AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsHealth Care
MyocardiumHeartMyocardial StunningMyocardial ContractionMyocardial IschemiaHeart VentriclesMyocardial InfarctionCoronary CirculationDogsMyocardial Reperfusion InjuryMyocytes, CardiacMyocardial ReperfusionCardiotonic AgentsVentricular RemodelingCardiomyopathiesPericardiumVentricular Function, LeftTissue SurvivalVentricular FunctionHemodynamicsCoronary VesselsEchocardiographyCardiomegalyHeart AtriaCoronary DiseaseCardiomyopathy, DilatedIsolated Noncompaction of the Ventricular MyocardiumIschemic Preconditioning, MyocardialDobutamineTime FactorsVentricular Dysfunction, LeftMyocarditisSwineHeart FailureDisease Models, AnimalIodobenzenesPerfusionTomography, Emission-Computed, Single-PhotonHeart Conduction SystemRats, Sprague-DawleyTomography, Emission-ComputedRats, WistarMitochondria, HeartCreatine KinaseElectrocardiographyModels, CardiovascularCalciumOrganotechnetium CompoundsFibrosisThallium RadioisotopesRabbitsMagnetic Resonance Imaging, CineContrast MediaMyofibrilsFetal HeartCollateral CirculationHeart Function TestsArrhythmias, CardiacSarcolemmaRadiopharmaceuticalsSystoleHeart RateGadolinium DTPAThiadiazinesCardiac MyosinsTroponin IMyocardial RevascularizationTechnetium Tc 99m SestamibiStroke VolumeEndomyocardial FibrosisMyoblasts, CardiacDiastoleNitrogen RadioisotopesEdema, CardiacSwine, MiniatureNecrosisImmunohistochemistryVentricular PressureNeovascularization, PhysiologicCicatrixHeart Arrest, InducedConnexin 43Myoblasts, SkeletalThalliumAdrenergic beta-AgonistsMicrospheresRNA, MessengerStem Cell TransplantationHypertrophy, Left VentricularReceptors, Adrenergic, betaHeart DiseasesHeart ValvesSarcoplasmic ReticulumOxygen ConsumptionAction PotentialsMagnetic Resonance ImagingSarcomeresCells, CulturedVentricular DysfunctionPhosphocreatine
InfarctionAcuteDysfunctionTakotsuboReperfusionIschemicNeurogenicTransientNecrosisRegional myocardialVentricularPersistentPerfusion ImagingIncrease myocardialImagingOcclusionHibernatingIschaemiaCoronary heart dToxicityViabilityAnaerobicExperimentalContractileOxygen consumptionFunctionSkeletalMetabolicSevereModerateInjury2001OnsetSyndromeStressHemodynamicPatientsPatientCardiovascularBlood vessels
Infarction15
Acute5
  • Stunned myocardium is myocardium that suffers transient reversible myocardial contractile dysfunction that is caused by acute ischemia during which the blood supply is almost completely restored by reperfusion, with no metabolic deterioration. (medscape.com)
  • Acute treatment with troglitazone increases susceptibility to ventricular fibrillation during myocardial ischemia and reperfusion. (diabetesjournals.org)
  • We report the case of a 45-year-old male who presented with transient neurogenic stunned myocardium, or takotsubo cardiomyopathy, secondary to acute hydrocephalus caused by obstruction of the third ventricle by neurocysticercosis. (elsevierpure.com)
  • In the United States, although 18% of ED patients have severely elevated blood pressure at or above 180/110 mmHg upon presentation, 3 far fewer have hypertensive emergency, as previously defined, which occurs in conjunction with acute or impending target organ damage. (nursingcenter.com)
  • Current technologies, however, cannot capture rapid transitions between cellular states in highly dynamic scenarios, such as during acute inflammatory responses, which are characterized by continuous changes in the motility and morphology of individual cells as they adapt to local cues and anatomical barriers. (studylib.net)
Dysfunction9
  • Strain rate imaging after dynamic stress provides objective evidence of persistent regional myocardial dysfunction in ischaemic myocardium: regional stunning identified? (bmj.com)
  • The term hibernating myocardium is also used to indicate chronic myocardial contractile dysfunction due to ischemia, in which there is reduced coronary blood flow at rest and increased myocardial demand results in impaired contractility. (medscape.com)
  • Finding all 3 entities in the same patient with chronic myocardial dysfunction is not uncommon (see the image above). (medscape.com)
  • Myocardial stunning or transient post-ischemic myocardial dysfunction is a state of mechanical cardiac dysfunction that can occur in a portion of myocardium without necrosis after a brief interruption in perfusion, despite the timely restoration of normal coronary blood flow. (wikipedia.org)
