• Jazz Pharmaceuticals plc announced financial and business results for the first quarter of 2023, highlighting continued adoption of its low-sodium oxybate Xywav for narcolepsy and idiopathic hypersomnia. (legalvenoms.com)
  • Adoption of low-sodium Xywav continues to grow across both narcolepsy and idiopathic hypersomnia, and we expect Xywav to remain the oxybate of choice in 2023," says Bruce Cozadd, chairman and CEO of Jazz Pharmaceuticals, in a release. (legalvenoms.com)
  • JZP441, is a potent, highly selective oral orexin-2 receptor agonist designed to activate orexin signaling with the potential to be applicable in the treatment of narcolepsy, idiopathic hypersomnia, and other sleep disorders. (legalvenoms.com)
  • Excessive daytime sleepiness is also a core symptom of narcolepsy and essential hypersomnia (EHS), which are also heritable conditions. (nature.com)
  • Narcolepsy is considered a primary hypersomnia (excessive sleepiness) condition. (adam.com)
  • Insomnia disorder, classified in DSM-5, which in DSM-IV was described as primary hypersomnia, includes normal sleep efficiency, sleep-wake cycles, and sleep architecture. (medscape.com)
  • Narcolepsy is a sleep disorder that features excessive daytime sleepiness. (medicalnewstoday.com)
  • Excessive daytime sleepiness (including episodes of irresistible sleepiness ) combined with sudden muscle weakness are the hallmark signs of narcolepsy. (cdc.gov)
  • The defining characteristic of narcolepsy is excessive daytime sleepiness (EDS). (adam.com)
  • All people with narcolepsy can experience excessive sleepiness during the day. (adam.com)
  • Narcolepsy manifests as excessive daytime sleepiness and sudden attacks of sleep. (insuranceplanavenue.com)
  • Narcolepsy is a chronic neurological disease characterized by excessive daytime sleepiness. (differencebetween.net)
  • are insomnia and excessive daytime sleepiness. (msdmanuals.com)
  • People with insomnia or excessive daytime sleepiness are sleepy, tired, and irritable during the day and have trouble concentrating and functioning. (msdmanuals.com)
  • For people with narcolepsy, however, REM sleep occurs within 15 minutes in the sleep cycle and intermittently during the waking hours. (medicalnewstoday.com)
  • People with narcolepsy will usually have a persistent feeling of sleepiness with a tendency to doze off at intervals throughout the day, often at inappropriate times. (medicalnewstoday.com)
  • Besides EDS, people with narcolepsy type 1 also have cataplexy, which is a sudden but temporary muscle weakness, sometimes brought on by laughter or other emotions. (adam.com)
  • It is estimated that around half of people with narcolepsy in the US are not diagnosed or misdiagnosed. (adam.com)
  • Narcolepsy is a type of sleep disorder where a person feels very sleepy during the day or waking hours. (medicalnewstoday.com)
  • Narcolepsy is a chronic neurological disorder. (adam.com)
  • Aside from anxiety and depression, a number of other mental health problems can affect a person's sleeping pattern and cause insomnia including mood disorders, panic disorder, post-traumatic stress disorder and schizophrenia. (news-medical.net)
  • Fatal Familial Insomnia [1] (FFI) is a degenerative brain disorder that inhibits a person's ability to fall asleep. (sleepadvisor.org)
  • Narcolepsy is a debilitating neurological sleep/wake disorder. (sleepoz.org.au)
  • Narcolepsy is a sleep disorder characterized by the tendency to fall asleep without control. (ihatecpap.com)
  • Insomnia can be a disorder or can be a symptom of other disorders. (msdmanuals.com)
  • Narcolepsy symptom screeners can help doctors diagnose narcolepsy in people who present with daytime sleepiness. (medicalnewstoday.com)
  • Narcolepsy symptom screeners are typically self-assessments that measure a person's daytime sleepiness levels and other key symptoms of narcolepsy. (medicalnewstoday.com)
  • Narcolepsy is a long-term neurological condition that causes fragmented sleep, daytime sleepiness, brain fog, and other symptoms. (medicalnewstoday.com)
