DiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyHealth Care
DronabinolProchlorperazineHeadache Disorders, SecondaryCannabinoid Receptor AgonistsCannabinoidsBornanesCodeineDizzinessAnti-Anxiety AgentsMarijuana AbuseVomitingAntiemeticsNauseaDouble-Blind MethodTreatment Outcome
CesametCannabinoidMarinolDronabinol and nabiloneNauseaAnalgesicsCannabinoidsCannabisIndicationsAdjunctiveOralPostoperative painNightmaresPatientsMetoclopramideDecreasesCannabidiolAntidepressantsInteractionsDoseDrugsPlacebo-controlledMedicationCapsuleSignificantlyAnalogueBaselineTreatmentEffectivenessClinicalChronicDizzinessGroupIncreaseDrugSummaryControlUnited KingdomFormsStudyTotalLabelTrialPeople
Cesamet8
  • Nabilone, sold under the brand name Cesamet among others, is a synthetic cannabinoid with therapeutic use as an antiemetic and as an adjunct analgesic for neuropathic pain. (wikipedia.org)
  • Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). (drugbank.com)
  • In Canada, the United States, the United Kingdom and Mexico, nabilone is marketed as Cesamet. (drugbank.com)
  • A prospective observational study assessed the effectiveness of adjuvant nabilone (Cesamet) therapy in managing pain and symptoms experienced by advanced cancer patients. (cannabisclinicians.org)
  • It included clinical trials related to oral cannabis extract, oromucosal cannabis extract (nabiximols [Sativex]), dronabinol (Marinol), and nabilone (Cesamet). (medpagetoday.com)
  • Cesamet (nabilone) is also approved for treating post-chemo nausea. (koreaherald.com)
  • The prescribing information for Cesamet , with the active ingredient nabilone, contains warnings regarding a number of potential interactions. (factcheck.org)
  • The FDA has approved two oral forms of synthetic THC: dronabinol (Marinol) and nabilone (Cesamet). (clinicaladvisor.com)
Cannabinoid10
  • Nabilone is a partial agonist of the cannabinoid CB1 and CB2 receptors. (wikipedia.org)
  • It was hypothesized that nabilone, an oral cannabinoid synthetic tetrahydrocannabinol analogue, decreases morphine consumption, pain scores, nausea and vomiting following major surgery. (nih.gov)
  • Therefore, we decided to design a proof-of-concept study to assess the synthetic cannabinoid nabilone for the treatment of NMS. (springer.com)
  • Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, however it is considered to be twice as active as Δ⁹-THC. (drugbank.com)
  • Nabilone is a cannabinoid with therapeutic uses. (drugbank.com)
  • Abstract Objective To compare the analgesic efficacy and side effects of the synthetic cannabinoid nabilone with those of the weak opioid dihydrocodeine for chronic neuropathic pain. (realmofcaring.org)
  • Abstract: Nabilone is a synthetic cannabinoid that has shown promise for the treatment of posttraumatic stress disorder (PTSD)Yrelated insomnia and nightmares as well as efficacy in the management of chronic pain. (realmofcaring.org)
  • When compared with those not taking nabilone, patients using this cannabinoid had a lower rate of starting nonsteroidal anti-inflammatory agents, tricyclic antidepressants, gabapentin, dexamethasone, metoclopramide, and ondansetron and a greater tendency to discontinue these drugs. (cannabisclinicians.org)
  • A retrospective analysis of the efficacy and safety of the THC analogue nabilone, which was administered in 6 patients with refractory chronic diarrhoea, showed that the cannabinoid significantly improved symptoms. (cannabis-med.org)
  • Dronabinol and nabilone, a synthetic cannabinoid drug, are frequently used to treat some health conditions. (bolsademulher.com)
Marinol2
Dronabinol and nabilone3
  • Dronabinol and nabilone are synthetic versions of THC. (medpagetoday.com)
  • 2017). Synthetic cannabidiols, such as dronabinol and nabilone, have treated insomnia and excessive daytime sleepiness. (chartattack.com)
  • Cannabis and cannabinoids fall into the illegal substances category under the federal Controlled Substances Act, except for industrial hemp-derived CBD, which was deregulated in 2018 and the two FDA-approved drugs containing modified forms of THC (dronabinol and nabilone). (cancer.gov)
Nausea15
  • The Food and Drug Administration in the United States has indicated nabilone for chemotherapy-induced nausea/vomiting. (wikipedia.org)
  • Nabilone is used to treat nausea and vomiting in people under chemotherapy. (wikipedia.org)
