Dimenhydrinate is an over-the-counter (OTC) antihistamine indicated for the prevention and relief of nausea and vomiting from a number of causes, including motion-sickness and post-operative nausea. (wikipedia.org)
Similarly, ginger organically fosters relief from pregnancy-induced and post-operative nausea. (vitacost.com)
Cambridge, UK - Acacia Pharma announces positive results from its Phase II study of APD421, in the prevention of post-operative nausea & vomiting (PONV). (gildehealthcare.com)
Subjects were eligible for inclusion if they were at least 18 years of age, had given written, informed consent, had at least two of the four Apfel risk factors for PONV (history of PONV or motion sickness, habitual nonsmoking status, female sex, and expectation of receiving postoperative opioids for analgesia), and were scheduled to undergo any elective surgery during general anesthesia (3). (anesthesiologydfw.com)
The primary endpoint was the composite measure complete response (CR), defined as no episodes of emesis (vomiting or retching) and no use of rescue medication in the first 24 hours after wound closure, the opposite of which was defined as PONV (3). (anesthesiologydfw.com)
A consistent relative risk reduction (RRR) of around 20% was seen in respect of the composite PONV measure, as well as for emesis, nausea, and requirement for rescue medication individually (3) The predominantly antinausea efficacy for amisulpride may offer potentially important benefits in the clinical management of PONV. (anesthesiologydfw.com)
Droperidol was formerly considered by experts to be the drug of choice in PONV prophylaxis, because of its general efficacy and particular benefit in respect of nausea. (anesthesiologydfw.com)
Postoperative nausea and vomiting (PONV) are distressing and common occurrences after operative procedures requiring general anesthesia, more so following laparoscopic surgeries. (ispub.com)
Although the use of postoperative opioids is a well-known risk factor for postoperative nausea and vomiting (PONV), few studies have been performed on the effects of intraoperative opioids on PONV. (ekja.org)
Anesthesia was maintained with sevoflurane and 50% N 2 O. The incidence and severity of PONV and use of rescue antiemetics were recorded at 2, 6, and 24 h postoperatively. (ekja.org)
However, there were no significant differences in the incidence of PONV between Groups C and R. The overall incidences of PONV for postoperative 24 h were 49%, 73%, and 59% in Groups C, F, and R, respectively (P = 0.008). (ekja.org)
Postoperative nausea and vomiting (PONV) is a distressing adverse effect that may result in postoperative complications including bleeding, wound dehiscence, aspiration pneumonitis, and fluid and electrolyte imbalances [ 1 ]. (ekja.org)
The etiology of PONV remains unclear, but the contributing factors are complex including gender, smoking, a history of motion sickness or previous PONV, anesthetic technique, type of surgery, and the use of opioids [ 5 ]. (ekja.org)
Among the risk factors of PONV, the use of postoperative opioids is one of the four major risk factors in the simplified risk scoring system devised by Apfel et al. (ekja.org)
6 ]. The use of postoperative opioids strongly affects the incidence of PONV in a doserelated manner [ 7 ]. (ekja.org)
In the Society for Ambulatory Anesthesia Consensus Guidelines for the management of PONV, one of the strategies for reducing the baseline risk factors of PONV is the minimization of intraoperative and postoperative opioid use [ 5 ]. (ekja.org)
Most anesthesiologists prefer shortacting opioids such as remifentanil or fentanyl rather than longacting opioids for this purpose because long-acting opioids may cause postoperative adverse effects including respiratory depression, PONV, urinary retention, and pruritus. (ekja.org)
Although a number of clinical reports have identified the use of postoperative opioids as one of the major risk factors of PONV, few studies have been performed that focus on the effects of intraoperative opioid use on the incidence and severity of PONV [ 12 , 13 , 14 ]. (ekja.org)
The study showed that APD421 significantly reduced the incidence of nausea and vomiting compared to placebo in adult surgical patients at moderate-to-high risk of suffering PONV. (gildehealthcare.com)
The primary endpoint was protection against PONV, defined as no vomiting or retching and no requirement for anti-emetic rescue medication in the first 24 hours after surgery. (gildehealthcare.com)
The four established "Apfel" risk factors for PONV are female sex, non-smoking status, prior history of PONV or motion sickness and use of opioid analgesia in the post-operative period. (gildehealthcare.com)
Many studies support this: P6 acupressure has been shown to produce clinically significant reductions in PONV, as well as nausea related to early pregnancy, labor, delivery, and chemotherapy. (soothing-scents.com)
