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  • filaments
  • The present results suggest that the down-regulation of myosin II activity achieved by the phosphorylation at the Ser1/Ser2 sites plays an important role in the normal reorganization of actomyosin filaments triggered by PDGF receptor stimulation. (umassmed.edu)
  • ATPase
  • The effects of SV are reversed by inhibition of myosin heavy chain (MHC) ATPase (blebbistatin), MLCK (ML-7) or MEK (U0126), but not by inhibiting Rho-kinase with Y-27632. (umassmed.edu)
  • cell
  • Supervillin slows cell spreading by facilitating myosin II activation " by Norio Takizawa, Reiko Ikebe et al. (umassmed.edu)
  • During cell migration, myosin II modulates adhesion, cell protrusion and actin organization at the leading edge. (umassmed.edu)
  • SV inhibits cell spreading via an MLCK- and myosin II-dependent mechanism. (umassmed.edu)
  • Endogenous and EGFP-tagged SV colocalize with, and enhance the formation of, cortical bundles of F-actin and activated myosin II during early cell spreading. (umassmed.edu)
  • light
  • The L-MLCK- and myosin-binding site in SV, SV1-171, rearranges and co-localizes with mono- and di-phosphorylated myosin light chain and with L-MLCK, but not with the short form of MLCK (S-MLCK) or with myosin phosphatase. (umassmed.edu)
  • filament
  • Strong actin-myosin interaction can further shift the thin filament into the "open" position. (wikipedia.org)
  • The availability of cTnI148-159 depends on the blocked-closed-open equilibrium of tropomyosin on actin, which can be impacted by any interactions involving the thin filament, including actin-myosin cross-bridging and length dependent activation (also known as stretch activation or the Frank Starling law of the heart). (wikipedia.org)
  • The myosin heads bind and hydrolyze ATP, which provides the energy to walk toward the plus end of an actin filament. (wikipedia.org)
  • inhibitors
  • Furthermore, the UCN II effect on MLC20 was dependent on RhoA translocation to the membrane and subsequent activation of RhoA-associated kinase, as shown by the use of the specific inhibitors exoenzyme C3 and Y27632. (warwick.ac.uk)
  • These results were supported also by studying the impact of these myosin inhibitors on chromaffin granule mobility using direct visualization by dynamic confocal microscopy. (biochemj.org)
  • receptor
  • Using RT-PCR and fluorescent in situ hybridization, we demonstrated that UCN II and type-2 CRH receptor (CRH-R2) mRNAs were expressed in human nonpregnant and pregnant myometrium. (warwick.ac.uk)
  • Rab27a is an essential component of melanosome receptor for myosin Va". Molecular Biology of the Cell. (wikipedia.org)
  • intracellular
  • In this study we investigated the expression of urocortin II (UCN II) in human myometrium and its ability to phosphorylate intracellular components that can be involved in modulating myometrial contractility. (warwick.ac.uk)
  • For example, myosin is involved in intracellular organization and the protrusion of actin-rich structures at the cell surface. (wikipedia.org)