Ischemic myocardiumRatsAtrial fibrillationApoptosisCoronaryHypertrophy inducedMyocarditisOverloadDobutamineArrhythmiasEndothelialMetabolismPneumonitisInfiltratesTissuesChronotropicContractionViablePathophysiologyOxidative stressHypertrophicIsoproterenolAngiotensinVitroInflammatoryDeletionEnzymesHeartIncidenceStem cellsActivationMolecularSignificantlyMethodsDamageTachycardiaMiceNormalPatientsEvidenceLeftCellsCell typesPresence
Ischemic myocardium2
- Direct measurement of free radical generation following reperfusion of ischemic myocardium. (google.ca)
- MMP 9-instructed assembly of bFGF nanofibers in ischemic myocardium to promote heart repair. (nih.gov)
Rats5
- Mild cardiac hypertrophy was induced in young female rats by an exercise model and in young male rats by surgical stenosis of the left renal artery. (ac.be)
- Wang JY, Shen J, Gao Q et al (2008) Ischemic postconditioning protects against global cerebral ischemia/reperfusion-induced injury in rats. (springer.com)
- Isoproterenol was administered in rats to induce myocardial infarction. (scialert.net)
- The effect of rosuvastatin and simvastatin therapy (10 mg/kg) for 5 weeks on blood-brain barrier (BBB), blood-retinal barrier (BRB), and cardiac muscle permeability of streptozotocin-induced diabetic rats was studied. (diabetesjournals.org)
- Priscilla DH and Prince PS: Cardioprotective effect of gallic acid on cardiac troponin-T, cardiac marker enzymes, lipid peroxidation products and antioxidants in experimentally induced myocardial infarction in Wistar rats. (spandidos-publications.com)
Atrial fibrillation3
- 2. The effects of experimentally induced atrial fibrillation compared with atrial tachycardia, therefore, were tested in 22 anaesthetized dogs. (portlandpress.com)
- 6. Thus atrial fibrillation may reduce coronary blood flow and induce myocardial ischaemia in the presence of coronary stenosis in excess of atrial tachycardia. (portlandpress.com)
- TY - JOUR T1 - Upregulation of matrix metalloproteinase-9 and tissue inhibitors of metalloproteinases in rapid atrial pacing-induced atrial fibrillation. (unboundmedicine.com)
Apoptosis3
- Res effectively suppress the cardiomyocytes hypertrophy and apoptosis induced by ISO, characterized by the reduction of the myocardial cell surface area, the ANP gene expression, the LDH and MDA leakage amount and the rate of cell apoptosis, while decrease of the protein expression of GRP78, GRP94 and CHOP, and reverse the expression of Bcl-2 and Bax. (karger.com)
- Myocardial I/R injury may induce cell apoptosis and autophagy by activating oxidative stress and upregulating inflammatory mediators, ultimately resulting in irreversible fibrotic damage ( 3 ). (spandidos-publications.com)
- Yuan Y, Guo Q, Ye Z et al (2011) Ischemic postconditioning protects brain from ischemia/reperfusion injury by attenuating endoplasmic reticulum stress-induced apoptosis through PI3K-Akt pathway. (springer.com)
Coronary3
- Stress is induced by either exercise or a pharmaceutical agent (dobutamine, dipyridamole, or adenosine), which increases coronary blood flow to the myocardium. (cadth.ca)
- As the myocardium becomes ischemic, coronary sinus blood pH falls, cellular potassium is lost, lactate accumulates, ECG abnormalities appear, and ventricular function (both systolic and diastolic) deteriorates. (msdmanuals.com)
- HN - 2008 BX - Granulosa Cells, Cumulus MH - Coronary Sinus UI - D054326 MN - A07.231.908.194.500 MS - A short vein that collects about two thirds of the venous blood from the MYOCARDIUM and drains into the RIGHT ATRIUM. (bvsalud.org)
Hypertrophy induced2
- At exercise induced hypertrophy V v , S v and L v of capillaries per tissue volume remained unchanged, whereas all these estimates were significantly decreased at hypertrophy induced by pressure overload. (ac.be)
- We hypothesize that LV systolic impairment is largely due to the acute effect of RV hypertrophy-induced reduction in diastolic filling whereas the chronic response of structural remodeling plays only a minor role. (frontiersin.org)
Myocarditis3
- Myocarditis is an inflammatory disease of the myocardium. (unl.edu)
- To fill these gaps, we sought to dissect the cellular compositions of heart tissues and infiltrates in CVB3-induced myocarditis, and developed a vaccine candidate to prevent CVB infections. (unl.edu)
- Immunization with Mt 10 vaccine completely protected mice against CVB3-induced myocarditis and pancreatitis by inducing VP1-reactive virus-neutralizing antibodies and antigen-specific T cell responses. (unl.edu)
Overload5
- The dynamics of iron regulation in the body is multifaceted and is altered in transfusion-induced iron overload. (medscape.com)
