• in their book Lipid Nanoparticles: Production, Characterization and Stability discuss these in detail. (wikipedia.org)
  • A lipid nanoparticle is typically spherical with an average diameter between 10 and 1000 nanometers. (wikipedia.org)
  • This research line has extensive experience in the use of polymeric nanoparticles with biodegradable and biocompatible properties as drug delivery systems and is focused on the preclinical development of numerous nanotherapeutic platforms as drug delivery systems for various diseases or pathophysiological conditions including chronic pain, endometrial, prostate and colorectal cancer, as well as muscular dystrophies. (cedenna.cl)
  • In this context, the inhibition of glial cells by pentoxifylline-loaded nanoparticles, the inhibition of pannexin channels by carbenoxolone, probenecid or 10panx administered in polymeric nanoparticles, or the use of drug delivery systems with ketamine to perform NMDA channel inhibition, are some of the strategies developed for the management of chronic pain. (cedenna.cl)
  • In vitro release studies of the antigen from PLGA:poloxamer and CS-coated PLGA:poloxamer nanoparticles were performed in water containing the bacteriostatic agent thimerosal, at a concentration of 5 µg/ml. (medscape.com)
  • Aliquots (1 ml) of rHBsAg-loaded PLGA:poloxamer and CS-coated PLGA:poloxamer nanoparticles suspensions (2 mg/ml) were freeze-dried in the presence of trehalose or sucrose as cryoprotectants at a concentration of 1, 2.5 or 5% (w/v). Therefore, the cryoprotectant:nanoparticle weight ratios were 5:1, 12.5:1 or 25:1, respectively. (medscape.com)
  • The stability of rHBsAg within PLGA:poloxamer and CS-coated PLGA:poloxamer nanoparticles as an aqueous suspension and as a lyophilized product was investigated. (medscape.com)
  • Furthermore, the stability of antigen-loaded PLGA:poloxamer and CS-coated PLGA:poloxamer nanoparticles in the freeze-dried form was investigated. (medscape.com)
  • Percentage of antigenically active rHBsAg that remained associated to PLGA:poloxamer and chitosan-coated PLGA:poloxamer nanoparticles after storage at 4°C for 14 days or after freeze-drying in the presence of 2.5 % (w/v) trehalose. (medscape.com)
  • citation needed] The conventional approaches such as use of permeation enhancers, surface modification, prodrug synthesis, complex formation and colloidal lipid carrier-based strategies have been developed for the delivery of drugs to intestinal lymphatics. (wikipedia.org)
  • In this study, we report a preclinical development process of the carrier-free prodrug nanoparticles designed as an alternative formulation to overcome limitations of conventional nanomedicines in the terms of technical- and industrial-aspects. (ewha.ac.kr)
  • Conclusions: Collectively, these results provide potential preclinical development process of an alternative approach, new formulation of carrier-free prodrug nanoparticles, for clinical translation of nanomedicines. (ewha.ac.kr)
  • F. Nguyen, I. Alferiev, P. Guan, D.T. Guerrero, V. Kolla, G.S. Moorthy, M. Chorny*, G.M. Brodeur*: Enhanced intratumoral delivery of SN38 as a tocopherol oxyacetate prodrug using nanoparticles in a neuroblastoma xenograft model. (chop.edu)
  • 10. Antitumor activity of gemcitabine hydrochloride loaded lipid polymer hybrid nanoparticles (LPHNs): In vitro and in vivo. (nih.gov)
  • and development of high-strength PLA polymer films with lignin nanoparticles to improve the fixation of natural pesticides such as cinnamaldehyde. (cedenna.cl)
  • Concentration of polymer (%) (Poloxamer 407), concentration of gelling agent (%) HPMC and stirring speed (rpm) were selected as a independent variables, whereas viscosity(mpa), drug release (%) and gelation time (sec) were selected as a dependent variables. (jclmm.com)
  • Tissue slice model of human lung cancer to investigate telomerase inhibition by nanoparticle delivery of antisense 2'-O-methyl-RNA. (shengsci.com)
  • One possible approach involves encapsulation of water-soluble or -insoluble X-ray contrast agents in various nanoparticle carriers ( 1 , 8 , 10 , 11 ). (nih.gov)
  • In this review, the current state of the art in the encapsulation of carotenoids and coenzyme Q10 in lipid nanoparticles to improve their bioavailability, chemical stability, and skin absorption is discussed. (mdpi.com)
  • Aqueous suspensions of nanoparticles were stored for 14 days and after this time, the nanoparticles were isolated by centrifugation (40 min, 10,000 × g, 15°C), resuspended in ultrapure water and degraded, as previously described. (medscape.com)
  • 2. Design and evaluation of an intravesical delivery system for superficial bladder cancer: preparation of gemcitabine HCl-loaded chitosan-thioglycolic acid nanoparticles and comparison of chitosan/poloxamer gels as carriers. (nih.gov)
  • In order to overcome this limit, our attention focused on the development of innovative AST-loaded stealth lipid nanoparticles (AST-SSLNs) able to improve AST bioavailability in the brain. (nih.gov)
  • This mild medium was selected in order to ensure the stability of the colloidal carrier during the study. (medscape.com)
  • PACkET formed through controlled precipitation loaded ~30% enzyme and protected it from proteolytic degradation, whereas attachment of PECAM monoclonal antibodies to surface of the enzyme-loaded carriers, achieved without adversely affecting their stability and functionality, provided targeting. (nih.gov)
