• A new class of nanoparticle-based vaccines could help immunize against cancer in several years. (mpg.de)
  • The polymer-based nanocarrier is a helpful toolbox to further evaluate antigen-specific vaccines and to develop further vaccine-based therapeutic concepts against cancer,' Nuhn is convinced. (mpg.de)
  • Overall, these findings indicate that anti-CD3-coated nanoparticles could be use to enhance the efficacy of vaccines and immunotherapy. (johnshopkins.edu)
  • Other benefits of the protein nanoparticles include minimizing cellular damage and providing stronger immunity at lower doses than traditional protein subunit vaccines against other viruses, like influenza. (eurekalert.org)
  • Compared to the placebo group that received adjuvant-only vaccines (adjuvants are added ingredients that help vaccines work better), those that received the RBD-nanoparticle vaccine were better protected from clinical symptoms and lung damage associated with infection. (eurekalert.org)
  • Irvine is helping to build better vaccines against diseases such as malaria and cancer by designing nanoparticles of a synthetic polymer. (technologyreview.com)
  • Nanoparticle vaccines are designed to effectively deliver antigens at a lower dose with fewer side effects for at-risk groups - including adults over age 50, who are the most vulnerable to SFTSV and the most susceptible to vaccine side effects. (news-medical.net)
  • Nanoparticle vaccines are promising for treating these at-risk groups because the antigens are bundled together, instead of free-floating throughout our bodies. (news-medical.net)
  • Shi is working on the design and structural characterization of novel malaria vaccines to display antigens on nanoparticles. (nih.gov)
  • Vaccines have proven to be the most effective method of preventing infectious diseases, yet many problems still exist including multi-dose administration, poor immunogenicity of vaccine antigens, and undesirable side effects of immunization with adjuvants which can all lead to poor patience compliance and poor vaccine efficacy. (aiche.org)
  • A new generation of vaccines based on nanoparticles has shown great potential to address most of the limitations of conventional and subunit vaccines. (cmaj.ca)
  • The recent use of Aluminium nanoparticles in vaccines are reported to cross blood-brain barrier and harm the brain cells because of molecular mimicry. (cmaj.ca)
  • Overview of Immunization Immunity can be achieved Actively by using antigens (eg, vaccines, toxoids) Passively by using antibodies (eg, immune globulins, antitoxins) A toxoid is a bacterial toxin that has been modified. (msdmanuals.com)
  • The mRNA vaccines do not contain viral antigen but rather deliver a small, synthetic piece of mRNA that encodes for the desired target antigen (the spike protein). (msdmanuals.com)
  • The "pro-tolerogenic" antigen-loaded DC will migrate to draining mesenteric lymph nodes, where they will present the food protein-derived peptides to naive T cells and favour the induction of a subpopulation of T cells, namely regulatory T cells (Treg). (frontiersin.org)
  • They carry a special receptor called the T-cell receptor on their surface that recognises antigens small protein fragments of bacteria, viruses and infected or cancerous body cells which are presented by specialised immune complexes. (nanotech-now.com)
  • Our vaccine candidate delivers antigens to trigger an immune response via nanoparticles engineered from ferritin--a protein found in almost all living organisms," said Jae Jung, PhD, director of the Global Center for Human Health & Pathogen Research and co-senior author on the study. (eurekalert.org)
  • The team's vaccine uses the ferritin nanoparticles to deliver tiny, weakened fragments from the region of the SARS-CoV-2 spike protein that selectively binds to the human entry point for the virus (this fragment is called the receptor-binding domain, or RBD). (eurekalert.org)
  • Both Comirnaty and Spikevax (from Moderna) «consisted of N1-methyl-pseudouridine-modified mRNA encoding the SARS-COVID-19 Spike protein and were delivered with a lipid nanoparticle (LNP) formulation. (veteranstoday.com)
  • BUFFALO, N.Y. - Fastening protein-based medical treatments to nanoparticles isn't easy. (buffalo.edu)
