Narcoleptic patients with cataplexy. Medical search. Frequent questions

Zimelidine was able to improve cataplexy without causing daytime sleepiness. (wikipedia.org)
Narcolepsy is characterized by the classic tetrad of excessive daytime sleepiness (EDS), cataplexy, hypnagogic hallucinations, and sleep paralysis. (medscape.com)
Sleep-disordered breathing and excessive daytime sleepiness in patients with epilepsy - a polysomnographic study. (nel.edu)
The aim of this study was to evaluate the relationship between SDB and daytime sleepiness in patients with epilepsy, who underwent polysomnography (PSG) due to problems with breathing during sleep or due to excessive daytime sleepiness. (nel.edu)
Klobucnikova K, Siarnik P, Sivakova M, Kollar B. Sleep-disordered breathing and excessive daytime sleepiness in patients with epilepsy - a polysomnographic study. (nel.edu)
Narcolepsy is defined as a sleep-wake disorder with REM and non-REM sleep associated symptoms existing longer than 6 months, such as daytime sleepiness, cataplexy, fractionated sleep at night and automatic behaviors. (uni-marburg.de)
Cataplexy, extreme daytime sleepiness , hypnagogic hallucinations, and sleep paralysis are the most frequent symptoms of narcolepsy. (therapynyc.net)
In addition to excessive sleepiness, patients with narcolepsy may suffer from sleep paralysis, headaches, and memory problems. (therapynyc.net)
Although initially these patients are fatigued, they subsequently have difficulty differentiating fatigue from sleepiness. (medscape.com)
To fight tiredness, these patients nap and eventually present with complaints of excessive daytime sleepiness. (medscape.com)
This presents clinically with excessive daytime sleepiness (EDS) and manifestations of impaired REM sleep, which may include cataplexy, hypnagogic or hypnopompic hallucinations, and sleep paralysis (1). (thoracic.org)
In the past, standard treatment has consisted of amphetamines for excessive daytime sleepiness (EDS) and antidepressants for cataplexy. (touchneurology.com)
Narcolepsy cataplexy syndrome, characterised by excessive daytime sleepiness and cataplexy, is strongly associated with a genetic marker, human leukocyte antigen (HLA) DQB1*06:02. (plos.org)
Narcolepsy with cataplexy is characterised by an excessive daytime sleepiness, cataplexy and disturbed nocturnal sleep. (plos.org)
In 1966, William Dement proposed that patients with excessive daytime sleepiness, but without cataplexy, sleep paralysis, or sleep-onset rapid eye movement (REM), should not be considered narcoleptic. (medscape.com)
In between the symptomatic periods, the patients have normal sleep requirements and do not have excessive daytime sleepiness. (medscape.com)
Narcolepsy is a chronic neurological disorder associated with abnormal regulation of the sleep-wake cycle, resulting in excessive daytime sleepiness, disturbed nocturnal sleep, and rapid eye movement (REM) sleep phenomena including cataplexy. (pfmjournal.org)
Narcolepsy is a chronic neurological disorder characterized by excessive daytime sleepiness, disruption of sleep-wake behavior, cataplexy, and other rapid eye movement (REM) sleep phenomena, such as sleep paralysis and hypnagogic hallucination [ 1 ]. (pfmjournal.org)
The purpose of this study is to assess the safety and efficacy of AXS-12 in narcoleptic subjects with cataplexy and excessive daytime sleepiness (EDS). (mayo.edu)
There are times that cataplexy may occur prior to the sleepiness symptoms. (ghostbed.com)
Narcolepsy patients experience excessive daytime sleepiness, cataplexy (i.e. (thetechlane.com)
Patients with narcolepsy had higher crash rates due to their sleepiness. (thetechlane.com)
Narcolepsy is a sleep disorder characterized by excessive daytime sleepiness and cataplexy (a sudden weakening of posture muscle tone usually triggered by emotion) caused by the loss of orexin neurons in the hypothalamus. (urosario.edu.co)
Narcolepsy type 1 is characterized by excessive daytime sleepiness and cataplexy and is associated with hypocretin-1 deficiency. (lesswrong.com)
Narcolepsy is characterized by chronic excessive daytime sleepiness, often with sudden loss of muscle tone (cataplexy). (msdmanuals.com)
At a recent conference, Jazz Pharmaceuticals presented positive efficacy results from the JZP-110 (TONES) studies in adult patients with sleep impairment conditions and the excessive sleepiness associated with these diseases. (patientworthy.com)
However, this drug can greatly help with the sleepiness whereas people who also experience cataplexy might be prescribed another medication for this part of their ailment. (buyonlinerx.com)

