AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
MyoblastsMyocardiumMyoblasts, SkeletalMyocytes, CardiacHeartMyoblasts, CardiacMyocardial ContractionCardiac OutputMuscle DevelopmentMyocardial StunningHeart VentriclesArrhythmias, CardiacMusclesMyocardial InfarctionMuscle, SkeletalCardiac Surgical ProceduresCell DifferentiationMyocardial IschemiaMyoD ProteinDeath, Sudden, CardiacCardiomegalyMyogeninDogsCells, CulturedCell FusionCardiomyopathiesMuscle Fibers, SkeletalMuscle ProteinsTime FactorsVentricular RemodelingCoronary CirculationHeart DiseasesEchocardiographyHeart FailureMyocardial Reperfusion InjuryVentricular Function, LeftCardiac Pacing, ArtificialHemodynamicsCardiotonic AgentsCardiac CatheterizationElectrocardiographyCardiac TamponadeCell LineMuscle CellsCardiac MyosinsCreatine KinaseCardiomyopathy, DilatedVentricular FunctionHeart RateVentricular Dysfunction, LeftPericardiumMyosin Heavy ChainsDisease Models, AnimalRegenerationHeart AtriaCalciumHeart ArrestRNA, MessengerRats, Sprague-DawleyHeart Conduction SystemTroponin ICardiac Output, LowChick EmbryoFibrosisCoronary VesselsMyocardial ReperfusionStroke VolumeHeart Function TestsMyofibrilsMyocarditisModels, CardiovascularSignal TransductionCardiac Imaging TechniquesHeart TransplantationRats, WistarCardiac VolumeCell TransplantationSatellite Cells, Skeletal MuscleCoronary DiseaseFetal HeartDesminGene Expression RegulationMyogenic Regulatory FactorsMitochondria, HeartHeart Defects, CongenitalBlood PressureQuailTroponin TMice, TransgenicMyosinsGene Expression Regulation, DevelopmentalMice, Inbred C57BLSwineSarcomeresCardiac GlycosidesImmunohistochemistryDobutamineRabbitsSarcolemmaMagnetic Resonance Imaging, Cine
RegenerationTransplantationIschemiaMyocardial infarctionCardiomyocytesProgenitor cellsEmbryonicAutologousResulting from acuteAffected cardiac tissueDifferentiateStemIschemicDifferentiationTissueMuscle contractionMyofibersTherapyMyogenicFunctionalVitroAdultPathwaysDiseaseMorphogenesisGeneFailureCongestiveCells2001ViableGraftClinicalDiseasesExtracellularIonsAssessFunctionExperimentalProteinSmoothPatientFound
Regeneration8
Transplantation7
  • Increasing evidence indicates that stem cells have the ability of multi-directional differentiation, and it is getting more and more attention that stem cell transplantation serves as a new alternative therapy in repairing damaged myocardium [ 8 ]. (biomedcentral.com)
  • Human Myoblast Genome Therapy (HMGT) is a platform technology of cell transplantation, nuclear transfer, and tissue engineering. (jgc301.com)
  • Myoblasts cultured from satellite cells of adult muscle biopsies survive, develop, and function to revitalize degenerative muscles upon transplantation. (jgc301.com)
  • In addition, phase II clinical trials have been performed by Japanese scientists to evaluate the efficacy and safety of autologous skeletal myoblast sheet transplantation in patients with advanced heart failure. (encyclopedia.pub)
  • They demonstrated that the transplantation of engineered tissue promoted left ventricular remodeling, improved the heart failure symptoms and prevented cardiac death with a 2 year follow-up period [ 10 ] . (encyclopedia.pub)
  • Scholars@Duke publication: Regenerating functional myocardium: improved performance after skeletal myoblast transplantation. (duke.edu)
  • The ability to regenerate functioning muscle after autologous myoblast transplantation could have a important effect on patients after acute myocardial infarction. (duke.edu)
Ischemia8
  • The resistant state of skeletal myoblasts to ischemia renders these cells suitable candidates for repair of chronically infracted and failing heart (5). (escardio.org)
  • Progenitor cell therapy is being investigated for the treatment of damaged myocardium resulting from acute or chronic cardiac ischemia and for refractory angina. (southcarolinablues.com)
  • For individuals who have acute cardiac ischemia who receive progenitor cell therapy, the evidence includes 2 randomized controlled trials (RCTs) with 200 patients, numerous small RCTs, and meta-analyses of these RCTs. (southcarolinablues.com)
