Kinetically and thermodynamically controlled one-pot growth of goldnanoshells with NIR-II absorption for multimodal imaging-guided photothermal therapy. (bvsalud.org)
Silica core1
Nanoshells consist of a dielectric silica core covered with a thin shell of gold. (chemistryworld.com)
Nanorods2
A series of nanoparticles: nanoshells, nanorods, core-corona nanoparticles and hollow nanoshells, were synthesized and examined to compare their properties and suitability as photothermal agents. (mdpi.com)
Gold nanoparticles, especially nanorods, nanoshells and nanoplates, absorb strongly in the near-infrared (NIR) region of the spectrum, generating localized heat. (materialstoday.com)
Gold25
A nanoshell, or rather a nanoshell plasmon, is a type of spherical nanoparticle consisting of a dielectric core which is covered by a thin metallic shell (usually gold). (wikipedia.org)
A state of the art method for synthesizing goldnanoshells is the use of the Microfluidic Composite Foams. (wikipedia.org)
The reason this method is revolutionary is that the size and relative thickness of the goldnanoshell can be controlled by changing the amount of time the reaction is allowed to take place as well as the concentration of the plating solution. (wikipedia.org)
Metal nanoshells having a dielectric core with a thin gold layer are generating new interest due to the unique optical, electric and magnetic properties exhibited by the local field enhancement near the metal - dielectric core interface. (degruyter.com)
Taking advantage of the characteristic near-infrared transparency window of many biological systems, i.e. the low light absorption coefficient of biological systems between 750−1100 nm, we were able to identify a 100−150 nm diameter barium titanate-gold nanoshell inside the h9c2 mouse cells. (degruyter.com)
5] Lin A.W.H., Halas N.J., Drezek R.A., Optically tunable nanoparticle contrast agents for early cancer detection: model-based analysis of goldnanoshells, J. Biomed Opt. (degruyter.com)
15] Le D., SURE Project, Spectroscopic Characterization of Silica-Gold Nanoshells, available at http://www.cmmp.ucl. (degruyter.com)
Now, a team of investigators from The Methodist Hospital, Baylor College of Medicine, and The University of Texas M. D. Anderson Cancer Center have found that goldnanoshells can be used to deliver just a little heat to breast tumor cells already treated with radiation, boosting the killing power of both therapies. (nanowerk.com)
Indeed, as the investigators report in the journal Science Translational Medicine ( 'Thermal Enhancement with Optically Activated GoldNanoshells Sensitizes Breast Cancer Stem Cells to Radiation Therapy' ), the combination therapy not only shrank the tumors but dramatically decreased the population of cancer stem cells. (nanowerk.com)
In this case, the goldnanoshells, which are 100-nanometer silica spheres with gold shells, invade the tumor through the leaky blood vessels that provide it nourishment. (nanowerk.com)
The use of goldnanoshells with heating and radiation could eliminate cancer stem cells as well as the bulk of the tumor, which may improve survival in women with breast cancer," said Chang. (nanowerk.com)
In a preclinical model of mouse xenografted with human renal cancer, we analysed the bio-distribution of a single dose (160 μg/kg) intravenously injected of poly-ethylene glycol (PEG)ylated goldnanoshells (~150 nm), in blood, normal and tumoral tissues. (springer.com)
In addition, goldnanoshells did not induce any tissue damage, such as necrosis, inflammatory infiltrate or fibrosis in mouse liver, spleen, kidney or bone marrow after 6 months. (springer.com)
Dark field microscopy showed gold particles within the vessel lumen 5 to 30 min after nanoshell injection, while 24 h later, gold particle distribution was mainly intracellular. (springer.com)
In conclusion, no toxicity was observed in mice 6 months after administration of PEGylated goldnanoshells and the distribution kinetics progressed from intravascular flow at 30 min to intratumoral cells 24 h later. (springer.com)
Large-sized gold nanoparticles (NPs) such as nanoshells about 150 nm in diameter are also promising tools for imaging and therapeutic approaches in cancer [ 2 ]. (springer.com)
We performed a sequential analysis of uptake and distribution of large-sized PEGylated goldnanoshells and focussed the study on their intracellular distribution in the xenografted human cancers, as well as on their long-term tolerance in normal mouse organs. (springer.com)