Narcolepsy is characterized by excessive diurnal drowsiness with irresistible sleep attacks and cataplexy. (bvsalud.org)
The drug being promoted by the sales rep was Xyrem, a powerful central nervous system depressant, approved for "narcolepsy patients who experience cataplexy" and "narcolepsy patients with excessive daytimesleepiness. (pharma-mkting.com)

A hypocretin levels test determines those in the cerebrospinal fluid and is useful in the identification of narcolepsy with cataplexy. (steptohealth.com)
Studies in animal models have shown that deficient hypocretin transmission causes narcolepsy with cataplexy [ 4 ], and lower cerebrospinal fluid hypocretin levels have been observed in those with narcolepsy with cataplexy [ 5 ]. (pfmjournal.org)
Cataplexy, an attack of extreme muscular weakness is also associated with the destruction of hypocretin producing cells in the brain, probably as the result of an autoimmune attack. (sleepandhealth.com)
The neuropeptide hypocretin-1 is deficient in cerebrospinal fluid (CSF) of narcoleptic animals and most human patients, suggesting that the cause may be HLA-associated autoimmune destruction of hypocretin-containing neurons in the lateral hypothalamus. (msdmanuals.com)
Narcoleptic patients are believed to suffer from selective destruction of Hypothalamic neurons, which are responsible for producing Orexin, also termed Hypocretin (HCRT), a neurotransmitter involved in regulating sleep-wake states. (substack.com)
In the late 1990s, his team discovered that narcoleptics lack hypocretin, a hormone produced by a few brain cells that helps keep people and animals awake. (astrodigi.com)
Although later studies found no further evidence of an immune link, the coincidence made Mignot and many other sleep researchers suspect that an autoimmune attack was ravaging narcoleptics' hypocretin-producing cells. (astrodigi.com)
The result indicates that T cells and HLA, which together regulate much of the body's immune response, gang up in a unique way to destroy narcoleptics' hypocretin cells, the team reports online this week in Nature Genetics. (astrodigi.com)
Type one narcolepsy is often diagnosed not only by the presence of cataplexy but by levels of a brain hormone (neurotransmitter) called hypocretin . (sleep-centers.com)
patients with type two narcolepsy have normal levels of hypocretin. (sleep-centers.com)

SDB has negative influence on quality of sleep and daytime vigility in patients with epilepsy. (nel.edu)
Authors evaluated quality of sleep and daytime vigilance in patients with nocturnal epilepsy and compared it to those with daytime epilepsy. (nel.edu)
Similarities from all, however, include daily periods of irresistible sleep or daytime lapses into sleep, absence of cataplexy, and that the hypersomnolence is not better accounted for by either insufficient sleep or by another sleep disorder. (medscape.com)
The narcoleptic person just doses off into short nap right in the middle of the daytime activities. (treatnarcolepsy.com)
Narcolepsy patients experience exorbitant daytime drowsiness, cataplexy (for example abrupt loss of muscle control and development capacity) and wild nodding off consistently of the day. (fashionsgalaxy.com)
The disorder encompasses an odd constellation of symptoms, including overwhelming daytime drowsiness, uncontrollable sleep attacks, and cataplexy, a sudden loss of muscle tone after an intense emotional outburst, like a good laugh. (astrodigi.com)

In addition, patients may have other rapid eye movement (REM) sleep-related symptoms such as hypnagogic hallucinations and sleep paralysis [1] . (plos.org)
Other symptoms that a narcoleptic can experience are hypnagogic hallucinations and sleep paralysis. (ghostbed.com)
Narcoleptics who experience cataplexy, hallucinations, and sleep paralysis are diagnosed to have REM related abnormalities. (ghostbed.com)
Approximately 50-percent of narcoleptics will experience the hallucinations. (ghostbed.com)
Hypnagogic hallucinations are hell, And cataplexy, that odd startled spell. (pwn4pwn.org)
Narcoleptics can also suffer from hallucinations and temporary paralysis that can last from a few seconds to several minutes after waking up. (polysleep.ca)
Narcolepsy is most commonly treated with drug therapy, which often involves not only treating EDS with alertness-inducing drugs, but alleviating cataplexy, hallucinations, and paralysis. (sleep-centers.com)