The patients who are at risk are young females, 20-40 years and those undergoing laparoscopic gynecological procedures with residual pneumoperitoneum, use of nitrous oxide, opioid anesthesia, past history of nausea, vomiting and motion sickness 6 7 8 . (ispub.com)
The 4Q-TAP block enhanced multimodal analgesia and decreased opioid requirements in patients with CRS with HIPEC, but did not change postoperative recovery outcomes. (anesth-pain-med.org)
Patients indicate that among the most feared side effects of cancer are chemotherapy-induced nausea and vomiting (CINV), with up to 80% of patients affected if appropriate prophylaxis is not administered. (emjreviews.com)
Postoperative pain occurring after cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) is difficult to control because of extensive surgical injuries and long incisions. (anesth-pain-med.org)
Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS with HIPEC) causes severe postoperative pain due to the long incision from the xiphoid process to the pelvic cavity and the severe invasiveness of the surgery, despite the use of IV PCA [ 7 ]. (anesth-pain-med.org)
Lorazepam, diphenhydramine, and haloperidol transdermal gel for rescue from chemotherapy-induced nausea/vomiting: results of two pilot trials. (druglib.com)
However, promising results have emerged, for example, showing efficacy of acupuncture in adult postoperative and chemotherapy nausea and vomiting and in postoperative dental pain. (meridianhealthnc.com)
Analgesia2
In addition to postoperative analgesia, opioids have often been used to reduce the hemodynamic response to laryngoscopy and tracheal intubation or to blunt surgical stimulation during anesthesia management. (ekja.org)
With the increasing use of minimally invasive techniques, fast-track protocols, and multimodal analgesic techniques, multimodal analgesia with IV PCA has been shown to be comparable to epidural analgesia in postoperative pain control after abdominal surgery [ 3 ]. (anesth-pain-med.org)
Prevention4
The drug is administered as a single intravenous dose infused over 1-2 minutes at the time of induction of anesthesia (for prevention) or in the event of nausea and/or vomiting after a surgical procedure (for treatment) (2). (anesthesiologydfw.com)
Introduction: The aim of the study was to compare the antiemetic effects of intravenous ondansetron 80 mcg/kg and granisetron 40 mcg/kg in a double blind placebo controlled manner for prevention of postoperative nausea and vomiting in patients undergoing gynecological laparoscopic surgeries. (ispub.com)
The DuoBAND can be used with our QueaseEASE 'Clippy' essential oil inhaler compact, combining the nausea prevention of P6 with the rescue relief of essential oils. (soothing-scents.com)
Studies have shown that maropitant doses are safe and effective in the treatment and prevention of cisplatin-induced vomiting. (welovedoodles.com)
Placebo4
To confirm these findings, the following year, G.D. Searle & Co. conducted a trial in which dimenhydrinate or placebo was given to U.S. troops crossing the Atlantic during "a rough passage" in a converted freight ship, the General Ballou, for 10 days as a rescue therapy for sea sickness. (wikipedia.org)
Results: The incidence of nausea and vomiting over a period of 24 hour were found in 20% of patients who had received granisetron, 45% of patients who had received ondansetron and 77.5% of patients who had received placebo. (ispub.com)
Conclusion: It was concluded that granisetron is more effective than ondansetron and placebo in controlling postoperative nausea & vomiting after laparoscopic gynecological surgery. (ispub.com)
Exclusion criteria included a history of allergy to drug(s), pregnancy & lactation, menstruation, vomiting or retching within 24 h before the operation, administration of antiemetic or psychoactive medication within 24 h before surgery, active alcohol or drug abuse. (ispub.com)
A study that assessed eight common remedies for nausea in pregnancy found that ginger came out tops in terms of decreasing nausea and vomiting. (vitacost.com)
Anesthesia1
Oxycodone in the post-anesthesia care unit (PACU) and pethidine or tramadol in the ward were used as rescue analgesics. (anesth-pain-med.org)
Efficacy1
Many are drawn to Cerenia as an effective treatment for vomiting as it is non-sedating, administered only once a day, and is fast-acting with 24-hour efficacy. (welovedoodles.com)
Healthcare1
For those of us from conventional healthcare backgrounds, understanding alternative therapies for nausea, like P6 acupressure bands, hasn't come easy. (soothing-scents.com)
Apfel1
This was a robust, well-conducted trial in leading European and US centres and has shown an unequivocal benefit for APD421 in patients who are the hardest to protect from post-operative sickness, those with multiple Apfel risk factors. (gildehealthcare.com)
