Leukoencephalopathy, Progressive MultifocalMultiple Sclerosis, Relapsing-RemittingIntegrin alpha4Antibodies, Monoclonal, HumanizedJC VirusMultiple SclerosisIntegrin alpha ChainsAntibodies, MonoclonalIntegrin alpha4beta1Immunologic FactorsInterferon-betaClorazepate DipotassiumCell Migration InhibitionImmune Reconstitution Inflammatory SyndromePlasma ExchangePropylene GlycolsRecurrenceImmunosuppressive AgentsOpportunistic InfectionsMagnetic Resonance ImagingGadoliniumCrohn DiseaseCentral Nervous SystemDrug HypersensitivityProtein BindingMethylprednisoloneLeukocytosisComparative Effectiveness ResearchBrainPeptidesFatigueMolecular Sequence DataDisease ProgressionBinding SitesCell Adhesion MoleculesInfusions, IntravenousLongitudinal StudiesChemotaxis, LeukocyteDouble-Blind MethodTreatment OutcomeClinical Trials as TopicAmino Acid SequenceDNA, ViralMarkov ChainsDisability EvaluationQuality of LifeRemission InductionBase SequenceBlood-Brain BarrierCD4-Positive T-LymphocytesT-LymphocytesProtein Structure, TertiaryCells, CulturedAntibodies, ViralDNA-Binding ProteinsModels, MolecularCell LineTime FactorsBiological MarkersTranscription FactorsBinding, CompetitiveKineticsRecombinant ProteinsCarrier ProteinsLymphocyte ActivationRecombinant Fusion ProteinsPromoter Regions, GeneticSequence Homology, Amino AcidCase-Control StudiesMutationProtein ConformationDNAFollow-Up StudiesCohort StudiesNuclear ProteinsLigandsEscherichia coliTransfectionHeLa CellsCloning, MolecularBacterial ProteinsCrystallography, X-RayMutagenesis, Site-DirectedRNA-Binding ProteinsAmino Acid MotifsSequence AlignmentDimerizationTwo-Hybrid System TechniquesMembrane ProteinsRepressor ProteinsElectrophoresis, Polyacrylamide GelPeptide FragmentsSurface Plasmon ResonanceGene Expression RegulationSignal TransductionPlasmidsCOS CellsMacromolecular SubstancesCell MembraneProtein Structure, Secondary