Even after their infectious disease resolves, these patients continue to require significantly more nocturnal sleep and continue to feel very tired. (medscape.com)
Modafinil-induced wakefulness does not influence nocturnal sleep patterns or the incidence of cataplexy in narcoleptic patients. (empowerpharmacy.com)

In addition to cataplexy, narcoleptics can also suffer from other sleep disorders that arise from the out-of-sequence sleep patterns. (sleepaidguide.com)

Consequently narcoleptic patients have very low cerebrospinal fluid levels of orexin. (uni-marburg.de)

Not every narcoleptic will suffer from cataplexy. (ghostbed.com)
They also frequently suffer night terrors and cataplexy, remaining conscious but losing all muscle control so they randomly flop on the spot like rag dolls. (greenmedinfo.com)
70% of them suffer from cataplexy: the partial or total loss of muscle control. (polysleep.ca)

This research provides new understandings into treatment of cataplexy and offers health care professionals another option for treating this symptom. (sleepandhealth.com)

Therefore, we recommend that patients with sleep disorders should be queried about the symptoms of narcolepsy. (nel.edu)
However, over the past decade modafinil has become the first-line treatment for EDS, 6 and sodium oxybate has been introduced to treat not only cataplexy, but also EDS and other symptoms of narcolepsy with cataplexy. (touchneurology.com)

The central nervous system disease of narcolepsy can also cause a sudden muscle tone loss known as cataplexy. (ghostbed.com)
A sudden loss of solid tone or strength known as cataplexy might be welcomed in major areas of strength like fury, bliss, or joy. (fastnewsmagazine.com)

Our attention then turned to the early onset of REM sleep documented on her polysomnogram (Figure) and to the history suggestive of recent cataplexy episodes. (thoracic.org)
The diagnosis of cataplexy follows a clinical examination with emphasis on the description of the episodes of muscle weakness. (steptohealth.com)
The patients have recurrent episodes of hypersomnia, which are often associated with compulsive overeating and hypersexuality. (medscape.com)
Cataplexy is sudden episodes of partial or complete paralysis of voluntary muscles, triggered by emotional stimulation [ 2 ]. (pfmjournal.org)
Patients may also experience sleep attacks-episodes of sleep that strike without warning. (msdmanuals.com)
Episodes of cataplexy usually last just a few seconds, and they may occur from several times a day to a few times a year. (medlineplus.gov)
Most of the signs and symptoms persist throughout life, although episodes of cataplexy may become less frequent with age and treatment. (medlineplus.gov)
In more severe cases, narcolepsy is accompanied by episodes of cataplexy. (ancientgreecereloaded.com)
Episodes of cataplexy may even be risky. (ancientgreecereloaded.com)

Cataplexy caused by narcolepsy might be disregard as distal muscle weakness of CMT1. (nel.edu)

A single case report study indicates that HF rTMS over the left DLPFC might represent an alternative choice for symptom control in narcoleptic patients with cataplexy, and a pilot study also raises the possibility of therapeutic benefits from rTMS in patients with sleep bruxism. (tmssolutions.com)

Seventy-five patients diagnosed with NC were assessed by a structured interview (focused on RBD manifestations and the use of antidepressants) and night video-polysomnography followed by the multiple sleep latency test. (nel.edu)
Generally, narcoleptic persons have a REM latency of fewer than 8 minutes. (steptohealth.com)

Polysomnography is one of the most commonly used studies in the diagnosis of narcolepsy associated with cataplexy. (steptohealth.com)

Cataplectic facies is an unusual facial feature only recently described in children with narcolepsy with cataplexy, usually at disease onset. (medscape.com)

Cataplexy is a sudden muscular weakness triggered by an intense emotional experience, usually laughter. (barkersleep.com)

Most people diagnosed with narcolepsy also have cataplexy. (medlineplus.gov)

