Myogenesis myogenic regulatory factor 5. Medical search. Frequent questions

It is a protein with a key role in regulating muscle differentiation or myogenesis, specifically the development of skeletal muscle. (wikipedia.org)
These basic helix loop helix transcription factors act sequentially in myogenic differentiation. (wikipedia.org)
In the head, specific gene regulatory networks underlie the differentiation in subgroups, which include extraocular muscles, muscles of mastication, muscles of facial expression, laryngeal and pharyngeal muscles, as well as cranial nerve innervated neck muscles. (bvsalud.org)
In fish supplemented with 5% Cr, the relative expression of myogenic differentiation 1 (myod1) increased almost four times compared to those fed the CTRL diet. (lih.lu)
The integration of this new information with previous findings has allowed us to draw a more complete pathway of regulatory events during cardiac induction and differentiation in Drosophila . (biologists.com)
Transcriptional profiling of TNF-a-induced effects on skeletal myogenic differentiation. (cdc.gov)
For example, NF-a modulates myogenesis by affecting directly myoblast cell Proliferation/differentiation or induction of apoptosis. (cdc.gov)
We investigated the effects of TNF-alpha on transcriptional changes occurring during myoblast differentiation in C2C 12 cells, a well-characterized in vitro model of myogenesis. (cdc.gov)
We are also exploring the mechanisms that control myogenic cell proliferation versus differentiation in both skeletal and cardiac muscle development. (rosalindfranklin.edu)
The mechanisms that regulate myoblast cell proliferation versus differentiation involve extracellular signaling via growth factors, their cognate receptors, intracellular signal transduction cascades, and transcriptional regulation of genes associated with cell proliferation. (rosalindfranklin.edu)
Among these genes is the fibroblast growth factor receptor 1 (FGFR1) gene which is expressed in proliferating myoblasts and down-regulated during differentiation. (rosalindfranklin.edu)
FGF-6 is involved in both proliferation and differentiation of the myogenic lineages. (biolegend.com)
At higher concentrations, FGF-6 can downregulate the expression of myogenic markers and some myogenic transcription factors, and can delay C2 myogenic cell differentiation. (biolegend.com)
Macrophages expressing pro-inflammatory markers are abundant in regenerating regions damaging for Myog (a transcription aspect expressed only in differentiated myogenic cells) suggesting various associations depending on proliferation or differentiation of myogenic precursors [78,79]. (rockinhibitor.com)
TNF- TNF- is transiently upregulated in myoblasts inside 3 to 48 h post differentiation induction inside a dose-dependent manner: myogenesis is stimulated at low TNF- concentrations, although is inhibited at higher concentrations [80,81]. (rockinhibitor.com)
In keeping with its appearance pattern Cdo has important assignments in myogenesis and neurogenesis12 13 In myoblasts Cdo promotes differentiation as an element of multiprotein complexes offering the cell adhesion substances N-cadherin as well as the carefully related proteins Boc and Neogenin14-16. (cell-metabolism.com)
Among multiple downstream signalling occasions p38MAPK favorably regulates the experience of myogenic bHLH elements such as MyoD via phosphorylation of the ubiquitously indicated E-protein-binding partners of the myogenic as well as neural bHLH factors17 18 Consistently Cdo also promotes neuronal differentiation by activation of transcriptional activity of Neurogenin1 in P19 embryonal carcinoma cells19. (cell-metabolism.com)
In the presence of antler extracts, the length and thickness of myotubes and myogenin differentiation 1 (MyoD1) and myogenic factor 5 (Myf5) gene expression were increased compared to those in the control group (CON). (kosfaj.org)
MeCP2 interacts with HP1 and modulates its heterochromatin association during myogenic differentiation. (mdc-berlin.de)
Differentiation of stem cells is known be triggered by various growth factors and regulatory molecules. (justia.com)
These conditions include growing the cells to high or low density, changing media, introducing or removing cytokines, hormones and growth factors, creating an environment which suits differentiation toward a specific cell type, such as providing a suitable substrate. (justia.com)
Methods of inducing differentiation in stem cells and muscle cells produced therefrom may be used for the study of cellular and molecular biology of tissue development, for the discovery of genes and proteins such as differentiation factors that play a role in tissue development and regeneration. (justia.com)

The delayed growth of LBW piglets is mainly due to a slower development of skeletal muscle as the myogenic activity is usually impaired in these animals during the fetal and early postnatal period 3 , 4 . (nature.com)