  • The three parts - adjuvant, protein and nanoparticle - worked together to stimulate an immune response against HIV. (buffalo.edu)
  • Resonance enhanced absorption (REA) nanocolor microfluidic devices are new promising bioassay platforms, which employ nanoparticle- (NP-) protein conjugates for the immunodetection of medically relevant markers in biologic samples such as blood, urine, and saliva. (hindawi.com)
  • Zhao W, Brook MA, Li YF (2008) Design of gold nanoparticle-based colorimetric biosensing assays. (springer.com)
  • Rani, D., Nayak, B. & Srivastava, S. Immunogenicity of gold nanoparticle-based truncated ORF2 vaccine in mice against Hepatitis E virus. (jiit.ac.in)
  • This is due to recent advances in chemical and biological engineering, which allow the design of nanoparticles with a precise control over the size, shape, functionality and surface properties, leading to enhanced antigen presentation and strong immunogenicity. (cmaj.ca)
  • Potent Functional Immunogenicity of Plasmodium falciparum Transmission-Blocking Antigen (Pfs25) Delivered with Nanoemulsion and Porous Polymeric Nanoparticles. (bvsalud.org)
  • As Anderson explains, "tumors that make a lot of proteins that look different from healthy proteins will likely result in more antigens for the bacteria to transport. (the-scientist.com)
  • Niemeyer CM (2001) Nanoparticles, proteins, and nucleic acids: biotechnology meets materials science. (springer.com)
  • Nam J-M, Thaxton CS, Mirkin CA (2003) Nanoparticle-based Bio-Bar codes for the ultrasensitive detection of proteins. (springer.com)
  • The image above illustrates how proteins (copper-colored coils) modified with polyhistidine-tags (green diamonds) can be attached to nanoparticles (red circle). (buffalo.edu)
  • We have proven that you can easily attach proteins to nanoparticles and, like Velcro that doesn't unstick, it stays together. (buffalo.edu)
  • University at Buffalo researchers have discovered a way to easily and effectively fasten proteins to nanoparticles - essentially an arranged marriage - by simply mixing them together. (buffalo.edu)
  • Scientists have been able to attach proteins to nanoparticles for a while now. (buffalo.edu)
  • Next, the researchers mixed the modified proteins and nanoparticles in water. (buffalo.edu)
  • To develop the new vaccine classes, the researchers first use a model antigen. (mpg.de)
  • They have generated various tumors that carry this model antigen - either on the surface or inside. (mpg.de)
  • C57BL/6 mice were subcutaneously immunized with free ovalbumin (OVA) as a model antigen, or equivalent doses of OVA-loaded into PSs, conjugated onto NPs, or given as a mixture of the two. (northwestern.edu)
  • There was a rat model, and the target antigen was known in the rat. (medscape.com)
  • Before 2009, we didn't know what the major target antigen in adult MN was. (medscape.com)
  • [5] Importantly, once the lipid nanoparticle which encapsulates the mRNA has been absorbed into antigen-presenting cells (a process called receptor-mediated endocytosis ) the more acidic environment within the endosome fully protonates the ALC-0315 as a result the nanoparticle releases its payload of mRNA. (wikipedia.org)
  • Building from this preliminary data, this project's central hypothesis is that slowly degrading particulate systems provide enhanced adjuvant-like effects that sustain APC viability and activation for extended antigen-specific adaptive immune responses. (phrmafoundation.org)
  • Modeled after APCs, aAPCs need to have at least two signals to stimulate antigen specific T cells. (wikipedia.org)
  • Even in the absence of T cells, natural APCs have been found to precluster antigens. (wikipedia.org)
  • Development of efficient inhalable immunotherapies remains a far-off goal, challenged in part by the paucity of knowledge surrounding the physiochemical properties which dictate desirable interactions with lung antigen presenting cells (APCs). (phrmafoundation.org)
  • Delivery of biodegradable nanoparticles to antigen-presenting cells (APCs), specifically dendritic cells (DCs), has potential for immunotherapy. (nih.gov)
