As of 2006, between 1000 and 3000 cases of clostridial myonecrosis were reported in the United States each year, typically accompanied by another pre-existing medical condition. (wikipedia.org)
Metastatic clostridial myonecrosis is an uncommon complication of malignancy, particularly of the gastrointestinal tract, and of leukemia. (oaepublish.com)
Gas Gangrene, also known as clostridial myonecrosis , is a fast spreading and life threatening[1]. (bartleby.com)
Muscle necrosis and soft-tissue infection, which is characterized by crepitant cellulitis, myositis, and clostridial myonecrosis, can be caused by C. perfringens . (msdmanuals.com)
Clostridium perfringens is the classic organism responsible for "gas gangrene" or clostridial myonecrosis, although any Clostridial species can produce such infections. (crashingpatient.com)
The diagnosis was clostridial myonecrosis. (medscape.com)
Although the incidence of clostridial myonecrosis infections has dropped precipitously in recent decades, it always remins a threat in injuries where contamination and severe tissue disruption have occurred. (bestpub.com)
The decreased incidence of clostridial myonecrosis is attributed to the increased diligence of clinicians in preventing clostridial organisms from proliferating. (bestpub.com)
C. septicum is one of several bacteria responsible for myonecrosis, otherwise known as gas gangrene. (wikipedia.org)
One of the more aggressive progenitors of gas gangrene, C. septicum infection progresses very rapidly, with a mortality rate of approximately 79% in adults, typically occurring within 48 hours of infection. (wikipedia.org)
Clostridium septicum derived gas gangrene has shown strong correlations with increased levels of malignancy. (wikipedia.org)
Spontaneous gas gangrene is most often caused by hematogenous spread of C septicum from the gastrointestinal tract in patients with colon cancer or other portals of entry. (medscape.com)
Gas gangrene is a condition of rapidly developing and spreading infection mediated by toxins released by the bacteria Clostridium spp. (bmj.com)
Abstract: Gas Gangreneis a potentially deadly form of tissue death.The Clostridium species C.perfringens , C.septicum and C.histolyticum are the principal causative agent of the trauma associated gas gangrene and their incidence increases dramatically in times of war, hurricanes , earthquakes and other mass casualty condition. (bartleby.com)
Unlike C perfringens, C septicum is aerotolerant and can infect normal tissues. (medscape.com)
The most commonly encountered, clinically important clostridia include Clostridium perfringens , C. clostridioforme , C. ramosum , C. butyricum , C. innocuum , C. septicum , C. tertium , and C. difficile ( 1 ). (cdc.gov)
the following information is not yet verified Gram positive, straight rods, 0.3-1.4 x 1.3-16.0 µm, occur singly Size â The size of Clostridium perfringens is about 4â 6 µm × 1 µm (micrometer). (labionix.kz)
Shape â Clostridium perfringens is a large, rod shape (bacillus) bacterium with straight, parallel sides and rounded or truncated ends. (labionix.kz)
Clostridium perfringens is especially likely in wounds contaminated with soil. (crashingpatient.com)
Clostridium species are gram-positive, spore-forming, anaerobic rods normally found in soil and the gastrointestinal tract of humans and animals. (medscape.com)
Clostridium sporogenes is a species of Gram-positive bacteria that belongs to the genus Clostridium. (labionix.kz)
Nearly 100 Clostridium species have been identified, but only 25 to 30 commonly cause human or animal disease. (msdmanuals.com)
The 16S rRNA gene sequences of pathogenic Clostridium species were found in the nucleic acid of five tissue specimens from four P. nayaur . (bmsw.net.cn)
Anaerobic7
Clostridium septicum is a gram positive, spore forming, obligate anaerobic bacterium. (wikipedia.org)
Infection by C. septicum was once thought to be extremely rare, however anaerobic laboratory techniques allowed for the discovery of the true potential of this infectious microbe. (wikipedia.org)
the myonecrosis seems to only develop when sufficient devitalized tissue is present to support anaerobic metabolism. (medscape.com)
The blood and abscess isolates did not grow aerobically, although anaerobic growth on brucella blood agar media (PML Microbiologicals, Wilsonville, OR) showed identical-looking, nonhemolytic, motile organisms, with colonial and microscopic morphologic features typical of Clostridium spp. (cdc.gov)
Clostridium sporogenes is an anaerobic, gram-positive bacillus that comprises a part of the normal intestinal flora. (labionix.kz)
Like other strains of Clostridium, it is an anaerobic, rod-shaped bacterium that produces oval, subterminal endospores[2] and is commonly found in soil. (labionix.kz)
Clostridia are spore-forming, gram-positive, anaerobic bacilli present widely in dust, soil, and vegetation and as normal flora in mammalian gastrointestinal tracts. (msdmanuals.com)
Bacteria3
At the outset, the bacteria were classified into genus Clostridium based on the morphological and physiological characteristics above. (labionix.kz)
