AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation Science
Myogenic Regulatory Factor 5Myogenic Regulatory FactorsMyoD ProteinMyogeninMuscle DevelopmentInterferon Regulatory FactorsMuscle, SkeletalMyoblastsMuscle ProteinsSomitesPAX7 Transcription FactorSatellite Cells, Skeletal MuscleMyoblasts, SkeletalE-Box ElementsMuscle Fibers, SkeletalGene Expression Regulation, DevelopmentalCell DifferentiationDNA-Binding ProteinsMyosin Heavy ChainsTrans-ActivatorsPaired Box Transcription FactorsMEF2 Transcription FactorsInterferon Regulatory Factor-3Transcription FactorsInterferon Regulatory Factor-1RegenerationTranscription Factor 7-Like 1 ProteinMusclesRNA, MessengerInterferon Regulatory Factor-7Gene Expression RegulationCell LineInterferon Regulatory Factor-2Base SequenceMuscle Fibers, Fast-TwitchMolecular Sequence DataIn Situ HybridizationPromoter Regions, GeneticTranscription, GeneticDNA PrimersReverse Transcriptase Polymerase Chain ReactionCells, CulturedStem CellsSignal TransductionGene ExpressionInterferon-betaImmunohistochemistryMice, TransgenicPhosphoproteinsTime FactorsSodium-Hydrogen AntiporterSendai virusInterferon Type IInterferonsToll-Like Receptor 3Repressor ProteinsInterferon-Stimulated Gene Factor 3, gamma SubunitSTAT1 Transcription FactorInterferon-Stimulated Gene Factor 3Protein BindingTranscriptional ActivationInterferon-alphaAmino Acid SequenceBinding SitesTransfectionNuclear ProteinsLower Extremity Deformities, CongenitalMice, KnockoutMice, Inbred C57BLImmunity, Innate
DifferentiationMyoDProteinsMyogeninSkeletal MuscleExpressionTranscriptionalMyogenesisSupplementationLineageRegulatesVIVOGeneticInsulinRegulationElongation FactorsSerum responEffectsExerciseCellsAdultStudyShownSystemMRFsMyf5GenesSkeletalProgenitor cellPax3Elongation factorsEmbryonicEnhancer factorPax7MechanismsEpigeneticChromatinRegulateInhibitorRhabdomyosarcomaNeurogenicEnhancersRegenerationBHLHDepletionEmbryosCellularCommitmentDeterminationProteinMolecular eventsActivateAbstractRolesFamilyEncodesResponse
Differentiation10
  • A number of different local transcription factors called myogenic regulatory factors (MRFs), including MyoD, myf-5, myogenin, and myf-6, stimulate proliferation and differentiation of satellite cells [ 9 ]. (hindawi.com)
  • In addition, insulin, such as growth factor (IGF) 1Ea and/or IGF-1Ec (MGF), also stimulates proliferation and differentiation of satellite cells. (hindawi.com)
  • The C2C12 cell line, a mouse myoblast line, was used here to study the regulatory factors in myogenic differentiation. (cellimagelibrary.org)
  • In fish supplemented with 5% Cr, the relative expression of myogenic differentiation 1 (myod1) increased almost four times compared to those fed the CTRL diet. (lih.lu)
  • The 8·48 g/kg creatine-supplemented diet significantly increased the contents of protein, total amino acids (AA), essential AA and free flavour AAs in muscle, the protein levels of insulin-like growth factor I, myogenic differentiation antigen and PPAR- γ coactlvator-1 α in muscle and stimulated the phosphorylation of target of rapamycin (TOR) pathway in muscle. (cambridge.org)
  • In addition, the CDK9/cyclin T2a complex promotes muscle differentiation and enhances the function of some myogenic regulatory factors. (umbc.edu)
  • Hence, deflazacort promoted functional gains and myogenic differentiation in regenerating dystrophic muscle, and these findings encourage future studies to optimize early treatment of DMD. (umanitoba.ca)
  • Cell differentiation was detected via cell immunofluorescence and the quantification of myogenic regulatory factors (MRFs). (bvsalud.org)
  • A basic helix-loop-helix transcription factor that plays a critical role in HEMATOPOIESIS and as a positive regulator in the differentiation of ERYTHROID CELLS. (bvsalud.org)
  • Transcriptional profiling of TNF-a-induced effects on skeletal myogenic differentiation. (cdc.gov)
MyoD3
  • Myogenic regulatory factors (MRF) are basic helix-loop-helix (bHLH) transcription factors that regulate myogenesis: MyoD, Myf5, myogenin, and MRF4. (wikipedia.org)
  • The regulation of SC activity is governed by myogenic regulatory factors (MRF), including MyoD, Myf5, myogenin, and MRF4. (mcmaster.ca)
  • Skeletal muscle development is orchestrated by the myogenic regulatory factor MyoD, whose activity is blocked in myoblasts by proteins preventing its nuclear translocation and/or binding to G/C-centered E-boxes in target genes. (wustl.edu)
Proteins3