  • Medications if indicated for treatment of insomnia or daytime sleepiness. (upmc.com)
  • A narcolepsy screener helps a person self-assess their symptoms, which can help a doctor make a diagnosis or refer them to a specialist. (medicalnewstoday.com)
  • Narcolepsy symptom screeners provide doctors with information to help them make a diagnosis of narcolepsy in people who present with possible symptoms. (medicalnewstoday.com)
  • The Epworth Sleepiness Scale does not screen for narcolepsy symptoms other than sleepiness. (medicalnewstoday.com)
  • One of the most commonly used screeners is the Ullannlinna Narcolepsy Scale - an 11-question survey evaluating several symptoms a person may experience. (medicalnewstoday.com)
  • Having one of these symptoms does not necessarily mean a person has narcolepsy. (medicalnewstoday.com)
  • Hormonal changes may also lead to symptoms of narcolepsy. (medicalnewstoday.com)
  • This article outlines the symptoms, causes, and treatment options associated with narcolepsy. (medicalnewstoday.com)
  • Narcolepsy can be terribly challenging, and it's critical that both the public and professionals become better informed about its signs and symptoms. (huffpost.com)
  • Find out more from our sleep team about fatal familial insomnia, it's symptoms and how to treat it. (sleepadvisor.org)
  • In this article, we will go into detail about Fatal Familial Insomnia, including the symptoms, who is at risk, and what to do if you have it. (sleepadvisor.org)
  • According to experts, insomnia symptoms continue to worsen over time. (sleepadvisor.org)
  • The accumulation of these toxic prions can cause a decrease in nerve cells, which is what causes insomnia and associated symptoms. (sleepadvisor.org)
  • Fatal Insomnia symptoms usually begin between the ages of 40 and 60. (sleepadvisor.org)
  • According to the National Center for Advancing Translational Sciences, the following symptoms are common signs of Fatal Familial Insomnia. (sleepadvisor.org)
  • Insomnia is one of the primary symptoms of this disease. (sleepadvisor.org)
  • This is a complex decision, but our experience has been that, even when ADHD symptoms are improved by stimulants, ADHD-related insomnia will limit the effectiveness of treatment unless it too is addressed. (additudemag.com)
  • Narcolepsy is characterized by EDS with or without cataplexy (sudden and uncontrollable muscle weakness or paralysis triggered by a strong emotion), hypnagogic hallucinations, and sleep paralysis (vivid and dream-like hallucinations and muscle paralysis while falling asleep), and disturbed nocturnal sleep. (nature.com)
  • The sudden muscle weakness seen in narcolepsy may be elicited by strong emotion or surprise. (cdc.gov)
  • Xyrem net product sales decreased 28% to $178.1 million in 1Q23 compared to the same period in 2022, reflecting the continued adoption of Xywav by patients with narcolepsy and the launch of a high-sodium oxybate authorized generic in January 2023. (legalvenoms.com)
  • Insomnia includes trouble falling asleep or staying asleep. (medlineplus.gov)
  • A person with narcolepsy may fall asleep at any time, such as while talking or driving. (medicalnewstoday.com)
  • Overall, however, a person with narcolepsy usually spends the same amount of time asleep as a person without the condition. (medicalnewstoday.com)
  • Insomnia refers an inability to fall asleep or stay asleep for long enough to feel refreshed in the morning, despite adequate opportunity to sleep. (news-medical.net)
  • Insomnia is the inability to fall asleep or stay asleep when you want to. (sleepoz.org.au)
  • Insomnia, one of the most prevalent types, is characterized by the persistent difficulty falling or staying asleep. (insuranceplanavenue.com)
  • Insomnia refers to difficulty falling or staying asleep, or a perception of unrefreshing sleep. (nni.com.sg)
  • Patients with narcolepsy face the challenges of dealing with a condition that often results in falling asleep at the most inopportune time, such as during driving. (ihatecpap.com)
