• The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the National Institute of Allergy and Infectious Diseases (NIAID) and the Arthritis Foundation are joining forces to support a national consortium of 12 research centers in the search for genes that determine susceptibility to rheumatoid arthritis. (sciencedaily.com)
  • Genetic factors are known to play a role in predisposing people to the disease, in part because rheumatoid arthritis tends to run in families. (sciencedaily.com)
  • In what is the largest such effort in the world, researchers participating in the North American Rheumatoid Arthritis Consortium (NARAC) hope to learn more about genes that play a role in the disease. (sciencedaily.com)
  • They plan to collect medical information and genetic material (DNA) from 1,000 families nationwide in which two or more siblings have rheumatoid arthritis that began when they were between 18 and 60 years old. (sciencedaily.com)
  • North Shore will serve as a central registry of information on sibling pairs with rheumatoid arthritis (including clinical, x-ray and laboratory data) and as a repository of serum, blood cells and DNA from patients. (sciencedaily.com)
  • Findings from this project should give us a window onto the causes of rheumatoid arthritis, which opens up the possibility of developing new ways to diagnose and treat the disease," says Stephen I. Katz, M.D., Ph.D., director of the NIAMS. (sciencedaily.com)
  • Rheumatoid arthritis, which affects over 2 million people in the United States, or about one percent of the adult population, is a potentially disabling inflammatory form of arthritis that causes pain, swelling, stiffness and loss of function in the joints, and may also affect other body systems. (sciencedaily.com)
  • As rheumatoid arthritis progresses, the inflammation processówhose hallmarks include redness, swelling, warmth and pain--can cause erosion, or destruction, of bone and cartilage in the joints. (sciencedaily.com)
  • Rheumatoid arthritis is an autoimmune disease, so-called because a personís immune system attacks his or her own body tissues. (sciencedaily.com)
  • Treatment for rheumatoid arthritis includes a variety of medications as well as lifestyle strategies such as exercise and self-management programs. (sciencedaily.com)
  • The consortium's first goal in the next 3 to 5 years is to find and begin to study 1,000 families with two or more siblings who have rheumatoid arthritis and, if possible, at least one surviving parent. (sciencedaily.com)
  • What Is Rheumatoid Arthritis? (everydayhealth.com)
  • Rheumatoid arthritis (RA) is a chronic inflammatory disease of the joints. (everydayhealth.com)
  • Rheumatoid arthritis (RA) is a chronic autoimmune condition in which your immune system mistakes the linings of your joints as foreign and attacks them. (everydayhealth.com)
  • What is the difference between rheumatoid arthritis and osteoarthritis? (everydayhealth.com)
  • Rheumatoid arthritis inflames the joint lining, eventually eroding the joint. (everydayhealth.com)
  • No single test can diagnose rheumatoid arthritis. (everydayhealth.com)
  • Are there home remedies for rheumatoid arthritis? (everydayhealth.com)
  • Rheumatoid arthritis is a complex disease that is not well understood by medical practitioners or researchers. (everydayhealth.com)
  • Rheumatoid Arthritis: Can You Ease Other People's Pain? (everydayhealth.com)
  • Rheumatoid Arthritis: Are Hand Cramps a Symptom? (everydayhealth.com)
  • In a small study, the researchers also discovered that people with a type of itch from an unknown cause, a condition called chronic idiopathic pruritus, improve when given tofacitinib (Xeljanz), a drug approved for rheumatoid arthritis. (wustl.edu)
  • Examples include osteoarthritis (OA), rheumatoid arthritis (RA), and gout. (healthline.com)
  • Initially approved for the treatment of rheumatoid arthritis (RA), IL-1 blockade strategies have diversified in number and in the diseases for which they are used. (medscape.com)
  • The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) is one of the institutes and centers that make up the National Institutes of Health, an agency of the United States Department of Health and Human Services (HHS). (wikipedia.org)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
  • The US Centers for Disease Control and Prevention now estimates that nearly 500,000 new cases are diagnosed and treated for Lyme disease annually in the United States ( 1 ). (cdc.gov)
  • There is no cure, but RA can be managed with good treatment, according to the Centers for Disease Control and Prevention (CDC). (everydayhealth.com)