  • Studies previously conducted show that HS negatively affects the skeletal muscle growth and development by changing its effects on myogenic regulatory factors, insulin growth factor-1, and heat-shock proteins. (frontiersin.org)
  • MSY3 (MSY4, YB-2, CSDA, dbpA, ZONAB) is a member of the cold shock domain (CSD) family of proteins also known as Y-box proteins, which are evolutionarily conserved proteins that function as transcription factors and regulators of RNA metabolism and protein synthesis. (biomedcentral.com)
  • Within this conserved region is a consensus site for myocyte enhancer factor 2 (MEF2) proteins that we show is bound efficiently by MEF2 and is required for transgene expression in all three muscle lineages in vivo. (ox.ac.uk)
Myogenin3
  • While Akt over-expression rescued myogenin expression in MSY3 overexpressing myogenic cells, ablation of the Akt substrate, (Ser126 located in the MSY3 cold shock domain) promoted MSY3 accumulation in the nucleus and abolished this rescue. (biomedcentral.com)
  • This study highlights a previously undescribed Akt-mediated signaling pathway involved in the repression of myogenin expression in myogenic cells and in mature muscle. (biomedcentral.com)
  • Given the significance of myogenin regulation in adult muscle, the Akt/MSY3/myogenin regulatory circuit is a potential therapeutic target to counteract muscle degenerative disease. (biomedcentral.com)
Skeletal Muscle5
  • The delayed growth of LBW piglets is mainly due to a slower development of skeletal muscle as the myogenic activity is usually impaired in these animals during the fetal and early postnatal period 3 , 4 . (nature.com)
  • Therefore, we complemented our investigations into the cellular development of the skeletal muscle of neonatal piglets with in vitro studies using a primary porcine myogenic cell culture model with Gln supplementation. (nature.com)
  • Skeletal muscle and myogenic C2C12 cells were used to study the effects of MSY3 phosphorylation in vivo and in vitro on its sub-cellular localization and activity, by blocking the IGF1/PI3K/Akt pathway, by Akt depletion and over-expression, and by mutating potential MSY3 phosphorylation sites. (biomedcentral.com)
  • Basic helix-loop-helix (bHLH) myogenic regulatory factors coordinate the correct function and organization of many skeletal muscle functions. (biomedcentral.com)
  • DUX4‐fl transcription factor misexpression in skeletal muscle leads to disrupted RNA splicing, nonsense mediated decay (NMD), and protein degradation, possibly causing damaged associated molecular pattern (DAMP) release, which may elicit an immune response to targeted damaged muscles. (comprehensivephysiology.com)
Expression6
  • Cell culture experiments indicated that Gln could promote cell proliferation in a dose dependent manner, but expression of myogenesis regulatory genes was not altered. (nature.com)
  • On androgen receptor mRNA and myogenic regulatory factors expression of rats. (tyeishadowner.com)
  • Expression of myogenic regulatory factor gene transcripts in cells identified as mpc can be studied using 'in situ' hybridization (ISH). (umanitoba.ca)
  • These data show that dietary ARA supplementation can rapidly and safely modulate plasma and muscle fatty acid profile and promote myogenic gene expression in resistance trained men, without a risk of increasing basal systemic or intramuscular inflammation. (edu.au)
  • This study provides a basis for further understanding the regulatory mechanisms that control utrophin expression in muscle and may facilitate the development of reagents to effect therapeutic up-regulation of utrophin in DMD. (ox.ac.uk)
  • DUX4 expression was visualized in differentiated 17ABic myogenic cells (104) using an integrated DUX4‐GFP reporter (198). (comprehensivephysiology.com)
Transcriptional1
  • The role of basal and myogenic factors in the transcriptional activation of utrophin promoter A: implications for therapeutic up-regulation in Duchenne muscular dystrophy. (ox.ac.uk)
Myogenesis1
  • This study supports the hypothesis that a complex regulatory role of TNF-alpha exits in skeletal myogenesis. (cdc.gov)
Supplementation2
  • Overall, Gln supplementation stimulated cell proliferation in muscle tissue and in vitro in myogenic cell culture, whereas muscle growth regulatory genes were barely altered. (nature.com)
  • Creatine supplementation upregulated the mRNA expressions of myogenic regulatory factors. (cambridge.org)
Lineage1