  • The main settings that have seen published clinical trials of nabilone include movement disorders such as parkinsonism, chronic pain, dystonia and spasticity neurological disorders, multiple sclerosis, and the nausea of cancer chemotherapy. (wikipedia.org)
  • A study comparing nabilone with metoclopramide, conducted before the development of modern 5-HT3 antagonist anti-emetics such as ondansetron, revealed that patients taking cisplatin chemotherapy preferred metoclopramide, while patients taking carboplatin preferred nabilone to control nausea and vomiting. (wikipedia.org)
  • Nabilone is used to treat nausea and vomiting caused by cancer chemotherapy in people who have already taken other medications to treat this type of nausea and vomiting without good results. (medlineplus.gov)
  • Nabilone helps control nausea and vomiting caused by cancer chemotherapy when taken as directed. (medlineplus.gov)
  • Always take nabilone according to the schedule prescribed by your doctor even if you are not experiencing nausea or vomiting. (medlineplus.gov)
  • Nabilone is a synthetic delta-9-THC used in the treatment of anorexia and weight loss in HIV patients as well as nausea and vomiting in cancer chemotherapy. (drugbank.com)
  • Nabilone is approved by the FDA for the treatment of nausea and vomiting associated with cancer chemotherapy in patients who have failed to respond adequately to conventional antiemetic treatments Label . (drugbank.com)
  • Although there are different causes of intractable or persistent nausea and vomiting, evidence was only identified for the use of delta-9-tetrahydrocannabinol (THC), nabilone and dronabinol in people with chemotherapy-induced and radiotherapy-induced nausea and vomiting. (nice.org.uk)
  • Limited evidence showed that nabilone, which is licensed in the UK for adults, resulted in complete or partial reduction in chemotherapy-induced nausea and vomiting. (nice.org.uk)
  • The committee agreed that nabilone may play a role in treating intractable chemotherapy-induced nausea and vomiting in people who have not had a full response to optimised conventional antiemetics. (nice.org.uk)
  • Based on the limited evidence, the committee only recommended that nabilone could be considered as an add-on treatment in adults with intractable chemotherapy-induced nausea and vomiting which persists despite the use of optimised conventional antiemetics. (nice.org.uk)
  • The committee highlighted that the use of nabilone is uncommon in current practice and it is not used as first-line treatment for chemotherapy-induced nausea and vomiting. (nice.org.uk)
  • The recommendations could result in an increase in use of nabilone as an add-on treatment for adults with chemotherapy-induced nausea and vomiting, but the current level of use is uncertain. (nice.org.uk)
Analgesics1
  • About one-third of patients have adverse effects despite treatment with opioid analgesics, e.g., nabilone, nabiximols, and other medications, such as anti-convulsants and anti-inflammatories. (news-medical.net)
Cannabinoids2
Cannabis1
  • In one study of current daily users of cannabis, oral nabilone at 4, 6, and 8 mg produced sustained and dose-dependent mood elevation and psychomotor slowing comparable to 10 or 20 mg oral dronabinol (THC). (wikipedia.org)
Indications2
  • This retrospective study of 104 male inmates with serious mental illness prescribed nabilone analyzes the indications, efficacy, and safety of its use. (realmofcaring.org)
  • The results showed nabilone targeting a mean of 3.5 indications per patient, thus. (realmofcaring.org)
Adjunctive4
  • Methods: Charts of 47 patients diagnosed with PTSD and having continuing nightmares in spite of conventional antidepressants and hypnotics were reviewed after adjunctive treatment with nabilone was initiated. (realmofcaring.org)
  • Adjunctive nabilone in cancer pain and symptom management: a prospective observational study using propensity scoring. (cannabisclinicians.org)
  • Home 1 / Cancer 2 / Adjunctive nabilone in cancer pain and symptom management: a prospective. (cannabisclinicians.org)
  • Maida V, Ennis M, Irani S, Corbo M, Dolzhykov M. Adjunctive nabilone in cancer pain and symptom management: A prospective observational study using propensity scoring. (cannabisclinicians.org)
Oral1