  • With the intrinsic merits of stability, biocompatibility, low immunogenicity, and large capacity, EVs are widely regarded as effective carriers of drug delivery. (thno.org)
  • Due to their unique size-dependent properties, lipid nanoparticles offer the possibility to develop new therapeutics. (wikipedia.org)
  • Although these nanoparticle carriers are naturally taken up by the reticuloendothelial system, they can be modified with specific targeting moieties to increase the affinity of nanoparticles for target tissues, organs, and cells ( 1 , 11-13 ). (nih.gov)
  • Extracellular vesicles (EVs), of which exosomes are a representative subgroup, are naturally secreted nanoparticles with a variety of payloads. (thno.org)
  • Nanoparticle contrast media have also been developed to improve the circulation time and target specificity of contrast agents ( 8 , 9 ). (nih.gov)
  • Due to the large ratio of surface area to volume, excellent biocompatibility, and prolonged circulation time, artificially assembled nanoparticles are considered a fascinating carrier, bringing about revolutionary changes in treatment. (thno.org)
  • Dr. Luis Constantil focuses his research on understanding the neurophysiology of pain and developing new therapeutic strategies based on drug-loaded nanoparticles for the relief of chronic pain. (cedenna.cl)
  • They are a novel pharmaceutical drug delivery system (and part of nanoparticle drug delivery), and a novel pharmaceutical formulation. (wikipedia.org)
  • LNPs became more widely known in late 2020, as some COVID-19 vaccines that use RNA vaccine technology coat the fragile mRNA strands with PEGylated lipid nanoparticles as their delivery vehicle (including both the Moderna and the Pfizer-BioNTech COVID-19 vaccines). (wikipedia.org)
  • Here we describe Protective Antioxidant Carriers for Endothelial Targeting (PACkET), the first carriers capable of targeted endothelial delivery of both catalase and SOD. (nih.gov)
  • R. Iyer, J. L. Croucher, M. Chorny, J. L. Mangino, I. S. Alferiev, R. J. Levy, V. Kolla, G. M. Brodeur, Nanoparticle delivery of an SN38 conjugate is more effective than irinotecan in a mouse model of neuroblastoma. (chop.edu)
  • M. Chorny, I. Fishbein, J. E. Tengood, R. F. Adamo, I. S. Alferiev, R. J. Levy, Site-specific gene delivery to stented arteries using magnetically guided zinc oleate-based nanoparticles loaded with adenoviral vectors. (chop.edu)
  • Recent advances on chitosan-based micro-and nanoparticles in drug delivery. (jclmm.com)
  • Extracellular vesicles (EVs), including microvesicles (MVs) and exosomes or exosome-like vesicles (ELVs), have been used as effective carriers in drug delivery with remarkable capability to extravasate through vessel fenestrations and move through extracellular matrix [ 5 ]. (thno.org)
  • This review highlights recent development of non-viral carrier based CRISPR system delivery to achieve gene editing in various immune cells for enhanced immunotherapy. (rsc.org)
  • abstract: UNLABELLED:This work describes innovative niosomes, composed of diolein alone or in association with the hydrophilic penetration enhancer Labrasol(®), as carriers for cutaneous drug delivery. (shengsci.com)
  • Nanoparticles delivery of oligonucleotides represents a potential approach for cancer treatment. (shengsci.com)
  • Punasiya R, Joshi A, Gupta S, Punasiya J. Transfersomes- A Novel Carrier for Transdermal Drug Delivery. (rjpdft.com)
  • In additon, the nanoparticles were degraded for further evaluation of the structural integrity of the associated antigen by western blot. (medscape.com)
  • In this study, nanostructured lipid carriers (NLC) were developed and employed to obtain in situ thermosensitive formulations for the ductal administration and prolonged retention of drugs as a new strategy for breast cancer local treatment. (pharmaexcipients.com)
  • The present study revealed that ionic gelation technique followed by sonication can be used as an effective tool for preparation of Capecitabine nanoparticles. (ijprt.org)
  • Reconstituted nanoparticles were analyzed for their physicochemical properties (size, PDI and zeta potential) and the ability to preserve the antigenicity and structural integrity of the associated antigen were evaluated by ELISA and western blot, respectively. (medscape.com)
  • J. E. Tengood, I. S. Alferiev, K. Zhang, I. Fishbein, R. J. Levy, M. Chorny, Real-time analysis of composite magnetic nanoparticle disassembly in vascular cells and biomimetic media. (chop.edu)
  • Also, Prof. Constandil, in collaboration with Monash University, has worked on pH-sensitive nanoparticles capable of blocking theintracellular NK1 receptor with the neurokinin receptor antagonist (aprepitant), achieving publication in the prestigious journal Nature Biotechnology. (cedenna.cl)
  • Another current line of research is a collaborative project with the company Biofresco Ltda, related to the loading of MgO2-PEG nanoparticles with maqui and celery plant extracts for the treatment of endometrial cancer and leiomyomas. (cedenna.cl)
  • Biological lipids having minimum carrier cytotoxicity and the solid state of the lipid permit better controlled drug release due to increased mass transfer resistance. (wikipedia.org)
  • Miller SC, Donovan MD. Effect of poloxamer 407 gel on the miotic activity of pilocarpine nitrate in rabbits. (jclmm.com)
  • However, several shortcomings, such as low drug loading capacity, low tumor targeting, difficulty in mass production and potential toxicity of carrier materials, have hindered the successful clinical translation of nanomedicines. (ewha.ac.kr)