Myopathy creatine kinase. Medical search. Frequent questions

Acute rhabdomyolysis with hyperkalemia followed by ventricular dysrhythmias, cardiac arrest, and death has occurred after use in apparently healthy pediatric patients who were subsequently found to have undiagnosed skeletal muscle myopathy. (nih.gov)
Here, we report for the first time a case of myopathy with severe rhabdomyolysis and fasciitis following mRNA vaccination against SARS-CoV-2. (springer.com)
COVID-19 mRNA vaccine induced myopathy with rhabdomyolysis and fasciitis in a 28-year-old female. (springer.com)
For example, alcohol can cause an acute or subacute painful myopathy and may precipitate rhabdomyolysis, but, paradoxically, more often produces a slowly progressive painless myopathy. (musculoskeletalkey.com)
Lipitor can cause muscle pain, weakness, and tenderness with elevated creatine kinase (CK) and rhabdomyolysis. (insulin-store.com)
Cyclosporine and gemfibrozil used concomitantly with Lipitor can increase one's risk of myopathy and rhabdomyolysis. (insulin-store.com)
Inform patients of the risk of myopathy and rhabdomyolysis when starting or increasing the ZYPITAMAG dosage. (zypitamag.com)

questions CKQ010 CKD070) collects survey participant interview data to help interpret NHANES laboratory data for serum Creatine Phosphokinase (CPK). (cdc.gov)
Serum creatine kinase levels and renal function measures in exertional muscle damage. (cdc.gov)
In hospital, his serum creatine kinase (CK) was 2130 U/L, alanine aminotransferase (ALT) was 51 U/L, C-reactive protein (CRP) was 39 mg/L and erythrocyte sedimentation rate (ESR) was 45 mm/hr. (cdc.gov)
Acutely, affected dogs had increased serum creatine kinase and aspartate aminotransferase activities, corresponding with the histological finding of skeletal muscle degeneration in the absence of inflammation. (massey.ac.nz)
Serum creatine kinase may be elevated. (arizona.edu)
Serum creatine kinase concentration is usually normal but is sometimes increased by up to 3-fold. (wikidoc.org)
In EDMD serum creatine of elbow flexors was 3/5, shoulder abducc kinase (CK) level is normal or moderately tors 3/5 and other muscles 4/5. (who.int)

Autoimmune myositis is characterized by inflammatory and degenerative changes in the muscles (polymyositis, necrotizing immune-mediated myopathy) or in the skin and muscles (dermatomyositis). (msdmanuals.com)
For example, zidovudine, used in the treatment of AIDS, threw light on mitochondrial DNA turnover, and the recent delineation of statin myositis has shown how innate immune mechanisms provoked by muscle fibre injury can lead to secondary autoimmune attack and a progressive myopathy. (musculoskeletalkey.com)
However, there is a type of autoimmune mediated myopathy characterised by the persistence of muscle weakness and CK elevation after stopping statins. (bmj.com)
Herein, we discuss a case of autoimmune myopathy associated with statin exposure and responsive to immunossupresive drugs. (bmj.com)
Inflammatory myopathies (IM) are a heterogeneous group of autoimmune muscle diseases that include polymyositis, dermatomyositis and inclusion body myositis (MCI). (reumatologiaclinica.org)
An autoimmune myopathy known as immune-mediated necrotizing myopathy (IMNM) has occurred in patients using statins. (insulin-store.com)
There have been rare reports of IMNM, an autoimmune myopathy, associated with statin use. (zypitamag.com)

Cardiac disease may be prominent in nemaline myopathy or, at times, in other congenital myopathies. (medscape.com)
Nemaline myopathy - a clinically and genetically complex heterogenous group of disorders - is described uncommonly in humans and rarely in animals, and is characterised by progressive muscle weakness. (scielo.org.za)
Baseline diagnostics ruled out endocrinopathies and after histological and ultrastructural evaluation of thoracic limb muscles and nerve biopsies confirmed nemaline myopathy. (scielo.org.za)
Nemaline myopathy (NM) is one of several histologically distinct complex congenital myopathies reported in humans (North et al. (scielo.org.za)
1994). This myopathy comprises a clinically and genetically heterogenous group of disorders, characterised by muscle weakness and the histological identification of thread-like, rod-shaped structures called nemaline rod bodies, within muscle fibres (Shy et al. (scielo.org.za)
Nemaline myopathy is broadly classified in humans as congenital, childhood-onset and adult-onset or late-onset (North & Ryan 1993). (scielo.org.za)
This test includes genes associated with central core disease, nemaline myopathy, and myotubular myopathy. (ohsu.edu)
Pharmacological Inhibition of Myostatin in a Mouse Model of Typical Nemaline Myopathy Increases Muscle Size and Force. (wroc.pl)

