SystemExtracellular Signal-Regulated MAP KinasesBacterial ProteinsTransforming Growth Factor betaRecombinant Fusion ProteinsAdaptor Proteins, Signal TransducingPhosphatidylinositol 3-KinasesProteinsCell CountCell NucleusHEK293 CellsMuscle, Smooth, VascularThymidineDisease Models, AnimalGene DeletionRats, Sprague-Dawleybeta CateninCyclin-Dependent Kinase Inhibitor p21Mitogen-Activated Protein KinasesDrosophila Proteins