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  • Skeletal
  • Multiple myosin II molecules generate force in skeletal muscle through a power stroke mechanism fuelled by the energy released from ATP hydrolysis. (wikipedia.org)
  • We postulated that metabolic activity was increased in the skeletal muscles of sedentary SPORTS rats and accompanied by a shift in myofiber type to allow effective glucose and lipid usage and adaptation to extreme running activity. (scirp.org)
  • molecular
  • To address potential molecular mechanisms underlying the family-specific prognosis, we determined the relative expression of mutant versus wild-type MYH7-mRNA. (duhnnae.com)
  • Together with our findings, this suggests that tuning of myosin levels is a conserved mechanism for the stabilization of intercellular bridges that can occur by diverse molecular mechanisms. (elsevier.com)
  • divergent
  • Following the discovery by Pollard and Korn (1973) of enzymes with myosin-like function in Acanthamoeba castellanii , a global range of divergent myosin genes have been discovered throughout the realm of eukaryotes. (wikipedia.org)
  • tail domain
  • Since Myo1p tail-only constructs are biologically active, the tail domain must have additional functions beyond its previously described role in myosin dimerization or trimerization. (g3journal.org)
  • Recent studies indicate that it is the C-terminal globular tail domain (GTD) that directly inhibits the motor activity of myosin Va. In the present study, we identified a conserved acidic residue in the motor domain (Asp-136) and two conserved basic residues in the GTD (Lys-1706 and Lys-1779) as critical residues for this regulation. (umassmed.edu)
  • Most myosin molecules are composed of a head , neck, and tail domain. (wikipedia.org)
  • The tail domain generally mediates interaction with cargo molecules and/or other myosin subunits . (wikipedia.org)
  • Subjects
  • For example, certain risk factors can be observed in subjects who subsequently develop INSULIN RESISTANCE as in type 2 diabetes (DIABETES MELLITUS, TYPE 2). (bioportfolio.com)
  • filament
  • Phosphorylation of the regulatory light chain of myosin II (MLC(20)) at the activation sites promotes both the motor activity and the filament formation of myosin II, thus playing an important role in various cell motile processes. (umassmed.edu)
  • amino acid
  • Analysis of the amino acid sequences of different myosins shows great variability among the tail domains, but strong conservation of head domain sequences. (wikipedia.org)
  • intercellular
  • Myr 3, a member of the myosin-I family from rat, is shown in this study to be localized at adherens-type intercellular junctions in epithelial and nonepithelial tissues. (biologists.org)
  • regulatory
  • Hence, the extent of unequal expression of mutated versus wild-type transcript and protein is characteristic for each mutation, implying cis-acting regulatory mechanisms. (duhnnae.com)
  • Cocultures were infected with a lentiviral vector expressing shRNA against the regulatory chain of myosin II (shMLC) or nontargeting scrambled sequence (shSCR). (nih.gov)
  • To further investigate the contribution of OL myosin II on myelin formation, we infected OPC-DRG cocultures with shRNA lentivirus against the regulatory chain of MLC. (nih.gov)
  • Activation
  • Supervillin slows cell spreading by facilitating myosin II activation " by Norio Takizawa, Reiko Ikebe et al. (umassmed.edu)
  • Conversely, activation of myosin II or treatment of phorbol ester induces macropinocytosis in the axons and elicits growth cone collapse and repulsive axon turning. (umassmed.edu)
  • sequence
  • Phylogenetic sequence comparisons of the head regions of a host of novel myosins-I reveals at least four subclasses. (rupress.org)
  • rats
  • The ratio of type IIa myofibers was higher and glucose tolerance was better in SED SPORTS than in Wistar rats that were sedentary and trained daily on treadmills, respectively. (scirp.org)