  • Here we show by in vivo fate mapping that brown, but not white, fat cells arise from precursors that express Myf5, a gene previously thought to be expressed only in the myogenic lineage. (bioseek.eu)
Regulates1
VIVO1
  • Through biological methods and immunofluorescence analysis both in vivo and in vitro , we found that this improvement was attributable in part to the clearance of M1 macrophages populations and the increase in M2 subtypes with the change of macrophage-mediated factors. (ijbs.com)
Genetic1
  • Abnormal samples can increase risk for poor data quality,15 we cardiac development appears to occur through a were interested in replicating these experiments process that is heterogeneous and complex, with using fresh frozen cardiac tissue instead of formalin both environmental and genetic risk factors.1 fixed tissue after decades of storage. (cdc.gov)
Insulin1
  • The mutation of insulin-like growth factor 2 (IGF2 mutation) that a single-nucleotide substitution (G→A) in the third intron of IGF2 abrogates the interaction with zinc finger BED-type containing 6 (ZBED6) and leads to increased muscle mass in pigs. (biomedcentral.com)
Regulation1
  • In this study, we have investigated basal regulation and myogenic induction of promoter A. Interactions between Ap2 and Sp1 and their cognate DNA motifs are critical for basal transcription from the minimal promoter region. (ox.ac.uk)
Elongation Factors1
  • CDK9 together with a cyclin partner (cyclin T1, T2a, T2b, or K) is the main component of distinct positive transcription elongation factors (P-TEFb), which function as Ser2 C-terminal domain kinases of RNA polymerase II. (umbc.edu)
Serum respon1
  • Furthermore, the entire HRC enhancer sequence lacks any discernible CArG motifs, the binding site for serum response factor (SRF), and we show that the enhancer is not activated by SRF. (ox.ac.uk)
Effects1
  • While the mechanism of action is unknown, effects on repair may be due to increased proliferation by myogenic precursor cells (mpc) or more recruitment to the cell cycle. (umanitoba.ca)
Exercise1
  • Moreover, sarcopenia is associated with decreases in ease of locomotion, resting energy expenditure (REE), nonstructured free living physical activity (physical activity not associated with exercise training, termed NEAT), and increased fat mass [ 9 ], and all factors that have been linked to obesity and metabolic health. (hindawi.com)
Cells2
  • Muscle samples were collected and myogenic cells were isolated and cultivated. (nature.com)
  • In C2C12 myogenic cells, blocking the IGF1/PI3K/Akt pathway using LY294002 inhibitor reduced MSY3 phosphorylation levels resulting in its accumulation in the nuclei. (biomedcentral.com)
Adult1
Study1
  • A quantitative study on regulatory molecules involved in the postnatal growth of pig. (unipd.it)
Shown2
  • Myogenic induction mapped to a conserved upstream muscle-specific E-box, which was shown to bind myogenic regulatory factors, transactivating the promoter up to 18-fold in transient assays. (ox.ac.uk)
  • Locations of the candidate genes and the DME1 and DME2 myogenic transcription enhancers (92) are shown. (comprehensivephysiology.com)
System1
  • The masticatory system is a regulatory or perturbing element of the postural system. (bvsalud.org)
MRFs2
  • 1991). Molecular and technical advances in the last two decades have resulted in a detailed understanding of the embryology of this tissue, and its genetic regulation by key transcription factors, including the paired/homeobox genes Pax3 and Pax7, and the myogenic regulatory genes Myf5, MyoD, Mrf4, and Myogenin (MRFs: myogenic regulatory factors (Kassar-Duchossoy et al. (huji.ac.il)
  • These Wnt signals received by somitic cells can lead to activation of Pax3/Pax7 and myogenic regulatory factors (MRFs), especially Myf5 and MyoD. (ncu.edu.tw)
Myf51
  • However, it is currently unknown whether Wnts activate Myf5 and MyoD through direct targeting of their cis-regulatory elements or via indirect pathways. (ncu.edu.tw)
Genes4
  • Cell culture experiments indicated that Gln could promote cell proliferation in a dose dependent manner, but expression of myogenesis regulatory genes was not altered. (nature.com)
  • Overall, Gln supplementation stimulated cell proliferation in muscle tissue and in vitro in myogenic cell culture, whereas muscle growth regulatory genes were barely altered. (nature.com)
  • Basic helix-loop-helix transcription factors encoded by the c-myc genes. (nih.gov)