  • The area of dysfunction should also maintain normal perfusion, detected via Positron Emission Tomography, echocardiography with contrast, and/or thallium scintigraphy in order for a diagnosis of myocardial stunning to be considered. (wikipedia.org)
  • Some evidence supports the use of inotropic drugs in the case of severe myocardial dysfunction. (wikipedia.org)
  • Summary: Postischaemic myocardial dysfunction (stunning) induced by partial occlusion of the left anterior descending coronary artery and its relation to lactate production during reperfusion were studied in nine swine. (elsevierpure.com)
  • Delay in revascularization is associated with increased mortality rate in patients with severe left ventricular dysfunction and viable myocardium on fluorine 18-fluorodeoxyglucose positron emission tomography imaging. (smw.ch)
  • The role of a huge increase in endogenous and/or exogenous catecholamine level in critically ill patients (severe sepsis, post cardiac resuscitation, post tachycardia) to explain the onset of myocardial dysfunction was discussed. (springeropen.com)
Takotsubo3
  • Current state of knowledge on Takotsubo Sindrome: a position statement from the Task-Force on Takotsubo Syndrome of the Heart Failure Association of the ESC. (sciendo.com)
  • Takotsubo cardiomyopathy is a type of non-ischaemic cardiomyopathy in which there is a sudden temporary weakening of the myocardium. (findmeacure.com)
  • While the original case studies reported on individuals in Japan , Takotsubo cardiomyopathy has been noted more recently in the United States and Western Europe. (findmeacure.com)
Reperfusion5
  • Myocardial stunning was first described in laboratory canine experiments in the 1970s where LV wall abnormalities were observed following coronary artery occlusion and subsequent reperfusion. (wikipedia.org)
  • The generation of oxygen-derived [free radicals] during the initial period of reperfusion after ischemia is believed to contribute to the pathogenesis of myocardial stunning. (wikipedia.org)
  • During open heart surgery, the myocardium suffers from ischemia-reperfusion injury (IR) despite perioperative cardioprotection. (oroboros.at)
  • Powers SK, Quindry JC, Kavazis AN (2008) Exercise-induced cardioprotection against myocardial ischemia-reperfusion injury. (oroboros.at)
  • Modulation of severity of reperfusion stunning in the isolated rat heart by agents altering calcium flux at onset of reperfusion. (wanfangdata.com.cn)
Ischemic6
  • This finding shows that ischemic but noninfarcted myocardium can exist in a state of hibernation without cell death. (medscape.com)
  • Subsequent to this is a period of "myocardial stunning," in which reversible ischemic damage is taking place. (wikipedia.org)
  • He also demonstrated the salvage of ischemic myocardium following coronary occlusion. (cmeindia.in)
  • Slagsvold KH, Rognmo O, Hoydal M, Wisloeff U, Wahba A (2014) Remote ischemic preconditioning preserves mitochondrial function and influences myocardial microrna expression in atrial myocardium during coronary bypass surgery. (oroboros.at)
  • The effects of ryanodine on calcium uptake by the sarcoplasmic reticulum of ischemic and reperfused rat myocardium. (wanfangdata.com.cn)
  • Similar with the result from another in vivo study on rat hearts [20], we observed a protective effect of exogenous NGF on myocardium from I/R injury, as well as an improvement of post-ischemic cardiac function in isolated perfused rat hearts. (beccajcampbell.com)
Neurogenic3
Transient1
  • We posited that the behavioural traits of individual cells contain biological insights on the individual cells' genetic and protein content, as well as their signalling networks9, which can be used to describe persistent cell identities or transient states in their native environment (Fig. 1a). (studylib.net)
Necrosis3
  • The concomitant presence of myocardial necrosis with myocardial ischemia, stunning, or hibernation may complicate appraisal of left ventricular (LV) function and patient management. (medscape.com)
  • Several imaging modalities have been proposed for accurate assessment of myocardial necrosis, viability, stunning, and hibernation, with mixed results. (medscape.com)
  • Myocardial necrosis induced by temporary occlusion of a coronary artery in the dog. (wanfangdata.com.cn)
Regional myocardial2
  • Regional myocardial function and electrophysiological alteration after coronary artery occlusion. (medscape.com)
  • Accurate detection of regional myocardial blood flow and contraction function abnormalities must be detected at levels of high sensitivity. (wikipedia.org)
