Bovine Serum APolymeric nanoparticlesPaclitaxelCharacterizationProteinsBiopolymer-based nanoparticlesDesolvation methodSatisfactory physicochemicalDoxorubicinMorphologyVitroSerumPhysicochemical characteristicsTumorCircular dichroismSynthesisFormulationEncapsulation2016TheranosticFluorescenceNanocarriersProtein-basedAntibodiesUptakeToxicityUnlikeInteractionCharacteristicsHumanAbsorptionGene deliveryDrugsAnalysis showedDetectionBiologicalScopeEvaluateDiameterMolecularTherapyFoundEffectsSizeStudyDrug deliverDelivery
Bovine Serum A2
- Alsamamra H, Hawwarin I, Abu-Sharkh S, Abuteir M (2018) Study the Interaction between Gold Nanoparticles and Bovine Serum Albumin: Spectroscopic Approach. (alquds.edu)
- Covalently Binding of Bovine Serum Albumin to Unsaturated Poly(Globalide-Co-ε-Caprolactone) Nanoparticles by Thiol-Ene Reactions. (mpg.de)
Polymeric nanoparticles1
- The methods of preparation of polymeric nanoparticles and nanocapsules on the basis of such polymers as human serum albumin and poly-D,L-lactic acid are shown in this article. (ksu.kz)
Paclitaxel10
- RATIONALE: Drugs used in chemotherapy, such as paclitaxel albumin-stabilized nanoparticle formulation, doxorubicin, and cyclophosphamide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. (clinicaltrialsgps.com)
- PURPOSE: This randomized phase II trial is studying paclitaxel albumin-stabilized nanoparticle formulation, doxorubicin, cyclophosphamide, and pegfilgrastim to compare how well they work when given with or without bevacizumab in treating women with inflammatory or locally advanced breast cancer. (clinicaltrialsgps.com)
- To compare the pathologic complete response rates in women with HER2/neu-negative inflammatory or locally advanced breast cancer treated with paclitaxel albumin-stabilized nanoparticle formulation, doxorubicin hydrochloride, cyclophosphamide, and pegfilgrastim with vs without bevacizumab. (clinicaltrialsgps.com)
- To evaluate biomarkers with respect to the sequence of paclitaxel albumin-stabilized nanoparticle formulation and doxorubicin hydrochloride/cyclophosphamide/pegfilgrastim administration in patients not receiving bevacizumab. (clinicaltrialsgps.com)
- Patients then receive paclitaxel albumin-stabilized nanoparticle formulation IV over 30 minutes on day 1 of weeks 14-25. (clinicaltrialsgps.com)
- The study treatment was nanoparticle-albumin-bound paclitaxel, which has been used since 2005 for certain refractory or relapsed cancers. (news-medical.net)
- Albumin-Bound Paclitaxel" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
- An injectable formulation of albumin-bound paclitaxel NANOPARTICLES. (umassmed.edu)
- This graph shows the total number of publications written about "Albumin-Bound Paclitaxel" by people in this website by year, and whether "Albumin-Bound Paclitaxel" was a major or minor topic of these publications. (umassmed.edu)
- Below are the most recent publications written about "Albumin-Bound Paclitaxel" by people in Profiles. (umassmed.edu)
Characterization4
- Physico-chemical characterization confirms that the prepared nanoparticles are spherical, highly monodispersed, and stable in aqueous systems. (rsc.org)
- Scanning electron microscope (SEM), transmission electron microscopy (TEM), dynamic light scattering (DLS), and FTIR were used for nanoparticle characterization. (hindawi.com)
- So, the aim of this study is the synthesis, characterization, and antibacterial evaluation of vancomycin-containing soy protein nanoparticles (vancomycin-SPNs) as a new antimicrobial agent. (hindawi.com)
- Supporting Information: LC-MS characterization of GSH-MDI reaction products, Tables of peptides matched to albumin or modified albumin, and MS/MS data on the GSH-MDI modified albumin peptide containing residues 411-428. (cdc.gov)
Proteins5
- A layer of proteins covers the nanoparticles by exposure to the nanoparticles in biological fluids. (magiran.com)
- After interaction with the protein, the nanoparticles showed less interaction with the protein due to the formation of a layer of water around them that reduces the probability of interaction with proteins. (magiran.com)
- Among proteins, soy protein is one of the exciting candidates for the preparation of nanoparticle delivery systems due to its biodegradability, biocompatibility, low toxicity, low immunogenicity, and symmetrical shape [ 12 , 13 ]. (hindawi.com)
- The ephedrine alkaloid-containing colloidal nanoparticles discovered in another licorice containing Chinese medicinal decoction [ 12 ] imply that licorice root proteins would hypothetically interact with aconitine to form aggregates thereafter affecting the toxicity. (springer.com)