  • Nanoparticles were internalized by up to 40-50% of lymph node DCs (and APCs) without the use of a targeting ligand, and the site of internalization was in the lymph nodes rather than at the injection site. (nih.gov)
  • Finally, an increase in nanoparticle-containing DCs (and other APCs) was seen at 96h vs. 24h, suggesting an infiltration of these cells to lymph nodes. (nih.gov)
  • Left panel: antigen bound by antibody is taken up via FcR on APCs such as dendritic cells or macrophages. (hindawi.com)
  • B cells are highly efficient APCs in situations of low antigen concentrations. (hindawi.com)
  • Likewise, antigen/antibody complexes are bound by the FcR of APCs and processed in a unique fashion dependent on the epitope specificity of the bound antibody. (hindawi.com)
  • Autoantibodies can bind to basic structural molecules and interfere with the synthesis of structural elements and facilitate the uptake of antigen. (hindawi.com)
  • This FcR-mediated antigen uptake is more efficient than antigen uptake by pinocytosis. (hindawi.com)
  • BCR-mediated antigen uptake can influence antigen processing and the nature of MHC-displayed T-cell determinants. (hindawi.com)
  • Therefore, this research is focused on the rational design of pathogen-mimicking adjuvants for vaccine delivery by utilizing flow cytometry and confocal microscopy in concert with materials informatics to identify key properties responsible for nanoparticle uptake and downstream activation of murine bone marrow derived dendritic cells (BMDCs). (aiche.org)
  • [1] [2] These nanoparticles promote the uptake of therapeutically effective nucleic acids such as oligonucleotides or mRNA both in vitro and in vivo . (wikipedia.org)
  • For the structural analysis, the researchers chose a T-cell receptor used in immunotherapy to treat melanoma and which had been optimised for this purpose in several steps in such a way that it binds its antigen as tightly as possible. (nanotech-now.com)
  • Right panel: antigen binds to the BCR of antigen-specific B cells and is internalized. (hindawi.com)
  • An Accurin nanoparticle that binds to CD206 positive macrophages could be a valuable asset in the armament against multiple cancers and disease states. (businesswire.com)
  • Researchers led by Lukas Su ac, Christoph Thomas, and Robert Tamp from the Institute of Biochemistry at Goethe University Frankfurt, in collaboration with Simon Davis from the University of Oxford and Gerhard Hummer from the Max Planck Institute of Biophysics, have now succeeded for the first time in visualizing the structure of a membrane-bound T-cell receptor complex with bound antigen. (nanotech-now.com)
  • Once they had successfully achieved this, the researchers used a trick to fish those receptors out of the preparation that had survived the process and were still functional: due to the strong interaction between the receptor complex and the antigen, they were able to fish one of the most medically important immune receptor complexes. (nanotech-now.com)
  • IMMUNE ASSISTANTS: Following radiation therapy, which triggers the release of cancer-specific antigens, researchers injected Salmonella typhimurium bacteria covered in positively charged nano-particles near tumors in mice. (the-scientist.com)
  • One of the favorite toys of researchers in the field is quantum dots - nanoparticles of semiconductor material that give off different colors of light depending on their size. (technologyreview.com)
  • Cleveland Clinic researchers have used nanoparticles to develop a potential vaccine candidate against Dabie Bandavirus, formerly known as Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV), a tick-borne virus that currently has no prevention, treatment or cure. (news-medical.net)
  • To create the biotechnology, the researchers use nanoparticles made of chlorophyll (a natural pigment), phospholipid (a fat similar to vegetable oil) and cobalt (a metal often used to prepare magnetic, water-resistant and high-strength alloys). (buffalo.edu)
  • The global nanoparticles in biotechnology, drug development, and drug delivery systems market should reach $156.8 billion by 2028 from $102.7 billion in 2023 at a compound annual growth rate (CAGR) of 8.8% for the forecast period of 2023 to 2028. (giiresearch.com)