The highly proteolytic nature of Clostridium sporogenes is thought possibly to act as an adjuvant and promote invasiveness of other bacteria in various mixed infections of animals and humans a generalized lethal disease, possibly egg-borne, in newly hatched chicks has been attributed to C. sporogenes. (labionix.kz)
Diagnostic testing may include, fluid, blood and tissue cultures to test for Clostridium perfrigens and other bacteria. (bartleby.com)
Clostridium septicum can cause spontaneous, nontraumatic necrotizing infections. (crashingpatient.com)
Difficile2
The long-term use of proton pump inhibitors has been linked to an increased risk for the development of gastric polyps, hip fractures, pneumonia, and Clostridium difficile colitis. (tobycornish.com)
Clostridium septicum can cause infection quickly if the gut tissue becomes necrotic or inflamed. (wikipedia.org)
Sites prone to infection are those with poor vascular supply, although because of pH, electrolyte and osmotic differences, the colon may promote the growth of C. septicum better than most other anatomical regions. (wikipedia.org)
This relationship suggests the opportunistic nature of this pathogen raising the possibility that immunosuppression plays a key role in the ability of C. septicum to cause infection. (wikipedia.org)
This case illustrates a possible association between proton pump inhibitor therapy and fatal C septicum infection. (tobycornish.com)
Microbiological examination revealed Gram-positive bacilli and culture demonstrated profuse C. septicum infection. (bmj.com)
Generally, patients with C. septicum infections present colonic carcinoma or a tumor that has metastasized to the colon. (wikipedia.org)
Clostridium strains are widely distributed in the environment and form part of the normal colonic microflora of humans and many animals ( 1 , 2 ). (cdc.gov)
Bowel2
We reported a case of a 67-year-old woman who developed sudden myonecrosis in her right thigh secondary to perforated large bowel cancer. (oaepublish.com)
A third line of questions deal with C. septicum infections and their high associations with bowel tumors. (bestpub.com)
Clinically1
Clinically, Clostridium infections begin within hours of an inciting trauma, or surgery, with the sudden onset of pain that rapidly extends beyond the wound. (crashingpatient.com)
Colon cancer1
Although rare, C. septicum infections are often found in individuals with a recent history of trauma, surgery, peripheral vascular disease, diabetes, colon cancer, skin infections or burns and septic abortions. (wikipedia.org)
Hemolytic1
Clostridium septicum causes myonecrosis through the release of exotoxins such as the alpha toxin, lethal toxin, and hemolytic toxin Clostridium septicum is a large, gram-positive, rod-shaped bacterium that is a member of the normal gut flora in humans as well as other animals. (wikipedia.org)
Gram4
the diagnosis of metastatic myonecrosis was based on a high index of suspicion, development of bullae containing gram-positive rods, and subcutaneous crepitus (although this was a late sign). (oaepublish.com)
We describe a 27-year-old man with acute cholecystitis, hepatic abscess, and bacteremia caused by Clostridium hathewayi , a newly described gram-negative, endospore-forming, rod-shaped bacterium. (cdc.gov)
Gram strain of Clostridium hathewayi from growth on solid agar media. (cdc.gov)
The authors state that clostridium sporogenes are spore forming and gram forming to produce carboxylic acids which are necessary during the reaction in cancer therapy. (labionix.kz)
Four toxins have been isolated from C. septicum: the lethal alpha toxin, DNase beta-toxin, hyaluronidase gamma toxin, and the thiol-activated (or septicolysin) delta toxin. (wikipedia.org)
Serious noninfectious disease can occur after ingestion of home-canned foods in which clostridia have produced toxins. (msdmanuals.com)
Endospores1
Under unfavorable conditions, C. septicum forms endospores allowing it to survive under harsh conditions such as extreme temperature, dry land, and nutrient-deficient habitats. (wikipedia.org)
Bacterium1
Clostridium septicum is a resident bacterium of the human microflora, however it can be found in almost any anoxic habitat in which exists organic compounds. (wikipedia.org)
Tissue necrosis2
Alpha toxin causes intravascular hemolysis and tissue necrosis and is well known as the main virulent factor in C. septicum. (wikipedia.org)
Skin and tissue necrosis can be caused by bloodborne C. septicum from the colon. (msdmanuals.com)
Botulinum1
C. sporogenes is very similar to Clostridium botulinum, which you might have heard of on the T.V. Do humans even contract it? (labionix.kz)
Malignancy1
It seems likely that either the treatment or the malignancy itself impairs the immune function of the gastrointestinal mucosa allowing C. septicum to gain access to the circulatory system. (wikipedia.org)
Acid1
Among the 16S rRNA gene clones in the nucleic acid of the other specimens, the abundance of non- Clostridium spp. (bmsw.net.cn)
Disease1
The hallmarks of this disease are rapid onset of myonecrosis with muscle swelling, severe pain, gas production, and sepsis. (medscape.com)
Patient1
Clostridium sporogenes produce metabolic which are used as source energy for the patient. (labionix.kz)