• Myogenin is a member of the MyoD family of transcription factors, which also includes MyoD, Myf5, and MRF4. (wikipedia.org)
  • myogenin, myoD, and myf6 are expressed in these embryoid bodies in a characteristic temporal pattern which precisely reflects the sequence observed during mouse development in vivo. (uni-luebeck.de)
  • Myf5 is the first gene to be expressed followed by myogenin, myoD, and myf6, in this order. (uni-luebeck.de)
  • In situ hybridization demonstrates transcripts for myogenin and myoD accumulating in mono- and multinucleated myogenic cells, while myf5 mRNA is already found in mononucleated myoblasts. (uni-luebeck.de)
  • MURF1, atrogin-1 and FBXO40, their substrate targets PKM2, myogenin, MYOD, MHC and EIF3F as well as MURF1 and atrogin-1 transcriptional regulators FOXO1 and FOXO3 gene and/or protein expression levels were measured via real time PCR and western blotting, respectively. (edu.au)
  • At basal, no age-related difference was observed in the gene/protein levels of atrogin-1, MURF1, myogenin, MYOD and FOXO1/3. (edu.au)
  • The MyoD gene was duplicated during the teleost whole genome duplication and, while a second MyoD gene ( MyoD2 ) was subsequently lost from the genomes of some lineages (including zebrafish), many fish lineages (including Alcolapia species) have retained both MyoD paralogues. (mdpi.com)
  • Here we reveal the expression patterns of the two MyoD genes in Oreochromis ( Alcolapia) alcalica using in situ hybridisation. (mdpi.com)
  • Regulation of skeletal myogenesis in C2C12 cells through modulation of Pax7, MyoD, and myogenin via different low-frequency electromagnetic field energies [med. (emf-portal.org)
  • MyoD and myogenin, but had no effect on a range of immune cell markers or inflammatory cytokines. (edu.au)
  • Skeletal muscle differentiation is triggered by a unique family of myogenic basic helix-loop-helix transcription factors, including MyoD, MRF-4, Myf-5, and Myogenin. (unipv.it)
  • Myoblasts from somites express myosin heavy chain (MHC) before they express MyoD or myogenin, while myoblasts from limb buds express MHC only after MyoD and. (webdarkwebsites.com)
  • Tamir, Y., and Bengal, E. (1998) p53 protein is activated during muscle differentiation and participates with MyoD in the transcription of muscle creatine kinase gene . (technion.ac.il)
  • Upon activation satellite cells rapidly initiate MyoD expression which leads to the activation of myogenin and terminally differentiated structural muscle mass genes such as myosin heavy chain (MHC) [1] [3]. (healthyguide.info)
  • Myogenin also identified as myogenic factor 4 is a muscle-specific transcription factorassociated with muscle differentiation and cell cycle. (sigmaaldrich.com)
  • Myogenin is required for the proper differentiation of most myogenic precursor cells during the process of myogenesis. (wikipedia.org)
  • For TNFa induced inhibition of myoblast differentiation myogenin expression was reduced. (cdc.gov)
  • Rho binds GTP and plays a critical role in muscle differentiation by regulating the expression of myogenin and MEF2 genes. (signalchem.com)
  • In addition, the expression levels of genes related to muscle differentiation and atrophy were confirmed through qRT-PCR. (kosfaj.org)
  • In the presence of antler extracts, the length and thickness of myotubes and myogenin differentiation 1 (MyoD1) and myogenic factor 5 (Myf5) gene expression were increased compared to those in the control group (CON). (kosfaj.org)
  • Therefore, our findings indicate that antler extract can increase the expression of MyoD1, Myf5 and myogenin, inhibit muscle atrophy, and promote muscle differentiation. (kosfaj.org)
  • Myogenin is a muscle-specific basic-helix-loop-helix (bHLH) transcription factor involved in the coordination of skeletal muscle development or myogenesis and repair. (wikipedia.org)
  • In cell culture, myogenin can induce myogenesis in a variety of non-muscle cell types. (wikipedia.org)
  • During myogenesis, the muscle transcription factor Myogenin plays a pivotal role in orchestrating the expression of other muscle-specific genes. (kcl.ac.uk)
  • Almost 25 years ago, two publications ( Nabeshima et al Nature 1993 and Hasty et al Nature 1993 ) showed that the lack of Myogenin blocked proper myogenesis in a mouse model. (kcl.ac.uk)
  • Since that time, no studies have identified a specific cellular or molecular function for Myogenin during myogenesis. (kcl.ac.uk)
  • Cell culture experiments indicated that Gln could promote cell proliferation in a dose dependent manner, but expression of myogenesis regulatory genes was not altered. (nature.com)
  • The mouse blastocyst-derived embryonic stem cell (ES cell) line BLC6 efficiently differentiates into myosin heavy chain-, desmin- and myogenin- positive skeletal muscle cells when cultivated in embryo-like aggregates (embryoid bodies). (uni-luebeck.de)