  • NIH is comprised of about 25 separate Institutes and Centers. (curefa.org)
  • On March 23, 2023, the National Institutes of Health (NIH) hosted Dr. Ashish Jha, the White House COVID-19 Response Coordinator, at the NIH Bethesda Campus. (nih.gov)
  • November 1985-The Health Research Extension Act of 1985, P.L. 99-158, established the National Institute of Arthritis and Musculoskeletal and Skin Diseases to increase research emphasis. (wikipedia.org)
  • October 2000-The Children's Health Act of 2000 (P.L. 106-310) directed NIAMS to expand and intensify research programs on juvenile arthritis and related conditions, in coordination with other NIH Institutes and the Arthritis and Musculoskeletal Diseases Interagency Coordinating Committee. (wikipedia.org)
  • Honoring Health: Resources for American Indians and Alaska Natives is an e-newsletter that features a different health topic in each issue.It is produced by the NIAMS on behalf of the National Institutes of Health, the Indian Health Service, and the Administration for Community Living's Administration on Aging. (nih.gov)
  • MedlinePlus links to health information from the National Institutes of Health and other federal government agencies. (medlineplus.gov)
  • The NHEFS originated as a joint project between the National Center for Health Statistics (NCHS) and NIA. (cdc.gov)
  • A. Any published material derived from the data should acknowledge the National Center for Health Statistics (NCHS) as the original source. (cdc.gov)
  • In general, the NHEFS data management team has not attempted to resolve substantive data discrepancies that may exist 1) within the 1992 NHEFS data tapes, or 2) between the 1992 NHEFS data tapes and the data tapes of the original National Health and Nutrition Examination Survey (NHANES I) and/or other NHEFS followup waves. (cdc.gov)
  • The NHANES I Epidemiologic Followup Study (NHEFS) is a longitudinal study which uses as its baseline those adult persons ages 25 to 74 years who were examined in the first National Health and Nutrition Examination Survey (NHANES I). The NHEFS is comprised of a series of four followup surveys. (cdc.gov)
  • Skin Health and Skin Diseases. (howstuffworks.com)
  • These two steroids differ by only two chemical groups," says Jyoti K. Jaiswal, MSC, Ph.D., a principal investigator at Children's National Health System and senior study author. (childrensnational.org)
  • the National Institute of Allergy and Infectious Diseases and the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health supported the work. (futurity.org)
  • Osteoporosis is a public health issue in the U.S. because the disease contributes to two million fractures (broken bones), including 300,000 hip fractures, annually. (emedicinehealth.com)
  • February 21, 2018 Source: Press Release, National Institutes of Health NIH program to accelerate therapies for arthritis, lupus releases first datasets Collaborative effort provides important clues about potential research targets NEW YORK, NY. (lupusresearch.org)
  • To combat these cardiac diseases, the AHA provides funding for biomedical research, advocates for public health policies and resources, and provides education training and tools to the greater community about heart health. (curefa.org)
  • Conducted in collaboration with the National Institute of Child Health and Human Development, the National Institute of Arthritis and Musculoskeletal and Skin Diseases, The National Institute of Diabetes and Digestive and Kidney Diseases, and the National Institute on Aging. (drugpatentwatch.com)
  • Find out more about links between exercise and bone health at the National Institute of Arthritis and Musculoskeletal and Skin Diseases . (msdmanuals.com)
  • J.M.K. was partially supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under Award Number K08AR063668 for this work. (medscape.com)
  • Data from the National Health Interview Survey (NHIS) were used to obtain national prevalence estimates of the prevalence of chronic diseases and impairments among farmers and to compare those rates with the rates for other currently employed workers in the United States. (cdc.gov)
  • Lupus is an autoimmune disease that triggers inflammation in different tissues of the body. (cdc.gov)
  • A role of Src family kinase members in causing sterile inflammation and human disease is only recently recognized. (nature.com)
  • Mutations in the DYSF gene that produces this essential protein causes limb girdle muscular dystrophy type 2B (LGMD2B), a disease characterized by chronic muscle inflammation and progressively weakened muscles in the pelvis and shoulder girdle. (childrensnational.org)