- In some disorders, such as β-thalassemia, excessive intestinal absorption also adds to the transfusion-induced iron overload. (medscape.com)
- When the plasma iron-binding protein transferrin is oversaturated, as in transfusion-induced iron overload, the excess iron circulates as relatively free non-transferrin-bound iron (NTBI). (medscape.com)
- Depressed Ca2+ activation of contraction as a consequence of reperfusion-induced cellular calcium overload in ferret hearts. (google.ca)
- Transfusion-induced iron overload superimposed on hepatitis C would accelerate the development of cirrhosis. (medscape.com)
Dobutamine4
- Stress was induced by dobutamine, dipyridamole, and exercise. (news-medical.net)
- Among the techniques routinely used to detect the presence of viable myocardium, special mention should be made of dobutamine stress echocardiography (DSE), isotopic testing in the form of Thallium-201 redistribution scintigraphy and, more recently introduced, the myocardial contrast echocardiography (MCE) techniques and magnetic resonance. (escardio.org)
- Low-dose dobutamine infusion is able to demonstrate the contractile reserve of myocardium as it shows an improved contractility following infusion of this positive inotropic drug. (escardio.org)
- In those situations where increased contractility is not induced by dobutamine, this technique defines the corresponding segment as non-viable. (escardio.org)
Arrhythmias3
- The immediate and completely reversible action of these chemicals on gap junctional communication paralleled their ability to sensitize the myocardium to catecholamine induced arrhythmias. (cdc.gov)
- Arrhythmogenic cardiomyopathy is a rare genetic entity characterized by progressive fibro-fatty replacement of myocardium leading to malignant arrhythmias, syncope, and sudden cardiac death. (intechopen.com)
- The disease affects mainly young males and arrhythmias are usually induced by exercise. (intechopen.com)
Endothelial3
- The discrepancies between studies on TMAO-induced endothelial dysfunction may be attributed to different cell types and animal models used, including different metabolic backgrounds, as well as to distinct TMAO treatment concentrations and durations. (nature.com)
- In particular, the invention relates to methods of inducing differentiation of embryonic stem cells into muscle cells or vascular endothelial cells. (justia.com)
- Therefore there remains a need for providing effective methods of inducing differentiation of stem cells into specific cell types, such as myocytes or endothelial cells. (justia.com)
Metabolism1
- Activation of the β3 receptors induces the metabolism of lipids. (wikipedia.org)
Pneumonitis3
- Pneumonitis or bronchitis induced by (Kress and Crispell 1944). (cdc.gov)
- RILI may include early radiation-induced pneumonitis and advanced stage radiation-induced lung fibrosis [ 1 ]. (hindawi.com)
- Radiation-induced pneumonitis and lung fibrosis are mostly observed in 4 to 30 weeks and 6 to 12 months after thoracic radiotherapy [ 3 ]. (hindawi.com)
Infiltrates1
- Acute necrotizing foci stippled with karyorrhexis and fibrin exudates and small plasmacytic infiltrates were found in myocardium, peripheral nerves and perineural tissues, liver, spleen, and lungs. (cdc.gov)
Tissues1
- Transfection with CXCR4 enhanced the quantity of transplanted HUMSCs in the radiation-induced injured lung tissues. (hindawi.com)
Chronotropic1
- Activation of β1 receptors induces positive inotropic, chronotropic output of the cardiac muscle, leading to increased heart rate and blood pressure, secretion of ghrelin from the stomach, and renin release from the kidneys. (wikipedia.org)
Contraction2
- cAMP then activates protein kinase A (PKA) which phosphorylates target proteins, ultimately inducing smooth muscle relaxation and contraction of the cardiac tissue. (wikipedia.org)
- Patients who are suffering from chronic inflammatory lung diseases such as asthma or COPD may be treated with medication targeted to induce more smooth muscle relaxation in the lungs and less contraction of the heart, including first-generation drugs like salbutamol (albuterol) and later-generation medications in the same class. (wikipedia.org)
Viable5
- Identification of viable and hibernating myocardium allows for a better selection of patients who need revascularisation. (escardio.org)
- Consequently, the noninvasive determination of viable myocardium is becoming increasingly important. (escardio.org)
- Thallium-201 with redistribution is a classical isotopic test used to detect viable myocardium in patients with ischemic heart disease and depressed ventricular function. (escardio.org)