Differential diagnoses include milder congenital myopathies ( central core disease and centronuclear myopathy ) and distal myopathies ( Udd distal myopathy , Nonaka distal myopathy , Markesbery-Griggs distal myopathy ) (see these terms). (wikidoc.org)

EMG/NCS should be considered in all cases of congenital myopathy given that creatine kinase level is not typically suggestive of a muscle disease given its typically normal range of values. (medscape.com)
Miyoshi myopathy is a muscle disorder that begins with weakness in the muscles that are located away from the center of the body (distal muscles), such as those in the legs. (medlineplus.gov)
As Miyoshi myopathy slowly worsens, the muscle weakness and atrophy spread up the leg to the muscles in the thigh and buttock and can also involve the upper arm and shoulder muscles. (medlineplus.gov)
Individuals with Miyoshi myopathy have highly elevated levels of an enzyme called creatine kinase (CK) in their blood, which often indicates muscle disease. (medlineplus.gov)
While chloride is necessary for normal muscle function, it is unknown how a lack of this chloride channel causes the signs and symptoms of Miyoshi myopathy. (medlineplus.gov)
The diagnosis of an idiopathic inflammatory myopathy is made by finding a combination of a typical clinical presentation in association with elevated levels of enzymes of muscle origin, myopathic changes on electromyography, edema in muscle on MRI, and characteristic muscle histopathology. (hcplive.com)
Muscle weakness is the chief complaint in patients with any of the idiopathic inflammatory myopathies. (hcplive.com)
A detailed family history may suggest the presence of an inherited muscle disorder, such as a muscular dystrophy or metabolic myopathy. (hcplive.com)
Other diseases that may cause the insidious onset of muscle weakness include the muscular dystrophies, metabolic myopathies (glycogen and lipid storage diseases), and endocrine myopathies. (hcplive.com)
The acute onset of muscle weakness suggests a neuropathic or myopathic cause other than the idiopathic inflammatory myopathies. (hcplive.com)
A previous muscle biopsy found only chronic myopathy with inflammatory infiltrates and fibrosis. (cdc.gov)
In severe cases, Myopathy leads to rhabdomylosis which is a condition when the muscle fibers are ruptured and a protein namely myoglobin is released. (targetwoman.com)
Diagnosis is by clinical findings and abnormalities on muscle tests, which may include creatine kinase test, MRI, electromyography, and muscle biopsy. (msdmanuals.com)
In contrast, polymyositis is characterized by direct T cell-mediated muscle injury, and necrotizing immune-mediated myopathies are characterized by macrophage-predominant infiltrates and myophagocytosis. (msdmanuals.com)
Electromyography of the left rectus muscle showed positive sharp waves and fibrillations with small and partly polyphasic motor unit potentials, compatible with an acute myopathy or myositis. (springer.com)
One case described local COVID-19 vaccine-related myopathy in the deltoid muscle with probable myositis [ 4 ]. (springer.com)
Muscle strength, creatine kinase levels and treatments were assessed in anti-HMGCR-positive patients at each clinical visit. (johnshopkins.edu)
Elevated creatine kinase, myositis-specific antibodies, diagnostic muscle biopsy. (mhmedical.com)
Other signs and symptoms of myofibrillar myopathy can include a weakened heart muscle (cardiomyopathy), muscle pain (myalgia), loss of sensation and weakness in the limbs (peripheral neuropathy), and respiratory failure. (beds.ac.uk)
Most people with this disorder begin to develop muscle weakness (myopathy) in mid-adulthood. (beds.ac.uk)
Myofibrillar myopathy is part of a group of disorders called muscular dystrophies that affect muscle function and cause weakness. (beds.ac.uk)
Muscle biopsies reveal changes consistent with myopathy. (arizona.edu)
Multi-minicore Disease (MmD) is a recessively inherited neuromuscular disorder characterized by multiple cores on muscle biopsy and clinical features of a congenital myopathy. (biomedcentral.com)
Multi-minicore Disease (MmD) is an inherited neuromuscular disorder defined by a) multiple areas with reduced oxidative activity running along an only limited extent of the longitudinal axis of the muscle fibre ("minicores") and b) clinical features of a congenital myopathy. (biomedcentral.com)
various different designations ("Minicore myopathy", "Multicore myopathy", "Multiminicore myopathy", "Minicore myopathy with external ophthalmoplegia", "Multicore myopathy with external ophthalmoplegia", "Multiminicore disease with external ophthalmoplegia") have been assigned to cases with similar histopathological features and reflect the wide variability of both core appearance on muscle biopsy and associated clinical findings. (biomedcentral.com)
Muscle enzymes (e.g., creatine kinase) are elevated in inclusion body myositis as they are in IIM but usually less so in inclusion body myositis (as much as 10 times normal) than in PM/DM (as much as 50 times normal). (rheumaknowledgy.com)
Clinical symptoms of SIM can include muscle pain, soreness, and/or weakness and are often accompanied by increases in creatine kinase (CK) levels. (walshmedicalmedia.com)
the possibility of muscle disease causing elevations in liver tests can be further explored by measuring muscle enzymes, including creatine kinase . (wikidoc.org)
Peak creatine kinase was elevated in 74% (mean 959 U/L, range 29-8,413 U/L). Muscle showed type 2 atrophy in 32 patients, necrotizing myopathy in 9, and myositis in 7. (neurology.org)
The authors describe a 47-year-old man who presented with proximal muscle weakness, myalgia, elevated creatine kinase, and features of a pure myopathic syndrome in whom they have identified a novel mutation in the mitochondrial tRNAAla gene. (ncl.ac.uk)

