• Sulfite reductase (NADPH) (EC 1.8.1.2, sulfite (reduced nicotinamide adenine dinucleotide phosphate) reductase, NADPH-sulfite reductase, NADPH-dependent sulfite reductase, H2S-NADP oxidoreductase, sulfite reductase (NADPH2)) is an enzyme with systematic name hydrogen-sulfide:NADP+ oxidoreductase. (wikipedia.org)
  • This enzyme catalises the following chemical reaction hydrogen sulfide + 3 NADP+ + 3 H2O ⇌ {\displaystyle \rightleftharpoons } sulfite + 3 NADPH + 3 H+ Sulfite reductase is an iron flavoprotein (FAD and FMN). (wikipedia.org)
  • G6PD deficiency can induce methemoglobinemia by inhibiting NADPH-flavine reductase, which prevents the reduction of methemoglobin. (cdc.gov)
  • We previously demonstrated in streptozotocin-induced diabetic mice that deficiency or inhibition of aldose reductase (AR) caused significant dephosphorylation of hepatic transcriptional factor PPAR α , leading to its activation and significant reductions in serum lipid levels. (hindawi.com)
  • The product of this gene is a small iron-sulfur protein that transfers electrons from NADPH through ferredoxin reductase to a terminal cytochrome P450. (sigmaaldrich.com)
  • This gene encodes an aldo-keto reductase that catalyzes the NADPH-dependent reduction of pteridine derivatives and is important in the biosynthesis of tetrahydrobiopterin (BH4). (origene.com)
  • The disulfide form is then reduced by NADPH in a reaction catalyzed by THIOREDOXIN REDUCTASE. (bvsalud.org)
  • Nach einer Übersicht über das Wesen der NADH- und NADPH-Tetrazoliumreduktase, die früher auch als Diaphorasen bezeichnet wurden, wird über das Vorkommen dieser Enzyme und ihre Histotopie in normaler menschlicher Haut berichtet. (springer.com)
  • Dem Reaktionsausfall nach zeigt die NADH-Tetrazoliumreduktase in der Regel eine größere Aktivität als die NADPH-Tetrazoliumreduktase. (springer.com)
  • Alle lebenden epithelialen Strukturen der Haut sind durch eine histochemisch faßbare NADH- und NADPH-Tetrazoliumreduktaseaktivität ausgezeichnet. (springer.com)
  • In der Gesamtheit lassen die Untersuchungsergebnisse vermuten, daß - vielleicht mit Ausnahme des infraseboglandulären Haarfollikels -alle übrigen epithelialen Zellen durch eine so intensive NADH- und NADPH-Tetrazoliumreduktaseaktivität charakterisiert sind, daß diese wahrscheinlich für den Nachweis von Dehydrogenasen, soweit er unter Verwendung von Tetrazoliumsalzen geführt wird, einen reaktionsbegrenzenden Faktor nicht darstellen. (springer.com)
  • Nor1p catalyzed the reduction of NO to N2O using NADH as the direct reductant. (nih.gov)
  • These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. (cancerindex.org)
  • Metabolic flux modeling of TMB3255 confirmed that the NADPH-producing pentose phosphate pathway was blocked and that xylose reduction was mediated only by NADH, leading to a lower rate of xylose consumption. (lu.se)
  • Some researchers suggested that excess reducing equivalents carried by surplus NADPH (Reduced Nicotinamide adenine dinucleotide phosphate) can be exported to the cytosol in the form of malate, which can then enter mitochondria through the malate-OAA shuttle, and converted into OAA and NADH in the mitochondrial matrix. (hku.hk)
  • To study this problem, Dr Lim's group introduced two novel sensors that measure real-time dynamic changes in NADPH levels and NADH/NAD + ratios (this ratio reflects the reduction/oxidation status of the cellular compartments) in Arabidopsis thaliana . (hku.hk)
  • Some D-xylose reductases have dual cofactor specificity, though they still prefer NADPH to NADH (cf. (expasy.org)
  • Biochemically, AR catalyzes the rate-limiting reduction of glucose to sorbitol, with the aid of cofactor NADPH. (hindawi.com)
  • Formate is an ideal electron donor for cofactor regeneration due to its general availability, low reduction potential, and benign byproduct (CO 2 ). (biorxiv.org)
  • Effects of an isolated dehydrogenase enzyme and flovoprotein on the reduction of triphenyltetrazolium chloride. (springer.com)
  • Again, the catalytic triad residues are present in GMER and they complete the reduction form of the enzyme. (prospecbio.com)
  • By selecting for growth with formate as sole NADPH source, we isolate several enzyme variants that support efficient NADPH regeneration. (biorxiv.org)
  • NADPH:protochlorophyllide (Pchlide) oxidoreductase (POR) is a key enzyme of chlorophyll biosynthesis in angiosperms. (upc.edu)
  • This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. (cancerindex.org)
  • In addition, to investigate the molecular mechanisms of AAI and AAII reduction by human NQO1, molecular modeling was used to compare interactions of AAI and AAII with the active site of this enzyme. (nel.edu)
  • 1-Deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) is a key enzyme of the pathway that catalyzes the rearrangement and nicotinamide adenine dinucleotide phosphate (NADPH)-dependent reduction of 1-deoxy-D-xylulose 5-phosphate (DXP) to MEP. (unboundmedicine.com)