  • It's an autoinflammatory disease, involving an immune-system malfunction that causes prolonged inflammation that in turn can damage the body. (mentalhelp.net)
  • The Receptor for Advanced Glycation End-products (or RAGE) has garnered great interest over the past 20 years for its role in the complications of diabetes mellitus and in Alzheimer's disease, atherosclerosis and other inflammatory disorders. (elifesciences.org)
  • This category includes systemic lupus erythematosus (SLE or lupus), dermatomyositis and scleroderma, disorders in which the body's immune defenses mistakenly attack healthy areas of the body, including the skin. (drugs.com)
  • Chronic itch affects up to 15 percent of the population and is most often caused by inflammatory conditions such as eczema and psoriasis but also is associated with kidney failure, liver disease and certain cancers and nerve disorders. (wustl.edu)
  • NIAMS' mission is to support the research of arthritis, musculoskeletal and skin diseases. (wikipedia.org)
  • became the Director of the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) in February, 2021. (nih.gov)
  • The NIAMS Update is a digest on the latest scientific news and resources on diseases of the bones, joints, muscles, and skin. (nih.gov)
  • Director of the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), encourages researchers she supports to think outside the box. (nih.gov)
  • The study, which was funded by NIH's National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), appeared online in Proceedings of the National Academy of Sciences on March 24, 2014. (nih.gov)
  • In 2004, Dr. Raphaela Goldbach-Mansky of the U.S. National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) was asked to assist in the case of a 10-year-old girl with SAVI that had not responded to any medications. (mentalhelp.net)
  • Not only do these discoveries have profound implications for children with SAVI, but they could have a broader impact by helping us to understand other, more common inflammatory conditions," NIAMS Director Dr. Stephen Katz said in an institute news release. (mentalhelp.net)
  • The name "NIAMS" clarifies the scope of the institute, which is very broad as it includes arthritis, the musculoskeletal system, and skin. (medlineplus.gov)
  • if untreated, the inflammatory disease may damage cartilage and bone. (everydayhealth.com)
  • Takeda expects topline results from a Phase 2b study in psoriatic arthritis in FY2023 and will be evaluating TAK-279 in additional immune-mediated diseases including systemic lupus erythematosus (SLE) and inflammatory bowel disease (IBD). (biospace.com)
  • Systemic lupus erythematosus (SLE), or lupus, is a chronic disease that involves the immune system and can damage any part of the body.iv Normally, the immune system works to fight off invaders, such as viruses and bacteria, by making antibodies. (gsk.com)
  • People with the disease may have a period of lupus symptoms every so often (called flares), sometimes even years apart, that go away at other times (called remission). (cdc.gov)
  • Lupus symptoms can include fatigue, pain or swelling in joints, skin rashes, and fevers. (cdc.gov)
  • Other symptoms can include gum disease and frequent fractures of the bones. (medicinenet.com)
  • However, a subset of patients have sequelae, such as headache, fatigue, sleep or memory disturbance, and arthralgias or myalgias that persist for months to years after antibiotic use, termed posttreatment Lyme disease symptoms or syndrome (PTLDS) ( 7 - 14 ). (cdc.gov)
  • Those sequelae might occur with each Lyme disease manifestation and are heterogenous, ranging from mild, self-resolving symptoms to debilitating syndromes that greatly impair the quality of life and require regular use of analgesics ( 7 - 13 , 15 ). (cdc.gov)
  • Early signs of disease, such as joint swelling, joint pain, and joint stiffness, typically begin in a gradual and subtle way, with symptoms slowly developing over a period of weeks to months and getting worse over time. (everydayhealth.com)
  • MD/PhD student Landon K. Oetjen (left) and Brian S. Kim, MD (center), examine chronic itch patient Donald E. Hodges, whose symptoms improved following treatment with the arthritis drug tofacitinib. (wustl.edu)
  • i The disease can be difficult to diagnose, even more challenging to treat, and is associated with a range of debilitating symptoms that can fluctuate over time. (gsk.com)
  • What are the symptoms of arthritis, including arthrosis? (healthline.com)
  • The symptoms of arthritis vary from one type to another. (healthline.com)
  • FDA notes that these symptoms are different from the skin irritation expected with normal use. (poison.org)