  • To gain insight into Myogenin function the team used the zebrafish as an animal model and created a mutant in which the expression of Myogenin protein was abolished. (kcl.ac.uk)
  • The genetic study showed promising results in "silencing" the genes that translate into tau protein, the primary component behind dementia. (medicaldaily.com)
  • BPH-related genes were identified using GeneCards and online Mendelian inheritance in man databases, and their intersection was used to construct a protein-protein interaction network analysis graph. (bvsalud.org)
  • Gene ontology enrichment analysis showed that QLXF affected several processes, such as DNA transcription factor binding, kinase binding, protein homodimerization activity, protein structure domain-specific binding, and protein-coupled amine receptor activity in BPH patients. (bvsalud.org)
  • RhoD is a member of the Rho gene family that interacts with protein kinases and serves as a target of activated GTPase. (signalchem.com)
  • We investigated the expression levels of the UPP-related genes and proteins involved in muscle protein degradation in 10 older ( 60-75 years ) vs. 10 younger ( 18-30 years ) healthy male subjects at basal as well as 2 h after a single-bout of RE. (edu.au)
  • In conclusion, UPP-related gene/protein expression is comparably regulated in healthy young and old male subjects at basal and following RE. (edu.au)
  • Gene expression of AMP-activated protein kinase (AMPK), MyoD1, and myogenin, along with the muscle atrophy factors muscle RING finger-1 (MuRF-1) and forkhead box O3a (FoxO3a) upon addition of deer antler extracts to muscle-atrophied C2C12 cells was determined by qRT-PCR after treatment with AICAR. (kosfaj.org)
  • The aim of the current study was to investigate the effects of Yes-associated protein 1 ( YAP1 ) gene expression after birth on the development of muscle and the relationship between YAP1 and myostatin ( MSTN ) and myogenin ( MyoG ). (geneticsmr.com)
  • Anti-myogenin reactivity isseen in the nuclei of myoblasts in developing muscle tissue. (sigmaaldrich.com)
  • Myoblasts from TNFR1 and TNFR2 deficient mice demonstrated that TNFa induced gene expression in primary myoblasts is dependent on both receptors. (cdc.gov)
  • Data normalized to corresponding myoblasts or myotubes transfected with pGL3 promoter vector in the case of pck2 assay (A), Myogenin data was normalized to myoblasts transfected with pGL4.15 containing myogenin construct, because pGL4.15 alone does not have any basal activity. (biomedcentral.com)
  • Here, we show that the muscle-specific determination genes myf5. (uni-luebeck.de)
  • Here we show by in vivo fate mapping that brown, but not white, fat cells arise from precursors that express Myf5, a gene previously thought to be expressed only in the myogenic lineage. (bioseek.eu)
  • Awareness of the possibility of PAX7 gene fusions in BSNS is important as it may aid in the diagnosis of PAX3 fusion negative tumors. (wustl.edu)
  • Microarray profiling of gene expression in C2C12 myotubes trained by electric pulse stimulation [med. (emf-portal.org)
  • In addition, the tumor was positive for desmin and MyoD1 but negative for myogenin, a pattern that is common among BSNS with variant fusions. (wustl.edu)
  • In addition, gene expression of MyoD1 and myogenin in the muscle atrophy cell model was significantly increased compared that into the CON. (kosfaj.org)
  • Additionally, bioinformatic analyses were conducted to discover target genes, signaling pathways and gene ontologies associated with the identified miRNAs. (biomedcentral.com)
  • MicroRNAs are small non-coding post-translational biomolecules which, when expressed, modify their target genes. (archivesofmedicalscience.com)
  • Overall, Gln supplementation stimulated cell proliferation in muscle tissue and in vitro in myogenic cell culture, whereas muscle growth regulatory genes were barely altered. (nature.com)
  • These transcription factors bind promoters and distant regulatory regions, including E-box elements, of genes whose expression is restricted to muscle cells. (unipv.it)
  • Myogenin, is a transcriptional activator encoded by the MYOG gene. (wikipedia.org)
  • MicroRNAs regulate gene expression at the post-transcriptional level by binding to 3′- or less often to 5′-untranslated regions of target messenger RNAs (mRNAs), which in consequence leads to inhibited translation and/or induces degradation of targeted mRNA [ 1 ]. (archivesofmedicalscience.com)
  • Kolpakova A*, Katz S*, Keren A, Rojtblat A, Bengal E . (2013) Transcriptional Regulation of Mesoderm Genes by MEF2D during Early Xenopus Development . (technion.ac.il)
  • In mice, myogenin is essential for the development of functional skeletal muscle. (wikipedia.org)