  • The most significant discovery has been that 10T1/2 lineage determination is under simple genetic control and that the regulatory genes that mediate the formation of myogenic cell lineages, and likely the chondrogenic and adipogenic lineages, can be demonstrated and studied by genomic DNA and cDNA transfection approaches. (nih.gov)
Skeletal8
  • Factors Regulating or Regulated by Myogenic Regulatory Factors in Skeletal Muscle Stem Cells. (nih.gov)
  • The delayed growth of LBW piglets is mainly due to a slower development of skeletal muscle as the myogenic activity is usually impaired in these animals during the fetal and early postnatal period 3 , 4 . (nature.com)
  • Therefore, we complemented our investigations into the cellular development of the skeletal muscle of neonatal piglets with in vitro studies using a primary porcine myogenic cell culture model with Gln supplementation. (nature.com)
  • Epicatechin has been described as a polyphenol compound that promotes skeletal muscle restructuring, by expressing muscle regulation factors, activation of satellite cells and modulation of the main pathways associated with catabolism. (preprints.org)
  • These factors are only found in skeletal muscle. (nih.gov)
  • Because many transcription factors that regulate the fate of muscle progenitors have been identified, skeletal muscle tissue constitutes an ideal model for the study of organogenesis and regeneration (Tajbakhsh 2005). (huji.ac.il)
  • Originally discovered as axon guidance factors, they have been implicated in cancer progression, embryonal organogenesis, skeletal muscle innervation, and other physiological and developmental functions in different tissues. (biomed.news)
  • This study supports the hypothesis that a complex regulatory role of TNF-alpha exits in skeletal myogenesis. (cdc.gov)
Progenitor cell1
  • Important regulatory factor of the myogenic progenitor cell population (By similarity). (nih.gov)
Pax31
  • Alveolar rhabdomyosarcoma is a life-threatening myogenic cancer of children and adolescent young adults, driven primarily by the chimeric transcription factor PAX3-FOXO1 (P3F). (nih.gov)
Elongation factors1
  • CDK9 together with a cyclin partner (cyclin T1, T2a, T2b, or K) is the main component of distinct positive transcription elongation factors (P-TEFb), which function as Ser2 C-terminal domain kinases of RNA polymerase II. (umbc.edu)
Embryonic1
  • To clarify this issue, in the present study, we tested the regulation of MyoD cis-regulatory elements by Wnt3a secreted from human embryonic kidney (HEK)-293T cells. (ncu.edu.tw)
Enhancer factor2
  • The transcription factors in the myocyte enhancer factor 2 (MEF2) family play important roles in cell survival by regulating nuclear gene expression. (nih.gov)
  • Mutations in the MEF2A gene, coding for a member of the myocyte enhancer factor 2 family of transcription factors, have been reported in patients with coronary artery disease and myocardial infarction (MI). (nih.gov)
Pax71
  • More specifically, I am interested in identifying the regulatory element(s) regulating the Muscle Stem Cells (MuSC) regulator, PAX7. (nih.gov)
Mechanisms3
  • The progression of the disease is affected by known immunological and mechanical factors, and possibly other unknown mechanisms. (plos.org)
  • I am interested in defining the epigenetic changes occurring during myogenic lineage specification and providing insight into molecular mechanisms of early muscle fate acquisition. (nih.gov)
  • The muscular (i.e., smooth muscle cells in the vessel wall) component's tension is actively regulated via the aforementioned regulatory mechanisms. (nih.gov)
Epigenetic2
  • Recent advances in large-scale functional genomics permit the use of omic approaches to delineate the regulatory roles of epigenetic modifiers in cell fate decision [ 5 ]. (springeropen.com)
  • The transitions of the epigenetic landscape accompanying the acquisition of the myogenic lineage starting from ESC are largely unknown. (nih.gov)
Chromatin4
  • The advent of high-throughput sequencing coupled to chromatin immunoprecipitation (ChIP-seq) has permitted the global assessment of DNA binding of numerous transcription factors. (biomedcentral.com)
  • Through comprehensive analyses of the omic datasets with an integration of myoblast chromatin states, we have determined the association of p300 and muscle master regulator MyoD with myogenic enhancers and defined a loci-specific enrichment of H4K8 and H3K9 acetylation [ 8 ]. (springeropen.com)
