• This transcription factor is the earliest of all MRFs to be expressed in the embryo, where it is only markedly expressed for a few days (specifically around 8 days post-somite formation and lasting until day 14 post-somite in mice). (wikipedia.org)
  • To avoid excessive MYOD1 levels, myogenic cells were induced from mesodermal precursors derived from hiPS cell clone number 28, without administration of Dox as shown in Physique 4(a). (southpadremaps.com)
  • Impairing the function of Mox2 will prevent the proliferation of myogenic precursors and will cause abnormal patterning of limb muscles. (wikipedia.org)
  • Skeletal muscle displays a great deal of plasticity and may have different morphofunctional characteristics as a result of the influences of various intrinsic and extrinsic factors including temperature, nutrition, fasting, and photoperiod. (hindawi.com)
  • The absence of all three of these factors results in a phenotype with no skeletal muscle. (wikipedia.org)
  • The STAT protein can be dephosphorylated by nuclear phosphatases which leads to inactivation of STAT and the transcription factor becomes transported out of the nucleus by exportin crm1/RanGTP. (bionity.com)
  • In addition to the analysis of the individual transcription factors, we found that histone 3 acetylation correlates with Srf- and Gata4-dependent gene expression and is complementarily reduced in cardiac Srf knockdown. (nih.gov)
  • Transcription factors are essential for the regulation of gene expression and are, as a consequence, found in all living organisms. (wikipedia.org)
  • The p300 interaction with transcription factors is managed by one or more of p300 domains: the nuclear receptor interaction domain (RID), the KIX domain (CREB and MYB interaction domain), the cysteine/histidine regions (TAZ1/CH1 and TAZ2/CH3) and the interferon response binding domain (IBiD). (wikipedia.org)
  • TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. (wikipedia.org)
  • Tumor necrosis factor receptor superfamily member 12A also known as the TWEAK receptor (TWEAKR) is a protein that in humans is encoded by the TNFRSF12A gene. (wikipedia.org)
  • TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L is an enzyme that in humans is encoded by the TAF6L gene. (wikipedia.org)
  • miR-133 enhances myoblast proliferation by repressing serum response factor (SRF) mIR-133 suppresses SP1 expression In rats, miR-133b is expressed in retinal dopaminergicamacrine cell, and this expression is significantly increased during early stage during retinal degeneration. (wikipedia.org)
  • The C/EBP proteins also contain activation domains at the N-terminus and regulatory domains. (bionity.com)
  • The regulation of C/EBPβ is exerted in many manners, phosphorylation , acetylation , activation and repression via others transcription factors, oncogenic elements or chemokines , autoregulation, etc. (bionity.com)
  • For example, phosphorylation of the Threonine 235 in human or of the Threonine 188 in mouse and rat is important for its trans-activation capacity or phosphorylation(s) in its regulatory domain modulate its function. (bionity.com)
  • The last four domains, KIX, TAZ1, TAZ2 and IBiD of p300, each bind tightly to a sequence spanning both transactivation domains 9aaTADs of transcription factor p53. (wikipedia.org)
  • In summary, we show the combinatorial contribution of four DNA-binding transcription factors in regulating the cardiac transcriptome and provide evidence that histone modifications and microRNAs modulate their functional consequence. (nih.gov)
  • Each stage has various associated genetic factors lack of which will result in muscular defects. (wikipedia.org)