Loss of muscle tone and weakness, conditions linked to neurological and psychiatric disorders such as cataplexy, lead to the sudden loss of control over the musculature. (steptohealth.com)
Firstly, Cataplexy is a condition linked to narcolepsy, a chronic pathology characterized by sleep disorders and generalized weakness . (steptohealth.com)
The individual might feel appendage weakness, slurred discourse, or even breakdown during a cataplexy episode. (fastnewsmagazine.com)
This chronic condition of central nervous system has such nasty symptoms as feeling of weakness, cataplexy and sudden urges to sleep which can not be stopped by mobilization of will or physical efforts. (treatnarcolepsy.com)
Have received an NT1 diagnosis within the past 10 years or are experiencing NT1 symptoms (characterized by cataplexy, or the sudden loss of muscle control and muscle weakness due to strong emotions or actions, like anger or laughter, while remaining conscious). (hypersomniafoundation.org)
Some people also experience cataplexy, or the sudden weakness of muscles throughout the body, which can lead to a complete collapse or even paralysis of the individual, while for the most part it only results in apparent or less apparent weakening and slouching of the muscles. (buyonlinerx.com)

Zimelidine was reported by Montplaisir and Godbout to be very effective for cataplexy in 1986, back when this was usually controlled by tricyclic antidepressants, which often had anticholinergic effects. (wikipedia.org)
Antidepressants substantially affect basic REM sleep characteristics in narcolepsy-cataplexy patients. (nel.edu)
Antidepressants substantially affect REM sleep characteristics and trigger manifestations of REM sleep behavior disorder (RBD) in the general, non-narcoleptic, population. (nel.edu)
Antidepressants are also frequently administrated in an attempt to suppress cataplexy. (nel.edu)
We investigated the role of antidepressants in the development of RBD in narcolepsy with cataplexy (NC) patients. (nel.edu)
Busková J, Kemlink D, Ibarburu V, Nevsímalová S, Sonka K. Antidepressants substantially affect basic REM sleep characteristics in narcolepsy-cataplexy patients. (nel.edu)
Antidepressants--such as tricyclic antidepressants, selective norepinephrine reuptake inhibitors (SNRIs), and selective serotonin reuptake inhibitors (SSRIs)--are often prescribed for narcolepsy as they have been shown to treat cataplexy. (sleep-centers.com)

Longitudinal MRI data have suggested progression in narcolepsy, showing progressive corticalthinning in disease, and that such progression may become fasterin the case of patients with earlier disease onset. (pfmjournal.org)

These observations suggest that paediatric narcolepsy with cataplexy often co-occurs with a complex movement disorder at disease CBL0137 onset, a phenomenon that may vanish later in the course of the disease. (abic2004.org)
We included patients aged 65 years and older who presented with new-onset neurological and cognitive symptoms or worsening in baseline mental status. (bvsalud.org)

Narcoleptics may have extreme difficulty staying awake, often falling asleep while at work, school, home, or even while driving. (trinityhealth.com)
Narcoleptics may undergo memory problems as well, having trouble remembering things people tell them because they were not fully awake when being spoken to. (barkersleep.com)
Such patients may awake to a messy bed, as sheets are tossed aside, and bed partners complain that the patients 'run a marathon' in their sleep. (sleepmedicine.com)

In narcoleptic patients, 90% of orexin-secreting cells are destroyed, and orexin receptors are downregulated. (shortform.com)
New drugs like suvorexant (meant to block orexin at night) caused patients to fall asleep just 6 minutes faster. (shortform.com)

Patients are typically treated for several weeks to months, depending on the severity of their condition. (therapynyc.net)

This is called cataplexy (sometimes referred to as a " sleep attack ") and can even occur during wakeful states and is generally triggered by strong emotions including laughing, being surprised or even sneezing. (sleepaidguide.com)
This may occur in two thirds of sleep apnea patients. (barkersleep.com)

Cataplexy is the sudden loss of voluntary muscle control during wakefulness. (sleep-centers.com)