  • By 2010, Goldbach-Mansky had seen two more children with the same symptoms and suspected that all three patients had the same disease. (mentalhelp.net)
  • The Institutes listed below cover one or more symptoms associated with Friedreich's ataxia. (curefa.org)
  • Bone mass can decrease without symptoms for a significant period of time before fracture occurs, and since fracture is the main clinical sign of the disease, many clinicians and researchers limit the definitions of osteoporosis to the presence of an atraumatic fracture. (cdc.gov)
  • Dr. Criswell talked with NIH MedlinePlus Magazine about how diverse ideas can help us better understand conditions such as autoimmune diseases (when the immune system attacks healthy cells by mistake) and initiatives that promote diversity and inclusion in research. (nih.gov)
  • Because it has something to do with the immune system, it is an internal disease even though it appears on the outside of your body. (webmd.com)
  • An uncommon disease of the immune system, pemphigus occurs when the immune system turns on healthy cells. (howstuffworks.com)
  • Psoriasis, like pemphigus, is an immune system disease. (howstuffworks.com)
  • Sores created by immune system diseases tend to be more stubborn, and require oral or injected medications and topical creams. (howstuffworks.com)
  • Dear Colleagues, Many studies have shown that autoimmune diseases disproportionately affect women - nearly 80 percent of those with an autoimmune disease are women. (nih.gov)
  • We look forward to participating in this important initiative to better understand this debilitating autoimmune disease. (sciencedaily.com)
  • Although patients with fibromyalgia do not have characteristic or consistent abnormalities on laboratory testing, routine laboratory and imaging studies can help to rule out diseases with similar manifestations and to assist in diagnosis of certain inflammatory diseases that frequently coexist with fibromyalgia. (medscape.com)
  • However, too many eosinophils in the bloodstream tissues, or organs can serve as a sign of eosinophilic inflammatory diseases. (gsk.com)
  • Repurposing drugs that target inflammatory cytokines has confirmed the prominent roles of pro-inflammatory cytokines, including IL-1, Type-I IFN, and TNF in the disease pathogenesis of autoinflammatory diseases, and identified the inflammasome and viral sensors as novel targets for drug development 2 . (nature.com)
  • The U.S. National Institute of Arthritis and Musculoskeletal and Skin Diseases has more about autoinflammatory diseases . (mentalhelp.net)
  • Of importance, clinical response to anti-IL-1 therapy does not always denote protection from autoinflammatory disease complications such as macrophage activation syndrome or amyloidosis. (medscape.com)
  • With help from the Arthritis Foundation, the researchers will be looking for pairs of siblings in which at least one sibling has relatively severe disease, as indicated by a hand X-ray that shows some erosion of bone. (sciencedaily.com)
  • Rickets is a disease of children and adolescents that affects growing bone. (medicinenet.com)
  • When you know that the microarchitecture is normal, you're a lot less concerned that they actually have a bone disease of osteoporosis," Thacker said. (medscape.com)
  • In the United States, 10 million people have osteoporosis (80% of those are women), and 44 million are at risk for developing the disease due to low bone density. (emedicinehealth.com)
  • The institute investigates the prevention, diagnosis, causes, treatments and cures for both common and rare diseases. (wikipedia.org)
  • Purpose This Funding Opportunity Announcement (FOA) encourages the translation of technology and therapeutic innovations from academic and other non-profit research sectors to the marketplace to advance the development of diagnostic and prevention tools or treatments for musculoskeletal, rheumatic, or skin diseases. (sbir.gov)
  • Recommendations and milestones for Alzheimer's disease (AD) and AD-related dementias (ADRD) research from the National Alzheimer's Project Act and the 2015, 2018, 2019, and 2021 Alzheimer's Disease Research Summits present a wide range of research and development proposals which, if pursued, have the potential to reduce the human burden and healthcare costs associated with AD/ADRD. (sbir.gov)
  • More than 300 million patients suffer from osteoarthritis 1 ,a progressive disease that currently cannot be cured. (sttinfo.fi)
  • Osteoarthritis (OA) can be defined as a group of distinct but overlapping diseases. (sttinfo.fi)