It was also observed that, 32 patients (80%) of group A and 22 patients (55%) in group B did not experience any nausea and vomiting, whereas only 9 patients (22.5%) of group C did not experience nausea and vomiting. (ispub.com)
The most important post-operative concerns frequently listed by most of the patients are pain, nausea and vomiting. (ispub.com)
Vomiting and especially nausea remain a major problem for patients after surgical operations, despite the availability of a number of approved anti-emetics. (gildehealthcare.com)
We hypothesized that the addition of a four-quadrant TAP (4Q-TAP) block [ 8 ], which is both a bilateral subcostal TAP block and a bilateral lateral TAP block, in patients who underwent CRS with HIPEC using multimodal IV PCA would effectively control severe postoperative pain and enhance postoperative recovery. (anesth-pain-med.org)
Unfortunately, unwanted side effects can also make an appearance, which is why many of us traditionalists are looking past the prescription pad towards more natural ways to manage our patients' nausea. (soothing-scents.com)
As our patients get seemingly older, sicker, and more medicated every day, it is reassuring to know that all-natural, evidence-based options exist when it comes to treating symptoms like nausea. (soothing-scents.com)
Medication4
Dimenhydrinate, sold under the brand name Dramamine, among others, is an over-the-counter medication used to treat motion sickness and nausea. (wikipedia.org)
It's the first and only FDA-approved anti-vomiting medication for dogs. (welovedoodles.com)
The results showed that 97% of dogs treated with maropitant did not vomit after treatment in comparison to 71% of dogs treated with metoclopramide (an anti-vomiting medication, also known as Reglan, that works by stimulating small intestinal movement to prevent esophageal reflux). (welovedoodles.com)
Results2
These results show that a dosage of Cerenia significantly decreases the likelihood of vomiting. (welovedoodles.com)
RESULTS: Seventy-seven MDES responsible for 989 rescue stations and 397 EMS- physician bases in 15 federal states took part in this survey. (bvsalud.org)
Symptoms3
This means it's tailored to your dog and gives pups the best relief from negative symptoms caused by vomiting. (welovedoodles.com)
If you're not sure why your dog has started vomiting, Cerenia can still be very effective in treating its symptoms. (welovedoodles.com)
The drug may greatly reduce negative symptoms such as weight loss due to poor appetite and vomiting. (welovedoodles.com)
History1
In a field study that tested 138 dogs with a history of motion sickness, it was found that 93% of those treated with Cerenia did not have a vomiting episode. (welovedoodles.com)
Pain1
During 5 postoperative days, there was no difference in pain scores and total rescue analgesic administration between two groups. (anesth-pain-med.org)
Control3
Although progress has been made, there are still unmet needs, the greatest of which is the lack of complete nausea control. (emjreviews.com)
This review set out to identify the initiatives needed to achieve better cancer-induced nausea and vomiting (CINV) control worldwide. (emjreviews.com)
since 06 i've had bouts of similar horrible soul destroying violent vomiting sometimes every hour for weeks with trips in and out of hospital on and off drips, heart monitors, etc…supposedly it relates to allergies, which i try to control. (allergy-details.com)
Hospital1
Hospital stay and incidence of postoperative morbidity were similar in both groups. (anesth-pain-med.org)
Days3
The primary outcome was less than 3 times of rescue analgesic administration (%) in the ward for 5 postoperative days. (anesth-pain-med.org)
When administering for motion sickness, dogs four months and older can receive a minimum tablet dosage of 3.6mg/lb (8mg/kg) for two consecutive days. (welovedoodles.com)
In cases of acute vomiting dogs 2-7 months of age, administer Cerenia tablets orally at a minimum dose of 0.9mg/lb (2mg/kg) once daily for up to five consecutive days. (welovedoodles.com)
I have found that after a few minutes, the level of nausea looses its intensity to the point where I can manage it, or disappears completely. (allergy-details.com)
Outcome1
No effects of anti-motion sickness drugs on vestibular evoked myogenic potentials outcome parameters. (druglib.com)
Mouth1
Acacia Pharma has generated a pipeline of product opportunities addressing a range of supportive care indications such as nausea & vomiting, xerostomia (dry mouth) and cachexia (muscle wasting) using a commercially driven approach to product discovery based on known drugs. (gildehealthcare.com)
Older1
In dogs seven months and older, administer a minimum dose of 0.9 mg/lb (2mg/kg) once daily orally until resolution of acute vomiting. (welovedoodles.com)