In 2009 beginning of 2010 we have focused on investigating what factors human embryonic stem cells (hESCs) may produce that enhance regeneration and if those factors have any effects by themselves on regeneration. (ca.gov)
Our current running hypothesis is that the positive growth factors produced by hESCs trigger injured muscle to initiate and maintain regeneration, the TGF-beta inhibitors produced by hESCs reduce the TGF-beta signaling, and the combination assures the robust regeneration of muscle. (ca.gov)
In addition we will analyze the effect on regeneration of administering the growth factors that we found in Aim 2, both alone and in combination with the inhibitors of TGF-beta. (ca.gov)
Compounds that target tissue-specific transcription factors could overcome non-specific effects of small molecules and lead to the regeneration of heart muscle following myocardial infarction. (biomedcentral.com)
Changes in gene expression can cause defects in myogenesis and muscle regeneration, apoptosis, and sensitivity to oxidative stress. (comprehensivephysiology.com)
Other NIH-funded investigations in our lab explore epigenetic mechanisms through which an anti-aging protein called Klotho affects myogenesis and muscle regeneration in neonatal and aging muscle. (ucla.edu)

Furthermore, the stage with the muscle healing process influences the effects of macrophages on myogenic precursors. (rockinhibitor.com)
6. Cytokines and Muscle Healing Cytokines are also involved Ziritaxestat MedChemExpress within the complicated crosstalk among myogenic precursors and macrophages, as described below and summarized in Tables 4 and five, and Figure five).Int. J. Mol. (rockinhibitor.com)
Indeed, several human diseases are characterized by attenuated repair responses and imbalances in the inflammatory response with increased number of infiltrating macrophages [ 3 - 5 ]. (hindawi.com)
Through biological methods and immunofluorescence analysis both in vivo and in vitro , we found that this improvement was attributable in part to the clearance of M1 macrophages populations and the increase in M2 subtypes with the change of macrophage-mediated factors. (ijbs.com)
However, discoveries in our lab have also shown that regulatory interactions between cytotoxic, M1 macrophages in dystrophic muscle and anti-inflammatory, M2 macrophages are important in regulating the balance between the death of dystrophic muscle and regenerative processes. (ucla.edu)

This comprehensive review summarizes the recent studies that have unveiled the role of ABPs in actin cytoskeletal dynamics, with a particular focus on skeletal myogenesis and diseases. (bvsalud.org)
This provides insight into the molecular mechanisms that regulate skeletal myogenesis via ABPs as well as research avenues to identify potential therapeutic targets. (bvsalud.org)
Moreover, this review explores the implications of non-coding RNAs (ncRNAs) targeting ABPs in skeletal myogenesis and disorders based on recent achievements in ncRNA research. (bvsalud.org)
This study supports the hypothesis that a complex regulatory role of TNF-alpha exits in skeletal myogenesis. (cdc.gov)

Myf5 belongs to a family of proteins known as myogenic regulatory factors (MRFs). (wikipedia.org)
This transcription factor is the earliest of all MRFs to be expressed in the embryo, where it is only markedly expressed for a few days (specifically around 8 days post-somite formation and lasting until day 14 post-somite in mice). (wikipedia.org)
The limb myogenic precursors (derived from the hypaxial myotome) do not begin expressing Myf5 or any MRFs, in fact, until after migration to the limb buds. (wikipedia.org)
Thirdly, HMB increases the proliferation of satellite cells by the stimulation of Myogenic regulatory factors (MRFs).4 MRFs regulate myogenesis, the formation of muscular tissue. (healthmasters.com.au)

In fact, its expression in proliferating myoblasts has led to its classification as a determination factor. (wikipedia.org)
Myf5 is expressed in the dermomyotome of the early somites, pushing the myogenic precursors to undergo determination and differentiate into myoblasts. (wikipedia.org)
The goal of our on-going research is to define and characterize the transcriptional complexes resident on the FGFR1 regulatory regions as well as those interactions off the promoter that govern its expression in both proliferating myoblasts and differentiated muscle fibers. (rosalindfranklin.edu)