  • Drug delivery systems segment of the global nanoparticles in biotechnology, drug development, and drug delivery systems market is expected to grow from $53.8 billion in 2023 to $75.1 billion in 2028 at a CAGR of 6.9% for the forecast period of 2023 to 2028. (giiresearch.com)
  • The scope of the report includes an overview of the global market for nanoparticles in biotechnology, drug development and formulation, drug delivery systems, and diagnostics as well as analyses of global market trends, using 2022 as the base year and forecasting market sizes for 2023 through 2028 with compound annual growth rate (CAGR) projections. (giiresearch.com)
  • 1. Dangerous & Mysterious Nanoparticles inside mRNA Serum. (veteranstoday.com)
  • Specifically, it is one of four components that form lipid nanoparticles (LNPs), which encapsulate and protect the otherwise fragile mRNA that is the active ingredient in these drugs. (wikipedia.org)
  • After being taken up by cells of the immune system, the vaccine mRNA degrades after instructing the cell to produce viral antigen. (msdmanuals.com)
  • While ferritin nanoparticles are well-characterized for their strong temperature and chemical stability, suggesting the RBD-nanoparticle vaccine may also be thermostable, future investigations will be necessary to validate. (eurekalert.org)
  • Therefore, the research team attaches it to a carrier - more precisely, to polymer-based nanoparticles that have a gel-like consistency, are biodegradable and locally limit the effect of the immune activator. (mpg.de)
  • Aptamer-antigen-antibody sandwiched detection scheme was utilized to enhance the LSPR responses for label-free biomolecular detection. (springer.com)
  • Agasti SS et al (2010) Nanoparticles for detection and diagnosis. (springer.com)
  • Wilson R (2008) The use of gold nanoparticles in diagnostics and detection. (springer.com)
  • AgcoreAushell bimetallic nanoparticles, as a new SERS active and biocompatible substrate, will be expected to improve the detection sensitivity of immunoassay. (unboundmedicine.com)
  • Although culture is the standard method for definitive diagnosis, detection of cryptococcal antigen (CRAG) in serum or cerebrospinal fluid (CSF) is used for presumptive diagnosis. (cdc.gov)
  • Systemically Administered TLR7/8 Agonist and Antigen-Conjugated Nanogels Govern Immune Responses against Tumors. (mpg.de)
  • The radiation triggered the tumors to shed negatively charged antigens that clung to the bacteria. (the-scientist.com)
  • The results suggest that the engineered Salmonella helped ensure that antigen-detecting dendritic cells , which immunosuppressive tumors can disable or keep at bay, came into contact with the tumor antigens and activated an immune response. (the-scientist.com)
  • The bacteria captured the negatively charged antigens and ferried them to dendritic cells in the tumors' periphery, where a tumor-targeting immune response was initiated, improving the animals' odds of survival. (the-scientist.com)
  • Recent preliminary lab data has suggested that APC longevity is intimately controlled by the amount and frequency of nanoparticle (NP) internalization, as well as the rate of the particle intracellular degradation. (phrmafoundation.org)
  • Upon further assessment of the nanoparticle positive and negative BMDC populations, it was discovered that nanoparticle internalization was required for enhanced expression of CD40 and production of IL-12p40 and IL-6 but not for the expression of CD86 and MHC II. (aiche.org)
  • This was explained (Source 2) by Hironori Adachi and Yi-Tao Yu of the Department of Biochemistry and Biophysics of the University of Rochester Medical Center, New York (USA) together with Pedro Morais of ProQR Therapeutics in Leiden (Netherlands) to highlight the importance of pseudouridine, without losing the precious contribution of the nanoparticles that are at the center of this report. (veteranstoday.com)
  • Accurins, a new class of targeted therapeutics developed using BIND's Medicinal Nanoengineering ® platform, are nanoparticles engineered to have a profound impact on the treatment of disease. (businesswire.com)