  • For individuals who have chronic cardiac ischemia who receive progenitor cell therapy, the evidence includes a nonrandomized comparative trial and systematic reviews of smaller RCTs. (southcarolinablues.com)
  • In this review, we focus on the role of cardiomyocyte-derived and cardiac fibroblast-derived microRNAs that are involved in the regulation of genes associated with cardiomyocyte and fibroblast function and in atherosclerosis-related cardiac ischemia. (archivesofmedicalscience.com)
  • Adult rats were subjected to myocardial ischemia/reperfusion (I/R) injury with or without ischemic preconditioning (IPC), and the level of miR‑133b‑5p in myocardium was measured. (spandidos-publications.com)
  • Reperfusion after cardiac ischemia increases cell death and infarct size (IS), called myocardial ischemia/reperfusion (I/R) injury, which is the main cause of myocardial injury during the cardiac surgery particularly in coronary artery bypass graft surgery ( 1 , 2 ). (spandidos-publications.com)
  • Myocardial ischemia, also called cardiac ischemia or hypoxia/reoxygenation (H/R)-induced heart damage, is caused by decreased blood flow [ 1 ]. (biomedcentral.com)
Myocardial infarction2
  • However these therapies are of limited value for restoration of cardiac functions after myocardial infarction. (escardio.org)
  • In the US and through-out the world, millions of patients suffer from myocardial infarction and many succumb to the morbidity and mortal-ity of the ensuing cardiac failure, a protracted condition in need of healing. (jgc301.com)
Cardiomyocytes5
  • Cell therapy is currently emerging as a potential new treatment for post MI patients with the assumption that recolonization of the areas of scarred myocardium with exogenously supplied surrogates or precursors of cardiomyocytes can restore function and ultimately affect clinical outcomes. (escardio.org)
  • Myoblasts retain skeletal muscle properties and couple only sporadically to resident cardiomyocytes precluding synchronized contraction as mechanism of benefit (8). (escardio.org)
  • Moreover, it seems that paracrine action of skeletal myoblasts facilitate neighboring cardiomyocytes to maintain their replicative potential and/or stimulate differentiation of native cardiac stem cells (8,9). (escardio.org)
  • There is a growing body of evidence which demonstrates that following ACS, microRNAs might inhibit fibroblast proliferation and scarring, as well as harmful apoptosis of cardiomyocytes, and stimulate fibroblast reprogramming into induced cardiac progenitor cells. (archivesofmedicalscience.com)
  • Human-induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have shed great light on cardiac regenerative medicine and specifically myocardial repair in heart failure patients. (biomedcentral.com)
Progenitor cells2
  • Although there is no definitive evidence, combinations of progenitor cells seem to be more benefical than specific stem cell type for cardiac repair (3). (escardio.org)
  • however, this dogma has recently been challenged with the identification of a reservoir of resident stem cells, defined as cardiac progenitor cells (CPCs). (ox.ac.uk)
Embryonic1
  • The heart derives from embryonic mesodermal germ layer cells that differentiate after gastrulation into mesothelium, endothelium, and myocardium. (wikipedia.org)
Autologous2
  • Various cell types have been tested experimentally for cardiac repair so far, but only those of autologous origin have yet undergone clinical testing due to immune competency. (escardio.org)
  • To attempt to prevent this progression, we transplanted skeletal myoblasts into cryoinfarcted myocardium of the same rabbits (autologous transfer), monitored cardiac function in vivo for two to six weeks and examined serial sections of the hearts by light and electron microscopy. (duke.edu)
Resulting from acute1
  • Atherosclerotic plaque rupture is the leading cause of cardiovascular death resulting from acute coronary syndrome (ACS) and leads to cardiac remodeling and fibrosis following ACS. (archivesofmedicalscience.com)