Improved in vivo targeting of BCL-2 phenotypic conversion through hollow goldnanoshell delivery. (oregonstate.edu)
We demonstrate a method that confronts both of these issues with the light-activated delivery of a Bcl-2 functional converting peptide, NuBCP-9, using hollow goldnanoshells. (oregonstate.edu)
To demonstrate the practical feasibility of this idea, the researchers developed nanoshells that consisted of 120nm-diameter silica particles surrounded by a 10nm-thick gold shell. (chemistryworld.com)
Here, we propose a seed -mediated successive growth approach to produce goldnanoshells on the surface of the nanoscale metal-organic framework (NMOF) of UiO-66-NH2 (UiO = the University of Oslo) in one pot. (bvsalud.org)
The goldnanoshells propagate through a well-oriented and controllable diffusion growth pattern (points â facets â octahedron), which has not been identified. (bvsalud.org)
Owing to such superior performance, these goldnanoshells show promising outcomes in photoacoustic (PA), computed tomography (CT), and photothermal imaging-guided photothermal therapy (PTT) for breast cancer , as demonstrated both in vitro and in vivo. (bvsalud.org)
Meanwhile, they are collaborating with researchers at MD Anderson Cancer Center in Texas who are using the goldnanoshells Halas invented to treat malignant tumors. (radiologytoday.net)
We demonstrate a strategy for label-free protein detection through monitoring the Surface Enhanced Raman Spectrum of an aptamer probe attached to a goldnanoshell . (rsc.org)
Plasmon4
These nanoshells involve a quasiparticle called a plasmon which is a collective excitation or quantum plasma oscillation where the electrons simultaneously oscillate with respect to all the ions. (wikipedia.org)
These nanoshells possess strong, highly tunable local plasmon resonances with frequencies dependent upon the nanoshell shape and core material. (degruyter.com)
Using the attained correct shell polarizability, we questioned the conclusion of the surface plasmon resonances of aluminum metal nanoshells that could be tuned into the near-infrared region in previous research. (rsc.org)
More importantly, the new reliable parameters are successfully searched to achieve controllable surface plasmon resonances of aluminum nanoshells, such as tuning into the near-infrared regime, based on the Mie theory. (rsc.org)
Hyperthermia2
Ms. Atkinson repeated her experiment with different kinds of tumor cells and was about to publish her data when she learned of a group at M.D. Anderson that used nanoshells to deliver hyperthermia and to sensitize tumors to radiation therapy. (nanowerk.com)
These original studies had demonstrated hyperthermia delivered through nanoshells increases perfusion of tumors with oxygen and also focally disrupts the blood supply to tumors, both of which enhance the effectiveness of radiation. (nanowerk.com)
Plasmonic1
This method has the potential to replace the standard lithographic method of synthesizing plasmonic nanoshells. (wikipedia.org)
Halas3
The discovery of the nanoshell was made by Professor Naomi J. Halas and her team at Rice University in 2003. (wikipedia.org)
3] Jackson J.B., Westcott S.L., Hirsch L.R., West J.L., Halas N.J., Controlling the Surface Enhanced Raman Effect via the Nanoshell Geometry.Appl. (degruyter.com)
Two decades ago, Halas invented nanoshells, layered nanoparticles that are about 20 times smaller than a red blood cell. (radiologytoday.net)
Antibodies2
In the field of cancer, the possibility to link antibodies to nanoshells using PEG enables the use of these biocompatible nanoshells for the delivery of drugs to targeted tumor cells. (springer.com)
Dietz's team had previously decorated the DNA nanoshells with antibodies that could grab viruses and stop them from infecting cells. (statnano.com)
Nanoparticles2
Researchers have previously decorated nanoparticles with heparan sulfate derivatives to snag viruses, and Jackman says that it would be useful to compare their performance with that of the new nanoshells. (statnano.com)
She found a way of loading conductive metal and nonconductive silica into nanoshells and concentric layered nanoparticles called nanomatryoshkas, named after the Russian nesting dolls. (radiologytoday.net)
Particles1
When the researchers combined roughly equivalent numbers of nanoshells and human papilloma virus particles on a surface, they saw that the shells could capture more than 90% of the virus particles. (statnano.com)