- Although DSE and Thallium-201 with redistribution have been validated for the diagnosis of viable myocardium, they frequently yield conflicting results. (escardio.org)
- When both DSE and Thallium-201 are performed in the same patient, discordant results are often obtained In fact, in comparative studies where both techniques have been used prior to revascularisation procedures, the sensitivity, specificity and predictive value for the detection of viable myocardium have been found to differ. (escardio.org)
Pathophysiology1
- Pathophysiology and pathogenesis of stunned myocardium. (google.ca)
Oxidative stress2
- TMAO treatment for either 24H or 48H induces reduced cell viability and enhanced oxidative stress. (nature.com)
- This study demonstrates that TMAO induces distinct time-dependent molecular signatures involving inflammation and remodelling pathways, while pathways such as oxidative stress are also modulated, but in a non-time-dependent manner. (nature.com)
Hypertrophic2
- One member of this family, rac, induces actin cytoskeletal reorganization in nonmuscle cells and hypertrophic changes in cultured cardiomyocytes. (jci.org)
- Myocardial strain imaging, a reproducible measure of LV systolic function, can identify subclinical LV dysfunction and patterns that suggest specific cardiomyopathies (eg, ischemic cardiomyopathy, amyloidosis, hypertrophic cardiomyopathy, chemotherapy-induced cardiotoxicity). (medscape.com)
Isoproterenol1
- This study was undertaken to investigate whether Res can protect the heart suffering from hypertrophy injuries induced by isoproterenol (ISO), and whether the protective effect is mediated by endoplasmic reticulum (ER) stress. (karger.com)
Angiotensin2
- Moreover, AMPK activation attenuated the proinflammatory actions induced by STAT1 activators such as interferon-γ and angiotensin II (AngII). (diabetesjournals.org)
- Muller DN, Mervaala EM, Dechend R, et al: Angiotensin II (AT(1)) receptor blockade reduces vascular tissue factor in angiotensin II-induced cardiac vasculopathy. (spandidos-publications.com)
Vitro1
- In in vivo and in vitro studies, MSCs were found to alleviate irradiation-induced lung injuries not only by the secretion of cytokines, growth factors, and paracrine molecules but also by immunomodulatory effect. (hindawi.com)
Inflammatory1
- The metabolic abnormalities of type 2 diabetes, including hyperglycemia, dyslipidemia, and insulin resistance, activate the Janus kinases/signal transducer and activator of transcription (JAK/STAT) signaling pathway, a major intracellular inflammatory cascade that transmits the intracellular signaling to the nucleus ( 2 ), promoting inflammatory response, inducing insulin resistance ( 3 ), and accelerating the development of cardiovascular complications ( 4 ). (diabetesjournals.org)
Deletion1
- Furthermore, genetic deletion of CITED4 in the heart prohibits regional exercise-induced microstructural helicity remodeling. (researchgate.net)
Enzymes1
- In addition treatment with T. terrestris decreased the leakage of CK-MB and LDH enzymes from myocardium, there was a significant improvement in cardiac function as evidenced by correction of MAP, HR, LVEDP and contractility and relaxation. (scialert.net)
Heart5
- Both exercise-induced molecular mechanisms and physiological cardiac remodeling have been previously studied on a whole heart level. (researchgate.net)
- Zellner JL, Spinale FG, Eble DM, Hewett KW, Crawford FA Jr.. Alterations in myocyte shape and basement attachment with tachycardia-induced heart failure. (wikidoc.org)
- MPI-SPECT imaging is a great asset for CAD diagnosis since it may offer a functional evaluation of the myocardium and heart arteries non-invasively. (news-medical.net)
- The left ventricular (LV) myocardium, eliminating the heart cavities, was delineated manually on rest-stress MPI-SPECT scans to determine the desired volume for investigation. (news-medical.net)
- Heart muscle cells die en masse after injury, yet the adult mammalian heart retains little capacity to regenerate them. (natureasia.com)
Incidence1
- The incidence rate of severe irradiation-induced lung injuries reported is 15% among patients treated by thoracic radiotherapy [ 4 ]. (hindawi.com)
Stem cells4
- The present invention relates to methods of inducing differentiation of stem cells. (justia.com)
- Whilst differentiation of some lineage specific stem cells can be induced with a degree of certainty, a differentiation outcome of a population of pluripotent stem cells is less predictable. (justia.com)
