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  • vivo
  • Considering that matrix treatment supports myogenesis only in in vivo models that exhibit necrosis, this study demonstrates that a necrotic environment is required to maximize matrix-mediated myogenesis. (biologists.org)
  • myoblasts
  • The α 7 β 1 -integrin is highly expressed in skeletal muscle and appears to be critical for skeletal muscle development due to its presence in myoblasts during myogenesis, and it is equally important for maintaining structural integrity based on its expression in the sarcolemma, Z bands, and myotendinous ( 2 ) and neuromuscular ( 19 ) junctions in fibers. (physiology.org)
  • These findings lay the foundation for the potential use of low-dose taxol and nocodazole in modulating myogenesis, particularly in the context of cellular cardiomyoplasty, where differentiation of myoblasts and stem cells into force-generating mature muscle cells is critical to their repair capacity. (ahajournals.org)
  • Although many components of the transcriptional network are known for the later phases of myogenesis, relatively little work has described the transcriptional landscape within the first 24 hours, when myoblasts commit to differentiate. (omicsdi.org)
  • Through dense temporal sampling of differentiating C2C12 myoblasts, we identify 266 transcriptional regulators (TRs) whose expression is altered within the first 12 hours of myogenesis. (omicsdi.org)
  • More importantly, in agreement with the defective myogenesis of cultured p38α Δ/Δ myoblasts, neonatal muscle deficient in p38α shows cellular hyperproliferation and delayed maturation. (embopress.org)
  • Myogenesis is a dynamic process in which mononucleated undifferentiated myoblasts first proliferate, then withdraw from the cell cycle, and finally differentiate and fuse to form the multinucleated mature muscle fibers in the animal. (embopress.org)
  • Genes
  • Myogenesis is a tightly controlled process involving the transcriptional activation and repression of thousands of genes. (omicsdi.org)
  • Several of these genes were then characterised using a range of experimental and computational analyses with the aim to better understand their role in myogenesis and their evolution in teleosts. (st-andrews.ac.uk)
  • embryonic
  • For example, co-ordinated embryonic expression patterns were revealed for six salmon MRFs (myod1a, myod1b, myod1c, myog, mrf4, myf5), as well as markers of distinct MPC populations (pax7, smlc1), providing insight into the regulatory networks governing myogenesis in a tetraploid teleost. (st-andrews.ac.uk)
  • Myf5
  • These include known regulators of myogenesis (Myod1, Myog and Myf5), as well as 26 regulators not previously associated with the process. (omicsdi.org)
  • process
  • However, despite the attention p38α/β has received as a modulator of myogenesis, the signaling mechanisms by which it is activated during this process are largely unknown. (rupress.org)
  • shown
  • Moreover, nocodazole, a microtubule-destabilizing agent, enhanced the inhibition of myogenesis exerted by TGF-β, an effect that could be restored by tubulin-polymerizing agent taxol, both of which have been shown to affect Smad-microtubule interaction and regulate TGF-β/Smad signaling. (ahajournals.org)
  • function
  • We demonstrate that a dominant gain-of-function mutant of mNotch suppresses neurogenesis, as well as myogenesis in P19 cells. (biologists.org)
  • Further analysis of intergenic binding sites showed that YY1 potentially regulates dozens of large intergenic non‐coding RNAs (lincRNAs), whose function in myogenesis is underexplored. (embopress.org)
  • However, the physiological function of Tid1 during skeletal myogenesis remains unclear. (biomedcentral.com)
  • component
  • Cdo is an immunoglobulin superfamily member that functions as a component of multiprotein cell surface complexes to promote myogenesis. (rupress.org)