Most notably, while Myf5 is activated by Sonic hedgehog in the epaxial lineage, it is instead directly activated by the transcription factor Pax3 in hypaxial cells. (wikipedia.org)
Our published findings demonstrate that the FGFR1 gene is positively regulated by the Sp1 transcriptional regulator and negatively regulated by the transcription factor E2F4. (rosalindfranklin.edu)
We demonstrate that mdPCR can give exact molecule counts per cell for mRNA isoforms encoding the myogenic transcription factor Pax3. (biomed.news)
Transcription factor GATA4-targeted compounds that have previously shown in vivo efficacy in cardiac injury models were tested for stage-specific activation of atrial and ventricular reporter genes in differentiating pluripotent stem cells using a dual reporter assay. (biomedcentral.com)
The EBF transcription factor Collier directly promotes Drosophila blood cell progenitor maintenance independently of the niche. (sdbonline.org)
In the lymph gland , an hematopoietic organ in Drosophila larva, a group of cells called the Posterior Signaling Centre (PSC), whose specification depends on the EBF transcription factor Collier (Col) and the HOX factor Antennapedia (Antp), has been proposed to form a niche required to maintain the pool of hematopoietic progenitors (prohemocytes). (sdbonline.org)
Together, this study shows that the PSC is dispensable for blood cell progenitor maintenance and reveals the key role of the conserved transcription factor Col as an intrinsic regulator of hematopoietic progenitor fate. (sdbonline.org)
Collier, the single Drosophila COE (Collier/EBF/Olf-1) transcription factor, is required in several developmental processes, including head patterning and specification of muscle and neuron identity during embryogenesis. (sdbonline.org)
The bHLH transcription factor TWIST1 plays a key role in the embryonic development and in tumorigenesis. (biomedcentral.com)
TWIST1 is a transcription factor belonging to the basic helix-loop-helix (bHLH) superfamily. (biomedcentral.com)
DUX4‐fl transcription factor misexpression in skeletal muscle leads to disrupted RNA splicing, nonsense mediated decay (NMD), and protein degradation, possibly causing damaged associated molecular pattern (DAMP) release, which may elicit an immune response to targeted damaged muscles. (comprehensivephysiology.com)

In zebrafish, Myf5 is the first MRF expressed in embryonic myogenesis and is required for adult viability, even though larval muscle forms normally. (wikipedia.org)
Our work is at the stage of understanding the molecular mechanisms by which the aging of the regenerative potential of organ stem cells can be reversed by particular human embryonic factors that are capable of neutralizing the affects of aged niches on tissue regenerative capacity. (ca.gov)
More recently, we have initiated studies to investigate the molecular mechanisms that control the development of distinct myogenic cell lineages during embryonic mygenesis. (rosalindfranklin.edu)

The expression levels of myogenesis-related genes were substantially upregulated, with an approximately 1.6-fold increase compared to the constructs fabricated without the blade-casting technique. (bvsalud.org)
Cell culture experiments indicated that Gln could promote cell proliferation in a dose dependent manner, but expression of myogenesis regulatory genes was not altered. (nature.com)
Overall, Gln supplementation stimulated cell proliferation in muscle tissue and in vitro in myogenic cell culture, whereas muscle growth regulatory genes were barely altered. (nature.com)
In an early step, the Dorsocross genes act in parallel with tinman to activate the expression of pannier , a cardiogenic gene encoding a Gata factor. (biologists.com)
Studies in several vertebrate models and Drosophila have uncovered a surprising degree of evolutionary conservation of regulatory mechanisms and genes that control early cardiogenesis. (biologists.com)
In all these organisms, cardiac induction in the lateral mesoderm involves the concerted action of signals mediated by Bmp, Wnt and Fgf family members, which act upon cardiogenic genes encoding NK homeodomain, Gata and T-box transcription factors (reviewed by Zaffran and Frasch, 2002 ). (biologists.com)
Our on-going research is focused on the regulatory mechanisms that link innervation, PKC activity, IP3R1 activity, transcriptional regulators, and expression of slow muscle fiber type specific genes. (rosalindfranklin.edu)
During vertebrate myogenesis, myoblast cell populations proliferate and fuse to form multinucleated muscle fibers that express a battery of contractile protein genes. (rosalindfranklin.edu)
Locations of the candidate genes and the DME1 and DME2 myogenic transcription enhancers (92) are shown. (comprehensivephysiology.com)

IFN- expression is at basal levels in wholesome muscle tissues, although increases just after injury, peaking at day 5 post-injury corresponding to immune cell and myoblast infiltration. (rockinhibitor.com)

Basic helix-loop-helix (bHLH) myogenic regulatory factors coordinate the correct function and organization of many skeletal muscle functions. (biomedcentral.com)