- Methods of inducing differentiation in stem cells and muscle cells produced therefrom may be used for the study of cellular and molecular biology of tissue development, for the discovery of genes and proteins such as differentiation factors that play a role in tissue development and regeneration. (justia.com)
- Less quantity of transplanted mesenchymal stem cells (MSCs) influences the therapeutic effects on radiation-induced lung injury (RILI). (hindawi.com)
Activation3
- Activation of β2 receptors induces smooth muscle relaxation in the lungs, gastrointestinal tract, uterus, and various blood vessels. (wikipedia.org)
- To examine the effect of rac1 activation upon cardiac structure and function, transgenic mice were created that express constitutively activated rac1 specifically in the myocardium. (jci.org)
- The rac1 target p21-activated kinase translocated from a cytosolic to a cytoskeletal distribution, suggesting that rac1 activation was inducing focal adhesion reorganization. (jci.org)
Molecular2
- Taken together, CITED4 expression is necessary for exercise-induced regional remodeling of the heart's microstructural helicity revealing how a key molecular regulator of cardiac remodeling manifests into downstream local tissue-level changes. (researchgate.net)
- Expression of transcription factor CITED4 is necessary for exercise-induced regional remodeling of the heart's microstructural helicity, revealing how a key molecular regulator of cardiac remodeling mediates local tissue-level changes. (researchgate.net)
Significantly1
- In AF atria, in situ gelatinase activity was mainly localized in the interstitium of atrial myocardium, and was significantly larger than that of sinus rhythm control (i.e., sham control). (unboundmedicine.com)
Methods1
- SUMMIT will also generate animals in which alteration of gene function can be induced in later life: this will involve both conventional methods (using tetracycline and tamoxifen) as well as a novel lentiviral transgenesis technology which allows in vivo siRNA-knockdown of genes that would be embryonic lethal using conventional technologies. (lu.se)
Damage1
- Preliminary Investigations Into the Effect of Exercise-Induced Muscle Damage on Systemic Extracellular Vesicle Release in Trained Younger and Older Men. (open.ac.uk)
Tachycardia2
- Tachycardia induced cardiomyopathy is a decline in left ventricular function and left ventricular dilation as a result of chronic or frequently recurring paroxysmal tachycardia. (wikidoc.org)
- The primary treatment for a tachycardia induced cardiomyopathy is correct the underlying tachycardia. (wikidoc.org)
Mice1
- In mice, Streptococcus pneumoniae can invade the myocardium, induce cardiomyocyte death, and disrupt cardiac function following bacteremia, but it is unknown whether the same occurs in humans with severe pneumonia. (jcvi.org)
Normal2
- Mechanism for electrical initiation of reentry in normal canine myocardium. (bvsalud.org)
- Used in LGE assessment, gadolinium is an extracellular chelating agent that permeates the interstitial space of both normal and abnormal myocardium . (medscape.com)
Patients2
- Radiotherapy, the commonly used treatment for thoracic malignant tumor, can lead to severe complications in some patients, like radiation-induced lung injury (RILI). (hindawi.com)
- bed into the left ventricle, from where or intramyocardial, However, when a Most patients with calcification of it could reach any part of the body cyst is located in subendocardial en- the cyst wall remain asymptomatic for through systemic circulation [1-3]. (who.int)
Evidence1
- In regard to interventional ASD closure our data do not provide evidence that the child's myocardium is more vulnerable. (bmj.com)
Left1
- [18] The pace of recovery of left ventricual dysfunctionis similar to that of hibernating myocardium [19] . (wikidoc.org)
Cells2
- Placing the cells under conditions which induce specific cell types has been one form of an attempt to regulate the differentiation outcome. (justia.com)
- Ferroptosis-inducing factors can directly or indirectly affect glutathione peroxidase through different pathways, resulting in a decrease in antioxidant capacity and accumulation of lipid reactive oxygen species (ROS) in cells, ultimately leading to oxidative cell death. (nature.com)
Cell types1
- Generally, when a stem cell culture is induced to differentiate, the differentiated population is analysed for particular cell types by expression of genes, markers or phenotypic analysis. (justia.com)
Presence1
- culturing a stem cell in the presence of an embryonic cell and/or extracellular medium of an embryonic cell, under conditions that induce differentiation of the stem cell. (justia.com)