  • Comparison of activation of aristolochic acid I and II with NADPH:quinone oxidoreductase, sulphotransferases and N-acetyltranferases. (nel.edu)
  • G6DP catalyzes the formation of nicotinamide adenine dinucleotide phosphate (NADPH) ( 3 ). (cdc.gov)
  • Nicotinamide adenine dinucleotide (NAD + ) and nicotinamide adenine dinucleotide phosphate (NADP + ) play key roles as carriers of electrons in the transfer of reduction potential. (newworldencyclopedia.org)
  • It is currently the only fungal 17β-HSD member that has been described and represents one of the model enzymes of the cP1 classical subfamily of NADPH-dependent SDR enzymes. (rcsb.org)
  • Most of the enzymes exhibit a strict requirement for NADPH (e.g. the enzymes from Saccharomyces cerevisiae, Aspergillus niger, Trichoderma reesei, Candida tropicalis, Saitozyma flava, and Candida intermedia). (expasy.org)
  • Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. (joplink.net)
  • An electron carrier, thioredoxin, carries out this reduction, and is then itself reduced by electrons from NADPH. (cliffsnotes.com)
  • Similarly, NADPH is the reduced form of NADP + , and NADP + is the oxidized form of NADPH. (newworldencyclopedia.org)
  • In contract, NADP (NADPH) is utilized in anabolic reactions (biosynthesis), such as synthesis of nucleic acids , fatty acids , and cholesterol (Higdon 2002). (newworldencyclopedia.org)
  • This particular oxidation/reduction system is found in steroidogenic tissues, and is involved with the synthesis of bile acid and vitamin D. In addition to the expressed gene at this chromosomal locus (11q22), there are pseudogenes located on chromosomes 20 and 21. (sigmaaldrich.com)
  • The low xylose fermentation rate is probably due to limited NADPH-mediated xylose reduction. (lu.se)
  • Xylose reductases catalyze the reduction of xylose to xylitol, the initial reaction in the fungal D-xylose degradation pathway. (expasy.org)
  • In the catalytic cycle, FMO binds to NADPH and to FAD, causing the reduction of FAD to FADH2. (wikipathways.org)
  • Anthranilate hydroxylase from Aspergillus niger: new type of NADPH-linked nonheme iron monooxygenase. (genome.jp)
  • Herein, we report that inhibition of AR by zopolrestat or by a short-hairpin RNA (shRNA) against AR caused a significant reduction in serum and hepatic triglycerides levels in 10-week old diabetic db/db mice. (hindawi.com)
  • Recently, we demonstrated that deficiency or inhibition of AR caused significant dephosphorylation of hepatic PPAR α , leading to the activation of this transcriptional factor as well significant reduction in serum TG levels in streptozotocin-(STZ-) diabetic mice, an experimental model for type I diabetes mellitus (T1DM) [ 17 ]. (hindawi.com)
  • Our data suggest that inhibition of AR in the T2DM db/db mice led to significant activation in hepatic PPAR α and significant reductions in serum triglycerides (TG) and hepatic TG, suggesting that under hyperglycemia, AR/the polyol pathway might be greatly upregulated to contribute significantly to the hepatic regulation of TG metabolism and the development of nonalcoholic steatohepatitis (NASH) or nonalcoholic fatty liver disease (NAFLD). (hindawi.com)
  • The reduction of HMG-CoA to mevalonate is regulated by feedback inhibition by sterols and non-sterol metabolites derived from mevalonate, including cholesterol. (embl.de)
  • Vigorous reduction gives tetrahydro derivatives and ultimately the fully saturated base. (inchem.org)
  • In this study we increased the ethanol yield and decreased the xylitol yield by lowering the flux through the NADPH-producing pentose phosphate pathway. (lu.se)
  • When dilute (10%) serum from exposed rats was perfused into the lumen of coronary arteries from unexposed, naïve rats, the O3-induced reduction in vasodilatory response to ACh was partially recapitulated. (cdc.gov)
  • Hydrogen-donating proteins that participates in a variety of biochemical reactions including ribonucleotide reduction and reduction of PEROXIREDOXINS. (bvsalud.org)
  • Here, we analyzed the metabolome of primary acute myeloid leukemia (AML) blasts and identified an mIDH1-specific reduction in fatty acids. (lu.se)
  • Gene reduction analysis revealed that the gene deletion processes are under selective pressure, and many of the inactivations are probably related to the organism's interaction with its host environment. (asm.org)
  • OTHER PROPERTIES Solutions of paraquat become intensely purple on reduction, due to the formation of a water soluble, relatively stable free radical, which absorbs at 400 nm. (inchem.org)
  • Therefore, under the in vitro conditions used, DNA adducts arise by enzymatic reduction of AAs through the formation of N-hydroxyaristolactams that are spontaneously decomposed to the reactive species forming DNA adducts. (nel.edu)
  • although both AAI and AAII are bound with similar binding affinities to the NQO1 active site, the binding orientation of AAII in the active site of NQO1 does not favor the effective reduction of its nitro group. (nel.edu)