  • Osteoarthritis is a joint disease in which the tissues in the joint break down over time. (sttinfo.fi)
  • Special thanks are extended to Joan Cornoni-Huntley of the National Institute on Aging (NIA) who played an important role in the development and continuation of the NHEFS. (cdc.gov)
  • Institute of Aging, the Food and Drug Administration and the U.S. Department of Agriculture. (cdc.gov)
  • To find out how common lupus is and how often it develops in different racial and ethnic groups, CDC supported five population-based lupus patient registries, which collected information on people who have been diagnosed with the disease. (cdc.gov)
  • The New York City and San Francisco studies also show that lupus-related kidney disease (lupus nephritis) - which can be fatal - appears to be more common among non-Hispanic Asian people and Hispanic people (of any race) compared with non-Hispanic White people. (cdc.gov)
  • Does it form a "butterfly" pattern over the cheeks and nose (a classic sign of lupus), or does it produce a bright red "slapped cheek" pattern (a sign of fifth disease)? (drugs.com)
  • GSK is committed to advancing treatment for people with lupus, one of the most complex autoimmune diseases, building on decades of research and leading with a long-term focus on innovative science. (gsk.com)
  • Because lupus is a chronic, complex and potentially isolating disease, we have a shared ambition with lupus advocacy organizations and patient groups to address unmet needs of people with this immuno-inflammatory condition. (gsk.com)
  • GSK's new patient engagement hub - our first direct-to-patient education platform - offers lupus information, resources, and webinars to drive patient understanding, help patients get the answers they need, and equip them with knowledge to better manage this disease. (gsk.com)
  • Stelara® is not approved for the treatment of lupus, but is approved by the FDA for certain autoimmune diseases. (lupusresearch.org)
  • Diseases such as lupus share some characteristics with SAVI, so this work may lead to novel insights and possibly new treatments for these debilitating conditions as well," he explained. (mentalhelp.net)
  • vi Moreover, of those adults who develop LN, up to 20% will develop end-stage kidney disease (ESKD) in the 10 years after diagnosis. (gsk.com)
  • Osteoporosis is a disease of the bones that causes bones to become weak and break easily. (womenshealth.gov)
  • Osteoporosis is a disease of the bones. (womenshealth.gov)
  • Osteoporosis is called a "silent" disease. (womenshealth.gov)
  • Though valid estimates of national prevalence are not available, recent reports estimate that osteoporosis affects 15-20 million people in the United States. (cdc.gov)
  • Osteoporosis does not have a discrete onset, and assessment of the disease is complicated by several problems. (cdc.gov)
  • Cleveland Clinic notes that people with darker skin tones might see these bumps appear on their legs, while younger people may get them on their torso. (yahoo.com)
  • however, the lighter patches it causes are often more noticeable on people with darker skin. (pfizer.com)
  • The institute also disseminates information on research progress in these diseases. (wikipedia.org)
  • It laid the groundwork for a national program encompassing research, research training, education and patient care. (wikipedia.org)
  • Dr. Kaplan's research focuses on identifying the molecular mechanisms that promote the initiation and perpetuation of perturbed immune responses and the development of organ damage and premature vascular disease in systemic autoimmunity. (nih.gov)
  • and the dissemination of information on research progress in these diseases. (nih.gov)
  • Research basic, translational, and clinical studies of extracellular matrix (ECM) biology and diseases. (nih.gov)
  • Development of new treatments and even ways to prevent the disease are active areas of research supported by both the NIH and the Arthritis Foundation. (sciencedaily.com)
  • Now, new research at Washington University School of Medicine in St. Louis has identified immune signaling molecules that are essential for activating neurons in the skin to cause chronic itching. (wustl.edu)
  • The NIH Institute with primary oversight of biomedical research on FA. (curefa.org)
  • Scientists donít know the cause, but they believe it results from a combination of genetic factors that make a person susceptible to the disease and some type of environmental trigger--possibly an infectious agent such as a virus or bacterium. (sciencedaily.com)