  • After three months of therapy, oral nabilone improved the health of nearly all patients, with visible improvements in reducing diarrheal symptoms and weight gain. (cannabis-med.org)
Postoperative pain1
  • Nabilone can increase - rather than decrease - postoperative pain. (wikipedia.org)
Nightmares4
  • Nabilone is sometimes used for nightmares in post-traumatic stress disorder, but there have not been studies longer than nine weeks, so effects of longer-term use are not known. (wikipedia.org)
  • This is the report of an open label clinical trial to evaluate the effects of nabilone, an endocannabinoid receptor agonist, on treatment-resistant nightmares in patients diagnosed with posttraumatic stress disorder (PTSD). (realmofcaring.org)
  • The majority of patients (72%) receiving nabilone experienced either cessation of nightmares or a significant reduction in nightmare intensity. (realmofcaring.org)
  • CBD may hold promise for REM sleep behavior disorder and excessive daytime sleepiness, while nabilone may reduce nightmares associated with PTSD and may improve sleep among patients with chronic pain. (springer.com)
Patients8
  • Contrary to the main hypothesis, high dose nabilone in the presence of morphine patient controlled analgesia is associated with an increase in pain scores in patients undergoing major surgery. (nih.gov)
  • We hypothesize that nabilone will improve NMS in patients with PD and have a favorable safety profile. (springer.com)
  • A total of 38 patients will have 80% power to detect a probability of 0.231 that an observation in the treatment group is less than an observation in the placebo group using a Wilcoxon rank-sum test with a 0.050 two-sided significance level assuming a true difference of 2.5 points between nabilone and placebo in the primary outcome measure and a standard deviation of the change of 2.4 points. (springer.com)
  • This restriction is required because a substantial proportion of any group of patients treated with Nabilone can be expected to experience disturbing psychotomimetic reactions not observed with other antiemetic agents. (drugbank.com)
  • Abstract A randomized, double-blind, placebo-controlled trial was conducted to determine the benefit of nabilone in pain management and quality of life improvement in 40 patients with fibromyalgia. (realmofcaring.org)
  • Data from 112 patients (47 treated, 65 untreated) met criteria for analyses.The propensity-adjusted pain scores and total MSE use in nabilone-treated patients were significantly lower than were those found in untreated patients (both P (cannabisclinicians.org)
  • In a double-blind 14-week clinical study with 38 patients suffering from Alzheimer's disease the THC analogue nabilone was shown to reduce agitation and this effect was associated with decreases in inflammation of the brain. (cannabis-med.org)
  • Also, nabilone drugs work similarly to dronabinol in cancer patients. (bolsademulher.com)
Metoclopramide1
Decreases1
  • nabilone increases and albuterol decreases sedation. (medscape.com)
Cannabidiol1
  • Different effects of nabilone and cannabidiol on binocular depth inversion in man. (bvsalud.org)
Antidepressants1
  • Combined with antidepressants, nabilone could cause some cardiovascular problems including tachycardia (an elevated heart rate) and high blood pressure. (factcheck.org)
Interactions2
  • The committee were aware that people may be taking other medication when using nabilone and were concerned about potential adverse drug interactions. (nice.org.uk)
  • They recommended that adverse drug interactions should be carefully considered when prescribing nabilone. (nice.org.uk)
Dose3
  • Nabilone had a slower onset of peak action and a greater dose-dependence of effects, which the investigators attributed to greater bioavailability. (wikipedia.org)
  • Treatment with nabilone should begin 1 to 3 hours before the first dose of chemotherapy and may be continued for up to 48 hours after the end of the chemotherapy cycle. (medlineplus.gov)
  • Your doctor will probably start you on a low dose of nabilone and may gradually increase your dose if needed. (medlineplus.gov)
Drugs1
  • The committee highlighted concerns for the use of nabilone with central nervous system depressants and other centrally active drugs. (nice.org.uk)
Placebo-controlled2