These patients have a positive family history, and associated clinical symptoms suggest dysfunction of the autonomic nervous system. (medscape.com)
Surveys of patient satisfaction in clinical trials for narcolepsy noted that modafinil produces a decreased sense of fatigue and an increase in mental alertness. (empowerpharmacy.com)
Further studies with larger patient samples, repeated sessions, an optimized rTMS setup, and clinical follow-up warranted to verify the initial findings, and to expand clinical and research interest towards neuromodulation in the different sleep disorders. (tmssolutions.com)
Together, they harness the full potential of biomedicine through collaborative research, education and clinical care for patients. (stanford.edu)
METHODS: In a multicentric cohort of 50 patients, we measured serum neurofilament light chain (sNfL) in relation to disease duration and disease phenotypes, applied automated MRI volumetry, and analyzed clinical characteristics. (bvsalud.org)
It is important to proficiently identify underlying factors and anticipate clinical outcomes for those patients. (bvsalud.org)
AIM: The primary objective of this study was to reveal and compare the clinical outcomes and etiologic factors of older patients with delirium, stupor, and coma. (bvsalud.org)

Some people who are chronically sleep-deprived mistakenly think they're narcoleptic. (shortform.com)
Patients with narcolepsy are typically young adults, though it can be found in children and older people. (therapynyc.net)
Narcolepsy with cataplexy affects approximately one in 2,000-3,000 people in most societies, 1 but about 80% of individuals are thought to remain undiagnosed despite recent refinements to diagnostic criteria. (touchneurology.com)
Cataplexy is also very common in people with this condition. (ghostbed.com)
Modavigil is a modern drug which alleviates all these symptoms allowing narcoleptic people to work and act just as if they were not ill. (treatnarcolepsy.com)
It isn't know whether patients experiencing rest apnea have unexpected driving encounters in comparison to the people who are solid. (fashionsgalaxy.com)
The Stanford narcoleptic dog colony, started by sleep pioneer William Dement , MD, PhD, professor of psychiatry and behavioral sciences, allowed Mignot to discover the genetic basis for canine narcolepsy and helped to enhance understanding of the human condition, which affects about 1 in 2,000 people. (stanford.edu)
Approach to the Patient With a Sleep or Wakefulness Disorder Almost half of all people in the US report sleep-related problems. (msdmanuals.com)
A 2021 study mentions that during the COVID-19 pandemic, people did not report worsening narcoleptic symptoms after discontinuing narcolepsy medication due to quarantining difficulties. (medicalnewstoday.com)
A variation of the HLA-DQB1 gene called HLA-DQB1*06:02 has been strongly associated with narcolepsy, particularly in people who also have cataplexy and a loss of hypocretins. (medlineplus.gov)
What is important to remember is that drug is extremely effective in helping people who feel drowsy battle sleep and this drug does this much better than most older stimulants which were never that beloved in the medical community, mostly for their tendency to cause addiction very quickly in patients who use them regularly. (buyonlinerx.com)

While many narcoleptics can control their symptoms, others have uncontrolled symptoms that are dangerous to themselves and their caregivers. (therapynyc.net)
Hypothesis 1and 2 were supported, but not hypothesis 3 because narcoleptics had shown lower control of affective reactionsthan non-narcoleptics. (bvsalud.org)
While there is no known cure for narcolepsy, there are some medications, including anti-depressants and stimulants, which can be used to control some of the more disturbing symptoms such as cataplexy. (sleepaidguide.com)

In cataplexy, patients aren't asleep - they're fully active but paralyzed. (shortform.com)
Restless Legs Syndrome patients often report having "creeping" or "crawling" sensations in their limbs, prior to falling asleep. (trinityhealth.com)
Patients may feel refreshed when they awaken yet fall asleep again in a few minutes. (msdmanuals.com)

Narcoleptics usually first experience this condition during childhood and early adulthood - between the ages of 10 and 25. (steptohealth.com)
Narcoleptics could experience these fantasies and battle to differentiate them from the real world. (fastnewsmagazine.com)
Narcoleptics will often experience cataplexy while laughing or when they are surprised. (barkersleep.com)

Narcolepsy with cataplexy affects about one in every 2,000 Americans. (therapynyc.net)

During a cataplectic episode, narcoleptics report a complete postural collapse and loss of muscle tonus. (therapynyc.net)

The state of cataplexy can be mild or severe. (steptohealth.com)
In addition to presenting without cataplexy, type two narcolepsy is typically less severe than type one. (sleep-centers.com)

Theobjective of this study was to assess, using the Rorschach test, affective characteristics of a sample of 16narcoleptics patients compared to 20 non-narcoleptics subjects. (bvsalud.org)