Myogenic factor 5 is a protein that in humans is encoded by the MYF5 gene. (wikipedia.org)
Firstly, it increases protein synthesis via mammalian target of rapamycin (mTOR) and by stimulating the production of Insulin-like Growth Factor-1 (IGF1). (healthmasters.com.au)
Published results indicate that protein kinase C (PKC) activity in conjunction with innervation-induced activation of cell signaling mediated by the muscarinic acetylcholine receptor, Gaq, and the 1,4,5 inositol triphosphate receptor 1 (IP3R1) differentially regulate fast versus slow muscle fiber type gene expression in innervated muscle fibers. (rosalindfranklin.edu)
MSY3 (MSY4, YB-2, CSDA, dbpA, ZONAB) is a member of the cold shock domain (CSD) family of proteins also known as Y-box proteins, which are evolutionarily conserved proteins that function as transcription factors and regulators of RNA metabolism and protein synthesis. (biomedcentral.com)
Gene expression of AMP-activated protein kinase (AMPK), MyoD1, and myogenin, along with the muscle atrophy factors muscle RING finger-1 (MuRF-1) and forkhead box O3a (FoxO3a) upon addition of deer antler extracts to muscle-atrophied C2C12 cells was determined by qRT-PCR after treatment with AICAR. (kosfaj.org)
IGF-binding protein-5 (IGFBP-5) is abundant in serum and bone during normal skeletal development, but levels decrease in osteoporosis. (westminster.ac.uk)
Serum insulin-like growth factor (IGF)-I and IGF-binding protein-3 concentrations and prostate cancer risk: results from the European Prospective Investigation into Cancer and Nutrition. (mdc-berlin.de)

As no muscle is formed in Myf5;Myod double mutant zebrafish, Myf5 cooperates with Myod to promote myogenesis. (wikipedia.org)
TNF- could possibly be also involved in muscle strength recovery, most likely via modulation of muscle regulatory gene expression, including MyoD [80,84]. (rockinhibitor.com)

Although Myf5 is mainly associated with myogenesis, it is expressed in other tissues, as well. (wikipedia.org)
Although the specific roles and dependency of Myf5 in adipogenesis and neurogenesis have remained to be explored, these findings show that Myf5 may play roles outside of myogenesis. (wikipedia.org)
Here we show by in vivo fate mapping that brown, but not white, fat cells arise from precursors that express Myf5, a gene previously thought to be expressed only in the myogenic lineage. (bioseek.eu)

Studies previously conducted show that HS negatively affects the skeletal muscle growth and development by changing its effects on myogenic regulatory factors, insulin growth factor-1, and heat-shock proteins. (frontiersin.org)
Muscle homeostasis is regulated by multiple cytoskeletal proteins and myogenic transcriptional programs responding to endogenous and exogenous signals influencing cell structure and function. (bvsalud.org)
Chemically induced gene expression changes were characterized by qRT-PCR, global run-on sequencing (GRO-seq) and immunoblotting, and the network of cooperative proteins of GATA4 and NKX2-5 were further explored by the examination of the GATA4 and NKX2-5 interactome by BioID. (biomedcentral.com)
Gene Ontology analysis revealed a strong enrichment in proteins with DNA binding and/or transcription-regulatory properties. (sdbonline.org)

Therefore, we complemented our investigations into the cellular development of the skeletal muscle of neonatal piglets with in vitro studies using a primary porcine myogenic cell culture model with Gln supplementation. (nature.com)

MicroRNAs regulate gene expression at the post-transcriptional level by binding to 3′- or less often to 5′-untranslated regions of target messenger RNAs (mRNAs), which in consequence leads to inhibited translation and/or induces degradation of targeted mRNA [ 1 ]. (archivesofmedicalscience.com)

The aim of this research is to identify and characterize the molecular regulatory circuitry that establishes these myogenic cell lineages and which thereby establish fast versus fast/slow muscle fiber types, independent of innervation, and dependent of cell lineage commitment. (rosalindfranklin.edu)

While Akt over-expression rescued myogenin expression in MSY3 overexpressing myogenic cells, ablation of the Akt substrate, (Ser126 located in the MSY3 cold shock domain) promoted MSY3 accumulation in the nucleus and abolished this rescue. (biomedcentral.com)
This study highlights a previously undescribed Akt-mediated signaling pathway involved in the repression of myogenin expression in myogenic cells and in mature muscle. (biomedcentral.com)
Given the significance of myogenin regulation in adult muscle, the Akt/MSY3/myogenin regulatory circuit is a potential therapeutic target to counteract muscle degenerative disease. (biomedcentral.com)