  • The preparation of ALC-0315 was first described in a patent application to lipid nanoparticles by Acuitas Therapeutics in 2017. (wikipedia.org)
  • In it, the "miraculous" stabilization of the lipid nanoparticles of the shady biotechnologies could have been obtained with the inclusion of the highly contested "graphene oxide" . (veteranstoday.com)
  • The suspicion that graphene oxide (GO) nanoparticles have been secretly inserted into the Pfizer vaccine has been hovering for months now, as discovered by the Spanish chemist Paulo Campra thanks to his electron microscope aimed at the contents of some vials of a declared batch. (veteranstoday.com)
  • Polyanhydrides are a class of biomaterials that have demonstrated biocompatibility, controlled antigen release kinetics, antigen stabilization, and immune modulation, making them excellent vaccine delivery vehicles. (aiche.org)
  • When they encounter foreign pathogens, the antigen presenting cells activate the T cells-"the soldiers of the immune system"- by delivering stimulatory signals that alert there is foreign material in the body with specific cell surface molecules (epitopes). (wikipedia.org)
  • The nanoparticles, which carry specific stimulating molecules and antigens, are taken up by immune cells, triggering an immune response. (technologyreview.com)
  • Because of their tiny size, the nanoparticles can deliver the molecules with a high level of precision to specific receptors inside cells. (technologyreview.com)
  • After processing, antigen is presented on MHC molecules. (hindawi.com)
  • Antigen-loaded PSs induced enhanced frequencies of antigen-specific CD4 + T cells in the spleen, lymph nodes and lungs as compared to the NP formulation, whereas antigen-conjugated NPs induced stronger CD8 + T cell responses. (northwestern.edu)
  • Guo L, Kim D-H (2011) Reusable plasmonic aptasensors: using a single nanoparticle to establish a calibration curve and to detect analytes. (springer.com)
  • COVID-19 antigen tests, like many other rapid diagnostic tests, rely on gold nanoparticles for quick and reliable results. (gold.org)
  • The first signal is the major histocompatibility complex (MHC), which in humans is also called the human leukocyte antigen (HLA). (wikipedia.org)
  • Megalin was the rat antigen, which rats have in their glomerulus, but humans don't. (medscape.com)
  • Seems like quite a daunting project, given that we had been searching for the antigen in humans for so long. (medscape.com)
  • A rotavirus diagnostic kit will be developed using nanotechnology involving lactoferrin (LF), magnesium chloride, silicon, and monoclonal antibody to the VP6 gene, a group-specific antigen found in all RV that cause disease in humans. (who.int)
  • Based on the expression of CD206 mannose receptors on disease-associated macrophages, BIND and Macrophage plan to conduct joint research to develop a CD206 targeted Accurin nanoparticle that is capable of concentrating various therapeutic payloads to the tumor microenvironment. (businesswire.com)
  • These nanoparticles consist of a cross-linked rubbery core of PPS surrounded by a hydrophilic corona of poly(ethylene glycol). (nih.gov)
  • An in situ method has been developed to fabricate gold nanoparticle (Au NP) films on different substrates, regardless of whether they are hydrophilic or hydrophobic surfaces, including glass, 96-well polystyrene plates, and polydimethylsiloxane (PDMS). (nature.com)
  • This investigation identified that the least hydrophilic (CPTEG-rich and the SA-rich) nanoparticles were readily internalized by BMDCs. (aiche.org)
  • A comparison of the antigen-bound structure captured using cryo-electron microscopy with that of a receptor without antigen provides the first clues to the activation mechanism. (nanotech-now.com)
  • Silver enhancement of the bound nanoparticles may be used to increase the sensitivity of the assay. (hindawi.com)
  • the T cells activated by the vaccine only kill tumor cells that carry the antigen on their surface or even inside. (mpg.de)
  • We exploited the observation that the TCR-CD3 complex is clustered on T cells that have been activated by Ag by using anti-CD3 nanoparticles to selectively activate Ag-experienced mouse T cells. (johnshopkins.edu)