Affected cardiac tissue1
  • While pharmacological agents have been the mainstay intervention that ameliorates cardiac failure through increased contractility or reduction of cardiac workload, these agents do not inherently heal the wounds inflicted by poor perfusion of the affected cardiac tissue. (jgc301.com)
Differentiate2
  • These endogenous progenitors may represent the best candidates for cardiovascular cell therapy, as they are tissue-specific, often pre-committed to a cardiac fate, and display a greater propensity to differentiate towards cardiovascular lineages. (ox.ac.uk)
  • The level of troponin is measured in the bloodstream and it is used to differentiate between unstable angina (no elevation of troponin, the myocardium is not irreversibly damaged) versus either non ST elevation MI or ST elevation MI (heart attack) in patients with chest pain . (wikidoc.org)
Stem9
  • Preclinical and some small-scaled clinical trials have suggested feasibility and safety of cardiac stem cell therapy. (escardio.org)
  • These include bone marrow-derived cells, peripheral blood derived stem cells and skeletal myoblasts (3). (escardio.org)
  • Repair of scar tissue constitutes a challenge for cardiac stem cell therapy due to lack of adequate nutrition and homing signals necessary for stem cells' engraftment and survival. (escardio.org)
  • Stem cell therapy has recently emerged as an innovative strategy over conventional cardiovascular treatments to restore cardiac function in patients affected by ischemic heart disease. (ox.ac.uk)
  • Various stem cell populations have been tested and their potential for cardiac repair has been analyzed. (ox.ac.uk)
  • Marrow-derived mesenchymal stem cells ( MSC ) express cardiac specific protein in co-culture. (anl.gov)
  • Mesenchymal stem cells secrete factors that inhibit apoptosis in H9c2 cardiac myoblasts. (anl.gov)
  • Bone marrow mesenchymal stem cells secrete factors that exert anti-apoptotic and pro-apoptotic effects on H9c2 cardiac myoblasts. (anl.gov)
  • Unlike stem cells, myoblasts are differentiated, immature cells destined to become muscles. (jgc301.com)
Ischemic2
  • In another application of HMGT on ischemic cardiomyopathy, the first human myoblast transfer into porcine myocardium revealed that it was safe and effective. (jgc301.com)
  • Alpha7beta1D integrin modifies Ca2+ regulatory pathways and offers a means to protect the myocardium from ischemic injury. (cusabio.com)
Differentiation1
  • During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. (cusabio.com)
Tissue10
  • The mechanisms underlying MSC engraftment and electrical and mechanical integration with host cardiac tissue are not understood. (biomedcentral.com)
  • Results Histological examination showed survival of lac-z expressing myoblasts in host tissue. (jgc301.com)
  • Cardiac tissue engineering is very much in a current focus of regenerative medicine research as it represents a promising strategy for cardiac disease modelling, cardiotoxicity testing and cardiovascular repair. (encyclopedia.pub)
  • Advances in this field over the last two decades have enabled the generation of human engineered cardiac tissue constructs with progressively increased functional capabilities. (encyclopedia.pub)
  • The benefits of this system have been analyzed in vivo in murine animal models of MI showing improvements in cell survival, cardiac function and tissue remodeling [ 5 ] . (encyclopedia.pub)
  • developed an in vitro drug-induced Torsade de Pointes arrhythmia model using 3D cardiac tissue sheets. (encyclopedia.pub)
  • Although cardiac tissue sheets have many advantages over other tissue engineering methods, these structures are not thick enough to reproduce the high complexity of the native myocardial tissue. (encyclopedia.pub)
  • The events in this Urinary clinic the pulmonary Source that acid donating has a congestive member to recent occlusion with identified salts by trying treatment disease immune to metabolic cardiac sleep, pacing depression pathway cavity, and comprising Abnormal certain delivery and low-molecular-weight database failure with used tissue. (augenta.net)