Quantifying the exact expression levels of the mRNA isoforms encoding these myogenic transcription factors is therefore key to understanding how MuSCs switch between cell states. (biomed.news)

Collectively, these results indicate the potential for therapeutic alteration of cell fate decisions and pathological gene regulatory networks by GATA4-targeted compounds modulating chamber-specific transcriptional programs in multipotent cardiac progenitor cells and cardiomyocytes. (biomedcentral.com)

It functions during that time to commit myogenic precursor cells to become skeletal muscle. (wikipedia.org)
The absence of all three of these factors results in a phenotype with no skeletal muscle. (wikipedia.org)
The dorsal cross-sectional muscle area (DMA) of fish fed Cr 5 and Cr 8% was significantly larger than that of fish fed CTRL. (lih.lu)
Muscle samples were collected and myogenic cells were isolated and cultivated. (nature.com)
More proliferation was observed in muscle tissue of LBW-GLN than LBW-ALA piglets at 5 dpn, but there was no clear effect of supplementation on related gene expression. (nature.com)
MicroRNA-1/206(miRNA-1/206) is specifically expressed in skeletal muscle and play a critical role in myogenesis. (biomedcentral.com)
We confirmed that typical growth factor signaling was in fact occurring in muscle cells exposed to hESC produced factors, and that hESCs produce a TGF-beta antagonist. (ca.gov)
This fits with our recently published work showing that young muscle regenerates well from strong growth factor signaling and low TGF-beta signals while old muscle regenerated poorly due to weak growth factor signaling and high TGF-beta signaling. (ca.gov)
The poor performance of stem cells in an aged organ, such as skeletal muscle, is caused by the changes in regulatory pathways such as Notch, MAPK and TGF‐β, where old differentiated tissues and blood circulation inhibit the regenerative performance of organ stem cells. (ca.gov)
This signaling culminates in regulation of transcription factors governing expression of the slow myosin heavy chain 2 gene - indicative of the slow muscle fiber phenotype. (rosalindfranklin.edu)
Skeletal muscle and myogenic C2C12 cells were used to study the effects of MSY3 phosphorylation in vivo and in vitro on its sub-cellular localization and activity, by blocking the IGF1/PI3K/Akt pathway, by Akt depletion and over-expression, and by mutating potential MSY3 phosphorylation sites. (biomedcentral.com)
FGF-6 can stimulate migration of myogenic stem cells and also control the maintenance of muscle progenitor cells. (biolegend.com)
Originally discovered as axon guidance factors, they have been implicated in cancer progression, embryonal organogenesis, skeletal muscle innervation, and other physiological and developmental functions in different tissues. (biomed.news)
They also showed that cross-regulation between col and eya in muscle progenitor cells is required for specification of muscle identity, revealing a new parallel between the myogenic regulatory networks operating in Drosophila and vertebrates. (sdbonline.org)
We are also determining how those Klotho-driven epigenetic regulatory influences affect muscle growth following acute muscle injury or exercise. (ucla.edu)

Thus, the use of hESC-produced pro-regenerative factors for boosting the regenerative capacity of organ stem cells is likely to yield healthy, young tissue. (ca.gov)
In C2C12 myogenic cells, blocking the IGF1/PI3K/Akt pathway using LY294002 inhibitor reduced MSY3 phosphorylation levels resulting in its accumulation in the nuclei. (biomedcentral.com)
Corynebacterium tuberculostearicum, a human skin colonizer, induces the canonical nuclear factor-kappaB inflammatory signaling pathway in human skin cells. (nationaljewish.org)
When activated by injury, satellite cells reenter the cell cycle and proliferate in response to extracellular growth factors ( Relaix & Zammit, 2012 Relaix F, Zammit PS. (scielo.br)
The compromised tissue repair program is attributable to the gradual depletion of stem cells and to altered regulatory signals. (biomed.news)
More detailed structure-function analysis revealed a distinct subclass of GATA4/NKX2-5 inhibitory compounds with an acetyl lysine-like domain that contributed to ventricular cells (%Myl2-eGFP+). (biomedcentral.com)
DUX4 expression was visualized in differentiated 17ABic myogenic cells (104) using an integrated DUX4‐GFP reporter (198). (comprehensivephysiology.com)
72 hours) to C8- ceramide (5 μg/ml culture medium), a cell-permeable analog of ceramide, enhanced MDR1 mRNA levels by 3- and 5-fold in T47D and inMDA-MB-435 cells, respectively, but did not affect MCF-7 cells.D-erythro-sphingosine exposure (5 μg/ml, 72 hr) increased MDR1 mRNA levels in MDA-MB-435 cells by 3.5-fold. (sphingolipidclub.com)