- The active endocytic machinery of kidney proximal tubules avidly internalizes filtered proteins, which may also be the case for filtered nanoparticles. (harvard.edu)
Biopolymer-based nanoparticles2
- 2016). Impact of the in vitro gastrointestinal passage of biopolymer-based nanoparticles on insulin absorption . (up.pt)
- 2017). In vivo biodistribution of antihyperglycemic biopolymer-based nanoparticles for the treatment of type 1 and type 2 diabetes . (up.pt)
Desolvation method1
- In this work niclosamide was encapsulated into albumin nanoparticles through a desolvation method to improve its scope of application in cancer therapy. (rsc.org)
Satisfactory physicochemical2
- Using optimal condi- tions which have been found out empty albumin nanoparticles with satisfactory physicochemical characteris- tics (particle diameter in the range of 50-100 nm, polydispersity 0.130-0.180 and ζ-potential -11,3-31,0 mV) have been obtained. (ksu.kz)
- Obtained nanoparticles of the polymers have satisfactory physicochemical characteristics: the particle sizes were in the interval of 100-300 nm with narrow particle size distribution which points on the formation of nanoparticles of similar size. (ksu.kz)
Doxorubicin1
- For this purpose, doxorubicin loaded magnetic albumin nanospheres (M-DOX-BSA-NPs) were synthesized. (iyte.edu.tr)
Morphology2
- In this study, the effects of gold nanoparticle morphology (spheres and rods) and surface functionalization (PEG and GSH) on glycosylated serum albumin, a model protein in diabetic patients, its secondary structure and chemical stability using circular dimorphism technique were investigated.PEG-AuNPs exhibit a larger hydrodynamic radius than GSH-AuNPs due to their large hydrophilic tails. (magiran.com)
- The surface morphology of the nanoparticles determined by transmission electron microscopy showed semi-spherical nanoparticle shapes. (ewha.ac.kr)
Vitro3
- These drug encapsulated albumin nanoparticles, unlike the free drug demonstrate better in vitro therapeutic efficacy against human lung and breast cancer cell lines, as assessed by cell viability assay and morphological analyses. (rsc.org)
- The present study deals with the development of pGL3-PEI-coated HSA nanoparticles and subsequent in vitro testing in cerebellar granular and HeLa cells. (uni-frankfurt.de)
- Liquid emulsions and solid nanoparticles are used with ultrasound to deliver genes in vitro and in vivo. (hindawi.com)
Serum12
- As viral vectors comprise the risk of immune and inflammatory responses, human serum albumin (HSA) nanoparticles were found to represent a safer and more convenient alternative. (uni-frankfurt.de)
- Human serum albumin and poly- D,L-lactic acid are well-known polymers used in medicine for different purposes including delivery of some potent drugs in the forms of nanoparticles. (ksu.kz)
- Empty nanoparticles of human serum albumin and poly-D,L-lactic acid have been successfully synthesized using desolvation and nanoprecipitation methods correspondingly. (ksu.kz)
- Optimal conditions of synthesizing the nanoparticles of human serum albumin and poly-D,L-lactic acid have been worked out. (ksu.kz)
- So the results of this study have shown that synthesized nanoparticles of human serum albumin and poly-D,L-lactic acid have good characteristics and hence they can further be used for loading them with different drugs. (ksu.kz)
- Human serum albumin (HSA), is the natural ligand carrier most abundant(40 mg/mL) and with the longest half-life in the blood (19 days). (cnr.it)
- Male C57BL/6 mice were exposed by oropharyngeal aspiration to 10 or 40 microg MWCNT-7 or vehicle dispersion media (0.6 mg/ml mouse albumin and 0.01mg/ml DPPC) with serum collected 4 h after. (cdc.gov)
- Consistent with barrier disruption and neuroinflammation in the brains of exposed animals, MWCNT-altered serum-exosomes promoted an astrogliosis phenotype that supports their involvement in driving neurological outcomes after nanoparticle exposure. (cdc.gov)
- To this end, we report cetyltrimethylammonium chloride-loaded mesoporous silica nanoparticles conjugated with human serum albumin (CTAC@MSNs-HSA) as a mitochondrion-targeting agent for anticancer treatment. (rsc.org)
- Small Surfactant Concentration Differences Influence Adsorption of Human Serum Albumin on Polystyrene Nanoparticles. (mpg.de)
- Aggregation Behavior of Polystyrene-Nanoparticles in Human Blood Serum and its Impact on the in vivo Distribution in Mice. (mpg.de)
- Since rare-earths can still be toxic, the nanoparticles are surrounded by human serum albumin for safe passage through the body. (medgadget.com)
Physicochemical characteristics1
