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  • membrane
  • The team reports* it has learned how to decode the electrical signals generated by a nanopore""a "gate" less than 2 nanometers wide in an artificial cell membrane. (redorbit.com)
  • Inside each coffee-grinder-sized machine is a plastic membrane containing a single flexible nanopore - a tiny hole which can be "tuned" by stretching and relaxing the plastic to allow particles of different sizes to pass through one-at-a-time. (macdiarmid.ac.nz)
  • A nanopore is a small hole in an electrically insulating membrane, that can be used as a single-molecule detector. (phys.org)
  • To achieve this, the team created a nanopore - a nanoscale sized opening in an ultrathin membrane - through which a single DNA molecule can pass when an electric field is applied to the microfluidics containing the device. (boisestate.edu)
  • detection
  • While current technologies rely on expensive fluorescent labels, optical equipment for signal detection and informatics to translate image data into sequence data, nanopores bypass the optical detection by providing a direct electrical recording of DNA base identification. (nanoporetech.com)
  • University of Ottawa researchers have developed an electrical method for fabricating solid-state nanopores based on a phenomenon called dielectric breakdown - an approach that they are touting as fast, affordable, and easily applicable within the context of existing solid-state detection systems. (genomeweb.com)
  • Here, we show that solid-state nanopores can be combined with silicon nanowire field-effect transistors to create sensors in which detection is localized and self-aligned at the nanopore. (nature.com)
  • semiconductor
  • This work brings us one step closer to realizing these nanopores as a powerful diagnostic tool for medical science," says Joseph Reiner, who performed the work with Joseph Robertson, and John Kasianowicz, all of NIST's Semiconductor Electronics Division. (redorbit.com)
  • interactions
  • In this paper, we investigate the conditions for the microemulsion droplet penetration into model nanopores, identify the penetration mechanisms and, following their penetration, analyze their interactions with model organic and inorganic walls, and study their behavior in confinement. (onepetro.org)
  • polymer
  • The study of the transport of ionic species through nanopores is a subject of wide interest covering several diverse fields such as biophysics, electrochemistry and polymer science. (nsti.org)
  • In the present investigation we focus our attention upon the transport of protons through the hydrated nanopores of polymer electrolyte membranes, the separator in a PEM fuel cell. (nsti.org)
  • membranes
  • The nanopores in these membranes are often characterized by the presence of pendant groups carrying negative charges, in sulfonic acid based ionomers due to the presence of ions. (nsti.org)
  • Solid-state nanopores are generally made in silicon compound membranes, one of the most common being silicon nitride. (phys.org)
  • Measurements
  • Using a combination of nanofabrication techniques, nanopore electrical measurements, atomic force microscopy imaging and all-atom simulations carried out on XSEDE supercomputer resources, the team's interdisciplinary approach has extended the practical use of solid-state nanopores to a new area of cancer research. (boisestate.edu)
  • antimicrobial
  • This presentation will review methods for which Nanopore sequencing and real-time antimicrobial resistance gene analysis can help to address the threat of CRO as a diagnostic tool in the Medical Microbiology Laboratory. (nanoporetech.com)
  • These applications of nanopore sequencing in the hospital setting has the potential to impact infection control and antimicrobial stewardship initiatives. (nanoporetech.com)
  • proteins
  • More recently, NIST scientists turned their attention to using nanopores to identify, quantify and characterize each of the more than 20,000 proteins the body produces""a capability that would provide a snapshot of a patient's overall health at a given moment. (redorbit.com)
  • Quantum tunneling detectors could reduce the cost and increase the scale of nanopore sequencing, but they require nanopores that are fabricated from synthetic materials, rather than proteins, which have already been shown to be optimizable and reliable nanopore components. (genengnews.com)
  • Moreover, SDS-treated proteins translocate through the nanopore in the direction prescribed by the electrophoretic force due to the negative charge impaired by SDS. (rsc.org)
  • passes
  • As late as 2015, tunneling developers were still striving to achieve single-base resolution by controlling how quickly the DNA passes through the nanopore. (genengnews.com)