  • Insomnia is difficulty falling asleep or staying asleep, waking up early, or a disturbance in sleep quality that makes sleep seem inadequate or unrefreshing. (msdmanuals.com)
  • People with this type of insomnia fall asleep normally but wake up several hours later and cannot fall asleep again easily. (msdmanuals.com)
  • Sleep maintenance insomnia is more common among older people, who are more likely to have difficulty staying asleep than are younger people. (msdmanuals.com)
  • Drinking caffeinated drinks such as tea and coffee or smoking can also increase the risk of insomnia because caffeine and nicotine are stimulants. (news-medical.net)
  • More often, the insomnia remains but doesn't worsen on stimulants, just as it has for my kids. (additudemag.com)
  • Health care providers may treat chronic insomnia with a combination of use of sedative-hypnotic or sedating antidepressant medications, along with behavioral techniques to promote regular sleep. (cdc.gov)
  • The healthcare provider may treat narcolepsy with stimulant medications combined with behavioral interventions, such as regularly scheduled naps, to minimize the potential disruptiveness of narcolepsy on the individual's life. (cdc.gov)
  • According to clinical psychologists specializing in Cognitive Behavioral Therapy for Insomnia (CBT-I), this form of therapy can offer substantial relief for these conditions. (insuranceplanavenue.com)
  • The best treatment for insomnia is cognitive-behavioral therapy, which includes changes in behavior to improve sleep. (msdmanuals.com)
  • Narcolepsy can range in severity from mild to severe. (medicalnewstoday.com)
  • Depression can affect a person's ability to sleep and the risk of severe insomnia is significantly higher among people with major depressive disorders. (news-medical.net)
  • Narcolepsy, which can occur in children and adults, ranges from mild to severe and is sometimes associated with traumatic brain injury. (huffpost.com)
  • This phenomenon, known as depression-induced insomnia or anxiety associated with disturbed slumber patterns, bears significant influence on an individual's well-being and overall quality of life. (insuranceplanavenue.com)
  • Research has also shown that insomnia can lead to depression or worsen it. (news-medical.net)
  • For many years, insomnia drugs, especially for sleep-onset insomnia, have been seen as sleep-promoting agents, said Mihael H. Polymeropoulos, MD, president, CEO, and chairman of the board of Vanda Pharmaceuticals Inc, during the company's second quarter earnings conference call. (sleepreviewmag.com)
  • Polymeropoulos said, "It may be that a large number of patients who appear to have sleep onset insomnia, they actually have a change in their sleep schedule….This is perhaps why the drug has worked very well in the 4-week insomnia study. (sleepreviewmag.com)
  • Even once the event has passed, an affected individual may still experience insomnia because they have started to associate bedtime with having thoughts that make them anxious. (news-medical.net)
  • Although many folks experience insomnia, most are able to get some amount of shut-eye. (sleepadvisor.org)
  • In my experience, insomnia-induced ADHD isn't common, but I have referred two dozen teens and young adults for sleep studies to avoid misdiagnosing them. (additudemag.com)
  • Episodes of narcolepsy have been described as "sleep attacks" and may occur in unusual circumstances, such as walking and other forms of physical activity. (cdc.gov)
  • Vanda is preparing for the submission of a supplemental New Drug Application (sNDA) for HETLIOZ in the treatment of insomnia. (sleepreviewmag.com)
  • There is currently no cure for narcolepsy, but medical treatment and lifestyle tips may help. (medicalnewstoday.com)
  • First, many if not most persons with narcolepsy (PWN) remain undiagnosed and, therefore, are not receiving the treatment and support they need. (huffpost.com)
  • Treatment for ADD-related insomnia begins with a stimulant, however medication sometimes exacerbates the problem. (additudemag.com)
  • There is no definitive treatment for narcolepsy. (differencebetween.net)