Ventricular2
Persistent3
  • The diagnosis of myocardial stunning must also be differentiated from other conditions such as hibernating myocardium and persistent (silent) subendocardial ischemia, which can also co-exist with superimposed stunning. (wikipedia.org)
  • Persistent stunning induces myocardial hibernation and protection: flow/function and metabolic mechanisms. (smw.ch)
  • Single-cell technologies have enabled the reconstruction of persistent cellular states and identities with extraordinary precision and resolution, in turn yielding valuable information on multiple biological scenarios6. (studylib.net)
Perfusion Imaging2
  • Myocardial perfusion imaging (MPI) is an important imaging modality in the management of patients with cardiovascular disease. (snmjournals.org)
  • Myocardial perfusion imaging (MPI) is a valuable tool in the management of patients with cardiovascular disease. (snmjournals.org)
Increase myocardial1
  • IPC involves single or multiple brief periods of sublethal ischemia, which increase myocardial resistance to a greater subsequent insult. (spandidos-publications.com)
Imaging2
  • The histology of viable and hibernating myocardium in relation to imaging characteristics. (smw.ch)
  • Imaging data suggests that dialysis increases myocardial blood flow (BF) heterogeneity, but its causes remain poorly understood. (frontiersin.org)
Occlusion1
  • In an in vivo dog model with left anterior descending coronary occlusion, Abe and his colleagues observed that both exogenous and endogenous NGF may protect the heart from neural stunning [17]. (beccajcampbell.com)
Hibernating10
  • In hibernating myocardium, contractile function can be partially or totally restored by improving coronary blood flow or by reducing oxygen demand of the myocardium. (medscape.com)
  • Rahimtoola suggested that hibernating myocardium is characterized by a state of persistently impaired myocardial and LV function at rest due to reduced coronary blood flow that can be partially or completely restored to normal by improving blood flow or by reducing oxygen demand (see the image below). (medscape.com)
  • Clinically, discerning the etiology of depressed myocardial contractile function is difficult, whether due to stunned myocardium, silent ischemia, or hibernating myocardium. (medscape.com)
  • Stunned and Hibernating Myocardium: Where are we nearly 4 decades later? (wikipedia.org)
  • The hibernating myocardium. (smw.ch)
  • Temporal and spatial variations in structural protein expression during the progression from stunned to hibernating myocardium. (smw.ch)
  • Hibernating myocardium: an incomplete adaptation to ischemia. (smw.ch)
  • Revascularization of chronic hibernating myocardium stimulates myocyte proliferation and partially reverses chronic adaptations to ischemia. (smw.ch)
  • Hibernating myocardium: diagnosis and patient outcomes. (smw.ch)
  • Sensitivity, specificity, and predictive accuracies of various noninvasive techniques for detecting hibernating myocardium. (smw.ch)
Ischaemia1
  • Effects of pretreatment with caffeine or ryanodine on the myocardial response to simulated ischaemia [J].1991,103(1). (wanfangdata.com.cn)
Coronary heart d1
  • Considering the prevalence of coronary heart disease among diabetic patients, surprisingly little is known about the effects of PPAR-γ activation in myocardium. (diabetesjournals.org)
Toxicity1
  • The mechanisms underlying the association between this generalized autonomic storm secondary to a life-threatening stress and myocardial toxicity are widely discussed. (springeropen.com)
Viability1
  • Noninvasive assessment myocardial viability: current status and future directions. (smw.ch)
Anaerobic1
  • After total ischemia occurs, the myocardium switches immediately from aerobic glycolysis to anaerobic glycolysis resulting in the reduced ability to produce high energy phosphates such as ATP and Creatinine Phosphate. (wikipedia.org)
Experimental4
  • This concept of an adaptive process that shuts down the contractile process and decreases myocardial oxygen demand in the presence of chronically or intermittently reduced blood flow has generated considerable interest in clinical and experimental settings. (medscape.com)
  • Results from canine experimental trials investigating the oxygen free-radical hypothesis for myocardial stunning have shown a reduction in free radical generation and improvement in myocardial function following anti-oxidant infusion. (wikipedia.org)