- The influence of different factors (pH of medium, nature and quantity of solvent, etc.) on physicochemical characteristics of polymeric albumin nanoparticles has been investigated in this article. (ksu.kz)
Tumor2
- The small packaging allows nanoparticles to extravasate into tumor tissues. (hindawi.com)
- Nanoparticle-based tumor detection schemes often rely on injecting particles that seek out and stick to cancer cells. (medgadget.com)
Circular dichroism2
- The circular dichroism also exhibits that different modified nanoparticles do not significantly influence secondary structure. (magiran.com)
- Further, the secondary structure of albumin in nanoparticles was determined via circular dichroism, which showed only slight structural changes versus native albumin, making it a promising, self-targeted drug delivery system. (ewha.ac.kr)
Synthesis1
- In addition, newly developed PNP synthesis methods such as electrospray or desolvation provide a more sustainable approach as compared to traditional nanoparticle methods. (wikipedia.org)
Formulation1
- Nanoparticles based drug delivery systems have the potential for realizing water soluble formulation of highly hydrophobic anticancer drugs like niclosamide, thus evading the drawbacks of poor solubility. (rsc.org)
Encapsulation3
- These nanoparticles can be used for encapsulation of various drugs [ 14 ]. (hindawi.com)
- For encapsulation of vancomycin-SPNs, ethanolic solution of vancomycin (EXIR Company, Iran) was added to the nanoparticle solution. (hindawi.com)
- Encapsulation of poisonous alkaloids into self-assembled herbal protein nanoparticles contributes to toxicity attenuation of combined use of herbs, implying a prototype nanostructure and a universal principle for the safer clinical applications of herbal medicines. (springer.com)
20161
- 2016). Dual chitosan/albumin-coated alginate/dextran sulfate nanoparticles for enhanced oral delivery of insulin . (up.pt)
Theranostic1
- LiGa 5 O 8 :Cr-based theranostic nanoparticles for imaging-guided X-ray induced photodynamic therapy of deep-seated tumors. (uga.edu)
Fluorescence1
- Interaction between gold nanoparticles of 40 & 60 nm with BSA has been investigated using UV-absorption spectrophotometry, fluorescence spectroscopy and FT-IR spectroscopy. (alquds.edu)
Nanocarriers2
- Various nanocarriers are being introduced and assessed, such as polymer nanoparticles, liposomes, and micelles. (hindawi.com)
- Nanoparticles have been widely used as nanocarriers in recent years. (hindawi.com)
Protein-based2
- This field assimilated into pharmaceutical research to give rise to a new classification of nanoparticles termed protein (or protein-based) nanoparticles (PNPs). (wikipedia.org)
- The aim of this study was to develop mechanical homogenization processes to fabricate protein-based nanoparticles. (ewha.ac.kr)
Antibodies1
- We present a simple methodology to design a pretargeted drug delivery system, based on clickable anti-PD-L1 antibodies and clickable BSA nanoparticles (NPs). (ucm.es)
Uptake3
- Studies on particle characteristics, their cellular uptake into aforementioned cell lines and on subcellular localisation, and transfection efficiency in the cerebellar cells proved the feasibility of nanoparticle-based gene delivery. (uni-frankfurt.de)
- Role of Nanoparticles' Surface Coating Mechanics on Cellular Uptake. (uga.edu)
- The expression of megalin, a receptor involved in albumin uptake, was also increased, but AQP1 expression was unaffected. (harvard.edu)
Toxicity2
- Biocompatibility, biodegradability, and low toxicity are the most important properties of these nanoparticles [ 11 ]. (hindawi.com)
- In this study, a boiling-stable 31-kDa protein (namely GP) was purified from licorice and self-assembled into nanoparticles (206.2 ± 2.0 nm) at pH 5.0, 25 °C. The aconitine-encapsulated GP nanoparticles (238.2 ± 1.2 nm) were prepared following the same procedure and tested for its toxicity by intraperitoneal injection on ICR mouse ( n = 8). (springer.com)
Unlike1
- Unlike synthetic nanoparticles, PNPs can be synthesized under mild conditions and without toxic chemicals or organic solvents. (wikipedia.org)
Interaction1
- Hydrophilic polymers form a layer of water molecules that reduces the interaction potential between nanoparticles and biomolecules. (magiran.com)
Characteristics1
- The characteristics of the optimized nanoparticles were within the desired range to meet the requirements of intravenous injection. (ewha.ac.kr)
Human2
- Hemolytic Activity, Cytotoxicity, and Antimicrobial Effects of Human Albumin- and Polysorbate-80-Coated Silver Nanoparticles. (almazovcentre.ru)