Tumor1
Using inductively coupled plasma mass spectrometry (ICP-MS), dark field and electron microscopy, we performed a sequential study of nanoshell uptake and distribution in the tumor. (springer.com)
Rice University2
By taking advantage of nanoshells' optical properties, researchers from Rice University, Houston, US, have developed a method to simultaneously image and kill cancer cells. (chemistryworld.com)
This ability led a team of Rice University bioengineers, headed by Rebekah Drezek, to wonder whether nanoshells could be used to both diagnose and treat cancer. (chemistryworld.com)
Mice3
The Baylor and M.D. Anderson groups decided to collaborate to determine what effect heat delivered by the nanoshells would have in highly resistant tumors in mice. (nanowerk.com)
They have already successfully demonstrated the separate imaging and therapy aspects of the nanoshells, and are now evaluating their combined ability to diagnose and treat cancer in mice. (chemistryworld.com)
Monferrer says that they plan to test such nanoshells in mice, as part of a consortium of European academic scientists called Virofight. (statnano.com)
Researchers4
The researchers used a near-infrared laser to heat the nanoshells for about 20 minutes. (nanowerk.com)
The researchers' basic idea was to use the nanoshells' ability to scatter light as a means to identify cancer cells and then use their ability to absorb light to destroy the cells, by heating them. (chemistryworld.com)
Incubating these nanoshells with breast cancer cells in vitro , the researchers discovered the nanoshells would naturally surround the cancer cells, causing them to light up so they could be detected using a microscope sensitive to scattered light. (chemistryworld.com)
In humans, it's likely that natural immune pathways would eventually break the nanoshells down, along with their virus cargo, the researchers say. (statnano.com)
He adds that it is now important to determine whether the nanoshells can actually sequester viruses in living organisms. (statnano.com)
Metal1
The synthesized nanoshell material is spray-painted in Chen's lab onto a metal substrate for thermal and mechanical testing. (phys.org)
Surface1
The resulting liquid has a layer of oil on the surface with a solution below that contains the nanoshells. (wikipedia.org)
Cancer1
They then irradiated the nanoshells with a NIR laser for seven minutes, after which they stained the breast cancer cells for viability and found that the vast majority had been killed. (chemistryworld.com)
Optical1
In this paper, we developed a theoretical, numerical and experimental approach based on a scanning near optical microscope to identify nanoshells inside mouse cells. (degruyter.com)
Materials1
The synthesis and characterization of two such value added carbon materials, graphite and multi-wall graphene nanoshells (MGNS), is presented in this thesis. (gwu.edu)
Advantage1
The advantage of the nanoshells is that you are not heating the whole mouse," said Dr. Rosen. (nanowerk.com)
Approach1
Few existing small-molecule drugs are active against multiple viruses, so these nanoshells might offer an alternative approach to developing broad-spectrum antiviral agents, says Alba Monferrer, part of the Technical University of Munich team that created the shells. (statnano.com)
Light2
Nanoshells can be varied across a broad range of the light spectrum that spans the visible and near infrared regions. (wikipedia.org)
They then showed that nanoshells with these specific dimensions are able to scatter and absorb light in the near infra-red (NIR), which is the wavelength of light that is most efficient at passing through bodily tissue. (chemistryworld.com)
Material1
Jin, along with professor Zhaowei Liu of the department of Electrical and Computer Engineering, and Mechanical Engineering professor Renkun Chen, developed the Silicon boride-coated nanoshell material. (phys.org)
Our recent research is focused on hex-Ge/SiGe nanoshells which feature type I band alignment. (lu.se)
Cells2
Adding just a little heat - from 37 degree C (98.6 degrees F) to 42 degrees C (107.6 degrees F) - via the nanoshells reduced the population of stem cells dramatically. (nanowerk.com)
Electron microscopy identified nanoshells within blood vessels at 5 and 30 min, within endothelial cells at 3 and 6 h and within cytoplasms of macrophages in the tumoral tissue after 24 h. (springer.com)