  • Recirculating cardiac delivery of AAV2/1SERCA2a improves myocardial function in an experimental model of heart failure in large animals. (wanfangdata.com.cn)
  • the objective of this article is to briefly introduce the characteristics of these ERP components, extending to current experimental findings, and to describe changes observed during pathophysiologic states. (beccajcampbell.com)
Contractile2
  • Recovery of myocardial contractile function after spontaneous restoration of flow may be protracted similarly after angioplasty or revascularization surgery. (medscape.com)
  • LS enhances the contractile function of stunned myocardium without increasing concetrations of intracellular calcium and myocardial oxygen consumption. (biomedcentral.com)
Oxygen consumption1
Function4
  • Myocardial ischemia is a clinical syndrome manifesting a variety of tissue effects and global cardiac effects that impair cardiac function. (medscape.com)
  • In this situation, even after ischemia has been relieved (by for instance angioplasty or coronary artery bypass surgery) and myocardial blood flow (MBF) returns to normal, myocardial function is still depressed for a variable period of time, usually days to weeks. (wikipedia.org)
  • These data show that acclimation to hypoxia has a direct effect on cod myocardial function and/or physiology, and suggest that the cod heart shows some adaptations to prolonged hypoxia. (biologists.com)
  • In addition, IPC reduced LDH and CK‑MB release, attenuated myocardial infarct size, improved cardiac function following I/R, and inhibited the elevation of ROS and MDA and the decrease in activities of the antioxidant enzymes SOD, CAT and GPx. (spandidos-publications.com)
Skeletal1
  • Although the clinical use of thiazolidinediones in type 2 diabetes is based on effects of these agents in adipose tissue, liver, and skeletal muscle to improve glycemic control, PPAR-γ is also expressed in myocardium ( 4 - 6 ). (diabetesjournals.org)
Metabolic1
  • Myocardial ischemia--metabolic pathways and implications of increased glycolysis. (smw.ch)
Severe1
  • Stress-rest 82 Rb myocardial perfusion PET images show moderate to severe reduction in tracer uptake to the mid/basal septum and inferior wall myocardium at peak stress which nearly normalizes at rest. (siemens-healthineers.com)
Moderate1
  • Elevation of myocardial enzymes is moderate at worst and there is absence of significant coronary artery disease. (findmeacure.com)
Injury1
  • Behavioural screening in 24 mouse mutants identified the kinase Fgr as a driver of this pathogenic state, and interference with Fgr protected mice from inflammatory injury. (studylib.net)
20011
  • Myocardial+Stunning at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Grund F (February 2001). (wikipedia.org)
Onset1
Syndrome1
Stress3
  • Der udføres sædvanligvis en optagelse i hvile og en under arbejdsbelastning (ergometercykling) eller farmakologisk stress. (ugeskriftet.dk)
  • Remaining LV myocardium including the LAD and LCX territories show normal values at stress and rest with normal MBFR. (siemens-healthineers.com)
  • Although non-invasive interventions may not affect existing large vessel structural defects such as stenosis, it is thought that adenosine stress and dialysate cooling therapy may improve myocardial BF by vasodilation of the smaller blood vessels. (frontiersin.org)
Hemodynamic1
Patients1
  • L'objectif de ce travail était de décrire le profi l des manifestations cardiovasculaires chez les patients vivants avec le VIH en le comparant à celui de patients séronégatifs. (bvsalud.org)
Patient2
  • The patient underwent a Rubidium 82 ( 82 Rb) PET/CT myocardial perfusion study on a Biograph Vision TM PET/CT system. (siemens-healthineers.com)
  • Early multiparametric CMR is able to localize areas of affected myocardium and may aid in the further management or diagnostic workup in this patient cohort. (biomedcentral.com)
Cardiovascular2
  • CaMKII in the Cardiovascular System: Sensing Redox States. (wanfangdata.com.cn)
  • As a member of neurotrophins with pro-survival effect on cardiovascular system buy real cytotec NGF was found to be crucial in maintaining normal myocardial performance [16]. (beccajcampbell.com)
Blood vessels1
  • These landscapes recognized leukocyte identities in the inflamed skin and trachea, and uncovered a continuum of neutrophil states inside blood vessels, including a large, sessile state that was embraced by the underlying endothelium and associated with pathogenic inflammation. (studylib.net)