- The "self"-protein albumin in mouse airway fluid was uniquely modified by GSH-MDI at position 414K, a preferred site of MDI reactivity on human albumin. (cdc.gov)
Absorption1
- UV-absorption spectrophotometry showed an increase in the absorption intensity with increasing the molecular ratios of gold nanoparticles of both sizes to BSA, it is found that the value of the binding constant is estimated to be 0.888 × 104 M-1 for gold nanoparticles (40 nm)- BSA complexes, and 1.16 × 104 M-1 for gold nanoparticles (60 nm)-BSA complexes. (alquds.edu)
Gene delivery1
- Nanoparticle, used as a drug/gene delivery vehicle, can not only target specific cells and tissues, but also retain the biological activity of the drug/gene during transport. (hindawi.com)
Drugs2
- Nanoparticles Transport of FDA-Approved Drugs across the Blood Brain Barrier in a Porcine Stroke Model. (uga.edu)
- Leukocyte membrane coated nanoparticles (NPs) have attracted a lot of interest as an effective approach for delivering targeted drugs, capitalizing on the natural attributes of leukocytes to achieve site-specific accumulation, and heightened therapeutic outcomes. (bvsalud.org)
Analysis showed2
- FT-IR spectroscopy analysis showed that intensities of gold nanoparticles of both sizes-BSA complexes decrease as the concentration increased. (alquds.edu)
- Finally, BT474 viability assays and western blot analysis showed the effectiveness of the tamoxifen-loaded albumin nanoparticles prepared via homogenization. (ewha.ac.kr)
Detection1
- Protein-Adsorbed Magnetic-Nanoparticle-Mediated Assay for Rapid Detection of Bacterial Antibiotic Resistance. (uga.edu)
Biological2
- Since the usage of nanoparticles in biological issues such as drug delivery, biosensor, and photothermal has increased, evaluating nanoparticles' interactions with biomolecules is necessary. (magiran.com)
- When exposed to biological medium or multiple composition dispersions like herbal decoction, protein corona formed on the nanoparticles (NPs) diversely alters the biological fate and pharmaceutical efficacy of particles [ 10 ]. (springer.com)
Scope1
- A detailed analysis with respect to types of nanoparticles and their scope in overcoming multidrug resistance as well as associated clinical trials has been discussed. (bvsalud.org)
Evaluate1
- Dynamic laser scattering (DLS) (SZ-100Z2, Horiba Company, Japan) and Dynamic Scattering software were used to evaluate nanoparticle size. (hindawi.com)
Diameter1
- Albumin-basednanoparticles (NP-HSA, diameter 100 Å ) is the newest frontier in thisfield since they retain most of the parent protein features, showing yet muchhigher stability and exhibiting the capability to encapsulate small moleculedrugs that are released over time. (cnr.it)
Molecular1
- In ourtechnology the molecular cues are attached in an oriented manner to NPs througha linker anchored to the free thiols of cysteine 34 of albumin. (cnr.it)
Therapy1
- Some of the recent focuses include salt nanoparticle therapeutics, nanoparticle-based adjuvants for enhancing immunotherapy, nanoparticle-based radiosensitizers, X-ray induced photodynamic therapy or radiodynamic therapy, and cell-based drug delivery. (uga.edu)
Found1
- In order to see where they found their target, light, usually in the near-infrared range, is used to excite and fluoresce the nanoparticles. (medgadget.com)
Effects1
- Injection of GP-AC nanoparticles and the mixed licorice-aconite decoction, respectively, caused mild recoverable toxic effects and no death, while the aconitine, particle-free GP-AC mixture and aconite decoction induced sever toxic effects and 100 % death. (springer.com)
Size2
- The results revealed that the rotational speed with HSH and the pressure with HPH were the main factors affecting the size, while increasing the residence time led to more homogenous nanoparticles. (ewha.ac.kr)
- To test whether such interactions affect kidney function, we injected mice with either 5 nm dextran-based nanoparticles (DNP) that are similar in composition to FDA-approved materials or poly(amido amine) dendrimer nanoparticles (PNP) of comparable size. (harvard.edu)
Study1
- This study aimed to investigate the antimicrobial activity of vancomycin-loaded soy protein nanoparticles (vancomycin-SPNs). (hindawi.com)
Drug deliver1
- Synthesized nanoparticles are promising as drug delivery systems. (ksu.kz)
Delivery2
- To restore intracellular calcium homeostasis and overcome chemoresistance, we developed lipid-coated albumin-PTX nanoparticles loaded with SRI-siRNA (LANP-PTX-siSRI) for PTX and SRI-siRNA co-delivery. (biomedcentral.com)
- 2007). Alginate/chitosan nanoparticles are effective for oral insulin delivery . (up.pt)