  • A double-blind, randomized, placebo-controlled, parallel-group pilot trial compared the effects of two different doses, 1 mg (n = 11) and 2 mg (n = 9) of nabilone, ketoprofen 50 mg (n = 11) or placebo (n = 10), given at eight-hour intervals for 24 hr. (nih.gov)
  • The reduction of harm through an ineffective treatment, the possibility of individualized dosing, the reduction of sample size, and the possible evaluation of the influence of the placebo effect on efficacy outcomes justify this design for a single-centered placebo-controlled investigator-initiated trial of nabilone. (springer.com)
Medication1
  • Nabilone has also been used for medication overuse headache. (wikipedia.org)
Capsule1
Significantly1
  • Cumulative 24-hr morphine consumption was not different between the four groups, but pain scores at rest and on movement were significantly higher in the 2 mg nabilone group compared to the other groups. (nih.gov)
Analogue1
  • Main outcome measures The primary outcome was difference between nabilone and dihydrocodeine in pain, as measured by the mean visual analogue score computed over the last 2 weeks of each treatment period. (realmofcaring.org)
Baseline1
  • After a baseline assessment, subjects were titrated up on nabilone, from 0.5 mg PO at bedtime to 1 mg BID over 4 weeks or received a corresponding placebo. (realmofcaring.org)
Treatment1
  • Nabilone is also effective in the treatment of inflammatory bowel disease, especially ulcerative colitis. (wikipedia.org)
Effectiveness1
  • Nabilone has shown modest effectiveness in relieving fibromyalgia. (wikipedia.org)
Clinical1
  • Agitation, Oxidative Stress, and Cytokines in Alzheimer Disease: Biomarker Analyses From a Clinical Trial With Nabilone for Agitation. (cannabis-med.org)
Chronic1
  • Pellesi L, Verga MC, De Maria N, Villa E, Pini LA, Guerzoni S. Nabilone administration in refractory chronic diarrhea: a case series. (cannabis-med.org)
Dizziness1
  • Nabilone was also associated with more adverse events (drowsiness, dizziness and dry mouth), particularly in children. (nice.org.uk)
Group1
Increase9
  • nabilone and olopatadine intranasal both increase sedation. (medscape.com)
  • ropeginterferon alfa 2b and nabilone both increase Other (see comment). (medscape.com)
  • alfentanil and nabilone both increase sedation. (medscape.com)
  • alprazolam and nabilone both increase sedation. (medscape.com)
  • amobarbital and nabilone both increase sedation. (medscape.com)
  • apomorphine and nabilone both increase sedation. (medscape.com)
  • baclofen and nabilone both increase sedation. (medscape.com)
  • belladonna and opium and nabilone both increase sedation. (medscape.com)
  • buprenorphine and nabilone both increase sedation. (medscape.com)
Drug1
  • Nabilone is a Schedule II drug, and dronabinol is a Schedule III drug, which indicate that these medications have less abuse potential, do not usually lead to dependence, and are approved for restricted use. (clinicaladvisor.com)
Summary1
  • They recommended that healthcare professionals should think about these when considering nabilone and refer to the summary of product characteristics for further information on dosing, patient monitoring, contraindications and adverse events. (nice.org.uk)
Control1
  • NABILONE.ORG does not control how a business partner may use Your Personal Data. (domaindirectory.com)
United Kingdom1
  • In 2007, Valeant acquired the United Kingdom and European Union rights to market nabilone from Cambridge Laboratories. (wikipedia.org)
Forms1
  • If not provided in their activated form (such as through synthetic forms like Nabilone or Dronabinol ), THC and CBD are obtained through conversion from their precursors, tetrahydrocannabinolic acid-A (THCA-A) and cannabidiolic acid (CBDA), through decarboxylation reactions. (drugbank.com)
Study1
  • In this study by researchers of the University of Toronto, Canada, participants received both nabilone and a placebo for 6 weeks each in a crossover design with one week between treatments. (cannabis-med.org)
Total1
  • Nabilone is given in 1 or 2 mg doses multiple times a day up to a total of 6 mg. (wikipedia.org)
Label1
Trial1
  • Design Randomised, double blind, crossover trial of 14 weeks' duration comparing dihydrocodeine and nabilone. (realmofcaring.org)
People1
  • Nabilone is not currently licensed in the UK for children and young people under 18 years because its safety and efficacy has not been established. (nice.org.uk)