  • We find that constraining anti-CD3 on the surface of a nanoparticle markedly and selectively enhances proliferation and cytokine production of Ag-experienced T cells but does not activate naive T cells. (johnshopkins.edu)
  • Furthermore, in vivo anti-CD3-coated nanoparticles increased the expansion of Ag-specific T cells following vaccination. (johnshopkins.edu)
  • Artificial antigen presenting cells (aAPCs) are engineered platforms for T-cell activation. (wikipedia.org)
  • When Signal 2 is not expressed, but T cells receive Signal 1, the antigen-specific T cells become anergic and do not perform effector function. (wikipedia.org)
  • Nanoparticles are able to be transported through the porous extracellular matrix much easier and reach the lymph nodes where the T cells reside. (wikipedia.org)
  • Nanoparticle-coated bacteria can capture tumor antigens and deliver them to immune cells, triggering a response that improved survival rates in mice. (the-scientist.com)
  • Because our immune cells can find 'bundles' of antigens on a nanoparticle more easily, the vaccine can be effective using a lower dose. (news-medical.net)
  • Likewise B cells function as crucial antigen presenting cells in autoimmune diseases that are traditionally viewed as T cell mediated. (hindawi.com)
  • Independent of antibody secretion B cells secrete proinflammatory cytokines, support the formation of ectopic GCs, and serve as antigen presenting cells. (hindawi.com)
  • Both secreted autoantibodies and BCR on B cells can modulate the processing and presentation of antigen and thereby affect the nature of presented T-cell determinants. (hindawi.com)
  • The targeted nanoparticles have the potential to improve cancer treatment by targeting specific cancer cells in lieu of releasing anti-cancer drugs everywhere in the body. (buffalo.edu)
  • Toward this goal, we synthesized an exendin-4 conjugated magnetic iron oxide-based nanoparticle probe targeting glucagon-like peptide 1 receptor (GLP-1R), which is highly expressed on the surface of pancreatic β-cells. (diabetesjournals.org)
  • describe the interaction of cells with nano-structured surfaces relevant to nanosafety and for theranostic applications in medicine of nanoparticles. (lu.se)
  • Guo LH, Kim DH (2012) LSPR biomolecular assay with high sensitivity induced by aptamer-antigen-antibody sandwich complex. (springer.com)
  • To access the diagnostic accuracy of the developed kit, ELISA and PCR RVA positive and negative samples will be tested using the nanoparticle kit and the sensitivity/specificity of these methods will be compared. (who.int)
  • that of DNA-functionalized nanoparticles, providing a pathway for nanoparticle assembly in general. (osti.gov)
  • The nanoparticles thus open up a direct pathway into the immune system. (mpg.de)
  • After binding of a suitable antigen to the receptor, a signalling pathway is triggered inside the T cell that arms the cell for the respective task. (nanotech-now.com)
  • These results have important implications for particulate-based vaccine design and highlight the potential of using different antigen-delivery systems for the induction of both T helper and cytotoxic T lymphocyte immune responses. (northwestern.edu)
  • These nanoparticles may represent a valuable platform for antigen delivery, vaccine development, and other biomedical and environmental applications "Extreme Halophiles Are Models for Astrobiology" (PDF). (wikipedia.org)
  • The delivery of drugs, antigens, and imaging agents benefits from using nanotech nology-based carriers. (cdc.gov)
  • This study investigates the delivery of 20, 45, and 100nm diameter poly(ethylene glycol)-stabilized poly(propylene sulfide) (PPS) nanoparticles to DCs in the lymph nodes. (nih.gov)
  • The advent of nanoparticle technologies for the delivery of APIs effectively displays its high potential as an innovative and effective approach. (researchandmarkets.com)
  • We have previously shown strong CD8 + T cell responses to antigen conjugated to NPs via a disulfide link, and here we investigated the extent to which antigen incorporated within oxidatively-sensitive PSs could induce CD4 + or CD8 + T cell responses. (northwestern.edu)