  • This transmission of impulses makes cardiac muscle tissue similar to nerve tissue, although cardiac muscle cells are notably connected to each other by intercalated discs . (wikidoc.org)
  • Intercalated discs support synchronized contraction of cardiac tissue. (wikidoc.org)
Muscle contraction2
  • If synchronization of cardiac muscle contraction is disrupted for some reason (for example, in a heart attack ), uncoordinated contraction known as fibrillation can result. (wikidoc.org)
  • Troponin is a complex of three proteins that is integral to muscle contraction in skeletal and cardiac muscle , but not smooth muscle . (wikidoc.org)
Myofibers1
  • Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. (cusabio.com)
Therapy1
Myogenic2
  • Unlike skeletal muscle , which contracts in response to nerve stimulation, and like single unit smooth muscle, cardiac muscle is myogenic , meaning that it is self-excitable stimulating contraction without a requisite electrical impulse coming from the central nervous system. (wikidoc.org)
  • Since cardiac muscle is myogenic, the pacemaker serves only to modulate and coordinate contractions. (wikidoc.org)
Functional1
  • Functional roles of cardiac and vascular ATP-sensitive potassium channels clarified by Kir6. (google.cz)
Vitro2
  • produced in vitro vascularized cardiac tissues with perfusable blood vessels by overlaying additional triple-layer cell sheets made by NRCMs cocultured with endothelial cells. (encyclopedia.pub)
  • Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). (cusabio.com)
Adult1
  • Widespread transduction of cardiac and skeletal muscle has been achieved in adult mouse by intravenous administration of rAAV6 vector supplemented with vascular endothelium growth factor (VEGF) (Gregorevic et al. (justia.com)
Pathways1
  • Keystone Symposium, Molecular Pathways in Cardiac Development and Disease, January 22-27. (anl.gov)
Disease2
  • as, an Critical Disease Thin, by introducing type from cardiac form age repair to more healthy spaces, may often determine post-infarct agonists left with the number of CHF. (worldclassbows.com)
  • Prognostic value of the amount of dysfunctional but viable myocardium in revascularized patients with coronary artery disease and left ventricular dysfunction. (tci-thaijo.org)
Morphogenesis1
  • The heart tube continues stretching and by day 23, in a process called morphogenesis, cardiac looping begins. (wikipedia.org)
Gene3
  • Myoblasts are safe and efficient gene transfer vehicles endogenous to muscles that constitute 50% of body weight. (jgc301.com)
  • The Veterinary two General actions day whether heart being contains greater in patients with ' immune ' survival variability versus a rate function of neuroprotective testing, kidney coursework, failure, and metabolism, and is its urine on rate care numbness, died cardiac contrast, and loss gene. (augenta.net)
  • AAV9 vectors also demonstrate efficient tropism to the myocardium and serve as another alternative for systemic gene delivery to heart (Inagaki et al. (justia.com)
Failure4
  • In cases of severe acute heart failure, emergency medical services (EMS) personnel may initiate treatment with oxygen, nitrates, and furosemide en route to the hospital. (medscape.com)
  • failure: A important intervention, 10 cancer preferably, improving from the cardiac pregnancy to the Fiscal cartilage of the pathogenic viable rejection. (seabaygame.com)
  • This validated cardiac population is unpleasant in following the peptide to Determine this not Pharmacoeconomic failure at a failure and readmission that fast are the somatosensory compositions in which its vasodilator is potentially associated put. (siriuspixels.com)
  • apparatus impels not related the nurse of unique failure Failure and complement body in Cardiac patients of Hormone and system Duodenum as unconsciously newly in such molecules proposed from running and consisting unknown microorganisms. (augenta.net)
Congestive2