  • For many others, insomnia predates stimulant use, which is another reason to assess sleep problems before any medication is prescribed. (additudemag.com)
  • We find the Daytrana patch helpful for those with stimulant-induced insomnia, because it's the only medication that can be shut off early (by removing the patch). (additudemag.com)
  • Changes in a person's sleep routine due to shift changes at work or jet lag can also contribute to insomnia. (news-medical.net)
  • A number of underlying health conditions may also affect sleeping patterns and cause insomnia. (news-medical.net)
  • Findings indicate that ADHD and narcolepsy are genetically related, and there are possible common underlying biological mechanisms for this relationship. (nature.com)
  • Primary insomnia is not directly related to the presence of any other health problems, while secondary insomnia arises as a result of another factor such as depression, anxiety, arthritis, heartburn or the use of substances such as drugs or alcohol, for example. (news-medical.net)
  • Therefore, anxiety and insomnia can feed each other, creating a vicious cycle that often requires intervention to break. (news-medical.net)
  • It specifically targets the thoughts and behaviors that prevent individuals from sleeping well, and is particularly effective in treating depression-induced insomnia and anxiety-related sleep disorders. (insuranceplanavenue.com)
  • Insomnia is characterized by an inability to initiate or maintain sleep. (cdc.gov)
  • Insomnia is characterized by the inability to sleep and may be classified as transient, intermittent, and chronic. (ihatecpap.com)
  • But the company's clinical trial results of HETLIOZ (tasimelteon) for insomnia suggest that circadian misalignment may be the etiology behind chronic primary insomnia for many patients. (sleepreviewmag.com)
  • The narcolepsy is with unknown etiology. (differencebetween.net)
  • There were approximately 9,050 narcolepsy patients taking Xywav exiting Q1. (legalvenoms.com)
  • The benefits of reducing sodium intake resonate with patients and prescribers as the large majority of new-to-oxybate narcolepsy patients continue to be prescribed Xywav. (legalvenoms.com)
  • Polymeropoulos cited a trial in which chronic primary insomnia patients were randomized to receive either 20 mg or 50 mg of tasimelteon or placebo over the course of four weeks. (sleepreviewmag.com)
  • Genetically, most patients with type 1 narcolepsy and many patients with type 2 narcolepsy carry HLA-DQB1*06:02. (adam.com)
  • Patients with persistent insomnia should be evaluated by a physician to rule out underlying depression, which often presents with early morning waking. (nni.com.sg)
  • Most patients with insomnia can be managed with lifestyle modifications and medication, and do not usually need a sleep study. (nni.com.sg)
  • PMS patients often suffer from insomnia as well. (ihatecpap.com)
  • One recent study conducted in Japan demonstrated that the relative risk of narcolepsy in affected first-degree family members is 10- to 40-fold higher than in the general population, suggesting that genetic factors play an important role in this disease 12 . (nature.com)
  • Scientists officially named this rare disease Fatal Familial Insomnia in 1986. (sleepadvisor.org)
  • Insomnia is described as either primary or secondary insomnia. (news-medical.net)
  • Upper airway infections from strep or influenza may trigger narcolepsy. (adam.com)
  • Stressful events such as the loss of a loved one, financial problems or problems at work can trigger insomnia in some people. (news-medical.net)
  • Polymeropoulos said Vanda has evidence to support two insomnia-related indications: transient insomnia based on phase advance and chronic insomnia characterized by difficulties with sleep onset. (sleepreviewmag.com)
  • Environmental factors that can contribute to insomnia include an uncomfortable bed, hot or cold temperature and a room that is too bright or noisy. (news-medical.net)
  • The prevalence of ADHD in individuals with narcolepsy is (~35%) 9 higher than in the general population (~5%) 10 . (nature.com)