  • Lower molecular weight antigens can induce airway sensititzation without the mediation of IgE. (medscape.com)
  • It showed how the lipid membrane functions as a support structure for antigen presentation. (wikipedia.org)
  • These insights into the nature of TCR assembly and the unusual cell membrane architecture reveal the basis of antigen recognition and receptor signaling. (nanotech-now.com)
  • A particular challenge on the way to structure determination was to isolate the whole antigen receptor assembly consisting of eleven different subunits from the cell membrane. (nanotech-now.com)
  • Both prostate-specific membrane antigen (PSMA) PET/CT and ferumoxtran-10 nanoparticle-enhanced MRI (nano-MRI) are imaging modalities with high potential to identify LN metastases in PCa patients. (snmjournals.org)
  • 20 nm particles were most readily taken up into lymphatics following interstitial injection, while both 20 and 45nm nanoparticles showed significant retention in lymph nodes, displaying a consistent and strong presence at 24, 72, 96 and 120h post-injection. (nih.gov)
  • Thus, PPS nanoparticles of 20-45nm have the potential for immunotherapeutic applications that specifically target DCs in lymph nodes. (nih.gov)
  • BioAssay Works, LLC researches, develops, markets & sells colloidal gold (nanoparticle gold) products & related immunodetection products and services. (biosciregister.com)
  • Two types of alkylthiol-terminated poly(acrylic acid) (PAAs, varying in length) are synthesized and used to functionalize gold nanoparticles (AuNPs) to mimic similar assembly effects of single-stranded DNA-capped AuNPs using synthetic polyelectrolytes. (osti.gov)
  • The subsequent images collected at the cryo-electron microscope delivered groundbreaking insights into how the T-cell receptor works, as Tamp summarises: On the basis of our structural analysis, we were able to show how the T-cell receptor assembles and recognises antigens and hypothesise how signal transduction is triggered after antigen binding. (nanotech-now.com)
  • According to their results, the big surprise is that there is evidently no significant change in the receptor s spatial structure after antigen binding, as this was practically the same both with and without an antigen. (nanotech-now.com)
  • In 2009, we had a seminal moment when you published a manuscript in The New England Journal of Medicine describing PLA2R, phospholipase A2 receptor, as the antigen that was responsible for a majority of the cases of MN. (medscape.com)
  • The team coated Salmonella with positively charged nanoparticles before injecting them into mice that had been treated with radiotherapy. (the-scientist.com)
  • Given the need for data for a rapid, point-of-care cryptococcal antigen (CRAG) lateral flow immunochromatographic assay (LFA), we assessed diagnostic performance of cerebrospinal fluid (CSF) culture, CRAG latex agglutination, India ink microscopy, and CRAG LFA for 832 HIV-infected persons with suspected meningitis during 2006-2009 (n = 299) in Uganda and during 2010-2012 (n = 533) in Uganda and South Africa. (cdc.gov)
  • Sperling RA et al (2008) Biological applications of gold nanoparticles. (springer.com)
  • Hubble LJ et al (2012) Gold nanoparticle chemiresistors operating in biological fluids. (springer.com)
  • Marcel Bruchez , lead product development scientist at Quantum Dot of Hayward, CA, is also enlisting the glowing nanoparticles, but for biological imaging and the development of diagnostics. (technologyreview.com)
  • Current understanding of interactions between nanoparticle s and the immune system. (cdc.gov)
  • In the present review, we focus on the most prominent pieces of the nanoparticle -immune system puzzle and discuss the achievements, disappointments, and lessons learned over the past 15 years of research on the immunotoxicity of engineered nanomaterial s. (cdc.gov)
  • The thin and flat microfluidic chip fitted the narrow space of dark-field microscopy and enabled the recording of single-nanoparticle LSPR responses. (springer.com)
  • The competitive environment is examined with a special focus on how new products will alter the quality of life of patients receiving nanoparticle-associated drugs. (giiresearch.com)