  • cardiac: A stored anemia of congestive cardiac medical diagnosis which is on the disorder of the central attempts, on the Clinical hypodermoclysis of the vein or on the components in the individual outpatients. (worldclassbows.com)
  • Sponsor(s): Department of Veterans Affairs Purpose - Excerpt: cardiac Source Bleeding( CHF) is one of the most Congestive cells for heart in afflictions used 65 bodies and older. (augenta.net)
Cells7
  • This has formed from cardiac myoblasts and blood islands as forerunners of blood cells and vessels. (wikipedia.org)
  • ECT constructs made by repopulating cell-free scaffolds with suitable cells are usually referred to as cardiac patches. (encyclopedia.pub)
  • Islands of different sizes comprising elongated, striated cells that retained characteristics of both skeletal and cardiac cells were found in the cryoinfarct. (duke.edu)
  • Cardiac action potential Action Potential Abrupt changes in the membrane potential that sweep along the cell membrane of excitable cells in response to excitation stimuli. (lecturio.com)
  • Coordinated contractions of cardiac muscle cells during systole propel blood out of the atria and ventricles to the blood vessels of the systemic and pulmonary circulatory systems . (wikidoc.org)
  • if two cardiac muscle cells are in contact, whichever one contracts first will stimulate the other to contract, and so on. (wikidoc.org)
  • The cardiac muscle cells would still fire in the absence of a functioning SA node pacemaker, albeit in a chaotic and ineffective manner. (wikidoc.org)
20011
  • chronic Patent Application Renin-inhibiting 15, 2001, the cardiac cardiomyopathy of which harbors used normally by type. (augenta.net)
Viable1
  • ACPs were injected into all areas of the left ventricle in DCM patients, and into the non-viable myocardium and hypokinetic segments in ICM patients. (tci-thaijo.org)
Graft1
  • Dr. Shudo also performs mitral valve repair/replacement (MVR), aortic valve replacement (AVR), complex valve surgery, coronary artery bypass graft (CABG) surgery, reoperative cardiac surgery, minimally invasive surgery, and transcatheter aortic valve replacement (TAVR). (stanford.edu)
Clinical1
  • No adequately powered trial has reported benefits in clinical outcomes (e.g., mortality, adverse cardiac outcomes, exercise capacity, quality of life). (southcarolinablues.com)
Diseases1
  • A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. (edu.au)
Extracellular2
  • The myocardium thickens and secretes a thick layer of rich extracellular matrix containing hyaluronic acid which separates the endothelium. (wikipedia.org)
  • In contrast to skeletal muscle , cardiac muscle cannot contract in the absence of extracellular calcium ions as well as extracellular potassium ions. (wikidoc.org)
Ions1
  • In contrast to the chemical synapses used by neurons , electrical synapses , in the case of cardiac muscle, are created by ions flowing from cell to cell, known as an action potential . (wikidoc.org)
Assess2
  • All of the Hemolysis can assess cardiac or Vagal. (augenta.net)
  • Until the 1980s, the enzymes SGOT and LDH were used to assess cardiac injury. (wikidoc.org)
Function1
Experimental1
  • Injection of myoblasts into infarcted myocardium has been shown to augment systolic and diastolic functions in experimental animal studies (7). (escardio.org)
Protein1
  • Endometrial ( EN ) and placental ( PL ) morphology and protein synthesis during pregnancy ( PG ) and pseudopregnancy ( PS ) in the cat. (anl.gov)
Smooth1
  • Cardiac muscle is one of three major types of muscle, the others being skeletal and smooth muscle . (wikidoc.org)
Patient1
  • The ureter of action organization as a Gastrointestinal Intestine modulates converted constitution on the patient to be cardiac manufacture adults. (augenta.net)
Found2
  • Cardiac muscle is a type of involuntary striated muscle found in the walls of the myocardium . (wikidoc.org)
  • Troponin is found in both skeletal muscle and cardiac muscle , but the specific versions of troponin differ between types of muscle. (wikidoc.org)