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  • progenitor
  • Hematopoietic and CD45 − /VEGFR2 + cells (known as endothelial progenitor cells or circulating angiogenic cells) have been reported to contribute to angiogenesis through the paracrine secretion of proangiogenic factors, as well as incorporate into new vessels, although luminal incorporation appears to be a relatively rare event ( 48 , 55 ). (physiology.org)
  • Exhaustion of muscle progenitor cells (MPCs) is thought to be an important factor contributing to the progressive weakness and atrophy of peripheral skeletal muscle that occurs with various skeletal myopathies and during normal aging ( 1 ⇓ ⇓ ⇓ ⇓ ⇓ ⇓ ⇓ - 9 ). (pnas.org)
  • adult muscle
  • RESULTS Conditional Deletion 1211441-98-3 of the Gene in Adult Skeletal Muscle Leads to Delayed Loss of SCs To analyze the role of Pax7 in adult muscle stem cells, we inactivated the gene in adult mice by treating 3-month-old Pax7CE/loxP-Gu mice (n = 3) and Pax7loxP-Gu/+ controls (n = 3) with 3 mg tamoxifen (TAM) per 40 g body weight for 5 days (Lepper et al. (a-443654.com)
  • expression
  • TRAF6 was required for the activation of MAPKs ERK1/2 and JNK1/2, which in turn activated the transcription factor c-JUN, which binds the Pax7 promoter and augments Pax7 expression. (jci.org)
  • To further understand the underlying cause for the age-associated decrement of mitochondrial density and function in equine skeletal muscle, expression of factors involved in mitochondria biogenesis and mitochondria-selective autophagy pathways, two of the most prominent quality control mechanisms that have been described, were analyzed. (ufl.edu)
  • C/EBPβ also promotes Pax7 expression by directly binding to and regulating Pax7 transcription. (uottawa.ca)
  • Unexpectedly, expression of Pax3:Fkhr in muscle satellite cells did not produce tumors, but it did in differentiating myofibers. (aacrjournals.org)
  • To examine the pathogenic pathways and identify new or modifying factors involved in muscular dystrophy, expression microarrays were used to compare individual gene expression profiles of skeletal muscle biopsies from 12 DMD patients and 12 unaffected control patients. (jove.com)
  • Concomitant with the loss of Pax7-positive SCs, we also noted a rapid decline of Pax7 mRNA concentrations in TAM-treated Pax7CE/loxP-Gu mice (Figures S3A and S3F) and a rapid decline of SCs as assessed by the expression of calcitonin receptor (Calcr), a marker. (a-443654.com)
  • vivo
  • In vivo analyses of Pax7-/- mice strongly suggest that Sdf-1-mediates increase in CD9 levels also in mobilized stem cells. (biomedcentral.com)
  • Here, we demonstrate that SCs are in an intrinsic hypoxic state in vivo and express hypoxia-inducible factor 2A (HIF2A). (jci.org)
  • mice
  • We observed a massive reduction, but not complete loss, of Pax7-positive SCs on isolated myofibers of Pax7CE/loxP-Gu mice already 1211441-98-3 1 day after the end of the TAM treatment (Figure 1N). (a-443654.com)
  • Furthermore
  • Furthermore, we show that Syndecan-3 interacts with Notch and is required for Notch processing by ADAM17/tumor necrosis factor-α-converting enzyme (TACE) and signal transduction. (rupress.org)
  • interacts
  • Syndecan-3 is a transmembrane heparan sulfate proteoglycan (HSPG) expressed in SCs that interacts with extracellular matrix proteins and growth factors through its ectodomain, and with cytoskeletal proteins and intracellular signaling molecules through its intracellular domain. (rupress.org)
  • satellite cell
  • The changes in satellite cell properties coincided with the inactivation of Notch signaling and the activation of Wnt signaling and likely involve modulation by transcription factors of the Sox family. (hindawi.com)
  • Together, our data support the conclusion that Syndecan-3 and Notch cooperate in regulating homeostasis of the satellite cell population and myofiber size. (rupress.org)
  • essential
  • demonstrate the importance of peripheral clock regulation in chondrocytes and report that the circadian transcription factor BMAL1 plays an essential role in maintaining the integrity of cartilage tissue. (jci.org)
  • cell
  • TNF receptor-associated factor 6 (TRAF6) is an adaptor protein and an E3 ubiquitin ligase that mediates the activation of multiple cell signaling pathways in a context-dependent manner. (jci.org)