  • The Third Intron of the Interferon Regulatory Factor-8 Is an Initiator of Repressed Chromatin Restricting Its Expression in Non-Immune Cells. (nih.gov)
  • ASF1 is a highly conserved histone H3/H4 chaperone that synergizes in vitro with two other histone chaperones, chromatin assembly factor 1 (CAF-1) and histone repression A factor (HIRA), in DNA synthesis-coupled and DNA synthesis-independent nucleosome assembly. (omicsdi.org)
Regulate1
Inhibitor1
  • The myogenic inhibitor MSC binds throughout the genome of rhabdomyosarcoma cells, in a pattern highly similar to that of MyoD, suggesting a broad role in buffering the activity of MyoD in development and rhabdomyosarcomas. (biomedcentral.com)
Rhabdomyosarcoma1
  • 13. Expression and activity of vascular endothelial growth factor and metalloproteinases in alveolar and embryonal rhabdomyosarcoma cell lines. (nih.gov)
Neurogenic3
  • Neurogenic factors are the most common cause of fetal akinesia presented in 70-80% of AMC patients. (diseasesdic.com)
  • MODEL NUMBER: 0367 MODEL NAME: CerebralBloodFlow_CCT_BS SHORT DESCRIPTION: A lumped parameter model of cerebral blood flow control combining cerebral autoregulation and neurovascular coupling DETAILED DESCRIPTION: The present model describes cerebral blood flow control including neurogenic, myogenic, metabolic, and shear stress based regulation. (nih.gov)
  • To recreate Figure 8 of the paper (representing a NVC overshoot from interaction of neurogenic, myogenic, and metabolic regulation), Tau_neuro should be changed from 5 seconds to 10 seconds and G_meta should be changed from 0 to -60. (nih.gov)
Enhancers1
  • This study found that P3F reprograms the cis-regulatory landscape by inducing (de novo) super enhancers (SEs). (nih.gov)
Regeneration1
  • These findings supported the hypothesis that repeated high mechanical force during eccentric contraction causes myofiber damage, which triggers the release of growth factors from within the myofiber and initiates regeneration and remodeling processes ( 11 ). (lww.com)
BHLH1
Depletion1
  • The compromised tissue repair program is attributable to the gradual depletion of stem cells and to altered regulatory signals. (biomed.news)
Embryos1
Cellular2
  • Together these studies indicate that musculin might have either positive or negative activities in gene transcription depending on a variety of factors and cellular context. (biomedcentral.com)
  • They are normally involved in nucleic acid metabolism and in mediating the cellular response to growth factors. (nih.gov)
Commitment1
Determination1
  • This protein is the testis-determining factor (TDF), which initiates male sex determination. (wikidoc.org)
Protein2
  • HN - 2017 (1997) MH - ADAM17 Protein UI - D000072198 MN - D8.811.277.656.675.374.102.375 MN - D9.400.430.500.375 MN - D12.776.395.33.375 MN - D23.50.301.264.35.57 MN - D23.101.100.110.57 MS - A disintegrin and metalloproteinase domain-containing protein that cleaves the membrane-bound precursor of TUMOR NECROSIS FACTOR-ALPHA to its mature form. (nih.gov)
  • The SRY gene encodes the testis determining factor , which is also referred to as the SRY protein . (wikidoc.org)
Molecular events1
  • These molecular events are orchestrated by myogenic regulatory factors and miRNAs. (biomedcentral.com)
Activate1
  • This suggests that the same transcription factors and signaling pathways could activate cell-type-specific responses in multiple components of the musculoskeletal complex that may help coordinate the development of this intricate system. (elifesciences.org)
Abstract1
  • Abstract Aim: To investigate the consequences of chronic eccentric exercise in histopathology, inflammatory, and myogenic regulatory factors response in gastrocnemius muscle of X-chromosome-linked muscular dystrophy (mdx) mice. (figshare.com)
Roles1
  • The roles of Na+/H+exchanger regulatory factor 1 and Aquaporin-1 in the pathomechanism of experimental acute pancreatitis. (u-szeged.hu)
Family1
  • Semaphorins are a wide family of extracellular regulatory signals with a multifaceted role in cell-cell communication. (biomed.news)
Encodes1
  • SDS results from biallelic mutations in SBDS, which encodes a ribosome assembly factor. (journaltocs.ac.uk)
Response1
  • Conclusion: In conclusion, an eccentric exercise in gastrocnemius of mdx mice was characterized by an intense inflammatory process without myogenic response. (figshare.com)