  • These results further support the potential of highly selective TYK2 inhibition to provide an effective and convenient oral treatment option for people living with moderate-to-severe plaque psoriasis who are not achieving optimal skin clearance with current therapies. (biospace.com)
  • If the disease is severe, even minor abrasions or chaffing can cause bleeding, tearing, and blistering. (rarediseases.org)
  • Highest IFN-α levels corresponded with severe disease. (cdc.gov)
  • The Food and Drug Administration (FDA) issued a warning about the possibility of severe allergic reactions to skin medicines containing two common drugs used to treat acne: benzoyl peroxide and salicylic acid. (poison.org)
  • Within 2 weeks, she developed red, itchy skin and severe swelling of her face. (poison.org)
  • FRIDAY, July 18, 2014 (HealthDay News) -- Researchers say they've identified a gene mutation tied to a rare but severe, and often fatal, disease in children. (mentalhelp.net)
  • Researchers only recently discovered that a common virus, called Merkel cell polyomavirus, plays a role in the development of this disease. (yahoo.com)
  • In laboratory studies, several existing drugs have shown promise against SAVI, and one is currently being tested in children with the disease, the researchers said. (mentalhelp.net)
  • They further validate the idea that this knock-in mouse, which preserves expression and binding of RAGE, may be a valuable model for studying this important molecule in disease pathogenesis. (elifesciences.org)
  • Available at: https://orthoinfo.aaos.org/en/diseases--conditions/compartment-syndrome. (epnet.com)
  • Lichen sclerosus is a chronic inflammatory skin disorder that most commonly affects women before puberty or after menopause. (rarediseases.org)
  • On darker skin tones, plaques may be dark brown or purplish with gray scales. (webmd.com)
  • The age adjusted prevalence risk ratio for arthritis among farmers, 1.4, was statistically significant after adjustment for age. (cdc.gov)
  • Farmers also had a statistically significant prevalence risk ratio for cardiovascular diseases and hypertension. (cdc.gov)
  • The prevalence of skin cancer was three times greater among farmers than among other currently employed respondents, but the age adjusted prevalence risk ratio did not remain statistically significant. (cdc.gov)
  • The institute directed to include resources on juvenile arthritis and associated conditions in its clearinghouse. (wikipedia.org)
  • Skin Conditions Related to AIDS. (howstuffworks.com)
  • Eosinophil-driven diseases are inflammatory conditions associated with high levels of eosinophils, a type of white blood cell. (gsk.com)
  • We have a basic understanding of [these] diseases and conditions, but the way we define or distinguish conditions is based on incomplete knowledge of what causes them. (medlineplus.gov)
  • October 1976-The Arthritis, Diabetes, and Digestive Diseases Amendments of 1976 (P.L. 94-562) established the National Arthritis Advisory Board to review and evaluate the implementation of the Arthritis Plan, prepared in response to the National Arthritis Act (P.L. 93-640). (wikipedia.org)
  • December 1980-P.L. 96-538 changed the name of the institute to the National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases. (wikipedia.org)
  • May 1972-P.L. 92-305 renamed the institute the National Institute of Arthritis, Metabolism, and Digestive Diseases. (wikipedia.org)
  • On lighter skin, the patches can be red with white scales. (webmd.com)
  • On lighter skin, this appears red, often covered with silver-colored scales. (webmd.com)
  • It also more commonly occurs in people who have a history of other skin cancers, older adults above the age of 50 and people with lighter skin tones. (yahoo.com)
  • Vitiligo is a condition in which some of the skin loses its pigmentation (color), causing patches of lighter skin to appear. (pfizer.com)
  • American Heart Association (AHA) - Founded in 1924, the AHA is the nation's largest and oldest organization dedicated to developing treatments and cures against heart disease and stroke. (curefa.org)
  • This study aimed to investigate whether n-3 fatty acid supplementation reduced cardiovascular disease (CVD) events in a novel analysis using hierarchical composite CVD outcomes based on win ratio in the VITamin D and OmegA-3 TriaL (VITAL). (bvsalud.org)
  • The presence of thin, easily irritated, and torn skin affects physical activity and clothing choice. (rarediseases.org)
  • The primary analysis estimated win ratios of a composite of major CVD outcomes prioritized as fatal coronary heart disease, other fatal CVD including stroke, non-fatal myocardial infarction (MI), and non-fatal stroke, comparing n-3 fatty acids to placebo. (bvsalud.org)