His former narcoleptic dog, Bear, predictably had sleep attacks when he saw any kind of new food, even broccoli, but Watson is a bit more variable, suffering attacks when Mignot arrives home from work or when he spots a favorite toy, Mignot said. (stanford.edu)

Another common feature of narcolepsy is cataplexy, which is a sudden loss of muscle tone in response to strong emotion (such as laughing, surprise, or anger). (medlineplus.gov)

Cataplexy occurs in more than half of patients with narcolepsy (1,2) and is highly specific for this disease (3). (thoracic.org)
Cataplexy" is another frequent problem for narcoleptics and occurs in more than two-thirds of cases. (topicsmedia.com)

2 The negative social impact of narcolepsy with cataplexy has been extensively studied, and includes impairment in driving skill, high prevalence of car, machine or domestic accidents and altered professional performance leading to unemployment, frequent changes of job, working disability and early retirement. (touchneurology.com)
Prevalence of narcolepsy with cataplexy in Norway. (nhi.no)

Numerous studies, exploring gray matter and white matter, showed distinct aspects of disease and symptoms in narcolepsy with cataplexy related to the hypothalamus, thalamus, amygdalo-hippocampus, and frontoparietal cortex. (pfmjournal.org)

alterations of the human striatal dopaminergic system in adult narcolepsy with cataplexy, and a significant impact of stimulant treatment on dopaminergic transmission (Staedt online. (abic2004.org)

However, some do not, which has led researchers to distinguish two major forms of the condition: narcolepsy with cataplexy and narcolepsy without cataplexy. (medlineplus.gov)

A really great resource with lots of scientific info about narcolepsy including the latest research, as well as other things like a medication guide, FAQs, and even a list of narcolepsy/cataplexy references in movies. (falling-asleep.com)

When Bear, the last member of Stanford's colony of narcoleptic dogs, died last year, Emmanuel Mignot , MD, PhD, professor of psychiatry and behavioral sciences, thought he was done keeping dogs with the chronic brain disorder. (stanford.edu)
Mignot, who is also the director of the Stanford Center for Sleep Sciences and Medicine , can trigger one of Watson's cataplexies by proffering certain foods, especially Whole Foods roast beef, or playing with the dog. (stanford.edu)

Narcoleptics may face difficulty doing justice to the work at hand. (ancientgreecereloaded.com)

In this review, we aimed at identifying the studies that have employed repetitive transcranial magnetic stimulation (rTMS) in patients with sleep disorders. (tmssolutions.com)
rTMS might be useful as therapeutical tool in particular in patients with PI, RLS, OSAS and narcolepsy, while its effect in other sleep disorders (ie, parasomnias) has not yet been explored. (tmssolutions.com)
Narcolepsy with cataplexy is one of the most studied sleep disorders in a number of scientific fields. (pfmjournal.org)
RESULTS: In patients with neurologic disorders associated with GAD65 antibodies, we detected elevated sNfL levels early in the disease course. (bvsalud.org)
Some of these sleep disorders can disrupt regular life and make it difficult for the patient to handle routine responsibilities. (ancientgreecereloaded.com)

Thus, the sleep dissociation theory suggests that cataplexy results from the intrusion of REM sleep during wakefulness. (steptohealth.com)

Diseases6

Chemicals and Drugs7

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Psychiatry and Psychology9

Phenomena and Processes3

Humanities1

Sleepiness27

Excessive2

Hypocretin10

Daytime6

Hallucinations7

Nocturnal2

Addition to cataplexy1

Cerebrospinal fluid1

Suffer3

Treatment of cataplexy1

Symptoms of narcolepsy2

Known as cataplexy2

Episodes9

Caused by narcolepsy1

Symptom1

Latency2

Diagnosis of narcolepsy1

Children with narcolepsy1

Muscular weakness1

Diagnosed with narcolepsy1

Weakness6

Antidepressants7

Disease onset1

Onset2

Awake3

Orexin2

Severity1

Occur2

Sudden loss of voluntary muscle1

Clinical7

People11

Control3

Asleep3

Experience3

2,0001

Cataplectic1

Severe2

Characteristics1

Attacks1

Muscle1

Occurs2

Prevalence2

Hypothalamus1

Stimulant treatment1

Researchers1

Medication1

Mignot2

Difficulty1

Disorders5

Wakefulness1