  • When the DNA coding for myogenin was knocked out of the mouse genome, severe skeletal muscle defects were observed. (wikipedia.org)
  • Mice lacking both copies of myogenin (homozygous-null) suffer from perinatal lethality due to the lack of mature secondary skeletal muscle fibers throughout the body. (wikipedia.org)
  • A miRNA-mRNA network was constructed, and Gene Ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed. (biomedcentral.com)
  • Subsequently, gene ontology and Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analyses were performed. (bvsalud.org)
  • Critical to sub-classify SRBCTs, Khan et al .6 used to measure genome-wide gene expres- .com decisions in cancer therapeutics are to microarrays to monitor the expression sion for a variety of biological samples. (lu.se)
  • The underlying hypothesis has been that differences in gene sequence between individuals could result in alteration in genome function that would create phenotypic differences that manifest themselves in mental or physical disorders. (biomedcentral.com)
  • A comparison of immune associated genes amid insect species On this review, the genome and transcriptome broad ana lysis revealed an intact innate immune network current ing in N. lugens. (cox2-inhibitors.com)
  • Defensins will be the distinctive antibacterial peptide genes out there within the N. lugens genome. (cox2-inhibitors.com)
  • Their findings also revealed that another molecule, named Hedgehog, promotes the formation of multinucleated muscle fibres via a second, Myogenin-independent, pathway. (kcl.ac.uk)
  • Myogenin has been shown to interact with: MDFI, POLR2C, Serum response factor Sp1 transcription factor, and TCF3. (wikipedia.org)
  • 0 pression patterns of 96 transcripts and prognosis based on a limited representing 80 known genes and 20 13 numbers of markers1-5. (lu.se)
  • Duxbl gene, a tandem triplicate produces two major transcripts, Duxbl and Duxbl-s. (ntnu.edu.tw)
  • The authors used artificial neural croarrays is to study changes in gene ex- .nature organ the tumor arose from, how big it networks (ANNs) to identify gene-ex- pression that accompany changes in is, and what it looks like after it has pression signatures associated with spe- cell physiology, such as during develop- been imbedded in wax and colored cific subtypes of tumors. (lu.se)
  • Rearrangements involving the PAX3 gene, usually with MAML3, are a hallmark of this tumor type and their identification are useful for diagnosis. (wustl.edu)
  • In a paper published in Nature Communications, the authors found that Myogenin is a master regulator of muscle cell fusion, therefore controlling the formation of functional muscle fibres and sustaining normal muscle growth during both embryonic and adult muscle development. (kcl.ac.uk)
  • In this review, we focus on the role of cardiomyocyte-derived and cardiac fibroblast-derived microRNAs that are involved in the regulation of genes associated with cardiomyocyte and fibroblast function and in atherosclerosis-related cardiac ischemia. (archivesofmedicalscience.com)
  • YAP1 expression was related to muscle fiber development after birth and might be a candidate gene for the regulation of muscle growth. (geneticsmr.com)
  • In C2C12 muscle cell line, Duxbl expression pattern is similar to differentiated marker gene, Myogenin, increased in expression from 2 days onward in differentiating medium. (ntnu.edu.tw)
  • These data show that dietary ARA supplementation can rapidly and safely modulate plasma and muscle fatty acid profile and promote myogenic gene expression in resistance trained men, without a risk of increasing basal systemic or intramuscular inflammation. (edu.au)
  • Hox genes are key developmental regulators required to specify segmental identity in the developing embryo ( Carroll,1995 ). (silverchair.com)
  • Experimental Biology Gene-nutrient interaction RIS Student ward. (rochester.edu)
  • The responses attributed to TNFa are not a direct result of TNFa, but rather its ability to regulate the expression of TNFa responsive genes whose products directly mediate the response. (cdc.gov)
  • Gene-expression patterns used to differentiate four type cause heart damage, and markable finding that genes cur- types of SRBCT. (lu.se)
  • We identified and cloned a mouse double homeobox gene (Duxbl), which encodes two homeodomains. (ntnu.edu.tw)
  • Myogenin Positive Control Slides, Product No. 296S , are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections). (sigmaaldrich.com)
  • Expression of muscle growth related genes was quantified with qPCR. (nature.com)
  • More proliferation was observed in muscle tissue of LBW-GLN than LBW-ALA piglets at 5 dpn, but there was no clear effect of supplementation on related gene expression. (nature.com)