In the evaluation of a patient with possible congenital myopathy, consideration of the pattern of clinical phenotype, laboratory examination, and electrodiagnostic studies are the first line of evaluations to ensure that patients clinically fit. (medscape.com)
5 times the upper range of normal) is unlikely to be a congenital myopathy and other diseases such as the muscular dystrophies should be considered. (medscape.com)
They can help to confirm the diagnosis, but results from these tests can be normal in a patient with congenital myopathy. (medscape.com)
The greatest value of EMG/NCS is to help exclude other causes of congenital myopathy. (medscape.com)
In congenital myopathy, NCS findings can be normal or demonstrate low-amplitude responses in the motor nerve conduction studies in severe cases, while the EMG findings are either normal or show the typical small-amplitude, narrow-duration motor unit potentials (MUPs) that are seen in myopathies. (medscape.com)
Bailey-Bloch Congenital Myopathy in Brazilian Patients: A Very Rare Myopathy with Malignant Hyperthermia Susceptibility. (wroc.pl)
Novel TTN Mutation Causing Severe Congenital Myopathy and Uncertain Association with Infantile Hydrocephalus. (wroc.pl)

Patients have persistently elevated creatine kinase and histopathology is typical of myofibrillar myopathy. (cdc.gov)
The signs and symptoms of myofibrillar myopathy vary widely among affected individuals, typically depending on the condition's genetic cause. (beds.ac.uk)
Myofibrillar myopathy primarily affects skeletal muscles, which are muscles that the body uses for movement. (beds.ac.uk)

Individual diseases included under the term "idiopathic inflammatory myopathy" are polymyositis and dermatomyositis, as well as myositis associated with neoplastic disease, myositis associated with collagen-vascular disease, and inclusion body myositis. (hcplive.com)
Immune-mediated inflammatory myopathies include polymyositis, dermatomyositis, myositis resulting from a rheumatic disease or overlap syndrome, inclusion body myositis (IBM), and immune-mediated necrotizing myopathy. (mhmedical.com)
There are four major categories of idiopathic inflammatory myopathy: dermatomyositis (DM), polymyositis (PM), immune-mediated necrotizing myopathy (IMNM), and inclusion body myositis (IBM), which are clinically, histologically, and pathogenically distinct ( Tables 33-1 , 33-2 , 33-3 ). (mhmedical.com)

Idiopathic inflammatory myopathy is a term applied to a group of relatively rare diseases that present with the gradual onset of weakness of shoulder and pelvic girdle muscles. (hcplive.com)
With an estimated incidence of only 5 cases per million adults, 1 the idiopathic inflammatory myopathies are rare diseases. (hcplive.com)
Inclusion body myositis also is the most common idiopathic inflammatory myopathy. (hcplive.com)
The idiopathic inflammatory myopathies must be differentiated from those caused by infections, toxins, endocrinopathies, muscular dystrophies, and inborn errors of metabolism. (hcplive.com)
In this article, we describe an approach to the diagnosis and management of the idiopathic inflammatory myopathies. (hcplive.com)
No single feature is diagnostic of an idiopathic inflammatory myopathy, and the diagnosis can be made only after the exclusion of other causes of these abnormalities. (hcplive.com)
The first step in diagnosing an idiopathic inflammatory myopathy is to determine the time course of the weakness. (hcplive.com)
It is important to emphasize that not all myopathies with inflammation are classified as "inflammatory myopathies. (mhmedical.com)
False Inflammatory Myopathies. (reumatologiaclinica.org)
Inflammatory myopathies are a heterogeneous group of myopathies in which there is biopsy-evident inflammation. (reumatologiaclinica.org)
This paper reviews the electromigram pattern characteristic of inflammatory myopathies, its diagnostic value, limitations, and some clues on the interpretation of the results of neurophysiological techniques in the assessment of inflammatory myopathies. (reumatologiaclinica.org)