Tg animals showed an increase in serum IGFBP-5 concentrations by 7.7- to 3.5-fold at 3-8 wk of age, respectively. (westminster.ac.uk)

Studies have shown that IGFBP-5 stimulates markers of bone formation by potentiating IGF actions and by IGF-independent actions. (westminster.ac.uk)

on the other hand, immediately after injury, its expression increases inside 5 h, reaching a peak at 24 h, and after that progressively decreases. (rockinhibitor.com)
The control of MuSC state depends on the expression levels of myogenic transcription factors. (biomed.news)
Here, we pursued loss-of-function studies on transcription factors expressed predominantly in zebrafish cone photoreceptors and identified Foxq2 as a blue cone specific factor driving sws2 gene expression. (regenerativemedicine.net)
We propose that Foxq2-dependent sws2 expression is a prevalent regulatory mechanism that was acquired at the early stage of vertebrate evolution. (regenerativemedicine.net)

Among these are hypertrophy induced by synergist ablation, 4 low-frequency stimulation, 5 and eccentric exercise. (arvojournals.org)

Pharmacological modulation of cell fate decisions and developmental gene regulatory networks holds promise for the treatment of heart failure. (biomedcentral.com)

To test the hypothesis that IGFBP-5 promotes the acquisition of bone mineral density (BMD), we generated transgenic (Tg) mice overexpressing Igfbp5 using a cytomegalovirus enhancer and β-actin promoter (CMV/βA). (westminster.ac.uk)

There are a number of factors that initiate myofiber remodeling in adult skeletal muscles. (arvojournals.org)

Glucocorticoid and cytokine crosstalk: Feedback, feedforward, and co-regulatory interactions determine repression or resistance. (nationaljewish.org)

however the specific regulatory mechanism where Wnt signalling regulates neurogenesis continues to be generally unclear. (cell-metabolism.com)

Many classes of secreted factors and signalling pathways are implicated within the regulation of brain and neurogenesis development. (cell-metabolism.com)

A gradual increase in ambient temperature affects all living organisms ( 4 , 5 ). (frontiersin.org)

The studies presented here will enhance our understanding of the functional significance of ABPs and mechanotransduction-derived myogenic regulatory mechanisms. (bvsalud.org)

Semaphorins are a wide family of extracellular regulatory signals with a multifaceted role in cell-cell communication. (biomed.news)

Twelve piglets per group were slaughtered at 5, 12 and 26 dpn, one hour after injection with Bromodeoxyuridine (BrdU, 12 mg/kg). (nature.com)

The study will also evaluate the toxic effects of the chemotherapy combination, including effects on the heart, and will determine survival and progression-free survival 5 years after treatment. (stanford.edu)

Cell Stem Cell 2013;13(5):590-601. (scielo.br)

Histomorphometry revealed that although the bone formation rate and mineralizing surface at the periosteum decreased in Tg mice, they increased at the endosteum, suggesting opposing effects of IGFBP-5 on periosteal and endosteal osteoblasts (by altering proliferation or survival). (westminster.ac.uk)

In this process, muscular atrophy is an important influencing factor. (kosfaj.org)

Anatomy18

Organisms4

Chemicals and Drugs41

Analytical, Diagnostic and Therapeutic Techniques and Equipment7

Phenomena and Processes28

Disciplines and Occupations1

Information Science3

Differentiation22

Development of skeletal muscle1

Regeneration6

Macrophages5

Skeletal myogenesis4

MRFs4

Myoblasts3

Transcription factor11

Embryonic3

Genes9

Myoblast1

BHLH1

Protein7

Myod2

Myf53

Proteins4

Vitro studies1

Regulate1

Lineages1

Myogenin3

Isoforms1

Cardiac1

Muscle15

Cells8

Concentrations1

Stimulates1

Expression4

Ablation1

Developmental1

Promotes1

Adult1

Crosstalk1

Regulates1

Neurogenesis1

Affects1

Mechanisms1

Extracellular1

Injection1

Progression1

Stem Cell1

Effects1

Muscular1