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  • cardiomyocytes
  • Cardiomyocytes also undergo cell death under a variety of other physiological stimuli such as oxidative stress due to hypoxia induced during cardiac ischemia and glucose limitation amongst others [ 11 ]. (hindawi.com)
  • Ccna2 mediated cardiac repair showed both a decrease in fibrosis in the peri-infarct tissue and a greater number of cardiomyocytes at the sites of injection. (wikipedia.org)
  • In cardiac muscle, N-cadherin is an integral component in adherens junctions residing at intercalated discs, which function to mechanically and electrically couple adjacent cardiomyocytes. (wikipedia.org)
  • In cardiac muscle, N-cadherin is found at intercalated disc structures which provide end-on cell-cell connections that facilitate mechanical and electrical coupling between adjacent cardiomyocytes. (wikipedia.org)
  • human cardiac
  • The titin-cap protein telethonin was previously identified by our group as an interaction partner for the protein kinase D (PKD) catalytic domain, through a yeast two-hybrid screen of a human cardiac cDNA library. (ovid.com)
  • atrial
  • Corin converts the atrial natriuretic peptide (ANP) precursor, pro-ANP, to mature ANP, a cardiac hormone that regulates salt-water balance and blood pressure. (wikipedia.org)
  • pathways
  • the activation of oxidative stress pathways in utero can program for cardiac dysfunction in adulthood such as responses to ischemia/reperfusion, cardiac function, coronary flow, and hypertension [ 4 - 7 ]. (hindawi.com)
  • maturation
  • The experimental paradigm contributes to a novel regenerative strategy that enhanced myocyte maturation occurred from converted human fat stem cells. (nasa.gov)
  • Cardiac Myocytes flies the cardiac progenitor cells (CPCs) in a Techshot Bioreactor on the ISS and evaluates myocyte maturation under microgravity conditions. (nasa.gov)
  • Here, a novel maturation paradigm is created by culturing 3D cardiospheroids that enhances electrical maturation of the cardiac myocytes. (nasa.gov)
  • Signaling
  • An alpha1A-adrenergic-extracellular signal-regulated kinase survival signaling pathway in cardiac myocytes. (nih.gov)
  • Therefore, we investigated alpha1A and alpha1B subtype-specific survival signaling in cultured cardiac myocytes to test for a direct protective effect of alpha1-ARs in cardiac myocytes. (nih.gov)
  • In addition, only the alpha1A-AR activated ERK in alpha1ABKO myocytes, and expression of a dominant-negative MEK1 completely blocked alpha1A survival signaling in alpha1ABKO myocytes. (nih.gov)
  • Our results demonstrate a direct protective effect of the alpha1A subtype in cardiac myocytes and define an alpha1A-ERK signaling pathway that is required for myocyte survival. (nih.gov)
  • Ang II activates multiple second-messenger systems in cardiac myocytes, 16 and each signaling molecule seems to mediate distinct hypertrophic responses. (ahajournals.org)
  • Therefore, we tested the hypothesis that IGF-1 and PI3K/Akt signaling, independently, decrease sarcolemmal potassium currents in cardiac myocytes of neonatal rats. (hindawi.com)
  • protein
  • Myostatin (also known as growth differentiation factor 8, abbreviated GDF-8) is a myokine, a protein produced and released by myocytes that acts on muscle cells' autocrine function to inhibit myogenesis: muscle cell growth and differentiation. (wikipedia.org)
  • In mice overexpressing a C-terminal mutated desmoplakin protein, desmoplakin binding to desmin is disrupted in cardiac muscle and hearts display abnormal intercalated disc formation and structure. (wikipedia.org)
  • Skeletal
  • There are various specialized forms of myocytes: cardiac, skeletal, and smooth muscle cells, with various properties. (wikipedia.org)
  • The striated cells of cardiac and skeletal muscles are referred to as muscle fibers. (wikipedia.org)
  • Telethonin has a unique β-sheet structure, which enables antiparallel association with the Titin Z1-Z2 domains in cardiac and skeletal muscle. (wikipedia.org)
  • Telethonin expression is developmentally regulated in both cardiac and skeletal muscle and is thought to be critical to sarcomere assembly. (wikipedia.org)
  • H2O2
  • Myocyte death was induced by norepinephrine, doxorubicin, or H2O2 and was measured by annexin V/propidium iodide staining. (nih.gov)
  • fatty acids
  • Post MI, as fatty acid oxidation decreases, it leads to reduced energy supply for the cardiac myocytes, accumulation of fatty acids to toxic levels, and dysfunction of mitochondria. (wikipedia.org)
  • peptides
  • Nevertheless, it is unclear whether these peptides protect against cardiac injury by directly reacting with lipid peroxidation products. (springer.com)