Wu AH, Smith A, Wians F. Interpretation of creatine kinase and aldolase for statin-induced myopathy: Reliance on serial testing based on biological variation. (cdc.gov)
2. Disease spectrum of myopathies with elevated aldolase and normal creatine kinase. (nih.gov)

Laing distal myopathy is characterized by early-onset selective weakness of the great toe and ankle dorsiflexors, and a very slowly progressive course. (wikidoc.org)

Muscular diseases like Myopathy which is characterized by soreness of muscles due the increase of enzyme (creatine Kinase) in the blood with the prolonged use of Statins. (targetwoman.com)
Some drug-related myopathies, such as those caused by statins, steroids and alcohol, are common, while others are very rare. (musculoskeletalkey.com)
The most common adverse effect of the statins is statin-induced myopathy (SIM). (walshmedicalmedia.com)

Sandercock, DA & Mitchell, MA 1996, ' Dose dependent myopathy in monensin supplemented broiler chickens: Effects of acute heat stress ', British Poultry Science , vol. 37, no. (sruc.ac.uk)
Go Slow' myopathy (GSM) is an idiopathic myopathy in dogs in New Zealand, characterised by an acute onset of trembling, weakness and collapse, followed by a prolonged period of exercise intolerance. (massey.ac.nz)

Mimics include infectious, metabolic, or drug-induced myopathies. (mhmedical.com)

Key Exclusion Criteria: - Patients who have documentation of any of the following: - epidermal growth factor receptor ( EGFR ) mutation - anaplastic lymphoma kinase ( ALK ) fusion oncogene or - ROS1 rearrangement - Patients who have received more than 1 prior line of systemic therapy in the advanced/metastatic setting. (mycancergenome.org)
However, many patients (upto 25%) cannot tolerate or discontinue statin therapy due to statin-induced myopathy (SIM). (walshmedicalmedia.com)
Patients are at greater risk for developing myopathy if they are 65 years of age or older, have uncontrolled hypothyroidism, have renal impairment, are on other drugs with myopathy risk, or are on high doses of Lipitor. (insulin-store.com)
Major histocompatibility complex-1 (MHC-1) expression was observed in all cases of necrotizing myopathy and myositis and in 8 additional patients. (neurology.org)
Needle gressive myopathy, but the disease spectrum electromyography showed polyphasicity, includes patients whose disease is much decreased duration and latency of motor more severe [ 8 ]. (who.int)

The most common adverse reactions that led to treatment discontinuation were: elevated creatine phosphokinase (0.6% on 4 mg) and myalgia (0.5% on 4 mg). (zypitamag.com)

Myopathy is a general term applied to disorders of muscles. (wroc.pl)
Genetically related (allelic) disorders are familial hypertrophic cardiomyopathy 1 and myosin storage myopathy , however, the clinical picture of MPD1 is distinct from that of these conditions. (wikidoc.org)

Macro-creatine kinase (macro-CK) is a macroenzyme, an enzyme of high molecular weight and prolonged half-life found in human serum. (wikipedia.org)

Comment: OATP1B1 inhibitors may increase risk of myopathy. (medscape.com)

Creatine kinase test diagnostic accuracy in neonatal screening for Duchenne Muscular Dystrophy: a systematic review. (cdc.gov)

Immune-mediated necrotizing myopathies include those associated with the signal recognition particle or with anti-3-hydroxy-3-methylglutaryl coenzyme A reductase (anti-HMGCR) autoantibodies in the setting of statin use. (mhmedical.com)
Statin-associated myopathy is more common in people who receive multiple drugs, the elderly or women but the mechanism underlying it is still unclear. (bmj.com)

It is unclear why this damage leads to the specific pattern of weakness and atrophy that is characteristic of Miyoshi myopathy. (medlineplus.gov)
At first presentation, she had a mild predominantly left-sided weakness of hip flexor and knee extension (MRC 4-/5 vs. MRC 4/5) with marked subcutaneous leg edema (Fig. 1 a), the creatine kinase was 17,959 U/l (normal range 26-140 U/l). (springer.com)
Four weeks after onset, creatine kinase was normal, the weakness and leg edema were gone, and she could do jogging again. (springer.com)
Weakness of the hip girdle and upper thigh muscles, for instance in myopathies, leads to an instability of the pelvis on standing and walking. (beds.ac.uk)

The aim of the present study was to investigate the clinical features and risk factors of CK elevations and myopathy associated with telbivudine. (nih.gov)
However, SLCO1B1 may also be clinically relevant for pravastatin- and pitavastatin-induced myopathy, but additional studies assessing SIM clinical outcome are needed. (walshmedicalmedia.com)

Taken together, the results of these studies suggest that 'Go Slow' myopathy is a toxic mitochondrial myopathy in dogs that is associated with the ingestion of wild pork. (massey.ac.nz)

Congenital myopathies are a group of genetic conditions and can be autosomal dominant, recessive or X-linked. (ohsu.edu)

The findings reported aid in the prevention, diagnosis, and management of cases, with the primary suggestion being that owners avoid feeding wild pork in areas where the myopathy occurs. (massey.ac.nz)
The differential diagnosis of inclusion body myositis includes other types of IIM as well as other endocrinologic, metabolic, infectious, and toxic etiologies (see Myopathy ). (rheumaknowledgy.com)

The animal presented elevated values of creatine kinase, cardiac troponin I and blood urea nitrogen, with some variations during the rehabilitation period. (ulpgc.es)
The severity of cardiac disease is much gene, which is located on the Xcchromoc greater than the myopathy [ 4 ]. (who.int)

Seven days following vaccination, a blood test revealed marked elevation of creatine kinase and transaminases. (springer.com)

Late-Onset Pompe Disease with Normal Creatine Kinase Levels: The Importance of Rheumatological Suspicion. (wroc.pl)
Myopa- thy is diagnosed when the creatine kinase blood levels exceeds 10 times normal. (topforex-brokers.com)
Discontinue ZYPITAMAG if markedly elevated CK levels occur or myopathy is diagnosed or suspected. (zypitamag.com)
Significantly elevated levels of ALT (SGPT) often suggest the existence of other medical problems such as viral hepatitis , diabetes , congestive heart failure , liver damage, bile duct problems, infectious mononucleosis , or myopathy , so ALT is commonly used as a way of screening for liver problems. (wikidoc.org)

Rarely, abnormal heart rhythms (arrhythmias) have developed in people with Miyoshi myopathy. (medlineplus.gov)

Capture myopathy (CM) is described in wild animals as a metabolic syndrome resulting from the extreme stress suffered during and after capture, handling, restraint, and transport. (ulpgc.es)

Subsequently, biochemical evaluation with a creatine kinase can rapidly help narrow the differential. (medscape.com)

Overall, the microscopic findings were consistent with a toxic myopathy. (massey.ac.nz)

myopathy associated with collagen-vascular disease occurs at the age that is associated with the particular collagen-vascular disease that is present. (hcplive.com)

CYP2D6*4 may be clinically relevant for atorvastatin-induced myopathy, but mechanistic studies are needed. (walshmedicalmedia.com)

The exact prevalence of Miyoshi myopathy is unknown. (medlineplus.gov)

Relating Structure to Mechanism in Creatine Kinase. (cdc.gov)

This may manifest as a myopathy and/or a peripheral neuropathy depending on the distribution of the granulomas. (medscape.com)

Anatomy18

Organisms9

Diseases32

Chemicals and Drugs122

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Phenomena and Processes33

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Information Science3

Rhabdomyolysis7

Serum creatine7

Autoimmune7

Nemaline8

Centronuclear myopathy1

Muscle30

Congenital myopathy7

Myofibrillar myopathy3

Polymyositis3

Inflammatory11

Aldolase2

Distal1

Statins3

Acute2

Drug-induced1

Patients5

Myalgia1

Disorders2

Enzyme1

Risk of myopathy1

Diagnostic1

Statin2

Weakness4

Clinical2

MITOCHONDRIAL MYOPATHY1

Autosomal1

Diagnosis2

Cardiac2

Elevation1

Levels4

Abnormal1

Metabolic1

Differential1

Findings1

Disease1

Clinically1

Prevalence1

Mechanism1

Peripheral neuropathy1